IDRONOXIL (BioDeep_00000858560)
代谢物信息卡片
IDRONOXIL
化学式: C15H12O3 (240.0786402)
中文名称: 脑益嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=CC2=C(O1)C=C(C=C2)O)C3=CC=C(C=C3)O
InChI: InChI=1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2
描述信息
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D04498
- PubChem: 219100
- DrugBank: DB04915
- ChEMBL: CHEMBL1957038
- CAS: 81267-65-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Makoto Isono, Akinori Sato, Takako Asano, Kazuki Okubo, Tomohiko Asano. Evaluation of Therapeutic Potential of Phenoxodiol, a Novel Isoflavone Analog, in Renal Cancer Cells.
Anticancer research.
2018 Oct; 38(10):5709-5716. doi:
10.21873/anticanres.12908. [PMID: 30275191] - P Russo, A Del Bufalo, A Cesario. Flavonoids acting on DNA topoisomerases: recent advances and future perspectives in cancer therapy.
Current medicinal chemistry.
2012; 19(31):5287-93. doi:
10.2174/092986712803833272. [PMID: 22998568] - Lian-Ying Wu, Thomas De Luca, Takahiro Watanabe, Dorothy M Morré, D James Morré. Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol.
Biochimica et biophysica acta.
2011 Aug; 1810(8):784-9. doi:
10.1016/j.bbagen.2011.04.011. [PMID: 21571040] - Jan B Howes, Paul L de Souza, Leanne West, Li Jiu Huang, Laurence G Howes. Pharmacokinetics of phenoxodiol, a novel isoflavone, following intravenous administration to patients with advanced cancer.
BMC clinical pharmacology.
2011 Feb; 11(?):1. doi:
10.1186/1472-6904-11-1. [PMID: 21291562] - Thomas De Luca, Dorothy M Morré, D James Morré. Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells.
Journal of cellular biochemistry.
2010 Aug; 110(6):1504-11. doi:
10.1002/jcb.22724. [PMID: 20518072] - Sylvianna Georgaki, Margarita Skopeliti, Marinos Tsiatas, Katerina A Nicolaou, Kyriaki Ioannou, Alan Husband, Aristotelis Bamias, Meletios A Dimopoulos, Andreas I Constantinou, Ourania E Tsitsilonis. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro and in vivo.
Journal of cellular and molecular medicine.
2009 Sep; 13(9B):3929-38. doi:
10.1111/j.1582-4934.2009.00695.x. [PMID: 19220577] - Patries M Herst, Joanne E Davis, Paul Neeson, Michael V Berridge, David S Ritchie. The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells.
Haematologica.
2009 Jul; 94(7):928-34. doi:
10.3324/haematol.2008.003996. [PMID: 19535345] - Dan-Arin Silasi, Ayesha B Alvero, Thomas J Rutherford, David Brown, Gil Mor. Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs.
Expert opinion on pharmacotherapy.
2009 Apr; 10(6):1059-67. doi:
10.1517/14656560902837980. [PMID: 19364253] - Thomas De Luca, Elena Bosneaga, Dorothy M Morré, D James Morré. Downstream targets of altered sphingolipid metabolism in response to inhibition of ENOX2 by phenoxodiol.
BioFactors (Oxford, England).
2008; 34(3):253-60. doi:
10.3233/bio-2009-1079. [PMID: 19734127] - P M Herst, T Petersen, P Jerram, J Baty, M V Berridge. The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells.
Biochemical pharmacology.
2007 Dec; 74(11):1587-95. doi:
10.1016/j.bcp.2007.08.019. [PMID: 17904534] - Fu Yu, Ralph N Watts, Xu Dong Zhang, Jodie M Borrow, Peter Hersey. Involvement of BH3-only proapoptotic proteins in mitochondrial-dependent Phenoxodiol-induced apoptosis of human melanoma cells.
Anti-cancer drugs.
2006 Nov; 17(10):1151-61. doi:
10.1097/01.cad.0000231484.17063.9a. [PMID: 17075314] - Paul L de Souza, Winston Liauw, Matthew Links, Saiyini Pirabhahar, Graham Kelly, Laurence G Howes. Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer.
Cancer chemotherapy and pharmacology.
2006 Oct; 58(4):427-33. doi:
10.1007/s00280-006-0189-6. [PMID: 16463060] - Jennifer R Gamble, Pu Xia, Christopher N Hahn, Jenny J Drew, Christopher J Drogemuller, David Brown, Mathew A Vadas. Phenoxodiol, an experimental anticancer drug, shows potent antiangiogenic properties in addition to its antitumour effects.
International journal of cancer.
2006 May; 118(10):2412-20. doi:
10.1002/ijc.21682. [PMID: 16353157] - T K Choueiri, T Mekhail, T E Hutson, R Ganapathi, G E Kelly, R M Bukowski. Phase I trial of phenoxodiol delivered by continuous intravenous infusion in patients with solid cancer.
Annals of oncology : official journal of the European Society for Medical Oncology.
2006 May; 17(5):860-5. doi:
10.1093/annonc/mdl010. [PMID: 16524966] - Toni K Choueiri, Robert Wesolowski, Tarek M Mekhail. Phenoxodiol: isoflavone analog with antineoplastic activity.
Current oncology reports.
2006 Mar; 8(2):104-7. doi:
10.1007/s11912-006-0044-2. [PMID: 16507219] - Linara Axanova, D James Morré, Dorothy M Morré. Growth of LNCaP cells in monoculture and coculture with osteoblasts and response to tNOX inhibitors.
Cancer letters.
2005 Jul; 225(1):35-40. doi:
10.1016/j.canlet.2004.11.017. [PMID: 15922855] - Thomas De Luca, Dorothy M Morré, Haiyun Zhao, D James Morré. NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis.
BioFactors (Oxford, England).
2005; 25(1-4):43-60. doi:
10.1002/biof.5520250106. [PMID: 16873929] - Andreas I Constantinou, Alan Husband. Phenoxodiol (2H-1-benzopyran-7-0,1,3-(4-hydroxyphenyl)), a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex.
Anticancer research.
2002 Sep; 22(5):2581-5. doi:
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