memantine hydrochloride (BioDeep_00000858619)
代谢物信息卡片
memantine hydrochloride
化学式: C12H22ClN (215.1440682)
中文名称: 美金刚胺盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl
InChI: 1H
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
C78272 - Agent Affecting Nervous System > C38149 - Antiparkinsonian Agent
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:64323
- KEGGdrug: D04905
- PubChem: 181458
- ChEMBL: CHEMBL1699
- MeSH: Memantine
- CAS: 41100-52-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mingjuan Yang, Xinyu Zhang, Ou Qiao, Jun Zhang, Xiaoqing Li, Xiaohui Ma, Shuiping Zhou, Wenyuan Gao. Effect of Cerebralcare Granule® combined with memantine on Alzheimer's disease.
Journal of ethnopharmacology.
2024 Apr; 323(?):117609. doi:
10.1016/j.jep.2023.117609. [PMID: 38142875] - Kholoud AbdEl-Raouf, Hussein S H Farrag, Rashed Rashed, Mohamed A Ismail, Monir A El-Ganzuri, Wael M El-Sayed. New bithiophene derivative attenuated Alzheimer's disease induced by aluminum in a rat model via antioxidant activity and restoration of neuronal and synaptic transmission.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2024 Mar; 82(?):127352. doi:
10.1016/j.jtemb.2023.127352. [PMID: 38070385] - Shaimaa Nasr Amin, Sherif Ahmed Shaltout, Walaa Bayoumie El Gazzar, Noha Samir Abdel Latif, Ghadah Nazar Al-Jussani, Yasmeen Jamal Alabdallat, Khaled Anwer Albakri, Dalia Azmy Elberry. Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome.
Advances in medical sciences.
2024 Mar; 69(1):176-189. doi:
10.1016/j.advms.2024.03.008. [PMID: 38561071] - Essmat A H Allam, Abdel-Azim Assi, Dalia M Badary, Magda M Y Farrag, Mariam A Nicola. Memantine versus Ginkgo biloba Extract: A Comparative Study on Cognitive Dysfunction Treatment in a Novel Rat Model.
Planta medica.
2024 Jan; ?(?):. doi:
10.1055/a-2245-3624. [PMID: 38286405] - Victor H B de Andrade, Erick Y M Rodrigues, Nayara A F Dias, Gabriela F C Ferreira, Diego B de Carvalho, Amarith R das Neves, Paola M V Coronel, Murilo K A Yonekawa, Eduardo B Parisotto, Edson A Dos Santos, Albert S Souza, Edgar J Paredes-Gamero, Kamylla S de Sousa, Letícia L de Souza, Leonardo B M Resstel, Adriano C M Baroni, Davi C Lagatta. Neuroprotective Profile of Triazole Grandisin Analogue against Amyloid-Beta Oligomer-Induced Cognitive Impairment.
ACS chemical neuroscience.
2023 Dec; 14(24):4298-4310. doi:
10.1021/acschemneuro.3c00443. [PMID: 38048522] - V V Grigoriev, E F Shevtsova, A Yu Aksinenko, I M Veselov, T V Goreva, A V Gabrelyan, S O Bachurin. New Hybrid Structures Based on Memanthine and Edaravone Molecules.
Doklady. Biochemistry and biophysics.
2023 Oct; 512(1):284-287. doi:
10.1134/s1607672923700461. [PMID: 38093132] - Kenan Yıldızhan, Mustafa Nazıroğlu. NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine.
Brain research.
2023 Mar; 1803(?):148232. doi:
10.1016/j.brainres.2023.148232. [PMID: 36610553] - Feng-Ling You, Gao-Fu Xia, Jing Cai. Behavioural Variant Frontotemporal Dementia due to CCNF Gene Mutation: A Case Report.
Current Alzheimer research.
2023; 20(5):371-378. doi:
10.2174/1567205020666230811092906. [PMID: 37872794] - Youyu Wang, Bo Jiang, Wang Luo. Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection.
Bioengineered.
2022 03; 13(3):6688-6697. doi:
10.1080/21655979.2022.2026553. [PMID: 35235756] - Alberto C S Costa, Ana C Brandão, Richard Boada, Veridiana L Barrionuevo, Hudson G Taylor, Elizabeth Roth, Melissa R Stasko, Mark W Johnson, Fernanda F Assir, Maria P Roberto, Patrícia Salmona, Guilherme Abreu-Silveira, Ilya Bederman, Erin Prendergast, Anke Hüls, Sarina Abrishamcar, Zan Mustacchi, Thomas Scheidemantel, Nancy J Roizen, Stephen Ruedrich. Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial.
The Lancet. Neurology.
2022 01; 21(1):31-41. doi:
10.1016/s1474-4422(21)00369-0. [PMID: 34942135] - Weijian Fan, Zhenhua Liu, Jianpeng Chen, Shaodong Liu, Tingxiang Chen, Zhijie Li, Dingsheng Lin. Effect of memantine on the survival of an ischemic random skin flap and the underlying mechanism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Nov; 143(?):112163. doi:
10.1016/j.biopha.2021.112163. [PMID: 34517281] - Anas Shamsi, Moyad Shahwan, Fahad A Alhumaydhi, Ameen S S Alwashmi, Mohammad Abdullah Aljasir, Suliman A Alsagaby, Waleed Al Abdulmonem, Md Imtaiyaz Hassan, Asimul Islam. Spectroscopic, calorimetric and in silico insight into the molecular interactions of Memantine with human transferrin: Implications of Alzheimer's drugs.
International journal of biological macromolecules.
2021 Nov; 190(?):660-666. doi:
10.1016/j.ijbiomac.2021.09.017. [PMID: 34508722] - Yuyong Zhou, Karen A Gammeltoft, Andrea Galli, Anna Offersgaard, Ulrik Fahnøe, Santseharay Ramirez, Jens Bukh, Judith M Gottwein. Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro.
Viruses.
2021 10; 13(10):. doi:
10.3390/v13102082. [PMID: 34696509] - Atsushi Kawase, Akira Kazaoka, Hiroaki Shimada, Masahiro Iwaki. Increased brain penetration of diphenhydramine and memantine in rats with adjuvant-induced arthritis.
Brain research.
2021 10; 1768(?):147581. doi:
10.1016/j.brainres.2021.147581. [PMID: 34280372] - Nahid Beladi Moghadam, Elham Pourheidar, Forouzan Ahmadpour, Hamidreza Kafi, Jamshid Salamzadeh, Saeed Nasiri, Mohammad Sistanizad. The effects of memantine on the serum concentrations of matrix metalloproteinases and neurologic function of patients with ischemic stroke.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2021 Aug; 90(?):268-272. doi:
10.1016/j.jocn.2021.06.005. [PMID: 34275562] - Guiliang Zhang, Jiahui Wu, Chunhui Huang, Jiehong Cheng, Zhiyang Su, Zeyu Zhu, Xifei Yang, Baojian Guo, Liangmiao Wu, Zaijun Zhang, Gaoxiao Zhang, Haiyun Chen, Yewei Sun, Yuqiang Wang. The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease.
Journal of molecular neuroscience : MN.
2021 Jul; 71(7):1456-1466. doi:
10.1007/s12031-020-01762-x. [PMID: 33403592] - Liangmiao Wu, Xinhua Zhou, Yiwan Cao, Shing Hung Mak, Ling Zha, Ning Li, Zhiyang Su, Yifan Han, Yuqiang Wang, Maggie Pui Man Hoi, Yewei Sun, Gaoxiao Zhang, Zaijun Zhang, Xifei Yang. Therapeutic efficacy of novel memantine nitrate MN-08 in animal models of Alzheimer's disease.
Aging cell.
2021 06; 20(6):e13371. doi:
10.1111/acel.13371. [PMID: 33955647] - Tadeusz Płusa. [Anti-inflammatory effects of amantadine and memantine in SARS-CoV-2 infection].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
2021 02; 49(289):67-70. doi:
. [PMID: 33713098] - Simon Couly, Morgane Denus, Mélanie Bouchet, Gilles Rubinstenn, Tangui Maurice. Anti-Amnesic and Neuroprotective Effects of Fluoroethylnormemantine in a Pharmacological Mouse Model of Alzheimer's Disease.
The international journal of neuropsychopharmacology.
2021 02; 24(2):142-157. doi:
10.1093/ijnp/pyaa075. [PMID: 32977336] - Ru-Band Lu, Tzu-Yun Wang, Sheng-Yu Lee, Yun-Hsuan Chang, Shiou-Lan Chen, Tsung-Yu Tsai, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong. Add-on memantine may improve cognitive functions and attenuate inflammation in middle- to old-aged bipolar II disorder patients.
Journal of affective disorders.
2021 01; 279(?):229-238. doi:
10.1016/j.jad.2020.10.003. [PMID: 33069121] - Moon Ho Park, Do Young Kwon. A retrospective review of memantine use and COVID-19-associated mortality from a national database.
Journal of medical virology.
2021 01; 93(1):168-169. doi:
10.1002/jmv.26266. [PMID: 32633865] - Gulsah Albayrak, Funda D Korkmaz, Elif B Bali, Emin U Bagriacik. Antitumorigenic Effect of Memantine via Interfering Glutamate Metabolism in Mouse 4T1 Breast Tumor Model.
Anti-cancer agents in medicinal chemistry.
2021; 21(12):1575-1580. doi:
10.2174/0929867327666201020155733. [PMID: 33081685] - Sandeep K Mishra, Mahendra Kumar Hidau, Shivika Rai. Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression.
Neurochemistry international.
2021 01; 142(?):104932. doi:
10.1016/j.neuint.2020.104932. [PMID: 33290797] - Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang. Activation of N-methyl-D-aspartate receptor regulates insulin sensitivity and lipid metabolism.
Theranostics.
2021; 11(5):2247-2262. doi:
10.7150/thno.51666. [PMID: 33500723] - Aleksandra Tencheva, Rui Liu, Tatyana V Volkova, Radoslav Chayrov, Yavor Mitrev, Martin Štícha, Yuhuan Li, Hailun Jiang, Zhuorong Li, Ivanka Stankova, German L Perlovich. Synthetic analogues of memantine as neuroprotective and influenza viral inhibitors: in vitro and physicochemical studies.
Amino acids.
2020 Dec; 52(11-12):1559-1580. doi:
10.1007/s00726-020-02914-4. [PMID: 33191465] - Xiaoxin Lv, Qiang Li, Shuai Mao, Limin Qin, Peikang Dong. The protective effects of memantine against inflammation and impairment of endothelial tube formation induced by oxygen-glucose deprivation/reperfusion.
Aging.
2020 11; 12(21):21469-21480. doi:
10.18632/aging.103914. [PMID: 33174867] - Steven R Brenner. The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects.
Journal of medical virology.
2020 11; 92(11):2341-2342. doi:
10.1002/jmv.26030. [PMID: 32436995] - Ileana Marinescu, Dragoş Marinescu, Laurenţiu Mogoantă, Ion Cristian Efrem, Puiu Olivian Stovicek. SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.
2020 Oct; 61(4):1007-1022. doi:
10.47162/rjme.61.4.03. [PMID: 34171050] - Juntao Zheng, Jiangying Chen, Jingjing Wu, Min Yang, Liping Mai, Xiyong Yu, Min Huang, Guoping Zhong. Bioequivalence study of two formulations of memantine hydrochloride tablets in healthy male Chinese subjects under fasting and fed conditions.
International journal of clinical pharmacology and therapeutics.
2020 Oct; 58(10):575-582. doi:
10.5414/cp203683. [PMID: 32729819] - Weize Huang, Nina Isoherranen. Novel Mechanistic PBPK Model to Predict Renal Clearance in Varying Stages of CKD by Incorporating Tubular Adaptation and Dynamic Passive Reabsorption.
CPT: pharmacometrics & systems pharmacology.
2020 10; 9(10):571-583. doi:
10.1002/psp4.12553. [PMID: 32977369] - Prabhat Pratap Singh Tomar, Isaiah T Arkin. SARS-CoV-2 E protein is a potential ion channel that can be inhibited by Gliclazide and Memantine.
Biochemical and biophysical research communications.
2020 09; 530(1):10-14. doi:
10.1016/j.bbrc.2020.05.206. [PMID: 32828269] - Kosar Jannesar, Samin Abbaszadeh, Hassan Malekinejad, Hamid Soraya. Cardioprotective effects of memantine in myocardial ischemia: Ex vivo and in vivo studies.
European journal of pharmacology.
2020 Sep; 882(?):173277. doi:
10.1016/j.ejphar.2020.173277. [PMID: 32544502] - Ljubica Vucicevic, Maja Misirkic, Darko Ciric, Tamara Martinovic, Maja Jovanovic, Aleksandra Isakovic, Ivanka Markovic, Jasna Saponjic, Marc Foretz, Yoana Rabanal-Ruiz, Viktor I Korolchuk, Vladimir Trajkovic. Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells.
Cellular and molecular life sciences : CMLS.
2020 Sep; 77(17):3383-3399. doi:
10.1007/s00018-019-03356-2. [PMID: 31720741] - Aixia Yue, Xiuqing Han, Enxia Mao, Guangling Wu, Junxiang Gao, Liping Huang, Bin Zhou. The effect of scalp electroacupuncture combined with Memantine in patients with vascular dementia: A retrospective study.
Medicine.
2020 Aug; 99(33):e21242. doi:
10.1097/md.0000000000021242. [PMID: 32871984] - Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A rapid FTIR spectroscopic assay for quantitative determination of Memantine hydrochloride and Amisulpride in human plasma and pharmaceutical formulations.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Aug; 236(?):118377. doi:
10.1016/j.saa.2020.118377. [PMID: 32330826] - Senad Hasanagic, Fadila Serdarevic. Potential role of memantine in the prevention and treatment of COVID-19: its antagonism of nicotinic acetylcholine receptors and beyond.
The European respiratory journal.
2020 08; 56(2):. doi:
10.1183/13993003.01610-2020. [PMID: 32554535] - Parisa Azadfar, Zahra Noormohammadi, Maryam Noroozian, Akram Eidi, Pejman Mortazavi. Effect of memantine on expression of Bace1-as and Bace1 genes in STZ-induced Alzheimeric rats.
Molecular biology reports.
2020 Aug; 47(8):5737-5745. doi:
10.1007/s11033-020-05629-7. [PMID: 32648077] - Konrad Rejdak, Paweł Grieb. Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment.
Multiple sclerosis and related disorders.
2020 Jul; 42(?):102163. doi:
10.1016/j.msard.2020.102163. [PMID: 32388458] - Md Tanvir Kabir, Md Sahab Uddin, Abdullah Al Mamun, Philippe Jeandet, Lotfi Aleya, Rasha A Mansouri, Ghulam Md Ashraf, Bijo Mathew, May N Bin-Jumah, Mohamed M Abdel-Daim. Combination Drug Therapy for the Management of Alzheimer's Disease.
International journal of molecular sciences.
2020 May; 21(9):. doi:
10.3390/ijms21093272. [PMID: 32380758] - Sean X Gu, Vijay K Sonkar, Parmeshwar B Katare, Rahul Kumar, Warren D Kruger, Erland Arning, Teodoro Bottiglieri, Steven R Lentz, Sanjana Dayal. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia.
Journal of the American Heart Association.
2020 02; 9(4):e013368. doi:
10.1161/jaha.119.013368. [PMID: 32067580] - Shinghung Mak, Zheng Liu, Liangmiao Wu, Baojian Guo, Fangcheng Luo, Ziyan Liu, Shengquan Hu, Jiajun Wang, Guozhen Cui, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Yifan Han, Zaijun Zhang. Pharmacological Characterizations of anti-Dementia Memantine Nitrate via Neuroprotection and Vasodilation in Vitro and in Vivo.
ACS chemical neuroscience.
2020 02; 11(3):314-327. doi:
10.1021/acschemneuro.9b00242. [PMID: 31922720] - Qiu-Jun Wang, Yue-E Shen, Xin Wang, Shuang Fu, Xin Zhang, Yi-Na Zhang, Rui-Tao Wang. Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice.
Aging.
2020 01; 12(1):628-649. doi:
10.18632/aging.102645. [PMID: 31907339] - Noha N Atia, Mostafa A Marzouq, Ahmed I Hassan, Walid E Eltoukhi. A new spectrofluorimetric assay for quantification of Amisulpride and Memantine hydrochloride in real human plasma sample and pharmaceutical formulations via Hantzsch reaction.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Jan; 224(?):117388. doi:
10.1016/j.saa.2019.117388. [PMID: 31357052] - Fardous A Mohamed, Pakinaz Y Khashaba, Mohamed M El-Wekil, Reem Y Shahin. Fabrication of water compatible and biodegradable super-paramagnetic molecularly imprinted nanoparticles for selective separation of memantine from human serum prior to its quantification: An efficient and green pathway.
International journal of biological macromolecules.
2019 Nov; 140(?):140-148. doi:
10.1016/j.ijbiomac.2019.08.099. [PMID: 31415858] - Yutaro Maekawa, Setsuo Hasegawa, Tomoko Ishizuka, Kazuhito Shiosakai, Hitoshi Ishizuka. Pharmacokinetics and Bioequivalence of Memantine Tablet and a New Dry Syrup Formulation in Healthy Japanese Males: Two Single-Dose Crossover Studies.
Advances in therapy.
2019 10; 36(10):2930-2940. doi:
10.1007/s12325-019-01044-y. [PMID: 31399883] - Yahdiana Harahap, Budi Prasaja, Monika Sandra, Tri Rahayu, Windy Lusthom, Anna Sofiana, Kristiyani Irawati, Yunia Trisari. Bioequivalence of two memantine tablet formulations in healthy Indonesian subjects.
International journal of clinical pharmacology and therapeutics.
2019 Sep; 57(9):478-482. doi:
10.5414/cp203386. [PMID: 31272528] - Fangcheng Luo, Liangmiao Wu, Zhixiang Zhang, Zeyu Zhu, Zheng Liu, Baojian Guo, Ning Li, Jun Ju, Qiang Zhou, Shupeng Li, Xifei Yang, Shinghung Mak, Yifan Han, Yewei Sun, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhang. The dual-functional memantine nitrate MN-08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models.
British journal of pharmacology.
2019 09; 176(17):3318-3335. doi:
10.1111/bph.14763. [PMID: 31180578] - Wei Zheng, Xiao-Min Zhu, Qing-E Zhang, Dong-Bin Cai, Xin-Hu Yang, Yan-Ling Zhou, Gabor S Ungvari, Chee H Ng, Shu-Hua He, Xiao-Jiang Peng, Yu-Ping Ning, Yu-Tao Xiang. Adjunctive memantine for major mental disorders: A systematic review and meta-analysis of randomized double-blind controlled trials.
Schizophrenia research.
2019 07; 209(?):12-21. doi:
10.1016/j.schres.2019.05.019. [PMID: 31164254] - Rosemary Kanasty, Susan Low, Nupura Bhise, Jung Yang, Erick Peeke, Marlene Schwarz, James Wright, Bennett Carter, Saumya Moorthy, Tyler Grant, Ben DeBenedictis, Megan Bishoff, Craig Simses, Andrew M Bellinger. A pharmaceutical answer to nonadherence: Once weekly oral memantine for Alzheimer's disease.
Journal of controlled release : official journal of the Controlled Release Society.
2019 06; 303(?):34-41. doi:
10.1016/j.jconrel.2019.03.022. [PMID: 30928488] - Samar S Khalaf, Mohamed M Hafez, Eman T Mehanna, Noha M Mesbah, Dina M Abo-Elmatty. Combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined Alzheimer's disease and type 2 diabetes.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 06; 392(6):685-695. doi:
10.1007/s00210-019-01616-3. [PMID: 30759264] - Onnita Thancharoen, Chulaporn Limwattananon, Onanong Waleekhachonloet, Thananan Rattanachotphanit, Phumtham Limwattananon, Panita Limpawattana. Ginkgo biloba Extract (EGb761), Cholinesterase Inhibitors, and Memantine for the Treatment of Mild-to-Moderate Alzheimer's Disease: A Network Meta-Analysis.
Drugs & aging.
2019 05; 36(5):435-452. doi:
10.1007/s40266-019-00648-x. [PMID: 30937879] - Pearl J C van Lonkhuizen, Kete M Klaver, Jeffrey S Wefel, Margriet M Sitskoorn, Sanne B Schagen, Karin Gehring. Interventions for cognitive problems in adults with brain cancer: A narrative review.
European journal of cancer care.
2019 May; 28(3):e13088. doi:
10.1111/ecc.13088. [PMID: 31090162] - Yunpeng Zhang, Shuping Li, Youxu Wang, Gang Deng, Ning Cao, Chao Wu, Wenzheng Ding, Yuwen Wang, Xuemei Cheng, Changhong Wang. Potential Pharmacokinetic Drug⁻Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071430. [PMID: 30978991] - M Göl, Ş Demiryürek, D S Kaplan, A Saracaloğlu, M Örkmez, A T Demiryürek. N-(p-amylcinnamoyl) anthranilic acid attenuates remedial effects of memantine on memory deficits following intracerebroventricular streptozotocin administration in rats.
Archives italiennes de biologie.
2019 Apr; 157(1):24-36. doi:
10.12871/00039829201913. [PMID: 31111954] - Qingmei Cheng, Lijuan Fang, Dandan Feng, Siyuan Tang, Shaojie Yue, Yanhong Huang, Jianzhong Han, Jinrong Lan, Wei Liu, Lihua Gao, Ziqiang Luo. Memantine ameliorates pulmonary inflammation in a mice model of COPD induced by cigarette smoke combined with LPS.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):2005-2013. doi:
10.1016/j.biopha.2018.11.002. [PMID: 30551456] - Takashi Matsumoto, Kyoji Sekiguchi, Zenji Kawakami, Junko Watanabe, Kazushige Mizoguchi, Yasushi Ikarashi, Masahiro Yamamoto. Basic Study of Drug-Drug Interaction between Memantine and the Traditional Japanese Kampo Medicine Yokukansan.
Molecules (Basel, Switzerland).
2018 Dec; 24(1):. doi:
10.3390/molecules24010115. [PMID: 30597998] - Samin Abbaszadeh, Asal Javidmehr, Behnam Askari, Paul M L Janssen, Hamid Soraya. Memantine, an NMDA receptor antagonist, attenuates cardiac remodeling, lipid peroxidation and neutrophil recruitment in heart failure: A cardioprotective agent?.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):1237-1243. doi:
10.1016/j.biopha.2018.09.153. [PMID: 30372825] - Hong Wei, Xiaolan Zhu, Yuefeng Li. Application value of serum biomarkers for choosing memantine therapy for moderate AD.
Journal of neurology.
2018 Aug; 265(8):1844-1849. doi:
10.1007/s00415-018-8926-4. [PMID: 29948244] - Nikolaos Pitsikas, Petros A Tarantilis. Effects of the active constituents of Crocus sativus L. crocins and their combination with memantine on recognition memory in rats.
Behavioural pharmacology.
2018 08; 29(5):400-412. doi:
10.1097/fbp.0000000000000380. [PMID: 29462109] - Naresh Mittapelly, Gitu Pandey, Sachin Laxman Tulsankar, Sadaf Arfi, Rabi Sankar Bhatta, Prabhat Ranjan Mishra. In Depth Analysis of Pressure-Sensitive Adhesive Patch-Assisted Delivery of Memantine and Donepezil Using Physiologically Based Pharmacokinetic Modeling and in Vitro/in Vivo Correlations.
Molecular pharmaceutics.
2018 07; 15(7):2646-2655. doi:
10.1021/acs.molpharmaceut.8b00176. [PMID: 29856631] - Joshua T Kantrowitz, Neal R Swerdlow, Walter Dunn, Sophia Vinogradov. Auditory System Target Engagement During Plasticity-Based Interventions in Schizophrenia: A Focus on Modulation of N-Methyl-D-Aspartate-Type Glutamate Receptor Function.
Biological psychiatry. Cognitive neuroscience and neuroimaging.
2018 07; 3(7):581-590. doi:
10.1016/j.bpsc.2018.02.002. [PMID: 29656951] - Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Ching Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu. Add-On Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study.
Alcoholism, clinical and experimental research.
2018 06; 42(6):1044-1050. doi:
10.1111/acer.13640. [PMID: 29656414] - Anne-Sophie Salabert, Erick Mora-Ramirez, Marie Beaurain, Mathieu Alonso, Charlotte Fontan, Hafid Belhadj Tahar, Marie Laure Boizeau, Mathieu Tafani, Manuel Bardiès, Pierre Payoux. Evaluation of [18F]FNM biodistribution and dosimetry based on whole-body PET imaging of rats.
Nuclear medicine and biology.
2018 04; 59(?):1-8. doi:
10.1016/j.nucmedbio.2017.12.003. [PMID: 29413751] - Kyeongjun Lee, Chowee Park, Yeonsoo Oh, Heesoon Lee, Jungsook Cho. Antioxidant and Neuroprotective Effects of N-((3,4-Dihydro-2H-benzo[h]chromen-2-yl)methyl)-4-methoxyaniline in Primary Cultured Rat Cortical Cells: Involvement of ERK-CREB Signaling.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030669. [PMID: 29543778] - Brian H May, Mei Feng, Anna J Hyde, Helmut Hügel, Su-Yueh Chang, Lin Dong, Xinfeng Guo, Anthony L Zhang, Chuanjian Lu, Charlie C Xue. Comparisons between traditional medicines and pharmacotherapies for Alzheimer disease: A systematic review and meta-analysis of cognitive outcomes.
International journal of geriatric psychiatry.
2018 03; 33(3):449-458. doi:
10.1002/gps.4830. [PMID: 29239495] - Mohsen Khalili-Fomeshi, Mohammad Golparvar Azizi, Mohammad Reza Esmaeili, Mohammad Gol, Sohrab Kazemi, Manouchehr Ashrafpour, Ali Akbar Moghadamnia, Soheila Hosseinzadeh. Piperine restores streptozotocin-induced cognitive impairments: Insights into oxidative balance in cerebrospinal fluid and hippocampus.
Behavioural brain research.
2018 Jan; 337(?):131-138. doi:
10.1016/j.bbr.2017.09.031. [PMID: 28939403] - Pauline Lemire, Antoine Brangier, Melinda Beaudenon, Guillaume T Duval, Cedric Annweiler. Cognitive changes under memantine according to vitamin D status in Alzheimer patients: An exposed/unexposed cohort pilot study.
The Journal of steroid biochemistry and molecular biology.
2018 01; 175(?):151-156. doi:
10.1016/j.jsbmb.2016.12.019. [PMID: 28042052] - Xiaoyan Zhang, Bohui Shu, Dongdong Zhang, Lina Huang, Qizhi Fu, Ganqin Du. The Efficacy and Safety of Pharmacological Treatments for Post-stroke Aphasia.
CNS & neurological disorders drug targets.
2018; 17(7):509-521. doi:
10.2174/1871527317666180706143051. [PMID: 29984673] - Majid Mokhtari, Hossein Nayeb-Aghaei, Mehran Kouchek, Mir Mohammad Miri, Reza Goharani, Arash Amoozandeh, Sina Akhavan Salamat, Mohammad Sistanizad. Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury.
Journal of clinical pharmacology.
2018 Jan; 58(1):42-47. doi:
10.1002/jcph.980. [PMID: 28724200] - Avadh Kumar, Borislav Dejanovic, Florian Hetsch, Marcus Semtner, Debora Fusca, Sita Arjune, Jose Angel Santamaria-Araujo, Aline Winkelmann, Scott Ayton, Ashley I Bush, Peter Kloppenburg, Jochen C Meier, Guenter Schwarz, Abdel Ali Belaidi. S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.
The Journal of clinical investigation.
2017 12; 127(12):4365-4378. doi:
10.1172/jci89885. [PMID: 29106383] - Daniella B Victorino, Ilya R Bederman, Alberto C S Costa. Pharmacokinetic Properties of Memantine after a Single Intraperitoneal Administration and Multiple Oral Doses in Euploid Mice and in the Ts65Dn Mouse Model of Down's Syndrome.
Basic & clinical pharmacology & toxicology.
2017 Nov; 121(5):382-389. doi:
10.1111/bcpt.12816. [PMID: 28557265] - Hui Hua Chang, Po See Chen, Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, San-Yuan Huang, Jau-Shyong Hong, Yen Kuang Yang, Ru-Band Lu. Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder.
Journal of affective disorders.
2017 10; 221(?):151-157. doi:
10.1016/j.jad.2017.05.052. [PMID: 28646711] - Fabian Müller, Dietmar Weitz, Volker Derdau, Martin Sandvoss, Katharina Mertsch, Jörg König, Martin F Fromm. Contribution of MATE1 to Renal Secretion of the NMDA Receptor Antagonist Memantine.
Molecular pharmaceutics.
2017 09; 14(9):2991-2998. doi:
10.1021/acs.molpharmaceut.7b00179. [PMID: 28708400] - Amira S Ahmed, Rehab M Elgharabawy, Amal H Al-Najjar. Ameliorating effect of anti-Alzheimer's drugs on the bidirectional association between type 2 diabetes mellitus and Alzheimer's disease.
Experimental biology and medicine (Maywood, N.J.).
2017 07; 242(13):1335-1344. doi:
10.1177/1535370217711440. [PMID: 28534431] - Hayder Amin, Thierry Nieus, Davide Lonardoni, Alessandro Maccione, Luca Berdondini. High-resolution bioelectrical imaging of Aβ-induced network dysfunction on CMOS-MEAs for neurotoxicity and rescue studies.
Scientific reports.
2017 05; 7(1):2460. doi:
10.1038/s41598-017-02635-x. [PMID: 28550283] - Fabricio Ferreira de Oliveira, Elizabeth Suchi Chen, Marilia Cardoso Smith, Paulo Henrique Ferreira Bertolucci. Longitudinal lipid profile variations and clinical change in Alzheimer's disease dementia.
Neuroscience letters.
2017 04; 646(?):36-42. doi:
10.1016/j.neulet.2017.03.003. [PMID: 28274859] - Bin Chen, Guoxiang Wang, Weiwei Li, Weilin Liu, Ruhui Lin, Jing Tao, Min Jiang, Lidian Chen, Yun Wang. Memantine attenuates cell apoptosis by suppressing the calpain-caspase-3 pathway in an experimental model of ischemic stroke.
Experimental cell research.
2017 02; 351(2):163-172. doi:
10.1016/j.yexcr.2016.12.028. [PMID: 28069373] - Irving H Gomolin, Michael J Papamichael, Melissa J Fazzari, Robert Rieger. Memantine Plasma Concentrations Among Patients With Dementia.
Journal of clinical psychopharmacology.
2017 Feb; 37(1):117-118. doi:
10.1097/jcp.0000000000000645. [PMID: 28027115] - S Del Río-Sancho, C E Serna-Jiménez, M Sebastián-Morelló, M A Calatayud-Pascual, C Balaguer-Fernández, A Femenía-Font, Y N Kalia, V Merino, A López-Castellano. Transdermal therapeutic systems for memantine delivery. Comparison of passive and iontophoretic transport.
International journal of pharmaceutics.
2017 Jan; 517(1-2):104-111. doi:
10.1016/j.ijpharm.2016.11.038. [PMID: 27865983] - Pablo Zambrano, Mario Suwalsky, Fernando Villena, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka. In vitro effects of the anti-Alzheimer drug memantine on the human erythrocyte membrane and molecular models.
Biochemical and biophysical research communications.
2017 01; 483(1):528-533. doi:
10.1016/j.bbrc.2016.12.111. [PMID: 27998775] - Hisakazu Izumida, Hiroshi Takagi, Haruki Fujisawa, Naoko Iwata, Kohtaro Nakashima, Seiji Takeuchi, Shintaro Iwama, Takashi Namba, Yukio Komatu, Kozo Kaibuchi, Yutaka Oiso, Hiroshi Arima, Yoshihisa Sugimura. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats.
Experimental neurology.
2017 Jan; 287(Pt 1):65-74. doi:
10.1016/j.expneurol.2016.08.007. [PMID: 27527984] - Ehsan Motaghi, Valiollah Hajhashemi, Parvin Mahzouni, Mohsen Minaiyan. The effect of memantine on trinitrobenzene sulfonic acid-induced ulcerative colitis in mice.
European journal of pharmacology.
2016 Dec; 793(?):28-34. doi:
10.1016/j.ejphar.2016.10.032. [PMID: 27983945] - Xiaobo Wei, Huimin Gao, Jing Zou, Xu Liu, Dan Chen, Jinchi Liao, Yunqi Xu, Long Ma, Beisha Tang, Zhuohua Zhang, Xiang Cai, Kunling Jin, Ying Xia, Qing Wang. Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mechanism for Memantine-Induced Anti-inflammation and Anti-mitochondrial Impairment.
Molecular neurobiology.
2016 11; 53(9):5876-5892. doi:
10.1007/s12035-015-9477-7. [PMID: 26497037] - Hila Roshanravan, Eun Young Kim, Stuart E Dryer. NMDA Receptors as Potential Therapeutic Targets in Diabetic Nephropathy: Increased Renal NMDA Receptor Subunit Expression in Akita Mice and Reduced Nephropathy Following Sustained Treatment With Memantine or MK-801.
Diabetes.
2016 10; 65(10):3139-50. doi:
10.2337/db16-0209. [PMID: 27388219] - A R Vijayakumar, H Anuradha, Nihar Ranjan Biswas, Vimla Menon, Rohit Saxena, Nabanita Halder, T Velpandian. Evaluation of the Protective Effect of NMDA/Non-NMDA Receptor Antagonists Against Ethambutol Induced Retinal Toxicity Using ERG in Wistar Rats.
Indian journal of physiology and pharmacology.
2016 Jul; 60(3):268-81. doi:
NULL. [PMID: 29957983] - Susmita Sil, Tusharkanti Ghosh, Rupsa Ghosh. NMDA receptor is involved in neuroinflammation in intracerebroventricular colchicine-injected rats.
Journal of immunotoxicology.
2016 07; 13(4):474-89. doi:
10.3109/1547691x.2015.1130760. [PMID: 26788903] - Tzu-Yun Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Liang-Jen Wang, Po See Chen, Shih-Heng Chen, Chun-Hsien Chu, San-Yuan Huang, Nian-Sheng Tzeng, Chia-Ling Li, Yi-Lun Chung, Tsai-Hsin Hsieh, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu. Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder.
Scientific reports.
2016 06; 6(?):27431. doi:
10.1038/srep27431. [PMID: 27270858] - Naresh Mittapelly, Ramakrishna Rachumallu, Gitu Pandey, Shweta Sharma, Abhishek Arya, Rabi Shankar Bhatta, Prabhat Ranjan Mishra. Investigation of salt formation between memantine and pamoic acid: Its exploitation in nanocrystalline form as long acting injection.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2016 Apr; 101(?):62-71. doi:
10.1016/j.ejpb.2016.01.003. [PMID: 26850817] - Soo-Han Lee, Seung-Hyun Kim, Yook-Hwan Noh, Byung-Moon Choi, Gyu-Jeong Noh, Woo-Dae Park, Eun-Jung Kim, Ik-Hyun Cho, Chun-Sik Bae. Pharmacokinetics of Memantine after a Single and Multiple Dose of Oral and Patch Administration in Rats.
Basic & clinical pharmacology & toxicology.
2016 Feb; 118(2):122-7. doi:
10.1111/bcpt.12479. [PMID: 26310825] - Shao-Jun Jing, Qing-Lian Li, Ye Jiang. A new simultaneous derivatization and microextration method for the determination of memantine hydrochloride in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Jan; 1008(?):26-31. doi:
10.1016/j.jchromb.2015.09.016. [PMID: 26613537] - Sayaka Nagasawa, Daisuke Yajima, Suguru Torimitsu, Fumiko Chiba, Hirotaro Iwase. Postmortem memantine concentration in a non-intoxication case, and the possibility of postmortem redistribution: A case report.
Forensic science international.
2015 Dec; 257(?):e12-e15. doi:
10.1016/j.forsciint.2015.08.015. [PMID: 26344557] - Manisha Bhateria, Rachumallu Ramakrishna, Dora Babu Pakala, Rabi Sankar Bhatta. Development of an LC-MS/MS method for simultaneous determination of memantine and donepezil in rat plasma and its application to pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Sep; 1001(?):131-9. doi:
10.1016/j.jchromb.2015.07.042. [PMID: 26280281] - Héctor Torres-Gómez, Kirstin Lehmkuhl, Bastian Frehland, Constantin Daniliuc, Dirk Schepmann, Christina Ehrhardt, Bernhard Wünsch. Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.
Bioorganic & medicinal chemistry.
2015 Aug; 23(15):4277-4285. doi:
10.1016/j.bmc.2015.06.030. [PMID: 26145819] - Ramesh Boinpally, Laishun Chen, Stephen R Zukin, Natalie McClure, Robert K Hofbauer, Antonia Periclou. A novel once-daily fixed-dose combination of memantine extended release and donepezil for the treatment of moderate to severe Alzheimer's disease: two phase I studies in healthy volunteers.
Clinical drug investigation.
2015 Jul; 35(7):427-35. doi:
10.1007/s40261-015-0296-4. [PMID: 26016820] - Hai-Wen Qiu, Lei Xia, Li-Min Gong, Lie-Min Ruan, Yong-Gang Zhao. Rapid determination of memantine in human plasma by using nanoring carboxyl-functionalized paramagnetic molecularly imprinted polymer d-μ-SPE and UFLC-MS/MS.
Drug testing and analysis.
2015 Jun; 7(6):535-43. doi:
10.1002/dta.1706. [PMID: 25209851] - Mansour A Al-Hazmi, Sayed M Rawi, Nadia Ms Arafa, Abeer Wagas, Ayat Os Montasser. The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats.
Toxicology and industrial health.
2015 Jun; 31(6):494-509. doi:
10.1177/0748233713475517. [PMID: 23406953] - Shaimaa Nasr Amin, Ahmed Amro El-Aidi, Mohamed Mostafa Ali, Yasser Mahmoud Attia, Laila Ahmed Rashed. Modification of hippocampal markers of synaptic plasticity by memantine in animal models of acute and repeated restraint stress: implications for memory and behavior.
Neuromolecular medicine.
2015 Jun; 17(2):121-36. doi:
10.1007/s12017-015-8343-0. [PMID: 25680935] - Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Tzu-Yun Wang, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu. Low-dose memantine attenuated methadone dose in opioid-dependent patients: a 12-week double-blind randomized controlled trial.
Scientific reports.
2015 May; 5(?):10140. doi:
10.1038/srep10140. [PMID: 25988317] - Sara Laserra, Abdul Basit, Piera Sozio, Lisa Marinelli, Erika Fornasari, Ivana Cacciatore, Michele Ciulla, Hasan Türkez, Fatime Geyikoglu, Antonio Di Stefano. Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization.
International journal of pharmaceutics.
2015 May; 485(1-2):183-91. doi:
10.1016/j.ijpharm.2015.03.001. [PMID: 25747452]