CNS-7056 (BioDeep_00000858681)
代谢物信息卡片
Remimazolam
化学式: C21H19BrN4O2 (438.0691294)
中文名称: 瑞米唑仑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C2N1C3=C(C=C(C=C3)Br)C(=NC2CCC(=O)OC)C4=CC=CC=N4
InChI: InChI=1S/C21H19BrN4O2/c1-13-12-24-21-17(7-9-19(27)28-2)25-20(16-5-3-4-10-23-16)15-11-14(22)6-8-18(15)26(13)21/h3-6,8,10-12,17H,7,9H2,1-2H3/t17-/m0/s1
描述信息
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CD - Benzodiazepine derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11788
- PubChem: 9867812
- DrugBank: DB12404
- ChEMBL: CHEMBL4297526
- CAS: 308242-62-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lidan Huang, Hong Liu, Xue Zou, Jiawang Ding, Song Tao. Adverse Drug Events Observed with the Newly Approved Remimazolam in Comparison to Propofol for General Anesthesia in Patients Undergoing Surgery: A Meta-analysis.
Advances in therapy.
2024 May; 41(5):1896-1910. doi:
10.1007/s12325-024-02820-1. [PMID: 38480661] - Jinfang Song, Wenqiang Yu, Shuangquan Chen, Jiamin Huang, Chujun Zhou, Hua Liang. Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
European journal of pharmacology.
2024 Mar; 966(?):176342. doi:
10.1016/j.ejphar.2024.176342. [PMID: 38290569] - Ling Zhou, Yang Jianying. Letter to the article by Yunoki et al.
Journal of anesthesia.
2024 Feb; 38(1):148. doi:
10.1007/s00540-023-03280-7. [PMID: 37930421] - Changyin Lu, Yin Kang, Quehua Luo, Fei Zhong, Yujing Cai, Guangyan Zhang, Zhimin Guo, Shaoting Zhang, Jue Ma, HaiHua Shu. Effectiveness of general anaesthesia with remimazolam tosilate on intraoperative haemodynamics and postoperative recovery: study protocol for a randomised, positive-controlled, pragmatic clinical trial (GARTH trial).
BMJ open.
2024 01; 14(1):e073024. doi:
10.1136/bmjopen-2023-073024. [PMID: 38176870] - Wenwen Ni, Xiuwen Yi, Lili Feng, Yilei Shen, Jiali Jiao, Yirong Cai, Danyun Fu, Yuan Han, Ji'e Jia, Wenxian Li. Comparison of different weight-based scalars of remimazolam tosylate for anesthesia induction in obese patients: study protocol for a prospective, controlled trial.
Trials.
2023 Nov; 24(1):719. doi:
10.1186/s13063-023-07739-6. [PMID: 37950290] - Mei-Ji Zhao, Hai-Feng Hu, Xin-Lei Li, Xiao-Ming Li, Da-Chuan Wang, Ming-Jie Kuang. The safety and efficacy between remimazolam and propofol in intravenous anesthesia of endoscopy operation: a systematic review and meta-analysis.
International journal of surgery (London, England).
2023 Nov; 109(11):3566-3577. doi:
10.1097/js9.0000000000000638. [PMID: 37534687] - Ai Wei, Shijin Ma, Yuzhe Dou, Xiaojun Wang, Jianxiong Wu, Shuzhi Zhou, Yanfang Deng, Xinquan Liu, Dongming Li, Mengchang Yang. The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial.
PloS one.
2023; 18(8):e0282930. doi:
10.1371/journal.pone.0282930. [PMID: 37535618] - Yusheng Yao, Jinsheng Guan, Linwei Liu, Bingbing Fu, Lei Chen, Xiaochun Zheng. Discharge readiness after remimazolam versus propofol for colonoscopy: A randomised, double-blind trial.
European journal of anaesthesiology.
2022 12; 39(12):911-917. doi:
10.1097/eja.0000000000001715. [PMID: 35796575] - Junbao Zhang, Xin Wang, Qing Zhang, Zicheng Wang, Shoufeng Zhu. Application effects of remimazolam and propofol on elderly patients undergoing hip replacement.
BMC anesthesiology.
2022 04; 22(1):118. doi:
10.1186/s12871-022-01641-5. [PMID: 35461223] - Zhixia Lu, Na Zhou, Yan Li, Li Yang, Wei Hao. Up-down determination of the 90\% effective dose (ED90) of remimazolam besylate for anesthesia induction.
Annals of palliative medicine.
2022 Feb; 11(2):568-573. doi:
10.21037/apm-22-89. [PMID: 35249335] - Yoko Shimamoto, Michiyoshi Sanuki, Shigeaki Kurita, Masaya Ueki, Yoshie Kuwahara, Ayumu Matsumoto. Factors affecting prolonged time to extubation in patients given remimazolam.
PloS one.
2022; 17(5):e0268568. doi:
10.1371/journal.pone.0268568. [PMID: 35584094] - Yulin Zhu, Chen Li, Jingui Yu, Lingzhi Yu, Wei Shao, Shujun Shang. Interaction of remimazolam benzenesulfonate and human serum albumin: a simulated physiological study.
Luminescence : the journal of biological and chemical luminescence.
2022 Jan; 37(1):51-57. doi:
10.1002/bio.4145. [PMID: 34610201] - Yuta Horikoshi, Norifumi Kuratani, Ken Tateno, Hiroshi Hoshijima, Tina Nakamura, Tsutomu Mieda, Katsushi Doi, Hiroshi Nagasaka. Anesthetic management with remimazolam for a pediatric patient with Duchenne muscular dystrophy.
Medicine.
2021 Dec; 100(49):e28209. doi:
10.1097/md.0000000000028209. [PMID: 34889305] - Tianxiao Liu, Ting Lai, Jing Chen, Yizhi Lu, Fang He, Yanhua Chen, Yubo Xie. Effect of remimazolam induction on hemodynamics in patients undergoing valve replacement surgery: A randomized, double-blind, controlled trial.
Pharmacology research & perspectives.
2021 10; 9(5):e00851. doi:
10.1002/prp2.851. [PMID: 34390228] - Thomas Stöhr, Pieter J Colin, Joachim Ossig, Marija Pesic, Keith Borkett, Peter Winkle, Michel M R F Struys, Frank Schippers. Pharmacokinetic properties of remimazolam in subjects with hepatic or renal impairment.
British journal of anaesthesia.
2021 Sep; 127(3):415-423. doi:
10.1016/j.bja.2021.05.027. [PMID: 34246461] - Kota Tsurumi, Shinji Takahashi, Yoshiyuki Hiramoto, Kazuhiro Nagumo, Tomonori Takazawa, Yoichiro Kamiyama. Remimazolam anaphylaxis during anesthesia induction.
Journal of anesthesia.
2021 08; 35(4):571-575. doi:
10.1007/s00540-021-02934-8. [PMID: 34050439] - Jie Zhou, Laura Curd, Lauren R L Lohmer, Natalie Delpratt, Joachim Ossig, Frank Schippers, Thomas Stoehr, Virginia D Schmith. A population pharmacodynamic Markov mixed-effects model for determining remimazolam-induced sedation when co-administered with fentanyl in procedural sedation.
Clinical and translational science.
2021 07; 14(4):1554-1565. doi:
10.1111/cts.13023. [PMID: 33768731] - Kun Hu, Qian Xiang, Zhe Wang, Xiaoyan Sheng, Li'e Li, Yan Liang, Xia Zhao, Xia Ye, Yimin Cui. Effects of Vitamin D Receptor, Cytochrome P450 3A, and Cytochrome P450 Oxidoreductase Genetic Polymorphisms on the Pharmacokinetics of Remimazolam in Healthy Chinese Volunteers.
Clinical pharmacology in drug development.
2021 01; 10(1):22-29. doi:
10.1002/cpdd.797. [PMID: 32250057] - Jie Zhou, Laura Curd, Lauren L Lohmer, Joachim Ossig, Frank Schippers, Thomas Stoehr, Virginia Schmith. Population Pharmacokinetics of Remimazolam in Procedural Sedation With Nonhomogeneously Mixed Arterial and Venous Concentrations.
Clinical and translational science.
2021 01; 14(1):326-334. doi:
10.1111/cts.12875. [PMID: 33045130] - Tomoyuki Watanabe, Hirotsugu Miyoshi, Yuko Noda, Soshi Narasaki, Atsushi Morio, Yukari Toyota, Hiroshi Kimura, Keiko Mukaida, Toshimichi Yasuda, Yasuo M Tsutsumi. Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation.
BioMed research international.
2021; 2021(?):8845129. doi:
10.1155/2021/8845129. [PMID: 33490280] - Jie Zhou, Cathrine Leonowens, Vijay D Ivaturi, Lauren L Lohmer, Laura Curd, Joachim Ossig, Frank Schippers, Karl-Uwe Petersen, Thomas Stoehr, Virginia Schmith. Population pharmacokinetic/pharmacodynamic modeling for remimazolam in the induction and maintenance of general anesthesia in healthy subjects and in surgical subjects.
Journal of clinical anesthesia.
2020 Nov; 66(?):109899. doi:
10.1016/j.jclinane.2020.109899. [PMID: 32585566] - Marija Pesic, Thomas Stöhr, Joachim Ossig, Keith Borkett, Martin Donsbach, Van-Anh Dao, Lynn Webster, Frank Schippers. Remimazolam Has Low Oral Bioavailability and No Potential for Misuse in Drug-Facilitated Sexual Assaults, with or Without Alcohol: Results from Two Randomised Clinical Trials.
Drugs in R&D.
2020 Sep; 20(3):267-277. doi:
10.1007/s40268-020-00317-0. [PMID: 32757149] - Frank Schippers, Marija Pesic, Robert Saunders, Keith Borkett, Shawn Searle, Lynn Webster, Thomas Stoehr. Randomized Crossover Trial to Compare Abuse Liability of Intravenous Remimazolam Versus Intravenous Midazolam and Placebo in Recreational Central Nervous System Depressant Users.
Journal of clinical pharmacology.
2020 09; 60(9):1189-1197. doi:
10.1002/jcph.1614. [PMID: 32495449] - Robert B Kleiman, Borje Darpo, Michael Thorn, Thomas Stoehr, Frank Schippers. Potential strategy for assessing QT/QTc interval for drugs that produce rapid changes in heart rate: Electrocardiographic assessment of the effects of intravenous remimazolam on cardiac repolarization.
British journal of clinical pharmacology.
2020 08; 86(8):1600-1609. doi:
10.1111/bcp.14270. [PMID: 32144789] - Jürgen Schüttler, Andreas Eisenried, Marco Lerch, Jörg Fechner, Christian Jeleazcov, Harald Ihmsen. Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part I. Pharmacokinetics and Clinical Pharmacodynamics.
Anesthesiology.
2020 04; 132(4):636-651. doi:
10.1097/aln.0000000000003103. [PMID: 31972655] - Andreas Eisenried, Jürgen Schüttler, Marco Lerch, Harald Ihmsen, Christian Jeleazcov. Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers: Part II. Pharmacodynamics of Electroencephalogram Effects.
Anesthesiology.
2020 04; 132(4):652-666. doi:
10.1097/aln.0000000000003102. [PMID: 31972657] - Xia Chen, Nuoer Sang, Kaicheng Song, Wen Zhong, Hongyun Wang, Ji Jiang, Yuguang Huang, Pei Hu. Psychomotor Recovery Following Remimazolam-induced Sedation and the Effectiveness of Flumazenil as an Antidote.
Clinical therapeutics.
2020 04; 42(4):614-624. doi:
10.1016/j.clinthera.2020.02.006. [PMID: 32178858] - Ying Zhou, Pei Hu, Ji Jiang. Metabolite characterization of a novel sedative drug, remimazolam in human plasma and urine using ultra high-performance liquid chromatography coupled with synapt high-definition mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2017 Apr; 137(?):78-83. doi:
10.1016/j.jpba.2017.01.016. [PMID: 28104560] - Ying Zhou, Hongyun Wang, Ji Jiang, Pei Hu. Simultaneous determination of remimazolam and its carboxylic acid metabolite in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jan; 976-977(?):78-83. doi:
10.1016/j.jchromb.2014.11.022. [PMID: 25486614] - Hugh R Wiltshire, Gavin J Kilpatrick, Gary S Tilbrook, Keith M Borkett. A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation.
Anesthesia and analgesia.
2012 Aug; 115(2):284-96. doi:
10.1213/ane.0b013e318241f68a. [PMID: 22253270] - R N Upton, A A Somogyi, A M Martinez, J Colvill, C Grant. Pharmacokinetics and pharmacodynamics of the short-acting sedative CNS 7056 in sheep.
British journal of anaesthesia.
2010 Dec; 105(6):798-809. doi:
10.1093/bja/aeq260. [PMID: 20926479]