Sertraline hydrochloride (BioDeep_00000858536)
代谢物信息卡片
Sertraline hydrochloride
化学式: C17H18Cl3N (341.0504758)
中文名称: 盐酸舍曲林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl.Cl
InChI: /m0./s1
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
C78272 - Agent Affecting Nervous System > C94725 - Selective Serotonin Reuptake Inhibitor
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:9124
- KEGGdrug: D00825
- PubChem: 63009
- ChEMBL: CHEMBL1709
- MeSH: Sertraline
- CAS: 79559-97-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Deniz Bozdag, Jeroen van Voorthuizen, Nikita Korpel, Sander Lentz, Hande Gurer-Orhan, Jorke H Kamstra. Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline.
Toxicology and applied pharmacology.
2024 May; 486(?):116937. doi:
10.1016/j.taap.2024.116937. [PMID: 38643950] - Ran Fu, Ze Yu, Chunhua Zhou, Jinyuan Zhang, Fei Gao, Donghan Wang, Xin Hao, Xiaolu Pang, Jing Yu. Artificial intelligence-based model for dose prediction of sertraline in adolescents: a real-world study.
Expert review of clinical pharmacology.
2024 Jan; 17(2):177-187. doi:
10.1080/17512433.2024.2304009. [PMID: 38197873] - Radka Kodešová, Helena Švecová, Aleš Klement, Miroslav Fér, Antonín Nikodem, Ganna Fedorova, Oleksandra Rieznyk, Martin Kočárek, Alina Sadchenko, Alica Chroňáková, Roman Grabic. Contamination of water, soil, and plants by micropollutants from reclaimed wastewater and sludge from a wastewater treatment plant.
The Science of the total environment.
2023 Oct; 907(?):167965. doi:
10.1016/j.scitotenv.2023.167965. [PMID: 37866592] - Zhen Liu, Chunhua Gu, Jian Lei. Meta-analysis of Shugan Jieyu Capsule for depression in patients with coronary heart disease.
Medicine.
2023 Aug; 102(34):e34685. doi:
10.1097/md.0000000000034685. [PMID: 37653746] - Dat T N Ngo, Tho H Ho, Lam K Huynh, Trang T Nguyen. The interplay of membrane fluidity, acyl chain order and area per lipid on the partitioning of two antidepressants paroxetine and sertraline.
Soft matter.
2023 Jul; ?(?):. doi:
10.1039/d3sm00462g. [PMID: 37435937] - Alvin Richards-Belle, Isabelle Austin-Zimmerman, Baihan Wang, Eirini Zartaloudi, Marius Cotic, Caitlin Gracie, Noushin Saadullah Khani, Yanisa Wannasuphoprasit, Marta Wronska, Yogita Dawda, David Pj Osborn, Elvira Bramon. Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19/CYP2D6 genes play a role? A UK population-based study.
Journal of psychopharmacology (Oxford, England).
2023 Feb; ?(?):2698811231152748. doi:
10.1177/02698811231152748. [PMID: 36772859] - Huili Jiang, Lu Chen, Yufei Li, Xingzhou Gao, Xinjing Yang, Bingcong Zhao, Yahuan Li, Yu Wang, Xue Yu, Xuhui Zhang, Shixing Feng, Yemao Chai, Hong Meng, Xiujun Ren, Tuya Bao. Effects of acupuncture on regulating the hippocampal inflammatory response in rats exposed to post-traumatic stress disorder.
Neuroscience letters.
2023 Feb; 796(?):137056. doi:
10.1016/j.neulet.2023.137056. [PMID: 36621587] - Furong Zhang, Wenting Gong, Zhou Cui, Jing Li, Yuanyuan Lu. Rhabdomyolysis in a male adolescent associated with monotherapy of fluvoxamine.
European journal of hospital pharmacy : science and practice.
2022 Dec; ?(?):. doi:
10.1136/ejhpharm-2022-003533. [PMID: 36460460] - Somayeh Golbaz, Mirzaman Zamanzadeh, Kamyar Yaghmaeian, Ramin Nabizadeh, Nushin Rastkari, Hadi Esfahani. Occurrence and removal of psychiatric pharmaceuticals in the Tehran South Municipal Wastewater Treatment Plant.
Environmental science and pollution research international.
2022 Nov; ?(?):. doi:
10.1007/s11356-022-23667-5. [PMID: 36374381] - Syed Gulfishan, Sumita Halder, Rajarshi Kar, Shruti Srivastava, Rachna Gupta. Association of serotonin transporter gene polymorphism with efficacy of the antidepressant drugs sertraline and mirtazapine in newly diagnosed patients with major depressive disorders.
Human psychopharmacology.
2022 07; 37(4):e2833. doi:
10.1002/hup.2833. [PMID: 35089613] - Catherine Drossou, Yannis Petrakis, Konstantina Tyrovola, Nikolaos P Xekoukoulotakis. Photochemical degradation of the antidepressant sertraline in aqueous solutions by UVC, UVC/H2O2, and UVC/S2O82.
Water research.
2022 Jun; 217(?):118442. doi:
10.1016/j.watres.2022.118442. [PMID: 35429888] - Magdalene M Assimon, Patrick H Pun, Sana M Al-Khatib, M Alan Brookhart, Bradley N Gaynes, Wolfgang C Winkelmayer, Jennifer E Flythe. Proton pump inhibitors may enhance the risk of citalopram- and escitalopram-associated sudden cardiac death among patients receiving hemodialysis.
Pharmacoepidemiology and drug safety.
2022 06; 31(6):670-679. doi:
10.1002/pds.5428. [PMID: 35285107] - Elvira Tini, Lukasz Smigielski, Marcel Romanos, Christoph Wewetzer, Andreas Karwautz, Karl Reitzle, Christoph U Correll, Paul L Plener, Uwe Malzahn, Peter Heuschmann, Stefan Unterecker, Maike Scherf-Clavel, Hans Rock, Gisela Antony, Wolfgang Briegel, Christian Fleischhaker, Tobias Banaschewski, Tobias Hellenschmidt, Hartmut Imgart, Michael Kaess, Michael Kölch, Tobias Renner, Su-Yin Reuter-Dang, Christian Rexroth, Gerd Schulte-Körne, Frank Theisen, Stefanie Fekete, Regina Taurines, Manfred Gerlach, Karin Maria Egberts, Susanne Walitza. Therapeutic drug monitoring of sertraline in children and adolescents: A naturalistic study with insights into the clinical response and treatment of obsessive-compulsive disorder.
Comprehensive psychiatry.
2022 05; 115(?):152301. doi:
10.1016/j.comppsych.2022.152301. [PMID: 35248877] - Esra Fidan, Z Isik Solak Gormus, İbrahim Kilinc, Mehmet Sinan İyisoy, Niyazi Gormus. Effects of Combined Sertraline and Magnesium in Rat Atrium.
Biological trace element research.
2022 Feb; 200(2):652-660. doi:
10.1007/s12011-021-02669-3. [PMID: 33774751] - Chih-Wei Hsu, Wei-Ting Tseng, Liang-Jen Wang, Yao-Hsu Yang, Hung-Yu Kao, Pao-Yen Lin. Comparative effectiveness of antidepressants on geriatric depression: Real-world evidence from a population-based study.
Journal of affective disorders.
2022 01; 296(?):609-615. doi:
10.1016/j.jad.2021.10.009. [PMID: 34655698] - Gulsah Aynaoglu Yildiz, Duran Yildiz, Omer Erkan Yapca, Bahadir Suleyman, Yusuf Kemal Arslan, Nezahat Kurt, Halis Suleyman. Effect of diazepam, sertraline and melatonin on the stress-induced reproductive disorders and intrauterine growth restriction in female rats.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2021 Dec; 34(24):4103-4109. doi:
10.1080/14767058.2019.1706469. [PMID: 31875735] - Yuhua Xing, Ting Sun, Guangxue Li, Guoan Xu, Jia Cheng, Shugui Gao. The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value.
Journal of clinical laboratory analysis.
2021 Nov; 35(11):e23993. doi:
10.1002/jcla.23993. [PMID: 34528295] - Line Kolding, Lars Henning Pedersen, Olav Bjørn Petersen, Niels Uldbjerg, Puk Sandager. Sertraline use during pregnancy and effect on fetal cardiac function.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2021 Nov; 34(22):3631-3638. doi:
10.1080/14767058.2019.1688297. [PMID: 31718339] - Gasper Razinger, Damjan Grenc, Tomaž Pezdir, Roman Kranvogl, Miran Brvar. Severe rhabdomyolysis and acute kidney failure due to synthetic opioid brorphine exposure in combination with chronic sertraline therapy.
European journal of clinical pharmacology.
2021 Nov; 77(11):1759-1761. doi:
10.1007/s00228-021-03136-7. [PMID: 34052902] - Tomiko Oskotsky, Ivana Maric, Alice Tang, Boris Oskotsky, Ronald J Wong, Nima Aghaeepour, Marina Sirota, David K Stevenson. Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants.
JAMA network open.
2021 11; 4(11):e2133090. doi:
10.1001/jamanetworkopen.2021.33090. [PMID: 34779847] - Hengzheng Cui, Wenya Zhou, Yu Deng, Binyu Zheng, Qi Zhang, Zhenyan Zhang, Tao Lu, Haifeng Qian. Meta-transcriptomic profiling of functional variation of freshwater microbial communities induced by an antidepressant sertraline hydrochloride.
The Science of the total environment.
2021 Sep; 786(?):147434. doi:
10.1016/j.scitotenv.2021.147434. [PMID: 33964776] - Alicja Kubanek, Przemysław Paul, Mateusz Przybylak, Katarzyna Kanclerz, Jakub Jan Rojek, Marcin Renke, Leszek Bidzan, Jakub Grabowski. Use of Sertraline in Hemodialysis Patients.
Medicina (Kaunas, Lithuania).
2021 Sep; 57(9):. doi:
10.3390/medicina57090949. [PMID: 34577872] - Tomoyuki Hioki, Haruhiko Tokuda, Kumiko Tanabe, Woo Kim, Junko Tachi, Shinobu Yamaguchi, Rie Matsushima-Nishiwaki, Osamu Kozawa, Hiroki Iida. Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of μ-opioid receptor and 5-HT transporter.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 09; 172(?):102323. doi:
10.1016/j.plefa.2021.102323. [PMID: 34392133] - E Heinonen, M Blennow, M Blomdahl-Wetterholm, M Hovstadius, J Nasiell, A Pohanka, L L Gustafsson, K Wide. Sertraline concentrations in pregnant women are steady and the drug transfer to their infants is low.
European journal of clinical pharmacology.
2021 Sep; 77(9):1323-1331. doi:
10.1007/s00228-021-03122-z. [PMID: 33751155] - Gwenn S Smith, Hiroto Kuwabara, Neda F Gould, Najilla Nassery, Alena Savonenko, Jin Hui Joo, Kristin L Bigos, Michael Kraut, James Brasic, Daniel P Holt, Andrew W Hall, William B Mathews, Robert F Dannals, Ayon Nandi, Clifford I Workman. Molecular imaging of the serotonin transporter availability and occupancy by antidepressant treatment in late-life depression.
Neuropharmacology.
2021 08; 194(?):108447. doi:
10.1016/j.neuropharm.2021.108447. [PMID: 33450276] - Eliza G West, Donna J Sellers, Russ Chess-Williams, Catherine McDermott. The anxiolytic sertraline reduces the impact of psychological stress on bladder function in mice.
Life sciences.
2021 Aug; 278(?):119598. doi:
10.1016/j.lfs.2021.119598. [PMID: 33984361] - Alastair J Flint, Anthony J Rothschild, Ellen M Whyte, George S Alexopoulos, Benoit H Mulsant, Patricia Marino, Samprit Banerjee, Cristina D Pollari, Yiyuan Wu, Aristotle N Voineskos, Barnett S Meyers. Effect of Older vs Younger Age on Anthropometric and Metabolic Variables During Treatment of Psychotic Depression With Sertraline Plus Olanzapine: The STOP-PD II Study.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2021 07; 29(7):645-654. doi:
10.1016/j.jagp.2020.11.003. [PMID: 33268022] - Aminah Almurjan, Hannah Macfarlane, Raj K S Badhan. The application of precision dosing in the use of sertraline throughout pregnancy for poor and ultrarapid metabolizer CYP 2C19 subjects: A virtual clinical trial pharmacokinetics study.
Biopharmaceutics & drug disposition.
2021 Jun; 42(6):252-262. doi:
10.1002/bdd.2278. [PMID: 33851424] - Ani Gasparyan, Francisco Navarrete, Jorge Manzanares. The administration of sertraline plus naltrexone reduces ethanol consumption and motivation in a long-lasting animal model of post-traumatic stress disorder.
Neuropharmacology.
2021 05; 189(?):108552. doi:
10.1016/j.neuropharm.2021.108552. [PMID: 33819457] - Sua Kim, Chor Ho Jo, Gheun-Ho Kim. Psychotropic drugs upregulate aquaporin-2 via vasopressin-2 receptor/cAMP/protein kinase A signaling in inner medullary collecting duct cells.
American journal of physiology. Renal physiology.
2021 05; 320(5):F963-F971. doi:
10.1152/ajprenal.00576.2020. [PMID: 33843270] - Jian-Lun Lian, Xiu-Min Wu, Xue Sun, Yan-Jun Wang, Yan-Hong Li. [Effect of Tiaodu Jieyu acupuncture on cancer-related depression: a randomized controlled trial].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2021 Apr; 41(4):381-5. doi:
10.13703/j.0255-2930.20200330-0004. [PMID: 33909357] - Hamidreza Ghorbani, Alireza Akhavanrezayat, Lida Jarahi, Bahram Memar, Sakineh Amouian, Armin Attaranzadeh, Sadegh Ebrahimi. Effects of Sertraline on Spermatogenesis of Male Rats and its Reversibility after Terminating the Drug.
Urology journal.
2021 Apr; 18(4):434-438. doi:
10.22037/uj.v18i.6458. [PMID: 33813731] - Emily Zhang, Elizabeth Lequesne, Anne Rohs, W Gordon Frankle. Suspected Recurrence of Symptomatic COVID-19: Management During Inpatient Psychiatric Treatment.
Journal of psychiatric practice.
2021 Mar; 27(2):137-144. doi:
10.1097/pra.0000000000000534. [PMID: 33656821] - Milad Ghani, Zahra Zayeri, Behrooz Maleki. Glutathione-stabilized Fe3 O4 nanoparticles as the sorbent for magnetic solid-phase extraction of diazepam and sertraline from urine samples through quantitation via high-performance liquid chromatography.
Journal of separation science.
2021 Mar; 44(6):1195-1202. doi:
10.1002/jssc.202000938. [PMID: 33137222] - Arnim Johannes Gaebler, Georgios Schoretsanitis, Nagia Ben Omar, Ekkehard Haen, Katharina Endres, Christoph Hiemke, Michael Paulzen. Metamizole but not ibuprofen reduces the plasma concentration of sertraline: Implications for the concurrent treatment of pain and depression/anxiety disorders.
British journal of clinical pharmacology.
2021 03; 87(3):1111-1119. doi:
10.1111/bcp.14471. [PMID: 32652557] - Zolfaghar Aladaghlo, Siamak Javanbakht, Ali Reza Fakhari, Ahmad Shaabani. Gelatin microsphere coated Fe3O4@graphene quantum dots nanoparticles as a novel magnetic sorbent for ultrasound-assisted dispersive magnetic solid-phase extraction of tricyclic antidepressants in biological samples.
Mikrochimica acta.
2021 02; 188(3):73. doi:
10.1007/s00604-021-04727-y. [PMID: 33550423] - Shauni Lien Geeraerts, Kim Rosalie Kampen, Gianmarco Rinaldi, Purvi Gupta, Mélanie Planque, Nikolaos Louros, Elien Heylen, Kaat De Cremer, Katrijn De Brucker, Stijn Vereecke, Benno Verbelen, Pieter Vermeersch, Joost Schymkowitz, Frederic Rousseau, David Cassiman, Sarah-Maria Fendt, Arnout Voet, Bruno P A Cammue, Karin Thevissen, Kim De Keersmaecker. Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth.
Molecular cancer therapeutics.
2021 01; 20(1):50-63. doi:
10.1158/1535-7163.mct-20-0480. [PMID: 33203732] - J Vaclavik, P Senohova, D Medkova, K Stastny, M Charvatova, M Faldyna, J Mares, Z Svobodova. High resolution mass spectrometry analysis of the sertraline residues contained in the tissues of rainbow trout reared in model experimental conditions.
Physiological research.
2020 Dec; 69(Suppl 4):S619-S625. doi:
10.33549/physiolres.934610. [PMID: 33656907] - Lindsey A Sjaarda, Jeannie G Radoc, Kerry S Flannagan, Sunni L Mumford, Keewan Kim, Neil J Perkins, Robert M Silver, Enrique F Schisterman. Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss.
Fertility and sterility.
2020 12; 114(6):1278-1287. doi:
10.1016/j.fertnstert.2020.06.037. [PMID: 33066974] - Arif Kalkanli, Cem Tugrul Gezmis, Onur Fikri, Nusret Can Cilesiz, Arif Ozkan, Ali Eroglu, Memduh Aydin. The effect of plasma melatonin levels in the treatment of lifelong premature ejaculation with selective serotonin reuptake inhibitors.
Andrologia.
2020 Dec; 52(11):e13785. doi:
10.1111/and.13785. [PMID: 32816318] - Wei-Hua Li, Zhuo-Wen Wei, Xiao-Feng Liu. Clinical efficacy of sertraline in the treatment of depression caused by Alzheimer disease: A protocol of systematic review.
Medicine.
2020 Nov; 99(45):e23076. doi:
10.1097/md.0000000000023076. [PMID: 33157972] - Blessy George, Annie Lumen, Christine Nguyen, Barbara Wesley, Jian Wang, Julie Beitz, Victor Crentsil. Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy.
NPJ systems biology and applications.
2020 11; 6(1):36. doi:
10.1038/s41540-020-00157-3. [PMID: 33159093] - Mohammed Gaber Mohamed Hamed, Radwa Samir Hagag. The possible immunoregulatory and anti-inflammatory effects of selective serotonin reuptake inhibitors in coronavirus disease patients.
Medical hypotheses.
2020 Nov; 144(?):110140. doi:
10.1016/j.mehy.2020.110140. [PMID: 32768893] - Mohamed Saleh Elgawish, Mohamed A Ali, Moftah A Moustafa, Sameh M Hafeez. Toxicity Profile, Pharmacokinetic, and Drug-Drug Interaction Study of Citalopram and Sertraline Following Oral Delivery in Rat: An LC-MS/MS Method for the Simultaneous Determination in Plasma.
Chemical research in toxicology.
2020 10; 33(10):2584-2592. doi:
10.1021/acs.chemrestox.0c00199. [PMID: 32957789] - Wei Shi, Yu Han, Shuge Sun, Yu Tang, Weishang Zhou, Xueying Du, Guangxu Liu. Immunotoxicities of microplastics and sertraline, alone and in combination, to a bivalve species: size-dependent interaction and potential toxication mechanism.
Journal of hazardous materials.
2020 09; 396(?):122603. doi:
10.1016/j.jhazmat.2020.122603. [PMID: 32289642] - L Parker Gregg, S Susan Hedayati. Pharmacologic and psychological interventions for depression treatment in patients with kidney disease.
Current opinion in nephrology and hypertension.
2020 09; 29(5):457-464. doi:
10.1097/mnh.0000000000000629. [PMID: 32701597] - Lauren Stoczynski, Peter van den Hurk. Effects of selective serotonin reuptake inhibitor sertraline on hybrid striped bass predatory behavior and brain chemistry.
Aquatic toxicology (Amsterdam, Netherlands).
2020 Sep; 226(?):105564. doi:
10.1016/j.aquatox.2020.105564. [PMID: 32683169] - Zhili Zou, Yulan Huang, Jinyu Wang, Wenjiao Min, Bo Zhou. The association between serotonin-related gene polymorphisms and susceptibility and early sertraline response in patients with panic disorder.
BMC psychiatry.
2020 07; 20(1):388. doi:
10.1186/s12888-020-02790-y. [PMID: 32723321] - Wei Sun, Fengyi Zhang, Hui Wang, Chen Wang, Zangong Zhou, Yu Zhou. Ginsenoside Rg1 fails to rescue PTSD-like behaviors in a mice model of single-prolonged stress.
Biochemical and biophysical research communications.
2020 07; 528(2):243-248. doi:
10.1016/j.bbrc.2020.05.159. [PMID: 32482388] - Ali A Alhadab, Richard C Brundage. Physiologically-Based Pharmacokinetic Model of Sertraline in Human to Predict Clinical Relevance of Concentrations at Target Tissues.
Clinical pharmacology and therapeutics.
2020 07; 108(1):136-144. doi:
10.1002/cpt.1824. [PMID: 32128758] - L Parker Gregg, Thomas Carmody, Dustin Le, Nina Bharadwaj, Madhukar H Trivedi, S Susan Hedayati. Depression and the Effect of Sertraline on Inflammatory Biomarkers in Patients with Nondialysis CKD.
Kidney360.
2020 06; 1(6):436-446. doi:
10.34067/kid.0000062020. [PMID: 35368605] - Maytham Hussein, Elena K Schneider-Futschik, Olivia K A Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Jian Li, Tony Velkov. Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline.
ACS infectious diseases.
2020 06; 6(6):1436-1450. doi:
10.1021/acsinfecdis.0c00108. [PMID: 32427476] - Merve Demirbugen Oz, Bora Baskak, Zuhal Uckun, Nazan Yuce Artun, Hatice Ozdemir, Tugba Kizil Ozel, Halise Devrimci Ozguven, H Sinan Suzen. Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients.
The pharmacogenomics journal.
2020 06; 20(3):443-450. doi:
10.1038/s41397-019-0127-8. [PMID: 31792367] - Ali A Alhadab, Richard C Brundage. Population Pharmacokinetics of Sertraline in Healthy Subjects: a Model-Based Meta-analysis.
The AAPS journal.
2020 05; 22(4):73. doi:
10.1208/s12248-020-00455-y. [PMID: 32430638] - Anderson Luiz Oenning, Letícia Birk, Sarah Eller, Tiago Franco de Oliveira, Josias Merib, Eduardo Carasek. A green and low-cost method employing switchable hydrophilicity solvent for the simultaneous determination of antidepressants in human urine by gas chromatography - mass spectrometry detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Apr; 1143(?):122069. doi:
10.1016/j.jchromb.2020.122069. [PMID: 32213465] - Richat Abbas, Steve Riley, Robert R LaBadie, Mary Bachinsky, Phillip B Chappell, Penelope H Crownover, Bharat Damle. A Thorough QT Study to Evaluate the Effects of a Supratherapeutic Dose of Sertraline on Cardiac Repolarization in Healthy Subjects.
Clinical pharmacology in drug development.
2020 04; 9(3):307-320. doi:
10.1002/cpdd.749. [PMID: 31777203] - Josef Vaclavik, Pavla Sehonova, Nikola Hodkovicova, Lenka Vecerkova, Jana Blahova, Ales Franc, Petr Marsalek, Jan Mares, Frantisek Tichy, Zdenka Svobodova, Caterina Faggio. The effect of foodborne sertraline on rainbow trout (Oncorhynchus mykiss).
The Science of the total environment.
2020 Mar; 708(?):135082. doi:
10.1016/j.scitotenv.2019.135082. [PMID: 31806328] - L Parker Gregg, Thomas Carmody, Dustin Le, Robert D Toto, Madhukar H Trivedi, S Susan Hedayati. Inflammation and Response to Sertraline Treatment in Patients With CKD and Major Depression.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2020 03; 75(3):457-460. doi:
10.1053/j.ajkd.2019.09.007. [PMID: 31866226] - Zsombor Szoke-Kovacs, Csaba More, Rita Szoke-Kovacs, Endre Mathe, Ede Frecska. Selective Inhibition of the Serotonin Transporter in the Treatment of Depression: Sertraline, Fluoxetine and Citalopram.
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.
2020 Mar; 22(1):4-15. doi:
. [PMID: 32329748] - Chao Shang, Ying Guo, Jun-Qi Yao, Xin-Xin Fang, Li-Jun Sun, Xiang-Yun Jiang, Zhen-Chun Ding, Yu-Hua Ran, Heng-Lin Wang, Li-Ming Zhang, Yun-Feng Li. Rapid anti-PTSD-like activity of the TSPO agonist YL-IPA08: Emphasis on brain GABA, neurosteroids and HPA axis function.
Behavioural brain research.
2020 02; 379(?):112320. doi:
10.1016/j.bbr.2019.112320. [PMID: 31669345] - Line S Bråten, Tore Haslemo, Marin M Jukic, Magnus Ingelman-Sundberg, Espen Molden, Marianne K Kringen. Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2020 02; 45(3):570-576. doi:
10.1038/s41386-019-0554-x. [PMID: 31649299] - Ahmed Jasim Twayej, Hussein Kadhem Al-Hakeim, Arafat Hussein Al-Dujaili, Michael Maes. Lowered zinc and copper levels in drug-naïve patients with major depression: Effects of antidepressants, ketoprofen and immune activation.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2020 02; 21(2):127-138. doi:
10.1080/15622975.2019.1612090. [PMID: 31062629] - Peishan Cai, Xiang Xiong, Dan Li, Yu Zhou, Chaomei Xiong. Magnetic solid-phase extraction coupled with UHPLC-MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples.
Bioanalysis.
2020 Jan; 12(1):35-52. doi:
10.4155/bio-2019-0171. [PMID: 31849264] - Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej, Arafat Hussein Al-Dujaili, Michael Maes. Plasma Indoleamine-2,3-Dioxygenase (IDO) is Increased in Drug-Naï ve Major Depressed Patients and Treatment with Sertraline and Ketoprofen Normalizes IDO in Association with Pro-Inflammatory and Immune- Regulatory Cytokines.
CNS & neurological disorders drug targets.
2020; 19(1):44-54. doi:
10.2174/1871527319666200102100307. [PMID: 31894751] - Sandra L McFadden, Brianna L Hooker. Comparing Perika St. John's Wort and Sertraline for Treatment of Posttraumatic Stress Disorder in Mice.
Journal of dietary supplements.
2020; 17(3):300-308. doi:
10.1080/19390211.2019.1572040. [PMID: 30773961] - Lakshmi P Digala, Scott Lucchese. IV Lidocaine Infusion Leading to the Toxic Levels in Serum Causing Asystole - A Case Report.
Headache.
2020 01; 60(1):269-270. doi:
10.1111/head.13699. [PMID: 31743428] - Xia Xiao, Conghui Wang, De Chang, Ying Wang, Xiaojing Dong, Tao Jiao, Zhendong Zhao, Lili Ren, Charles S Dela Cruz, Lokesh Sharma, Xiaobo Lei, Jianwei Wang. Identification of Potent and Safe Antiviral Therapeutic Candidates Against SARS-CoV-2.
Frontiers in immunology.
2020; 11(?):586572. doi:
10.3389/fimmu.2020.586572. [PMID: 33324406] - Mayara Samala Bezerra, Ana Beatriz Melo Martins, Francisco Mateus Gonçalves Trajano, Talles Henrique de Araújo Pontes, Luana Talinne da Costa Gomes, Elaine Cristina Gavioli, Edilson Dantas da Silva Junior. Fluoxetine and sertraline effects on rat distal cauda epididymis contraction, sperm count and sperm transit time trough epididymis.
European journal of pharmacology.
2019 Dec; 865(?):172774. doi:
10.1016/j.ejphar.2019.172774. [PMID: 31697932] - Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs.
Clinica chimica acta; international journal of clinical chemistry.
2019 Dec; 499(?):81-86. doi:
10.1016/j.cca.2019.09.001. [PMID: 31491368] - Mohammad Ahmadpanah, Fatemeh Ramezanshams, Ali Ghaleiha, Shahin Akhondzadeh, Dena Sadeghi Bahmani, Serge Brand. Crocus Sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders-a double-blind, randomized intervention study.
Psychiatry research.
2019 12; 282(?):112613. doi:
10.1016/j.psychres.2019.112613. [PMID: 31669837] - Ali A Alhadab, Joshua Rhein, Lillian Tugume, Abdu Musubire, Darlisha A Williams, Mahsa Abassi, Melanie R Nicol, David B Meya, David R Boulware, Richard C Brundage. Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis.
Journal of pharmacokinetics and pharmacodynamics.
2019 12; 46(6):565-576. doi:
10.1007/s10928-019-09657-0. [PMID: 31584146] - Hamida Hamdi. The preventive role of wheat germ oil against sertraline-induced testicular damage in male albino rats.
Andrologia.
2019 Nov; 51(10):e13369. doi:
10.1111/and.13369. [PMID: 31418462] - Nishank Jain, Fei Wan, Monica Kothari, Anuoluwapo Adelodun, Jerry Ware, Ravi Sarode, S Susan Hedayati. Association of platelet function with depression and its treatment with sertraline in patients with chronic kidney disease: analysis of a randomized trial.
BMC nephrology.
2019 10; 20(1):395. doi:
10.1186/s12882-019-1576-7. [PMID: 31664940] - Arafat Hussein Al-Dujaili, Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej, Michael Maes. Total and ionized calcium and magnesium are significantly lowered in drug-naïve depressed patients: effects of antidepressants and associations with immune activation.
Metabolic brain disease.
2019 10; 34(5):1493-1503. doi:
10.1007/s11011-019-00458-5. [PMID: 31292851] - Ruihua Hou, Gang Ye, Yansong Liu, Xinyun Chen, Mingzhi Pan, Feng Zhu, Jialin Fu, Tian Fu, Qichun Liu, Zhenyong Gao, David S Baldwin, Zhen Tang. Effects of SSRIs on peripheral inflammatory cytokines in patients with Generalized Anxiety Disorder.
Brain, behavior, and immunity.
2019 10; 81(?):105-110. doi:
10.1016/j.bbi.2019.06.001. [PMID: 31163212] - Abdullah Al Maruf, Alexandra Greenslade, Paul D Arnold, Chad Bousman. Antidepressant pharmacogenetics in children and young adults: A systematic review.
Journal of affective disorders.
2019 07; 254(?):98-108. doi:
10.1016/j.jad.2019.05.025. [PMID: 31112844] - Georgios Schoretsanitis, Marc Augustin, Helena Saßmannshausen, Cordula Franz, Gerhard Gründer, Michael Paulzen. Antidepressants in breast milk; comparative analysis of excretion ratios.
Archives of women's mental health.
2019 06; 22(3):383-390. doi:
10.1007/s00737-018-0905-3. [PMID: 30116895] - Jeffrey R Strawn, Ethan A Poweleit, Laura B Ramsey. CYP2C19-Guided Escitalopram and Sertraline Dosing in Pediatric Patients: A Pharmacokinetic Modeling Study.
Journal of child and adolescent psychopharmacology.
2019 06; 29(5):340-347. doi:
10.1089/cap.2018.0160. [PMID: 30817183] - Ethan A Poweleit, Stacey L Aldrich, Lisa J Martin, David Hahn, Jeffrey R Strawn, Laura B Ramsey. Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders.
Journal of child and adolescent psychopharmacology.
2019 06; 29(5):348-361. doi:
10.1089/cap.2019.0017. [PMID: 31066578] - Erlend Skaga, Ida Ø Skaga, Zanina Grieg, Cecilie J Sandberg, Iver A Langmoen, Einar O Vik-Mo. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy.
Journal of cancer research and clinical oncology.
2019 Jun; 145(6):1495-1507. doi:
10.1007/s00432-019-02920-4. [PMID: 31028540] - Biswa Ranjan Mishra, Rituparna Maiti, Santanu Nath, Pallabi Sahoo, Monalisa Jena, Archana Mishra. Effect of Sertraline, Dosulepin, and Venlafaxine on Non-BDNF Neurotrophins in Patients With Depression: A Cohort Study.
Journal of clinical psychopharmacology.
2019 May; 39(3):220-225. doi:
10.1097/jcp.0000000000001022. [PMID: 30932945] - Amanda Holck, Owen M Wolkowitz, Sindy H Mellon, Victor I Reus, J Craig Nelson, Åsa Westrin, Daniel Lindqvist. Plasma serotonin levels are associated with antidepressant response to SSRIs.
Journal of affective disorders.
2019 05; 250(?):65-70. doi:
10.1016/j.jad.2019.02.063. [PMID: 30831543] - Xiao-Yue Deng, Tian-Shu Xu. [Clinical observation of acupuncture combined with sertraline hydrochloride tablets on tumor-related depression].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2019 Apr; 39(4):379-83. doi:
10.13703/j.0255-2930.2019.04.009. [PMID: 30957448] - Magdalene M Assimon, M Alan Brookhart, Jennifer E Flythe. Comparative Cardiac Safety of Selective Serotonin Reuptake Inhibitors among Individuals Receiving Maintenance Hemodialysis.
Journal of the American Society of Nephrology : JASN.
2019 04; 30(4):611-623. doi:
10.1681/asn.2018101032. [PMID: 30885935] - Bin Feng, Ying Zhang, Li-Yuan Luo, Jian-Yong Wu, Sen-Jun Yang, Ning Zhang, Qing-Rong Tan, Hua-Ning Wang, Nan Ge, Fang Ning, Zi-Li Zheng, Rui-Ming Zhu, Min-Cai Qian, Zhi-Yu Chen, Zhang-Jin Zhang. Transcutaneous electrical acupoint stimulation for post-traumatic stress disorder: Assessor-blinded, randomized controlled study.
Psychiatry and clinical neurosciences.
2019 Apr; 73(4):179-186. doi:
10.1111/pcn.12810. [PMID: 30565342] - NULL. Comparing the Effectiveness of Depression Treatments for Patients Undergoing Maintenance Hemodialysis.
Annals of internal medicine.
2019 03; 170(6):. doi:
10.7326/p19-0001. [PMID: 30802906] - Rajnish Mehrotra, Daniel Cukor, Mark Unruh, Tessa Rue, Patrick Heagerty, Scott D Cohen, Laura M Dember, Yaminette Diaz-Linhart, Amelia Dubovsky, Tom Greene, Nancy Grote, Nancy Kutner, Madhukar H Trivedi, Davin K Quinn, Nisha Ver Halen, Steven D Weisbord, Bessie A Young, Paul L Kimmel, S Susan Hedayati. Comparative Efficacy of Therapies for Treatment of Depression for Patients Undergoing Maintenance Hemodialysis: A Randomized Clinical Trial.
Annals of internal medicine.
2019 03; 170(6):369-379. doi:
10.7326/m18-2229. [PMID: 30802897] - Ying Lu, Xiang Xu, Tong Jiang, Lan Jin, Xu-Dong Zhao, Jia-Hui Cheng, Xue-Jun Jin, Juan Ma, Hu-Nan Piao, Lian-Xun Piao. Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells.
International immunopharmacology.
2019 Feb; 67(?):119-128. doi:
10.1016/j.intimp.2018.12.011. [PMID: 30544065] - Chaima Rachdi, Rahma Damak, Feten Fekih Romdhane, Haroun Ouertani, Majda Cheour. Impact of sertraline on weight, waist circumference and glycemic control: A prospective clinical trial on depressive diabetic type 2 patients.
Primary care diabetes.
2019 02; 13(1):57-62. doi:
10.1016/j.pcd.2018.09.003. [PMID: 30287230] - Sofie Kromann, Anna Hvidtfeldt, Mette Boye, Dorte Bratbo Sørensen, Steffen Jørgensen, Jens Peter Nielsen, Rikke Heidemann Olsen. In vitro synergy of sertraline and tetracycline cannot be reproduced in pigs orally challenged with a tetracycline resistant Escherichia coli.
BMC microbiology.
2019 01; 19(1):12. doi:
10.1186/s12866-018-1383-5. [PMID: 30634900] - Takahito Moriyama, Kazunori Karasawa, Fumio Hasegawa, Keiko Uchida, Kosaku Nitta. Sertraline Reduces Albuminuria by Interfering with Caveolae-Mediated Endocytosis through Glomerular Endothelial and Epithelial Cells.
American journal of nephrology.
2019; 50(6):444-453. doi:
10.1159/000503917. [PMID: 31655808] - Mohammad A Rahman, Ranjit K Harwansh, Zeenat Iqbal. Systematic Development of Sertraline Loaded Solid Lipid Nanoparticle (SLN) by Emulsification-Ultrasonication Method and Pharmacokinetic Study in Sprague-Dawley Rats.
Pharmaceutical nanotechnology.
2019; 7(2):162-176. doi:
10.2174/2211738507666190327145628. [PMID: 30919786] - Ewelina Dziurkowska, Marek Wesolowski. Sertraline - isolation methods and quantitation in biological material.
Psychiatria polska.
2018 Dec; 52(6):997-1012. doi:
10.12740/pp/85788. [PMID: 30659562] - Alexander Fenwick, Alison Woodworth, Min Yu. An Unexpected Result of Meconium Drug Testing.
Clinical chemistry.
2018 11; 64(11):1671-1672. doi:
10.1373/clinchem.2018.293209. [PMID: 30377181] - Jun-Ichi Kurita, Yuuka Hirao, Hirofumi Nakano, Yoshifumi Fukunishi, Yoshifumi Nishimura. Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities.
Scientific reports.
2018 09; 8(1):13763. doi:
10.1038/s41598-018-31852-1. [PMID: 30213984] - Pavla Sehonova, Zdenka Svobodova, Petra Dolezelova, Petra Vosmerova, Caterina Faggio. Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review.
The Science of the total environment.
2018 Aug; 631-632(?):789-794. doi:
10.1016/j.scitotenv.2018.03.076. [PMID: 29727988] - Shuhui Zhang, Xiaodong Liu, Mingzhu Sun, Qiuping Zhang, Teng Li, Xiang Li, Jia Xu, Xin Zhao, Dongyan Chen, Xizeng Feng. Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).
Behavioral and brain functions : BBF.
2018 Jun; 14(1):13. doi:
10.1186/s12993-018-0145-8. [PMID: 29898741] - Cecilie Hurup Munkboel, Lizette Weber Larsen, Johan Juhl Weisser, David Møbjerg Kristensen, Bjarne Styrishave. Sertraline Suppresses Testis and Adrenal Steroid Production and Steroidogenic Gene Expression While Increasing LH in Plasma of Male Rats Resulting in Compensatory Hypogonadism.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 06; 163(2):609-619. doi:
10.1093/toxsci/kfy059. [PMID: 29850907] - Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W Klampfl, Wolfgang Buchberger. Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model.
Electrophoresis.
2018 05; 39(9-10):1301-1308. doi:
10.1002/elps.201700482. [PMID: 29427324]