Iprindole (BioDeep_00000858639)
代谢物信息卡片
化学式: C19H28N2 (284.2252)
中文名称: 伊普吲哚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCCN1C2=C(CCCCCC2)C3=C1C=CC=C3
InChI: InChI=1S/C19H28N2/c1-20(2)14-9-15-21-18-12-6-4-3-5-10-16(18)17-11-7-8-13-19(17)21/h7-8,11,13H,3-6,9-10,12,14-15H2,1-2H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
Iprindole, a tricyclic indole antidepressant, is a weak inhibitor of the uptake of noradrenaline and 5-HT[1].
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135177
- KEGGdrug: D04605
- PubChem: 21722
- DrugBank: DB13496
- ChEMBL: CHEMBL126224
- MeSH: Iprindole
- CAS: 5560-72-5
- medchemexpress: HY-12392
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
---|
文献列表
- P A Lavoie, G Beauchamp, R Elie. Atypical antidepressants inhibit depolarization-induced calcium uptake in rat hippocampus synaptosomes.
Canadian journal of physiology and pharmacology.
1997 Aug; 75(8):983-7. doi:
10.1139/cjpp-75-8-983
. [PMID: 9360012] - F Carvalho, F Remião, F Amado, P Domingues, A J Correia, M L Bastos. d-Amphetamine interaction with glutathione in freshly isolated rat hepatocytes.
Chemical research in toxicology.
1996 Sep; 9(6):1031-6. doi:
10.1021/tx9501750
. [PMID: 8870992] - L J Aspeslet, G B Baker, R T Coutts, G A Torok-Both. The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine.
Chirality.
1994; 6(2):86-90. doi:
10.1002/chir.530060208
. [PMID: 8204417] - R T Coutts, M S Hussain, G B Baker, M Daneshtalab, R G Micetich. Structural characterization of the urinary metabolites of iprindole in rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1991 Oct; 21(10):1393-405. doi:
10.3109/00498259109043214
. [PMID: 1796616] - H Bönisch, G Paulus, G Martiny-Baron, B Lingen, D Coppeneur. Molecular aspects of the neuronal noradrenaline transporter.
Journal of neural transmission. Supplementum.
1991; 34(?):11-7. doi:
10.1007/978-3-7091-9175-0_2
. [PMID: 1726219] - H Ozawa, M M Rasenick. Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs.
Journal of neurochemistry.
1991 Jan; 56(1):330-8. doi:
10.1111/j.1471-4159.1991.tb02599.x
. [PMID: 1898967] - W J Martin, D L Kachel. Iprindole reverses the lamellar body deficiency of cultured L-2 cells. Possible implications in the reversal of surfactant deficiency.
The American journal of pathology.
1987 Oct; 129(1):34-43. doi:
NULL
. [PMID: 2821815] - J A Jesberger, J S Richardson. Effects of antidepressant drugs on the behavior of olfactory bulbectomized and sham-operated rats.
Behavioral neuroscience.
1986 Apr; 100(2):256-74. doi:
10.1037//0735-7044.100.2.256
. [PMID: 3964427] - M L Sedlock, J Ravitch, D J Edwards. The effects of imipramine and iprindole on the metabolism of octopamine in the rat.
Neuropharmacology.
1985 Aug; 24(8):705-8. doi:
10.1016/0028-3908(85)90002-4
. [PMID: 3939325] - E Friedman, F D Yocca, T B Cooper. Antidepressant drugs with varying pharmacological profiles alter rat pineal beta adrenergic-mediated function.
The Journal of pharmacology and experimental therapeutics.
1984 Mar; 228(3):545-50. doi:
. [PMID: 6323672]
- G Duncker, F Hartmann, K Mohr. Adrenocortical function of rats under prolonged administration of lipidosis-inducing drugs.
Naunyn-Schmiedeberg's archives of pharmacology.
1982 Dec; 321(4):341-6. doi:
10.1007/bf00498524
. [PMID: 7167207] - M A Reilly, E B Sigg. Suppression of histamine-induced adrenocorticotropic hormone release by antihistamines and antidepressants.
The Journal of pharmacology and experimental therapeutics.
1982 Sep; 222(3):583-8. doi:
NULL
. [PMID: 6125582] - G Caillé, C de Montigny, J G Besner. Quantitation of iprindole in plasma by GLC.
Biopharmaceutics & drug disposition.
1982 Jan; 3(1):11-7. doi:
10.1002/bdd.2510030103
. [PMID: 7082775] - J W Maas, Y Huang. Noradrenergic function and depression, too much or too little?.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
1980 Aug; 7(3):267-8. doi:
10.1017/s0317167100023337
. [PMID: 6108796] - H Koenig, A D Goldstone, C Y Lu, G Blume, C T Hughes. Glucocorticosteroids, androgens and lysosomes. Experimental studies in mouse brain, muscle and kidney.
Progress in clinical and biological research.
1980; 39(?):275-90. doi:
NULL
. [PMID: 7403185] - A P Zis, F K Goodwin. Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin.
Archives of general psychiatry.
1979 Sep; 36(10):1097-1107. doi:
10.1001/archpsyc.1979.01780100067006
. [PMID: 475543] - W Frisch, R Lüllmann-Rauch. Differential effects of chloroquine and of several other amphiphilic cationic drugs upon rat choroid plexus.
Acta neuropathologica.
1979 May; 46(3):203-8. doi:
10.1007/bf00690845
. [PMID: 223364] - S F Sisenwine, C O Tio, H W Ruelius. The disposition of [14C]iprindole in man, dog, miniature swine, rhesus monkey and rat.
Xenobiotica; the fate of foreign compounds in biological systems.
1979 Apr; 9(4):237-46. doi:
10.3109/00498257909038726
. [PMID: 113942] - B B Wolfe, T K Harden, J R Sporn, P B Molinoff. Presynaptic modulation of beta adrenergic receptors in rat cerebral cortex after treatment with antidepressants.
The Journal of pharmacology and experimental therapeutics.
1978 Nov; 207(2):446-57. doi:
NULL
. [PMID: 213556] - B N Rosloff, J M Daivis. Decrease in brain NE turnover after chronic DMI treatment; no effect with iprindole.
Psychopharmacology.
1978 Apr; 56(3):335-41. doi:
10.1007/bf00432858
. [PMID: 418443] - D Drenckhahn, R Lüllmann-Rauch. Lens opacities associated with lipidosis-like ultrastructural alterations in rats treated with chloroquine, chlorphentermine, or iprindole.
Experimental eye research.
1977 Jun; 24(6):621-32. doi:
10.1016/0014-4835(77)90120-8
. [PMID: 872905] - A D Sherman, W C Hsiao, E M Gál. Cerebral metabolism of (3H)-p-chloroamphetamine.
Neuropharmacology.
1977 Jan; 16(1):17-24. doi:
10.1016/0028-3908(77)90041-7
. [PMID: 834359] - L E Dyck, A A Boulton. The effect of some drugs on the urinary excretion of some aryl alkyl amines in the rat.
Research communications in chemical pathology and pharmacology.
1975 May; 11(1):73-7. doi:
NULL
. [PMID: 125445] - B Lüllmann-Rauch. Lipidosislike renal changes in rats treated with chlorphentermine or with tricyclic antidepressants.
Virchows Archiv. B, Cell pathology.
1975; 18(1):51-60. doi:
10.1007/bf02889233
. [PMID: 167510] - I C Campbell, A Todrick. On the pharmacology and biochemistry of the amine-uptake mechanism in human blood platelets.
British journal of pharmacology.
1973 Oct; 49(2):279-87. doi:
10.1111/j.1476-5381.1973.tb08373.x
. [PMID: 4152219] - J J Freeman, F Sulser. Iprindole-amphetamine interactions in the rat: the role of aromatic hydroxylation of amphetamine in its mode of action.
The Journal of pharmacology and experimental therapeutics.
1972 Nov; 183(2):307-15. doi:
NULL
. [PMID: 4673401]