Pyrithione ZINC (BioDeep_00000858710)
代谢物信息卡片
Pyrithione ZINC
化学式: C10H8N2O2S2Zn (315.9318638)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=S)N(C=C1)[O-].C1=CC(=S)N(C=C1)[O-].[Zn+2]
InChI: +2
描述信息
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- KEGGdrug: D01938
- PubChem: 3005837
- ChEMBL: CHEMBL1200471
- ChEMBL: CHEMBL3392049
- ChEBI: CHEBI:32076
- PubChem: 586169
- CAS: 13463-41-7
- NIKKAJI: J10.212A
- KEGG: C13427
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Damla Dag, Jooyeoun Jung, Yanyun Zhao. Development and characterization of cellulose nanofiber reinforced hydroxypropyl methylcellulose films functionalized with propolis-loaded zein nanoparticles and its application for cheddar cheese storage.
International journal of biological macromolecules.
2024 Mar; 261(Pt 2):129790. doi:
10.1016/j.ijbiomac.2024.129790. [PMID: 38307431] - Dongju Shin, Youmi Choi, Zhi Yang Soon, Moonkoo Kim, Dae-Jung Kim, Jee-Hyun Jung. Comparative toxicity study of waterborne two booster biocides (CuPT and ZnPT) on embryonic flounder (Paralichthys olivaceus).
Ecotoxicology and environmental safety.
2022 Mar; 233(?):113337. doi:
10.1016/j.ecoenv.2022.113337. [PMID: 35219958] - Rajnish Prakash Singh, Dev Mani Pandey, Prabhat Nath Jha, Ying Ma. ACC deaminase producing rhizobacterium Enterobacter cloacae ZNP-4 enhance abiotic stress tolerance in wheat plant.
PloS one.
2022; 17(5):e0267127. doi:
10.1371/journal.pone.0267127. [PMID: 35522667] - Neeta Kumari, Sambit Nath Bhattacharya, Shukla Das, Shyama Datt, Taru Singh, Manjeet Jassal, Ashwini K Agrawal. In Situ Functionalization of Cellulose with Zinc Pyrithione for Antimicrobial Applications.
ACS applied materials & interfaces.
2021 Oct; 13(40):47382-47393. doi:
10.1021/acsami.1c14113. [PMID: 34606229] - Gary L Diamond, Nicholas P Skoulis, A Robert Jeffcoat, J Frank Nash. A Physiological-Based Pharmacokinetic Model For The Broad Spectrum Antimicrobial Zinc Pyrithione: II. Dermal Absorption And Dosimetry In The Rat.
Journal of toxicology and environmental health. Part A.
2021 08; 84(15):609-631. doi:
10.1080/15287394.2021.1912678. [PMID: 33886436] - Eric E Figueroa, Jerod S Denton. Zinc pyrithione activates the volume-regulated anion channel through an antioxidant-sensitive mechanism.
American journal of physiology. Cell physiology.
2021 06; 320(6):C1088-C1098. doi:
10.1152/ajpcell.00070.2021. [PMID: 33826406] - Cheryl Leong, Joyce Wang, Min Jet Toi, Yuen In Lam, Joleen Pz Goh, Shi Mun Lee, Thomas L Dawson. Effect of zinc pyrithione shampoo treatment on skin commensal Malassezia.
Medical mycology.
2021 Feb; 59(2):210-213. doi:
10.1093/mmy/myaa068. [PMID: 32785575] - Md Niamul Haque, Sang-Eun Nam, Hye-Jin Eom, Seung-Kyu Kim, Jae-Sung Rhee. Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage.
Marine pollution bulletin.
2020 Jul; 156(?):111276. doi:
10.1016/j.marpolbul.2020.111276. [PMID: 32510415] - Mingjun Yang, Jingying Hu, Minjie Xia, Yuzhu Wang, Fang Tian, Weihua Li, Yinqiang Sun, Zhijun Zhou. Zinc pyrithione induces immobilization of human spermatozoa and suppresses the response of the cAMP/PKA signaling pathway.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Sep; 137(?):104984. doi:
10.1016/j.ejps.2019.104984. [PMID: 31276740] - Byung-Hwa Min, Manoharan Saravanan, Sang-Eun Nam, Hye-Jin Eom, Jae-Sung Rhee. Waterborne zinc pyrithione modulates immunity, biochemical, and antioxidant parameters in the blood of olive flounder.
Fish & shellfish immunology.
2019 Sep; 92(?):469-479. doi:
10.1016/j.fsi.2019.06.048. [PMID: 31252041] - Ye Zhao, Yuyang Liu, Jing Sun, Hongtao Sha, Yu Yang, Qian Ye, Qi Yang, Baoqi Huang, Yadong Yu, He Huang. Acute toxic responses of embryo-larval zebrafish to zinc pyrithione (ZPT) reveal embryological and developmental toxicity.
Chemosphere.
2018 Aug; 205(?):62-70. doi:
10.1016/j.chemosphere.2018.04.010. [PMID: 29684692] - Tao Ren, Gui-Hong Fu, Teng-Fei Liu, Kun Hu, Hao-Ran Li, Wen-Hong Fang, Xian-Le Yang. Toxicity and accumulation of zinc pyrithione in the liver and kidneys of Carassius auratus gibelio: association with P-glycoprotein expression.
Fish physiology and biochemistry.
2017 Feb; 43(1):1-9. doi:
10.1007/s10695-016-0262-y. [PMID: 27387320] - Gary L Diamond, Nicholas P Skoulis, A Robert Jeffcoat, J Frank Nash. A physiologically based pharmacokinetic model for the broad-spectrum antimicrobial zinc pyrithione: I. Development and verification.
Journal of toxicology and environmental health. Part A.
2017; 80(2):69-90. doi:
10.1080/15287394.2016.1245123. [PMID: 28085645] - C Onlom, S Khanthawong, N Waranuch, K Ingkaninan. In vitro anti-Malassezia activity and potential use in anti-dandruff formulation of Asparagus racemosus.
International journal of cosmetic science.
2014 Feb; 36(1):74-8. doi:
10.1111/ics.12098. [PMID: 24117781] - K J Mills, P Hu, J Henry, M Tamura, J P Tiesman, J Xu. Dandruff/seborrhoeic dermatitis is characterized by an inflammatory genomic signature and possible immune dysfunction: transcriptional analysis of the condition and treatment effects of zinc pyrithione.
The British journal of dermatology.
2012 Jun; 166 Suppl 2(?):33-40. doi:
10.1111/j.1365-2133.2012.10863.x. [PMID: 22670617] - Sarah D Lamore, Georg T Wondrak. Zinc pyrithione impairs zinc homeostasis and upregulates stress response gene expression in reconstructed human epidermis.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2011 Oct; 24(5):875-90. doi:
10.1007/s10534-011-9441-6. [PMID: 21424779] - Stuart E Lind, Jong Sung Park, John W Drexler. Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes.
Translational research : the journal of laboratory and clinical medicine.
2009 Sep; 154(3):153-9. doi:
10.1016/j.trsl.2009.06.002. [PMID: 19665691] - J S Rogers, A E Moore, H Meldrum, C R Harding. Increased scalp skin lipids in response to antidandruff treatment containing zinc pyrithione.
Archives of dermatological research.
2003 Jul; 295(3):127-9. doi:
10.1007/s00403-003-0406-7. [PMID: 12811576] - R R Warner, J R Schwartz, Y Boissy, T L Dawson. Dandruff has an altered stratum corneum ultrastructure that is improved with zinc pyrithione shampoo.
Journal of the American Academy of Dermatology.
2001 Dec; 45(6):897-903. doi:
10.1067/mjd.2001.117849. [PMID: 11712036] - E Ermolayeva, D Sanders. Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa.
Applied and environmental microbiology.
1995 Sep; 61(9):3385-90. doi:
10.1128/aem.61.9.3385-3390.1995. [PMID: 7574648] - K Weismann. Chelating drugs and zinc.
Danish medical bulletin.
1986 Aug; 33(4):208-11. doi:
NULL. [PMID: 3091327] - W T Gibson, M Chamberlain, J F Parsons, J E Brunskill, D Leftwich, S Lock, R J Safford. The effect and mode of action of zinc pyrithione on cell growth. I. In vitro studies.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
1985 Jan; 23(1):93-102. doi:
10.1016/0278-6915(85)90226-1. [PMID: 3882533] - W B Gibson, A R Jeffcoat, T S Turan, R H Wendt, P F Hughes, M E Twine. Zinc pyridinethione: serum metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing.
Toxicology and applied pharmacology.
1982 Feb; 62(2):237-50. doi:
10.1016/0041-008x(82)90122-3. [PMID: 7058528] - A R Jeffcoat, W B Gibson, P A Rodriguez, T S Turan, P F Hughes, M E Twine. Zinc pyridinethione: urinary metabolites of zinc pyridinethione in rabbits, rats, monkeys, and dogs after oral dosing.
Toxicology and applied pharmacology.
1980 Oct; 56(1):141-54. doi:
10.1016/0041-008x(80)90139-8. [PMID: 7444962] - R C Spiker, H P Ciuchta. Effects of pyrithiones and surfactants on zinc and enzyme levels in rabbits.
American Industrial Hygiene Association journal.
1980 Apr; 41(4):248-52. doi:
10.1080/15298668091424690. [PMID: 7395740] - J H Wedig, R A Wentworth, M A Gallo, J G Babish, J D Henion. Disposition of zinc pyrithione in the rat.
Food and cosmetics toxicology.
1978 Dec; 16(6):553-61. doi:
10.1016/s0015-6264(78)80223-5. [PMID: 730082]