Mocetinostat (BioDeep_00000858601)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C23H20N6O (396.169851)
中文名称: 阿比特龙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)N)NC(=O)C2=CC=C(C=C2)CNC3=NC=CC(=N3)C4=CN=CC=C4
InChI: InChI=1S/C23H20N6O/c24-19-5-1-2-6-21(19)28-22(30)17-9-7-16(8-10-17)14-27-23-26-13-11-20(29-23)18-4-3-12-25-15-18/h1-13,15H,14,24H2,(H,28,30)(H,26,27,29)
描述信息
D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:94525
- KEGGdrug: D09641
- KEGGdrug: D09643
- PubChem: 9865515
- DrugBank: DB11830
- ChEMBL: CHEMBL272980
- CAS: 726169-73-9
- CAS: 9003-99-0
- KEGG: C05785
- PubChem: 8080
- KNApSAcK: 8027
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Emily G Hicks, Sylvie E Kandel, Jed N Lampe. Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (Mpro) inhibitors.
Bioorganic & medicinal chemistry letters.
2022 06; 66(?):128732. doi:
10.1016/j.bmcl.2022.128732. [PMID: 35427739] - Gun Jik Kim, Hanna Jung, Eunjo Lee, Sung Woon Chung. Histone deacetylase inhibitor, mocetinostat, regulates cardiac remodelling and renin-angiotensin system activity in rats with transverse aortic constriction-induced pressure overload cardiac hypertrophy.
Reviews in cardiovascular medicine.
2021 Sep; 22(3):1037-1045. doi:
10.31083/j.rcm2203113. [PMID: 34565105] - Hei-Jen Huang, Hsin-Yu Huang, Hsiu Mei Hsieh-Li. MGCD0103, a selective histone deacetylase inhibitor, coameliorates oligomeric Aβ25-35 -induced anxiety and cognitive deficits in a mouse model.
CNS neuroscience & therapeutics.
2019 02; 25(2):175-186. doi:
10.1111/cns.13029. [PMID: 29978554] - Charles M Marson, Christopher J Matthews, Stephen J Atkinson, Nermina Lamadema, N Shaun B Thomas. Potent and Selective Inhibitors of Histone Deacetylase-3 Containing Chiral Oxazoline Capping Groups and a N-(2-Aminophenyl)-benzamide Binding Unit.
Journal of medicinal chemistry.
2015 Sep; 58(17):6803-18. doi:
10.1021/acs.jmedchem.5b00545. [PMID: 26287310] - Jinzhang Cai, Qingwei Zhang, Kezhi Lin, Lufeng Hu, Yuancai Zheng. The Effect of MGCD0103 on CYP450 Isoforms Activity of Rats by Cocktail Method.
BioMed research international.
2015; 2015(?):517295. doi:
10.1155/2015/517295. [PMID: 26357656] - Nassera Aouali, Angeliki Broukou, Manon Bosseler, Olivier Keunen, Vincent Schlesser, Bassam Janji, Valerie Palissot, Philippe Stordeur, Guy Berchem. Epigenetic Activity of Peroxisome Proliferator-Activated Receptor Gamma Agonists Increases the Anticancer Effect of Histone Deacetylase Inhibitors on Multiple Myeloma Cells.
PloS one.
2015; 10(6):e0130339. doi:
10.1371/journal.pone.0130339. [PMID: 26091518] - Jianshe Ma, Qingwei Zhang, Xianqin Wang. Liquid chromatography mass spectrometry determination of mocetinostat (MGCD0103) in rat plasma and its application to a pharmacokinetic study.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Sep; 44(9):849-54. doi:
10.3109/00498254.2014.897012. [PMID: 24588344] - Philip B Busbee, Mitzi Nagarkatti, Prakash S Nagarkatti. Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression.
Toxicology and applied pharmacology.
2014 Jan; 274(1):7-16. doi:
10.1016/j.taap.2013.10.022. [PMID: 24200994] - E S K Assem, S Mann, B Y C Wan, C M Marson. Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2010 Mar; 59 Suppl 2(?):S235-7. doi:
10.1007/s00011-009-0137-0. [PMID: 20013027] - Guillermo Garcia-Manero, Sarit Assouline, Jorge Cortes, Zeev Estrov, Hagop Kantarjian, Hui Yang, Willie M Newsome, Wilson H Miller, Caroline Rousseau, Ann Kalita, Claire Bonfils, Marja Dubay, Tracy-Ann Patterson, Zuomei Li, Jeffrey M Besterman, Gregory Reid, Eric Laille, Robert E Martell, Mark Minden. Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia.
Blood.
2008 Aug; 112(4):981-9. doi:
10.1182/blood-2007-10-115873. [PMID: 18495956] - Philip Jones, Sergio Altamura, Raffaele De Francesco, Paola Gallinari, Armin Lahm, Petra Neddermann, Michael Rowley, Sergio Serafini, Christian Steinkühler. Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Bioorganic & medicinal chemistry letters.
2008 Mar; 18(6):1814-9. doi:
10.1016/j.bmcl.2008.02.025. [PMID: 18308563]