Oxybuprocaine (BioDeep_00000858547)

   


代谢物信息卡片


Oxybuprocaine

化学式: C17H28N2O3 (308.20998180000004)
中文名称: 丁氧卡因
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCOC1=C(C=CC(=C1)C(=O)OCCN(CC)CC)N
InChI: InChI=1S/C17H28N2O3/c1-4-7-11-21-16-13-14(8-9-15(16)18)17(20)22-12-10-19(5-2)6-3/h8-9,13H,4-7,10-12,18H2,1-3H3

描述信息

D - Dermatologicals > D04 - Antipruritics, incl. antihistamines, anesthetics, etc. > D04A - Antipruritics, incl. antihistamines, anesthetics, etc. > D04AB - Anesthetics for topical use
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
S - Sensory organs > S01 - Ophthalmologicals > S01H - Local anesthetics > S01HA - Local anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

1 个代谢物同义名

Oxybuprocaine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • W-Y Fan, D-P Wang, Q Wen, T-J Fan. The cytotoxic effect of oxybuprocaine on human corneal epithelial cells by inducing cell cycle arrest and mitochondria-dependent apoptosis. Human & experimental toxicology. 2017 Aug; 36(8):765-775. doi: 10.1177/0960327116665676. [PMID: 27590991]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Nadia Zakaria, Sigi Van Grasdorff, Kristien Wouters, Jos Rozema, Carina Koppen, Eva Lion, Nathalie Cools, Zwi Berneman, Marie-José Tassignon. Human tears reveal insights into corneal neovascularization. PloS one. 2012; 7(5):e36451. doi: 10.1371/journal.pone.0036451. [PMID: 22590547]
  • John Youshia, Amany O Kamel, Abdelhameed El Shamy, Samar Mansour. Design of cationic nanostructured heterolipid matrices for ocular delivery of methazolamide. International journal of nanomedicine. 2012; 7(?):2483-96. doi: 10.2147/ijn.s28307. [PMID: 22679362]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • R Russo, L Berliocchi, A Adornetto, G P Varano, F Cavaliere, C Nucci, D Rotiroti, L A Morrone, G Bagetta, M T Corasaniti. Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo. Cell death & disease. 2011 Apr; 2(?):e144. doi: 10.1038/cddis.2011.29. [PMID: 21490676]
  • Susi Burgalassi, Nadia Nicosia, Daniela Monti, Giulia Falcone, Enrico Boldrini, Ortenzio Fabiani, Carla Lenzi, Andrea Pirone, Patrizia Chetoni. Arabinogalactan as active compound in the management of corneal wounds: in vitro toxicity and in vivo investigations on rabbits. Current eye research. 2011 Jan; 36(1):21-8. doi: 10.3109/02713683.2010.523193. [PMID: 21174594]
  • Tais H Wakamatsu, Murat Dogru, Igarashi Ayako, Yoji Takano, Yukihiro Matsumoto, Osama M A Ibrahim, Naoko Okada, Yoshiyuki Satake, Kazumi Fukagawa, Jun Shimazaki, Kazuo Tsubota, Hiroshi Fujishima. Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease. Molecular vision. 2010 Nov; 16(?):2465-75. doi: ". [PMID: 21139696]
  • Shigeru Nakamura, Shigeru Kinoshita, Norihiko Yokoi, Yoko Ogawa, Michiko Shibuya, Hideo Nakashima, Ryuji Hisamura, Toshihiro Imada, Tomohiro Imagawa, Masato Uehara, Izumi Shibuya, Murat Dogru, Samantha Ward, Kazuo Tsubota. Lacrimal hypofunction as a new mechanism of dry eye in visual display terminal users. PloS one. 2010 Jun; 5(6):e11119. doi: 10.1371/journal.pone.0011119. [PMID: 20559543]
  • Berthold Pemp, Günther Weigert, Katharina Karl, Ursula Petzl, Michael Wolzt, Leopold Schmetterer, Gerhard Garhofer. Correlation of flicker-induced and flow-mediated vasodilatation in patients with endothelial dysfunction and healthy volunteers. Diabetes care. 2009 Aug; 32(8):1536-41. doi: 10.2337/dc08-2130. [PMID: 19478197]
  • Yukihiro Matsumoto, Enrique Adan Sato, Osama M A Ibrahim, Murat Dogru, Kazuo Tsubota. The application of in vivo laser confocal microscopy to the diagnosis and evaluation of meibomian gland dysfunction. Molecular vision. 2008 Jul; 14(?):1263-71. doi: . [PMID: 18618006]
  • F Kasuya, K Igarashi, M Fukui. Oxybuprocaine and five metabolites simultaneously determined in urine by gas chromatography and gas chromatography-mass spectrometry after extraction with Extrelut. Clinical chemistry. 1987 May; 33(5):697-700. doi: 10.1093/clinchem/33.5.697. [PMID: 3568356]
  • F Kasuya, K Igarashi, M Fukui. Determination of six metabolites of oxybuprocaine in urine by high-performance liquid chromatography. Journal of chromatography. 1987 Apr; 416(1):189-95. doi: NULL. [PMID: 3597636]
  • F Kasuya, K Igarashi, M Fukui. Metabolism of benoxinate in humans. Journal of pharmaceutical sciences. 1987 Apr; 76(4):303-5. doi: 10.1002/jps.2600760408. [PMID: 3598888]
  • R Dubbels, W Schloot. Studies on the metabolism of benoxinate by human pseudocholinesterase. Metabolic, pediatric, and systemic ophthalmology. 1983; 7(1):37-43. doi: NULL. [PMID: 6621359]
  • H Brewitt, E Bonatz, H Honegger. Morphological changes of the corneal epithelium after application of topical anaesthetic ointments. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 1980; 180(4):198-206. doi: 10.1159/000308974. [PMID: 7443191]
  • H DIAMANT. [Novesin-cyclosan local anesthesia in otorhinolaryngological endoscopy]. Svenska lakartidningen. 1957 Mar; 54(11):800-3. doi: ". [PMID: 13433525]