Cambendazol (BioDeep_00000858552)

   


代谢物信息卡片


Cambendazole

化学式: C14H14N4O2S (302.0837424)
中文名称: 康苯达唑
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)OC(=O)NC1=CC2=C(C=C1)N=C(N2)C3=CSC=N3
InChI: InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)

描述信息

B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AD - Enzymes
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent

同义名列表

2 个代谢物同义名

Cambendazole; Cambendazol



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ioannis Serafimidis, Gareth Bloomfield, Jason Skelton, Al Ivens, Robert R Kay. A new environmentally resistant cell type from Dictyostelium. Microbiology (Reading, England). 2007 Feb; 153(Pt 2):619-630. doi: 10.1099/mic.0.2006/000562-0. [PMID: 17259634]
  • Eugene Lyons. Population-S benzimidazole- and tetrahydropyrimidine-resistant small strongyles in a pony herd in Kentucky (1977-1999): effects of anthelmintic treatment on the parasites as determined in critical tests. Parasitology research. 2003 Nov; 91(5):407-11. doi: 10.1007/s00436-003-0983-6. [PMID: 14530968]
  • S K Katiyar, T D Edlind. In vitro susceptibilities of the AIDS-associated microsporidian Encephalitozoon intestinalis to albendazole, its sulfoxide metabolite, and 12 additional benzimidazole derivatives. Antimicrobial agents and chemotherapy. 1997 Dec; 41(12):2729-32. doi: 10.1128/aac.41.12.2729. [PMID: 9420047]
  • F H Borgsteede, G M Dvojnos, V A Kharchenko. Benzimidazole resistance in cyathostomes in horses in the Ukraine. Veterinary parasitology. 1997 Jan; 68(1-2):113-7. doi: 10.1016/s0304-4017(96)01050-3. [PMID: 9066057]
  • E T Lyons, J H Drudge, S C Tolliver, T W Swerczek, S Stamper, D E Granstrom. Control of cambendazole-resistant small strongyles (Population S) with oxibendazole in a pony band: an 8 year field test (1984-1992). Veterinary parasitology. 1994 Apr; 52(3-4):271-7. doi: 10.1016/0304-4017(94)90118-x. [PMID: 8073610]
  • J H Boersema, F H Borgsteede, M Eysker, T E Elema, C P Gaasenbeek, W P van der Burg. The prevalence of anthelmintic resistance of horse strongyles in The Netherlands. The veterinary quarterly. 1991 Oct; 13(4):209-17. doi: 10.1080/01652176.1991.9694310. [PMID: 1776235]
  • J H Drudge, E T Lyons, S C Tolliver. Resistance of population-B equine strongyles to thiabendazole, oxfendazole, and phenothiazine (1981 to 1987). American journal of veterinary research. 1991 Aug; 52(8):1308-12. doi: . [PMID: 1928913]
  • D I Grove, C Northern. Dissociation of the protective immune response in the mouse to Strongyloides ratti. Journal of helminthology. 1989 Dec; 63(4):307-14. doi: 10.1017/s0022149x00009202. [PMID: 2600413]
  • D I Grove, C Northern. The effects of thiabendazole, mebendazole and cambendazole in normal and immunosuppressed dogs infected with a human strain of Strongyloides stercoralis. Transactions of the Royal Society of Tropical Medicine and Hygiene. 1988; 82(1):146-9. doi: 10.1016/0035-9203(88)90290-8. [PMID: 3176142]
  • H J Bürger, C Bauer. Efficacy of four anthelmintics against benzimidazole-resistant cyathostomes of horses. The Veterinary record. 1987 Mar; 120(13):293-6. doi: 10.1136/vr.120.13.293. [PMID: 3590562]
  • M Eysker, J Jansen, M H Mirck. Control of strongylosis in horses by alternate grazing of horses and sheep and some other aspects of the epidemiology of Strongylidae infections. Veterinary parasitology. 1986 Jan; 19(1-2):103-15. doi: 10.1016/0304-4017(86)90037-3. [PMID: 3962151]
  • C Uhlinger, C Johnstone. Prevalence of benzimidazole-resistant small strongyles in horses in a southeastern Pennsylvania practice. Journal of the American Veterinary Medical Association. 1985 Dec; 187(12):1362-6. doi: NULL. [PMID: 4086354]
  • J H Drudge, E T Lyons, S C Tolliver, T W Swerczek. Use of oxibendazole for control of cambendazole-resistant small strongyles in a band of ponies: a six-year study. American journal of veterinary research. 1985 Dec; 46(12):2507-11. doi: NULL. [PMID: 4083584]
  • E L Bliss, E C Greiner. Efficacy of fenbendazole and cambendazole against Muellerius capillaris in dairy goats. American journal of veterinary research. 1985 Sep; 46(9):1923-5. doi: . [PMID: 4051297]
  • M Eysker, J Jansen, R Wemmenhove, M H Mirck. Alternate grazing of horses and sheep as control for gastro-intestinal helminthiasis in horses. Veterinary parasitology. 1983 Oct; 13(3):273-80. doi: 10.1016/0304-4017(83)90064-x. [PMID: 6686382]
  • J H Drudge, E T Lyons, T W Swerczek, S C Tolliver. Cambendazole for strongyle control in a pony band: selection of a drug-resistant population of small strongyles and teratologic implications. American journal of veterinary research. 1983 Jan; 44(1):110-4. doi: NULL. [PMID: 6824213]
  • M H Mirck, G K van Meurs. [Effect of albendazole and cambendazole on the egg output of Strongylidae in horses]. Tijdschrift voor diergeneeskunde. 1982 Oct; 107(19):731-6. doi: NULL. [PMID: 7147218]
  • D I Grove. Strongyloides ratti and S. stercoralis: the effects of thiabendazole, mebendazole, and cambendazole in infected mice. The American journal of tropical medicine and hygiene. 1982 May; 31(3 Pt 1):469-76. doi: 10.4269/ajtmh.1982.31.469. [PMID: 7081540]
  • R P Herd, T B Miller, A A Gabel. A field evaluation of pro-benzimidazole, benzimidazole, and non-benzimidazole anthelmintics in horses. Journal of the American Veterinary Medical Association. 1981 Oct; 179(7):686-91. doi: NULL. [PMID: 7341582]
  • J P Louw, S Meyer, J Schröder. A critical efficacy test of cambendazole in equids: the use of the geometric means to assess efficacy. Journal of the South African Veterinary Association. 1980 Dec; 51(4):259-61. doi: NULL. [PMID: 7017145]
  • J D Kelly, C A Hall. Resistance of animal helminths to anthelmintics. Advances in pharmacology and chemotherapy. 1979; 16(?):89-128. doi: 10.1016/s1054-3589(08)60243-4. [PMID: 382801]
  • W J VandenHeuvel, D E Wolf, B H Arison, R P Buhs, J R Carlin, R L Ellsworth, T A Jacob, F R Koniuszy, J L Smith, N R Trenner, R W Walker, F J Wolf. Urinary metabolites of cambendazole. Journal of agricultural and food chemistry. 1978 Nov; 26(6):1357-64. doi: 10.1021/jf60220a001. [PMID: 730947]
  • M L Colglazier, F D Enzie, K C Kates. Critical anthelmintic trials in ponies with four benzimidazoles: mebendazole, cambendazole, fenbendazole, and albendazole. The Journal of parasitology. 1977 Aug; 63(4):724-7. doi: 10.2307/3279582. [PMID: 886410]
  • E T Lyons, J H Drudge, S C Tolliver. Observations on development of Strongyloides westeri in foals nursing dams treated with cambendazole or thiabendazole. American journal of veterinary research. 1977 Jun; 38(6):889-92. doi: NULL. [PMID: 879586]
  • R P Amann, J M Bowen, B W Pickett, W E Berndtson, R S Stashak, J L Voss. Reproductive function in stallions treated with cambendazole. Journal of the American Veterinary Medical Association. 1977 Apr; 170(7):730-2. doi: NULL. [PMID: 870467]
  • J E Baer, T A Jacob, F J Wolf. Cambendazole and nondrug macromolecules in tissue residues. Journal of toxicology and environmental health. 1977 Mar; 2(4):895-903. doi: 10.1080/15287397709529487. [PMID: 853544]
  • F Ahmed, M S Bamji. Biochemical basis for the 'riboflavin defect' associated with the use of oral contraceptives. A study in female rats. Contraception. 1976 Sep; 14(3):297-307. doi: 10.1016/0010-7824(76)90097-4. [PMID: 10133]
  • H J Hilderson, M J De Wolf, A R Lagrou, W S Dierick. Subcellular structure of bovine thyroid gland. A study on bovine thyroid membranes by buoyant-density-gradient centrifugation in a B-XIV zonal rotor. The Biochemical journal. 1975 Dec; 152(3):601-7. doi: 10.1042/bj1520601. [PMID: 5997]
  • A Ardans, G Walters. Efficacy studies with three formulations of cambendazole in horses. American journal of veterinary research. 1975 Nov; 36(11):1589-90. doi: NULL. [PMID: 1190601]
  • W O Kester. Strongylus vulgaris-the horse killer. Modern veterinary practice. 1975 Aug; 56(8):569-72. doi: NULL. [PMID: 1143279]