Fexinidazole (BioDeep_00000858540)
代谢物信息卡片
化学式: C12H13N3O3S (279.06775880000004)
中文名称: 非昔硝唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=CN=C1COC2=CC=C(C=C2)SC)[N+](=O)[O-]
InChI: InChI=1S/C12H13N3O3S/c1-14-11(13-7-12(14)15(16)17)8-18-9-3-5-10(19-2)6-4-9/h3-7H,8H2,1-2H3
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01C - Agents against leishmaniasis and trypanosomiasis > P01CA - Nitroimidazole derivatives
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D11252
- PubChem: 68792
- DrugBank: DB12265
- ChEMBL: CHEMBL1631694
- CAS: 59729-37-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cyril Fersing, Clotilde Boudot, Caroline Castera-Ducros, Emilie Pinault, Sébastien Hutter, Romain Paoli-Lombardo, Nicolas Primas, Julien Pedron, Line Seguy, Sandra Bourgeade-Delmas, Alix Sournia-Saquet, Jean-Luc Stigliani, Jean-Yves Brossas, Luc Paris, Alexis Valentin, Susan Wyllie, Alan H Fairlamb, Élisa Boutet-Robinet, Sophie Corvaisier, Marc Since, Aurélie Malzert-Fréon, Alexandre Destere, Dominique Mazier, Pascal Rathelot, Bertrand Courtioux, Nadine Azas, Pierre Verhaeghe, Patrice Vanelle. 8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi.
European journal of medicinal chemistry.
2020 Sep; 202(?):112558. doi:
10.1016/j.ejmech.2020.112558. [PMID: 32652409] - James A Watson, Nathalie Strub-Wourgraft, Antoine Tarral, Isabela Ribeiro, Joel Tarning, Nicholas J White. Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole.
Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02515-18. [PMID: 30670439] - Hollie Burrell-Saward, Andrew J Harris, Raul de LaFlor, Hatem Sallam, Mo S Alavijeh, Theresa H Ward, Simon L Croft. Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis.
International journal of antimicrobial agents.
2017 Aug; 50(2):203-209. doi:
10.1016/j.ijantimicag.2017.01.038. [PMID: 28552771] - Amanda Fortes Francisco, Shiromani Jayawardhana, Michael D Lewis, Karen L White, David M Shackleford, Gong Chen, Jessica Saunders, Maria Osuna-Cabello, Kevin D Read, Susan A Charman, Eric Chatelain, John M Kelly. Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
Scientific reports.
2016 10; 6(?):35351. doi:
10.1038/srep35351. [PMID: 27748443] - Aziz Filali-Ansary, Cécile Augé, Audrey Abgrall, Marie Souchaud, Franck Pellissier, Olaf Valverde Mordt, Séverine Blesson, Ger-Jan Sanderink. A DBS method for quantitation of the new oral trypanocidal drug fexinidazole and its active metabolites.
Bioanalysis.
2016 Oct; 8(19):2045-63. doi:
10.4155/bio-2016-0110. [PMID: 27611920] - Maria T Bahia, Alvaro F S Nascimento, Ana Lia Mazzeti, Luiz F Marques, Karolina R Gonçalves, Ludmilla W R Mota, Lívia de F Diniz, Ivo S Caldas, André Talvani, David M Shackleford, Maria Koltun, Jessica Saunders, Karen L White, Ivan Scandale, Susan A Charman, Eric Chatelain. Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease.
Antimicrobial agents and chemotherapy.
2014 Aug; 58(8):4362-70. doi:
10.1128/aac.02754-13. [PMID: 24841257] - Antoine Tarral, Séverine Blesson, Olaf Valverde Mordt, Els Torreele, Daniela Sassella, Michael A Bray, Lionel Hovsepian, Eric Evène, Virginie Gualano, Mathieu Felices, Nathalie Strub-Wourgaft. Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies.
Clinical pharmacokinetics.
2014 Jun; 53(6):565-80. doi:
10.1007/s40262-014-0136-3. [PMID: 24535888] - Reto Brun, Robert Don, Robert T Jacobs, Michael Zhuo Wang, Michael P Barrett. Development of novel drugs for human African trypanosomiasis.
Future microbiology.
2011 Jun; 6(6):677-91. doi:
10.2217/fmb.11.44. [PMID: 21707314]