Yohimbine hydrochloride (BioDeep_00000858553)
Main id: BioDeep_00000230121
PANOMIX_OTCML-2023
代谢物信息卡片
Yohimbine hydrochloride
化学式: C21H27ClN2O3 (390.17101020000007)
中文名称: 盐酸育亨宾
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl
InChI: /m0./s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
D000089162 - Genitourinary Agents > D064804 - Urological Agents
Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
Yohimbine Hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D06671
- PubChem: 6169
- ChEMBL: CHEMBL537669
- MeSH: Yohimbine
- CAS: 65-19-0
- medchemexpress: HY-N0127
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Samuel A Bradley, Frederik G Hansson, Beata J Lehka, Daniela Rago, Pedro Pinho, Huadong Peng, Khem B Adhikari, Ahmad K Haidar, Lea G Hansen, Daria Volkova, Maxence Holtz, Sergi Muyo Abad, Xin Ma, Konstantinos Koudounas, Sébastien Besseau, Nicolas Gautron, Céline Mélin, Jillian Marc, Caroline Birer Williams, Vincent Courdavault, Emil D Jensen, Jay D Keasling, Jie Zhang, Michael K Jensen. Yeast Platforms for Production and Screening of Bioactive Derivatives of Rauwolscine.
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Chemistry & biodiversity.
2024 Mar; 21(3):e202302123. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Molecules (Basel, Switzerland).
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Luminescence : the journal of biological and chemical luminescence.
2022 Sep; 37(9):1532-1540. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
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European journal of pharmacology.
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International journal of molecular sciences.
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Journal of pharmacological sciences.
2021 Jan; 145(1):79-87. doi:
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Chemistry & biodiversity.
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Clinical pharmacokinetics.
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Bioanalysis.
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Pharmacology, biochemistry, and behavior.
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Biomedical chromatography : BMC.
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BMC anesthesiology.
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10.1186/s12871-015-0042-8. [PMID: 25929655] - Sai P Pydi, Appalaraju Jaggupilli, Ken M Nelson, Suzanne R Abrams, Rajinder P Bhullar, Michele C Loewen, Prashen Chelikani. Abscisic Acid Acts as a Blocker of the Bitter Taste G Protein-Coupled Receptor T2R4.
Biochemistry.
2015 Apr; 54(16):2622-31. doi:
10.1021/acs.biochem.5b00265. [PMID: 25844797] - J Kaufmann, P Martinka, O Moede, M Sendeski, A Steege, M Fähling, M Hultström, M Gaestel, I C Moraes-Silva, T Nikitina, Z Z Liu, O Zavaritskaya, A Patzak. Noradrenaline enhances angiotensin II responses via p38 MAPK activation after hypoxia/re-oxygenation in renal interlobar arteries.
Acta physiologica (Oxford, England).
2015 Apr; 213(4):920-32. doi:
10.1111/apha.12457. [PMID: 25594617] - I O Ishola, S O Olayemi, O K Yemitan, E A Umeh. Antidepressant and anxiolytic effects of the methanol root extract of Capparis thonningii: involvement of monoaminergic, cholinergic and GABAergic systems.
Drug research.
2015 Apr; 65(4):205-13. doi:
10.1055/s-0034-1376963. [PMID: 24886981] - Adjmal Nahimi, Steen Jakobsen, Ole L Munk, Kim Vang, Jenny A Phan, Anders Rodell, Albert Gjedde. Mapping α2 adrenoceptors of the human brain with 11C-yohimbine.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2015 Mar; 56(3):392-8. doi:
10.2967/jnumed.114.145565. [PMID: 25635132] - Derick Lucas, James Neal-Kababick, Jerry Zweigenbaum. Characterization and quantitation of yohimbine and its analogs in botanicals and dietary supplements using LC/QTOF-MS and LC/QQQ-MS for determination of the presence of bark extract and yohimbine adulteration.
Journal of AOAC International.
2015 Mar; 98(2):330-5. doi:
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PloS one.
2015; 10(10):e0141327. doi:
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Organic letters.
2014 Dec; 16(24):6330-3. doi:
10.1021/ol503072g. [PMID: 25454201] - John Malaty, Irene A Malaty. Hypertensive urgency: an important aetiology of rebound hypertension.
BMJ case reports.
2014 Oct; 2014(?):. doi:
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European journal of pharmacology.
2014 Oct; 741(?):316-22. doi:
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Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.
2014 Oct; 78(4):304-15. doi:
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Journal of ethnopharmacology.
2014 Sep; 155(3):1616-24. doi:
10.1016/j.jep.2014.08.006. [PMID: 25153020] - Theresa M Scott, Jillian K Yeakel, Barry K Logan. Identification of mitragynine and O-desmethyltramadol in Kratom and legal high products sold online.
Drug testing and analysis.
2014 Sep; 6(9):959-63. doi:
10.1002/dta.1673. [PMID: 24962931] - Andrea Luiza de Oliveira, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Rosane Marina Peralta, Adelar Bracht. The action of p-synephrine on hepatic carbohydrate metabolism and respiration occurs via both Ca(2+)-mobilization and cAMP production.
Molecular and cellular biochemistry.
2014 Mar; 388(1-2):135-47. doi:
10.1007/s11010-013-1905-2. [PMID: 24287564] - S Umukoro, A T Eduviere, A C Aladeokin, A S Olugbemide. Antidepressant-like property of Jobelyn®, an African unique herbal formulation, in mice.
Drug research.
2014 Mar; 64(3):146-50. doi:
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The Journal of veterinary medical science.
2014 Mar; 76(2):173-82. doi:
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Autonomic neuroscience : basic & clinical.
2014 Feb; 180(?):48-52. doi:
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Analytical and bioanalytical chemistry.
2014 Jan; 406(1):225-37. doi:
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Veterinary anaesthesia and analgesia.
2014 Jan; 41(1):36-47. doi:
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Lipids in health and disease.
2013 Oct; 12(?):148. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2013 Oct; 38(11):2120-30. doi:
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Psychopharmacology.
2013 Sep; 229(1):83-94. doi:
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Behavioural brain research.
2013 Jun; 246(?):76-85. doi:
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European review for medical and pharmacological sciences.
2013 Apr; 17(8):1082-9. doi:
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2013 Mar; 45(3):252-4. doi:
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Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2013 Mar; 29(3):222-5. doi:
10.3109/09513590.2012.665104. [PMID: 23230861] - Yiyang Wang, Xiaohui Yu, Faqiang Wang, Yuan Wang, Yanping Wang, Hongmei Li, Xiuxiu Lv, Daxiang Lu, Huadong Wang. Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic α2A-adrenergic receptor.
PloS one.
2013; 8(5):e63622. doi:
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Journal of natural medicines.
2013 Jan; 67(1):42-50. doi:
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Journal of ethnopharmacology.
2012 Dec; 144(3):683-91. doi:
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NeuroImage.
2012 Dec; 63(4):1854-63. doi:
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Veterinary anaesthesia and analgesia.
2012 Nov; 39(6):574-83. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2012 Sep; 37(10):2253-66. doi:
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Journal of ethnopharmacology.
2012 Jul; 142(2):401-6. doi:
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Croatian medical journal.
2012 Jun; 53(3):214-23. doi:
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Veterinary anaesthesia and analgesia.
2012 May; 39(3):221-9. doi:
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The Journal of pharmacology and experimental therapeutics.
2012 Mar; 340(3):801-9. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Mar; 59(3):650-6. doi:
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Addiction biology.
2012 Mar; 17(2):224-34. doi:
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Hypertension (Dallas, Tex. : 1979).
2012 Mar; 59(3):548-9. doi:
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Behavioural brain research.
2012 Mar; 228(1):66-73. doi:
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