Xylometazoline hydrochloride (BioDeep_00000858626)
代谢物信息卡片
化学式: C16H25ClN2 (280.170616)
中文名称: 盐酸赛洛唑啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1.Cl
InChI: 1H
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D019141 - Respiratory System Agents > D014663 - Nasal Decongestants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
Xylometazoline hydrochloride is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research[1][2].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D00757
- PubChem: 5282386
- ChEMBL: CHEMBL1256400
- CAS: 1218-35-5
- medchemexpress: HY-B0475
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ayse Ipek Akyuz Unsal, Yesim Basal, Serap Birincioglu, Tolga Kocaturk, Harun Cakmak, Alparslan Unsal, Gizem Cakiroz, Nüket Eliyatkın, Ozden Yukselen, Buket Demirci. Ophthalmic adverse effects of nasal decongestants on an experimental rat model.
Arquivos brasileiros de oftalmologia.
2018 Jan; 81(1):53-58. doi:
10.5935/0004-2749.20180012. [PMID: 29538595] - Henrike Hoeke, Stefan Roeder, Thilo Bertsche, Michael Borte, Martin von Bergen, Dirk K Wissenbach. Assessment of maternal drug intake by urinary bio monitoring during pregnancy and postpartally until the third perinatal year.
Pharmacoepidemiology and drug safety.
2016 Apr; 25(4):431-7. doi:
10.1002/pds.3943. [PMID: 26696520] - Frank Musshoff, Burkhard Madea, Joachim Woelfle, Dejan Vlanic. Xylometazoline poisoning: A 40-fold nasal overdose caused by a compounding error in 3 children.
Forensic science international.
2014 May; 238(?):e3-5. doi:
10.1016/j.forsciint.2014.02.011. [PMID: 24642023] - Hermann Ammerschläger, Peter Klein, Michael Weiser, Menachem Oberbaum. [Treatment of inflammatory diseases of the upper respiratory tract -- comparison of a homeopathic complex remedy with xylometazoline].
Forschende Komplementarmedizin und klassische Naturheilkunde = Research in complementary and natural classical medicine.
2005 Feb; 12(1):24-31. doi:
10.1159/000082934. [PMID: 15772459] - G J Westerveld, R A Scheeren, I Dekker, D H Griffioen, H P Voss, A Bast. Anti-oxidant actions of oxymethazoline and xylomethazoline.
European journal of pharmacology.
1995 Sep; 291(1):27-31. doi:
10.1016/0922-4106(95)90185-x. [PMID: 8549644] - N D Platt. Xylometazoline and porphyria.
British journal of anaesthesia.
1993 Apr; 70(4):491. doi:
10.1093/bja/70.4.491-a. [PMID: 7684598] - A Sioufi, F Leroux, J P Dubois. Determination of xylometazoline in plasma and urine by gas chromatography using a fused-silica capillary column and an electron-capture detector.
Journal of chromatography.
1989 Jan; 487(1):81-9. doi:
10.1016/s0378-4347(00)83009-1. [PMID: 2715277] - B Semczuk. [The results of clinical observations and experimental research of some preparations produced by the pharmaceutic industry plant 'Polfa' (author's transl)].
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina.
1979; 34(?):291-6. doi:
". [PMID: 400433]