Flurothyl (BioDeep_00000858659)
代谢物信息卡片
Fluorothyl
化学式: C4H4F6O (182.01663259999998)
中文名称: 双(2,2,2-三氟乙基)醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(F)(F)F)OCC(F)(F)F
InChI: InChI=1S/C4H4F6O/c5-3(6,7)1-11-2-4(8,9)10/h1-2H2
描述信息
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:134824
- KEGGdrug: D04236
- KEGGdrug: D88780
- PubChem: 9528
- DrugBank: DB08969
- ChEMBL: CHEMBL477874
- MeSH: Flurothyl
- CAS: 333-36-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Li-Li Li, Ya-Chao Li, Dong-Jing Zhao, Mei-Fang Jin, Hong Ni. Leptin-regulated autophagy plays a role in long-term neurobehavioral injury after neonatal seizures and the regulation of zinc/cPLA2 and CaMK II signaling in cerebral cortex.
Epilepsy research.
2018 10; 146(?):103-111. doi:
10.1016/j.eplepsyres.2018.07.023. [PMID: 30092488] - Tanya S McDonald, Karin Borges. Impaired hippocampal glucose metabolism during and after flurothyl-induced seizures in mice: Reduced phosphorylation coincides with reduced activity of pyruvate dehydrogenase.
Epilepsia.
2017 07; 58(7):1172-1180. doi:
10.1111/epi.13796. [PMID: 28632902] - Catalina Carrasco-Pozo, Kah Ni Tan, Karin Borges. Sulforaphane is anticonvulsant and improves mitochondrial function.
Journal of neurochemistry.
2015 Dec; 135(5):932-42. doi:
10.1111/jnc.13361. [PMID: 26365487] - Hong Ni, Qi Sun, Tian Tian, Xing Feng, Bao-liang Sun. Prophylactic treatment with melatonin before recurrent neonatal seizures: Effects on long-term neurobehavioral changes and the underlying expression of metabolism-related genes in rat hippocampus and cerebral cortex.
Pharmacology, biochemistry, and behavior.
2015 Jun; 133(?):25-30. doi:
10.1016/j.pbb.2015.03.012. [PMID: 25818576] - Tuan-Mei Wang, Tao Bo, Man-Zhi Wang, Xiao-Hua Zhu, Jian Li, Xing-Fang Li, Ding-An Mao. [Effects of neonatal recurrent seizures on glucocorticoid receptor expression in the rat brain].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2010 Jan; 12(1):47-50. doi:
NULL. [PMID: 20113635] - Todd H Ahern, Martin A Javors, Douglas A Eagles, Jared Martillotti, Heather A Mitchell, Larry Cameron Liles, David Weinshenker. The effects of chronic norepinephrine transporter inactivation on seizure susceptibility in mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2006 Apr; 31(4):730-8. doi:
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Neuropharmacology.
2001; 40(1):139-47. doi:
10.1016/s0028-3908(00)00103-9. [PMID: 11077080] - D C Silveira, G L Holmes, S C Schachter, C Geula, D L Schomer. Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats.
Brain research.
2000 Sep; 878(1-2):223-7. doi:
10.1016/s0006-8993(00)02703-7. [PMID: 10996157] - M D Krasowski. Differential modulatory actions of the volatile convulsant flurothyl and its anesthetic isomer at inhibitory ligand-gated ion channels.
Neuropharmacology.
2000 Apr; 39(7):1168-83. doi:
10.1016/s0028-3908(99)00221-x. [PMID: 10760360] - M Yamashita, Y Ikemoto, M Nielsen, T Yano. Effects of isoflurane and hexafluorodiethyl ether on human recombinant GABA(A) receptors expressed in Sf9 cells.
European journal of pharmacology.
1999 Aug; 378(2):223-31. doi:
10.1016/s0014-2999(99)00468-9. [PMID: 10478635] - J L Horn, P K Janicki, J J Franks. Lack of effect of flurothyl, a non-anesthetic fluorinated ether, on rat brain synaptic plasma membrane calcium-ATPase.
Life sciences.
1999; 64(14):PL179-83. doi:
10.1016/s0024-3205(99)00058-2. [PMID: 10210269] - D D Gilboe, D B Kintner, M E Anderson, J H Fitzpatrick. NMR-based identification of intra- and extracellular compartments of the brain Pi peak.
Journal of neurochemistry.
1998 Dec; 71(6):2542-8. doi:
10.1046/j.1471-4159.1998.71062542.x. [PMID: 9832154] - Z Fang, M J Laster, P Ionescu, D D Koblin, J Sonner, E I Eger, M J Halsey. Effects of inhaled nonimmobilizer, proconvulsant compounds on desflurane minimum alveolar anesthetic concentration in rats.
Anesthesia and analgesia.
1997 Nov; 85(5):1149-53. doi:
10.1097/00000539-199711000-00035. [PMID: 9356117] - G G Nomikos, A P Zis, G Damsma, H C Fibiger. Electroconvulsive shock increases interstitial concentrations of uric acid in the rat brain.
Brain research.
1994 Oct; 660(1):50-6. doi:
10.1016/0006-8993(94)90837-0. [PMID: 7828001] - G F Carl, M L Smith. Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.
Epilepsia.
1989 Mar; 30(2):217-24. doi:
10.1111/j.1528-1157.1989.tb05457.x. [PMID: 2924746] - J Folbergrová, M Ingvar, G Nevander, B K Siesjö. Cerebral metabolic changes during and following fluorothyl-induced seizures in ventilated rats.
Journal of neurochemistry.
1985 May; 44(5):1419-26. doi:
10.1111/j.1471-4159.1985.tb08778.x. [PMID: 3989540] - M Wilkinson, R Bhanot, J A Pincock, L Donald. Flurothyl-induced convulsions delay the onset of sexual maturation in the female rat.
The Journal of endocrinology.
1982 Oct; 95(1):37-41. doi:
10.1677/joe.0.0950037. [PMID: 6813415] - R Bhanot, M Wilkinson. Repeated convulsions induce pseudopregnancy in the intact rat and inhibit steroid-mediated gonadotrophin secretion in the ovariectomized rat.
The Journal of endocrinology.
1982 Oct; 95(1):43-8. doi:
10.1677/joe.0.0950043. [PMID: 6813416] - D B Smith, G F Carl. Interactions between folates and carbamazepine or valproate in the rat.
Neurology.
1982 Sep; 32(9):965-9. doi:
10.1212/wnl.32.9.965. [PMID: 6810206] - D D Koblin, E I Eger, B H Johnson, P Collins, R C Terrell, L Speers. Are convulsant gases also anesthetics?.
Anesthesia and analgesia.
1981 Jul; 60(7):464-70. doi:
". [PMID: 7195661] - R J Cenedella, W G Crouthamel, G G Bierkamper, D P Westfall. Alteration of drug pharmacodynamics by hyperlipidemia.
Archives internationales de pharmacodynamie et de therapie.
1975 Dec; 218(2):299-311. doi:
". [PMID: 1212025] - G H Glaser. Brain dysfunction in uremia.
Research publications - Association for Research in Nervous and Mental Disease.
1974; 53(?):173-99. doi:
NULL. [PMID: 4612659] - R G Cooper, O L Webb. Plasma fibrinolytic activity associated with flurothyl induced convulsion.
Thrombosis et diathesis haemorrhagica.
1972 Dec; 28(3):376-82. doi:
10.1055/s-0038-1649021. [PMID: 4649272]