Amitriptylinoxide (BioDeep_00000858676)

   


代谢物信息卡片


Amitriptylinoxide

化学式: C20H23NO (293.1779548)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C[N+](C)(CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31)[O-]
InChI: InChI=1S/C20H23NO/c1-21(2,22)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

描述信息

C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent

同义名列表

1 个代谢物同义名

Amitriptylinoxide



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Evi V Nagler, Angela C Webster, Raymond Vanholder, Carmine Zoccali. Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP). Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 Oct; 27(10):3736-45. doi: 10.1093/ndt/gfs295. [PMID: 22859791]
  • Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry. 2004 Feb; 47(5):1242-50. doi: 10.1021/jm030408h. [PMID: 14971904]
  • J Degen, E Wölke, M Seiberling, P Pintar, G Höxter, H B Steinhauer, W Fischer. [Comparative study of the pharmacokinetics of amitriptyline oxide and trimipramine after single administration in healthy male probands and patients with renal failure]. Medizinische Klinik (Munich, Germany : 1983). 1993 Mar; 88(3):129-33, 171. doi: NULL. [PMID: 8474401]
  • B Becher, W Fischer, Z Taneri, E Scholz, W E Müller, U Breyer-Pfaff. Urinary metabolites of amitriptylinoxide and amitriptyline in single-dose experiments and during continuous therapy. Psychopharmacology. 1992; 106(3):303-10. doi: 10.1007/bf02245409. [PMID: 1570375]
  • V Hutt, R Theodor, G Pabst, C Dilger, H Mosberg, W Fischer, H Jaeger. [Plasma and urine kinetics of amitriptyline oxide and its metabolites. Comparison of intravenous infusion and oral administration in volunteers]. Arzneimittel-Forschung. 1991 Apr; 41(4):367-72. doi: NULL. [PMID: 1859509]
  • H Koch. Steady-state plasma levels during antidepressant therapy with amitriptyline and amitriptylinoxide. The Israel journal of psychiatry and related sciences. 1990; 27(1):48-56. doi: NULL. [PMID: 2194992]
  • R Terlinden, H O Borbe. Determination of amitriptylinoxide and its major metabolites amitriptyline and nortriptyline in plasma by high-performance liquid chromatography. Journal of chromatography. 1986 Oct; 382(?):372-6. doi: 10.1016/s0378-4347(00)83546-x. [PMID: 3782407]
  • H J Kuss, G Jungkunz, K J Johannes. Single oral dose pharmacokinetics of amitriptylinoxide and amitriptyline in humans. Pharmacopsychiatry. 1985 Jul; 18(4):259-62. doi: 10.1055/s-2007-1017377. [PMID: 4023050]
  • K M Jensen. Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by high-performance liquid chromatography. Journal of chromatography. 1980 Sep; 183(3):321-9. doi: 10.1016/s0378-4347(00)81712-0. [PMID: 7419649]
  • G Santagostino, R M Facino, D Pirillo. Urinary excretion of amitriptyline N-oxide in humans. Journal of pharmaceutical sciences. 1974 Nov; 63(11):1690-2. doi: 10.1002/jps.2600631104. [PMID: 4610117]