Valnoctamide (BioDeep_00000858637)
代谢物信息卡片
化学式: C8H17NO (143.1310072)
中文名称: 戊诺酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C(C(N)=O)CC)C
InChI: InChI=1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)
描述信息
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
Valnoctamide (Valmethamide), a derivative of valproate, suppresses benzodiazepine-refractory status epilepticus. Valnoctamide (Valmethamide) acts directly on GABAA receptors[1].
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:134767
- KEGGdrug: D02717
- PubChem: 20140
- DrugBank: DB13099
- ChEMBL: CHEMBL1075733
- CAS: 4171-13-5
- medchemexpress: HY-121877
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Hiren R Modi, Kaizong Ma, Lisa Chang, Mei Chen, Stanley I Rapoport. Valnoctamide, which reduces rat brain arachidonic acid turnover, is a potential non-teratogenic valproate substitute to treat bipolar disorder.
Psychiatry research.
2017 08; 254(?):279-283. doi:
10.1016/j.psychres.2017.04.048. [PMID: 28500975] - Mark Weiser, Linda Levi, Stephen Z Levine, Meir Bialer, Tawfeeq Shekh-Ahmad, Valentin Matei, Alexandru Tiugan, Diana Cirjaliu, Cristinel Sava, Eugenia Sinita, Daisy Zamora, John M Davis. A randomized, double-blind, placebo- and risperidone-controlled study on valnoctamide for acute mania.
Bipolar disorders.
2017 06; 19(4):285-294. doi:
10.1111/bdi.12506. [PMID: 28605109] - Tawfeeq Shekh-Ahmad, Hafiz Mawasi, John H McDonough, Boris Yagen, Meir Bialer. The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus.
Epilepsy & behavior : E&B.
2015 Aug; 49(?):298-302. doi:
10.1016/j.yebeh.2015.04.012. [PMID: 25979572] - Tawfeeq Shekh-Ahmad, Naama Hen, Boris Yagen, John H McDonough, Richard H Finnell, Bogdan J Wlodarczyk, Meir Bialer. Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential.
Epilepsia.
2014 Feb; 55(2):353-61. doi:
10.1111/epi.12480. [PMID: 24313671] - H Steve White, Anitha B Alex, Amanda Pollock, Naama Hen, Tawfeeq Shekh-Ahmad, Karen S Wilcox, John H McDonough, James P Stables, Dan Kaufmann, Boris Yagen, Meir Bialer. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
Epilepsia.
2012 Jan; 53(1):134-46. doi:
10.1111/j.1528-1167.2011.03338.x. [PMID: 22150444] - Ilan Winkler, Simcha Blotnik, Jakob Shimshoni, Boris Yagen, Marshall Devor, Meir Bialer. Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain.
British journal of pharmacology.
2005 Sep; 146(2):198-208. doi:
10.1038/sj.bjp.0706310. [PMID: 15997234] - Nina Isoherranen, H Steve White, Brian D Klein, Michael Roeder, José H Woodhead, Volker Schurig, Boris Yagen, Meir Bialer. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.
Pharmaceutical research.
2003 Aug; 20(8):1293-301. doi:
10.1023/a:1025069519218. [PMID: 12948028] - O Spiegelstein, B Yagen, G D Bennett, R H Finnell, S Blotnik, M Bialer. Stereoselective pharmacokinetic analysis of valnoctamide, a CNS-active chiral amide analogue of valproic acid, in dogs, rats, and mice.
Therapeutic drug monitoring.
2000 Oct; 22(5):574-81. doi:
10.1097/00007691-200010000-00012. [PMID: 11034263] - M Radatz, K Ehlers, B Yagen, M Bialer, H Nau. Valnoctamide, valpromide and valnoctic acid are much less teratogenic in mice than valproic acid.
Epilepsy research.
1998 Mar; 30(1):41-8. doi:
10.1016/s0920-1211(97)00095-8. [PMID: 9551843] - S Barel, B Yagen, V Schurig, S Soback, F Pisani, E Perucca, M Bialer. Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and in patients with epilepsy.
Clinical pharmacology and therapeutics.
1997 Apr; 61(4):442-9. doi:
10.1016/s0009-9236(97)90194-6. [PMID: 9129561] - S Blotnik, F Bergman, M Bialer. Disposition of valpromide, valproic acid, and valnoctamide in the brain, liver, plasma, and urine of rats.
Drug metabolism and disposition: the biological fate of chemicals.
1996 May; 24(5):560-4. doi:
NULL. [PMID: 8723737] - F Pisani, A Haj-Yehia, A Fazio, C Artesi, G Oteri, E Perucca, D L Kroetz, R H Levy, M Bialer. Carbamazepine-valnoctamide interaction in epileptic patients: in vitro/in vivo correlation.
Epilepsia.
1993 Sep; 34(5):954-9. doi:
10.1111/j.1528-1157.1993.tb02117.x. [PMID: 8104783] - C F Melissant, A A Vinks, H P Sleeboom. [Coma due to an overdose of valnoctamide].
Nederlands tijdschrift voor geneeskunde.
1992 Apr; 136(16):793-4. doi:
NULL. [PMID: 1349428] - M Bialer, A Haj-Yehia, N Barzaghi, F Pisani, E Perucca. Pharmacokinetics of a valpromide isomer, valnoctamide, in healthy subjects.
European journal of clinical pharmacology.
1990; 38(3):289-91. doi:
10.1007/bf00315032. [PMID: 2111246] - A Haj-Yehia, M Bialer. Pharmacokinetics of a valpromide isomer, valnoctamide, in dogs.
Journal of pharmaceutical sciences.
1988 Oct; 77(10):831-4. doi:
10.1002/jps.2600771003. [PMID: 3148708] - M Bialer, B Hoch. Rapid gas chromatographic assay for monitoring valnoctamide in plasma.
Journal of chromatography.
1985 Feb; 337(2):408-11. doi:
10.1016/0378-4347(85)80055-4. [PMID: 2859299]