alpidem (BioDeep_00000858739)

   


代谢物信息卡片


alpidem

化学式: C21H23Cl2N3O (403.1218088)
中文名称: 阿尔吡登
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCN(CCC)C(=O)CC1=C(N=C2N1C=C(C=C2)Cl)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic

同义名列表

1 个代谢物同义名

alpidem



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Yi Luo, Payal Rana, Yvonne Will. Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicological sciences : an official journal of the Society of Toxicology. 2012 Oct; 129(2):346-62. doi: 10.1093/toxsci/kfs208. [PMID: 22700542]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Susanna J Fenwick, James P Scarth. In vitro metabolism of tiletamine, zolazepam and nonbenzodiazepine sedatives: Identification of target metabolites for equine doping control. Drug testing and analysis. 2011 Oct; 3(10):705-16. doi: 10.1002/dta.300. [PMID: 21916022]
  • Federico Da Settimo, Francesca Simorini, Sabrina Taliani, Concettina La Motta, Anna Maria Marini, Silvia Salerno, Marusca Bellandi, Ettore Novellino, Giovanni Greco, Barbara Cosimelli, Eleonora Da Pozzo, Barbara Costa, Nicola Simola, Micaela Morelli, Claudia Martini. Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. Journal of medicinal chemistry. 2008 Sep; 51(18):5798-806. doi: 10.1021/jm8003224. [PMID: 18729350]
  • Hugues Chevassus, Isabelle Mourand, Nathalie Molinier, Bruno Lacarelle, Jean-Frédéric Brun, Pierre Petit. Assessment of single-dose benzodiazepines on insulin secretion, insulin sensitivity and glucose effectiveness in healthy volunteers: a double-blind, placebo-controlled, randomized cross-over trial [ISRCTN08745124]. BMC clinical pharmacology. 2004 Mar; 4(?):3. doi: 10.1186/1472-6904-4-3. [PMID: 15102335]
  • Taketoshi Okubo, Ryoko Yoshikawa, Shigeyuki Chaki, Shigeru Okuyama, Atsuro Nakazato. Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands. Bioorganic & medicinal chemistry. 2004 Jan; 12(2):423-38. doi: 10.1016/j.bmc.2003.10.050. [PMID: 14723961]
  • Badia Ferzaz, Emmanuel Brault, Genevieve Bourliaud, Jean-Pierre Robert, Gilles Poughon, Yves Claustre, Franck Marguet, Philippe Liere, Michael Schumacher, Jean-Pierre Nowicki, Jacqueline Fournier, Benoit Marabout, Mireille Sevrin, Pascal George, Philippe Soubrie, Jesus Benavides, Bernard Scatton. SSR180575 (7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. The Journal of pharmacology and experimental therapeutics. 2002 Jun; 301(3):1067-78. doi: 10.1124/jpet.301.3.1067. [PMID: 12023539]
  • S Selleri, F Bruni, C Costagli, A Costanzo, G Guerrini, G Ciciani, B Costa, C Martini. 2-Arylpyrazolo[1,5-a]pyrimidin-3-yl acetamides. New potent and selective peripheral benzodiazepine receptor ligands. Bioorganic & medicinal chemistry. 2001 Oct; 9(10):2661-71. doi: 10.1016/s0968-0896(01)00192-4. [PMID: 11557354]
  • G Trapani, M Franco, L Ricciardi, A Latrofa, G Genchi, E Sanna, F Tuveri, E Cagetti, G Biggio, G Liso. Synthesis and binding affinity of 2-phenylimidazo[1,2-alpha]pyridine derivatives for both central and peripheral benzodiazepine receptors. A new series of high-affinity and selective ligands for the peripheral type. Journal of medicinal chemistry. 1997 Sep; 40(19):3109-18. doi: 10.1021/jm970112+. [PMID: 9301675]
  • P H Bernard, B Le Bail, J Carles, R Fawaz, C Balabaud, J Rosenbaum, P Bioulac-Sage. Morphology of hepatic stellate cells in patients with fulminant or subfulminant hepatitis requiring liver transplantation. Journal of submicroscopic cytology and pathology. 1996 Jan; 28(1):5-12. doi: NULL. [PMID: 8929622]
  • L Flaminio, M Ripamonti, V Ascalone. Determination of alpidem, an imidazopyridine anxiolytic, and its metabolites by column-switching high-performance liquid chromatography with fluorescence detection. Journal of chromatography. A. 1994 May; 668(2):403-11. doi: 10.1016/0021-9673(94)80132-0. [PMID: 7913366]
  • Y Gaillard, J P Gay-Montchamp, M Ollagnier. Simultaneous screening and quantitation of alpidem, zolpidem, buspirone and benzodiazepines by dual-channel gas chromatography using electron-capture and nitrogen-phosphorus detection after solid-phase extraction. Journal of chromatography. 1993 Dec; 622(2):197-208. doi: 10.1016/0378-4347(93)80266-7. [PMID: 7908670]
  • A Tracqui, P Kintz, P Mangin. High-performance liquid chromatographic assay with diode-array detection for toxicological screening of zopiclone, zolpidem, suriclone and alpidem in human plasma. Journal of chromatography. 1993 Jun; 616(1):95-103. doi: 10.1016/0378-4347(93)80476-k. [PMID: 8104192]
  • D Garrigou-Gadenne, A Durand, J P Thenot, P L Morselli. The disposition and pharmacokinetics of alpidem, a new anxiolytic, in the rat. Drug metabolism and disposition: the biological fate of chemicals. 1991 May; 19(3):574-9. doi: NULL. [PMID: 1680622]
  • J H Jonkman, G Bianchetti, G Grasmeijer, B Oosterhuis, J F Thiercelin, J P Thénot, P Guillet, P L Morselli. Clinical pharmacokinetics and tolerability of alpidem in healthy subjects given increasing single doses. European journal of clinical pharmacology. 1991; 41(4):369-74. doi: 10.1007/bf00314970. [PMID: 1687121]
  • J P Desager, R Hulhoven, C Harvengt, G Bianchetti. Effect of cimetidine on the pharmacodynamics, pharmacokinetics and biotransformation of a single oral dose of alpidem. International journal of clinical pharmacology, therapy, and toxicology. 1990 Dec; 28(12):498-503. doi: . [PMID: 1982281]
  • G M Pacifici, G Bianchetti, A Viani, G Rizzo, M Carrai, J Allen, P L Morselli. Plasma protein binding of alpidem in healthy volunteers, in neonates and in liver or renal insufficiency. European journal of clinical pharmacology. 1989; 37(1):29-32. doi: 10.1007/bf00609419. [PMID: 2574111]
  • S Z Langer, S Arbilla. Imidazopyridines as a tool for the characterization of benzodiazepine receptors: a proposal for a pharmacological classification as omega receptor subtypes. Pharmacology, biochemistry, and behavior. 1988 Apr; 29(4):763-6. doi: 10.1016/0091-3057(88)90202-x. [PMID: 2842809]
  • S Z Langer, S Arbilla. Limitations of the benzodiazepine receptor nomenclature: a proposal for a pharmacological classification as omega receptor subtypes. Fundamental & clinical pharmacology. 1988; 2(3):159-70. doi: 10.1111/j.1472-8206.1988.tb00629.x. [PMID: 2841212]
  • J Ganansia, G Bianchetti, J P Thénot. Correlation between reversed-phase high-performance liquid chromatography and plasma protein binding. Journal of chromatography. 1987 Oct; 421(1):83-90. doi: 10.1016/0378-4347(87)80381-x. [PMID: 2892848]
  • P Padovani, P Guinebault, S Vajta, A Durand, J Allen, J P Thenot, P L Morselli. A preliminary metabolic study of alpidem in rat and man. European journal of drug metabolism and pharmacokinetics. 1987 Oct; 12(4):295-8. doi: 10.1007/bf03189916. [PMID: 3449388]
  • V Ascalone, P Catalani, L Dal Bo', N Deschamps, P Guinebault. Determination of alpidem and its metabolites in human plasma by high-performance liquid chromatography and fluorimetric detection. Journal of chromatography. 1987 Feb; 414(1):101-8. doi: 10.1016/0378-4347(87)80028-2. [PMID: 2883194]