Difelikefalin (BioDeep_00000858678)
代谢物信息卡片
化学式: C36H53N7O6 (679.4057118000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC3=CC=CC=C3)N
InChI: InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
Difelikefalin (CR-845; FE-202845) is a peripherally restricted and selective agonist of kappa opioid receptor (KOR). Difelikefalin produces anti-inflammatory effects and has the potential in modulating pruritus in conditions such as chronic kidney disease[1][2].
同义名列表
3 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D11111
- PubChem: 24794466
- DrugBank: DB11938
- ChEMBL: CHEMBL3989915
- CAS: 1024828-77-0
- medchemexpress: HY-17609
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Emma Guttman-Yassky, Paola Facheris, Joel Correa Da Rosa, Camille Rothenberg-Lausell, Ester Del Duca, Eden David, Yeriel Estrada, Ying Liu, Swaroop Bose, Mashkura Chowdhury, Catherine Munera, Joana Goncalves, Kristine Nograles, Brian S Kim, Mark Lebwohl. Oral difelikefalin reduces moderate to severe pruritus and expression of pruritic and inflammatory biomarkers in subjects with atopic dermatitis.
The Journal of allergy and clinical immunology.
2023 10; 152(4):916-926. doi:
10.1016/j.jaci.2023.06.023. [PMID: 37453614] - Lana Gettman. New Drugs Update: Finerenone, Difelikefalin, and Avacopan.
The Senior care pharmacist.
2022 Apr; 37(4):130-138. doi:
10.4140/tcp.n.2022.130. [PMID: 35337427] - NULL. Difelikefalin (Korsuva) for chronic kidney disease-associated pruritus.
The Medical letter on drugs and therapeutics.
2022 Feb; 64(1643):18-19. doi:
NULL. [PMID: 35134047] - Emma D Deeks. Difelikefalin: First Approval.
Drugs.
2021 Nov; 81(16):1937-1944. doi:
10.1007/s40265-021-01619-6. [PMID: 34674115] - Zoe M Lipman, Gil Yosipovitch. An evaluation of difelikefalin as a treatment option for moderate-to-severe pruritus in end stage renal disease.
Expert opinion on pharmacotherapy.
2021 Apr; 22(5):549-555. doi:
10.1080/14656566.2020.1849142. [PMID: 33190563] - Margaret Vernon, Sonja Ständer, Catherine Munera, Robert H Spencer, Frédérique Menzaghi. Clinically meaningful change in itch intensity scores: An evaluation in patients with chronic kidney disease-associated pruritus.
Journal of the American Academy of Dermatology.
2021 Apr; 84(4):1132-1134. doi:
10.1016/j.jaad.2020.06.991. [PMID: 32603719] - Aaron J Trachtenberg, David Collister, Claudio Rigatto. Recent advances in the treatment of uremic pruritus.
Current opinion in nephrology and hypertension.
2020 09; 29(5):465-470. doi:
10.1097/mnh.0000000000000625. [PMID: 32740217] - Steven Fishbane, Aamir Jamal, Catherine Munera, Warren Wen, Frédérique Menzaghi. A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus.
The New England journal of medicine.
2020 01; 382(3):222-232. doi:
10.1056/nejmoa1912770. [PMID: 31702883] - A Janecka, R Perlikowska, K Gach, A Wyrebska, J Fichna. Development of opioid peptide analogs for pain relief.
Current pharmaceutical design.
2010; 16(9):1126-35. doi:
10.2174/138161210790963869. [PMID: 20030621]