clonixin (BioDeep_00000858535)
代谢物信息卡片
clonixin
化学式: C13H11ClN2O2 (262.0509016)
中文名称: 氯尼辛
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC=C1Cl)NC2=C(C=CC=N2)C(=O)O
InChI: InChI=1S/C13H11ClN2O2/c1-8-10(14)5-2-6-11(8)16-12-9(13(17)18)4-3-7-15-12/h2-7H,1H3,(H,15,16)(H,17,18)
描述信息
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:76200
- KEGGdrug: D03555
- KEGGdrug: D97348
- PubChem: 28718
- DrugBank: DB09218
- ChEMBL: CHEMBL1332971
- MeSH: Clonixin
- CAS: 17737-65-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Saad S Enouri, Terri L O'Sullivan, Steve Ramkissoon, Robert M Friendship, Yu Gu, Ron J Johnson. Pharmacokinetics of combined administration of iron dextran with meloxicam or flunixin meglumine in piglets.
The Canadian veterinary journal = La revue veterinaire canadienne.
2022 07; 63(7):727-734. doi:
. [PMID: 35784780] - M Röder, W Heuwieser, S Borchardt, J L Plenio, R Palme, F Sutter. The effect of transdermal flunixin meglumine on blood cortisol levels in dairy calves after cautery disbudding with local anesthesia.
Journal of dairy science.
2022 Apr; 105(4):3468-3476. doi:
10.3168/jds.2021-21257. [PMID: 35123779] - Tuba Parlak Ak, Pinar Tatli Seven, Seyfettin Gur, Burcu Gul, Mine Yaman, Ismail Seven. Chrysin and flunixin meglumine mitigate overloaded copper-induced testicular and spermatological damages via modulation of oxidative stress and apoptosis in rats.
Andrologia.
2022 Mar; 54(2):e14327. doi:
10.1111/and.14327. [PMID: 34817900] - Miriam S Martin, Michael D Kleinhenz, Brad J White, Blaine T Johnson, Shawnee R Montgomery, Andrew K Curtis, Mikaela M Weeder, Dale A Blasi, Kelli M Almes, Raghu G Amachawadi, Harith M Salih, Matt D Miesner, Angela K Baysinger, Jason S Nickell, Johann F Coetzee. Assessment of pain associated with bovine respiratory disease and its mitigation with flunixin meglumine in cattle with induced bacterial pneumonia.
Journal of animal science.
2022 Feb; 100(2):. doi:
10.1093/jas/skab373. [PMID: 34932121] - Enoch B de S Meira, Emily E Wiloch, Emma Nixon, James L Yeatts, Farha Ferdous Sheela, Geof W Smith, Ronald E Baynes. The pharmacokinetics of transdermal flunixin in lactating dairy goats.
Journal of dairy science.
2022 Jan; 105(1):549-559. doi:
10.3168/jds.2021-20460. [PMID: 34656343] - Georgios Malis, Elena Geromichalou, George D Geromichalos, Antonios G Hatzidimitriou, George Psomas. Copper(II) complexes with non-steroidal anti-inflammatory drugs: Structural characterization, in vitro and in silico biological profile.
Journal of inorganic biochemistry.
2021 11; 224(?):111563. doi:
10.1016/j.jinorgbio.2021.111563. [PMID: 34399232] - Heather K Knych, Rick M Arthur, Sophie R Gretler, Daniel S McKemie, Skyler Goldin, Philip H Kass. Pharmacokinetics of transdermal flunixin meglumine and effects on biomarkers of inflammation in horses.
Journal of veterinary pharmacology and therapeutics.
2021 Sep; 44(5):745-753. doi:
10.1111/jvp.12993. [PMID: 34173263] - Claire E Dixon, Denise Kelley, Jacob Michael Froehlich, Alisha Gruntman, Trisha Oura, Melissa R Mazan, Mary Anna Labato. Therapeutic plasma exchange to mitigate flunixin meglumine overdose in a cria.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2021 Jul; 31(4):521-524. doi:
10.1111/vec.13071. [PMID: 33955631] - Emmanuelle Marie Butty, Caroline Ann McKinney, Amanda Jane Prisk. Treatment of a flunixin meglumine overdose with intravenous administration of lipid emulsion and therapeutic plasma exchange in a Nigerian dwarf buck kid (Capra aegagrus hircus).
Journal of veterinary internal medicine.
2021 May; 35(3):1626-1630. doi:
10.1111/jvim.16124. [PMID: 33934401] - R Warner, M D Kleinhenz, J A Ydstie, J A Schleining, L W Wulf, J F Coetzee, P J Gorden. Randomized controlled trial comparison of analgesic drugs for control of pain associated with induced lameness in lactating dairy cattle.
Journal of dairy science.
2021 Feb; 104(2):2040-2055. doi:
10.3168/jds.2020-18563. [PMID: 33309349] - Shubhashis Chakrabarty, Weilin L Shelver, David J Smith. Electrospray Ionization Inlet Tandem Mass Spectrometry: A Hyphenated Method for the Sensitive Determination of Chemicals in Animal Tissues and Body Fluids.
Journal of the American Society for Mass Spectrometry.
2021 Jan; 32(1):14-20. doi:
10.1021/jasms.9b00114. [PMID: 33401917] - Heather K Knych, Rick M Arthur, Daniel S McKemie, Russell W Baden, Kelsey Seminoff, Philip H Kass. Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses.
Equine veterinary journal.
2021 Jan; 53(1):102-116. doi:
10.1111/evj.13260. [PMID: 32145701] - Ursula Bechert, J Mark Christensen, Jack Kottwitz, Dawn Boothe, Sultan Alshahrani, Sumeia Mohammed. PHARMACOKINETICS OF ORALLY ADMINISTERED FLUNIXIN MEGLUMINE IN AFRICAN (LOXODONTA AFRICANA) AND ASIAN (ELEPHAS MAXIMUS) ELEPHANTS.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Jan; 51(4):905-914. doi:
10.1638/2020-0053. [PMID: 33480571] - Emma Nixon, Alexandra R Carlson, Patricia A Routh, Liliana Hernandez, Glen W Almond, Ronald E Baynes, Kristen M Messenger. Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets.
PloS one.
2021; 16(11):e0254409. doi:
10.1371/journal.pone.0254409. [PMID: 34847143] - Shannon E Grady, Timothy B Lescun, George E Moore, Bruce R Cooper, Alec J Davern, Timothy J Brunner, Sandra D Taylor. Ketorolac Is Not More Effective Than Flunixin Meglumine or Phenylbutazone in Reducing Foot Pain in Horses.
Journal of equine veterinary science.
2020 11; 94(?):103204. doi:
10.1016/j.jevs.2020.103204. [PMID: 33077087] - Francielli Pereira Gobbi, Paula Alessandra Di Filippo, Luciana de Macêdo Mello, Gabriela Bravim Lemos, Carla Braga Martins, Antônio Peixoto Albernaz, Celia Raquel Quirino. Effects of Flunixin Meglumine, Firocoxib, and Meloxicam in Equines After Castration.
Journal of equine veterinary science.
2020 11; 94(?):103229. doi:
10.1016/j.jevs.2020.103229. [PMID: 33077071] - Emma Nixon, Travis P Mays, Patricia A Routh, James L Yeatts, Virginia R Fajt, Thomas Hairgrove, Ronald E Baynes. Plasma, urine and tissue concentrations of Flunixin and Meloxicam in Pigs.
BMC veterinary research.
2020 Sep; 16(1):340. doi:
10.1186/s12917-020-02556-4. [PMID: 32938437] - Jessica L Bates, Locke A Karriker, Suzanne M Rajewski, Zhoumeng Lin, Ronette Gehring, Mengjie Li, Jim E Riviere, Johann F Coetzee. A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing-age swine.
BMC veterinary research.
2020 Jun; 16(1):211. doi:
10.1186/s12917-020-02429-w. [PMID: 32571315] - Duygu Durna Corum, Orhan Corum, Ramazan Yildiz, Hatice Eser Faki, Merve Ider, Gul Cetin, Kamil Uney. Influences of tolfenamic acid and flunixin meglumine on the disposition kinetics of levofloxacin in sheep.
Acta veterinaria Hungarica.
2020 03; 68(1):65-70. doi:
10.1556/004.2020.00015. [PMID: 32384070] - Feray Altan, Orhan Corum, Ramazan Yildiz, Hatice Eser Faki, Merve Ider, Mahmut Ok, Kamil Uney. Intravenous pharmacokinetics of moxifloxacin following simultaneous administration with flunixin meglumine or diclofenac in sheep.
Journal of veterinary pharmacology and therapeutics.
2020 Mar; 43(2):108-114. doi:
10.1111/jvp.12841. [PMID: 32043623] - Amanda K Hartnack, Andrew J Niehaus, Jeffrey Lakritz, Johann F Coetzee, Michael D Kleinhenz. Pharmacokinetics of an intravenous constant rate infusion of a morphine-lidocaine-ketamine combination in Holstein calves undergoing umbilical herniorrhaphy.
American journal of veterinary research.
2020 Jan; 81(1):17-24. doi:
10.2460/ajvr.81.1.17. [PMID: 31887082] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Katarzyna Dudek, Dariusz Bednarek, Roger D Ayling, Anna Kycko, Michał Reichert. Preliminary study on the effects of enrofloxacin, flunixin meglumine and pegbovigrastim on Mycoplasma bovis pneumonia.
BMC veterinary research.
2019 Oct; 15(1):371. doi:
10.1186/s12917-019-2122-3. [PMID: 31655595] - Amir Saeed Samimi, Kamyab Samimi, Marzieh Karimiafshar, Javad Tajik. Comparative Anti-inflammatory Effects of Insulin and Flunixin on Acute-Phase Responses and Cardiovascular Biomarkers During Inflammatory Phase in Miniature Donkeys.
Journal of equine veterinary science.
2019 10; 81(?):102788. doi:
10.1016/j.jevs.2019.102788. [PMID: 31668307] - Emily J Reppert, Michael D Kleinhenz, Shawnee R Montgomery, Jared Heiman, Amanda Sura, Heather N Bornheim, Geraldine Magnin, Pritam K Sidhu, Yuntao Zhang, Hyun Joo, Johann F Coetzee. Pharmacokinetics and pharmacodynamics of intravenous and transdermal flunixin meglumine in alpacas.
Journal of veterinary pharmacology and therapeutics.
2019 Sep; 42(5):572-579. doi:
10.1111/jvp.12800. [PMID: 31353535] - Tim Morris, Stuart W Paine, Paul Zahra, Eric Li, Sally Colgan, Steven Karamatic. Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs.
Journal of veterinary pharmacology and therapeutics.
2019 Sep; 42(5):505-510. doi:
10.1111/jvp.12775. [PMID: 31090076] - Laura E Burns, David J Borts. Rapid untargeted screening for drug residues in animal tissues with liquid microjunction surface sampling probe mass spectrometry.
Analytica chimica acta.
2019 Jul; 1063(?):75-81. doi:
10.1016/j.aca.2019.01.029. [PMID: 30967188] - Mary C Cramer, Monique D Pairis-Garcia, Andrew S Bowman, Steven J Moeller, Yuntao Zhang, Pritam K Sidhu, Geraldine Magnin, Johann F Coetzee. Pharmacokinetics of transdermal flunixin in sows.
Journal of veterinary pharmacology and therapeutics.
2019 Jul; 42(4):492-495. doi:
10.1111/jvp.12772. [PMID: 31197844] - M D Kleinhenz, P J Gorden, J S Smith, J A Schleining, K E Kleinhenz, J R Juarez, D Rea, J F Coetzee. Effects of transdermal flunixin meglumine on experimentally induced lameness in adult dairy cattle.
Journal of dairy science.
2019 Jul; 102(7):6418-6430. doi:
10.3168/jds.2018-15091. [PMID: 31030917] - Brittni East, Lisa Tell, Scott B Citino, Daniel V Fredholm, Kathryn Gamble, Virginia Fajt. PHARMACOKINETICS OF A SINGLE ORAL DOSE OF FLUNIXIN MEGLUMINE IN THE WHITE RHINOCEROS (CERATOTHERIUM SIMUM).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2019 Jun; 50(2):322-329. doi:
10.1638/2018-0200. [PMID: 31260196] - A L Ziegler, C K Freeman, C A Fogle, M J Burke, J L Davis, V L Cook, L L Southwood, A T Blikslager. Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction.
Equine veterinary journal.
2019 May; 51(3):329-335. doi:
10.1111/evj.13013. [PMID: 30156312] - Claudia Eleni, Bruno Neri, Luigi Giannetti, Goffredo Grifoni, Roberta Meoli, Fiorentino Stravino, Klaus Gunther Friedrich, Francesco Scholl, Pilar Di Cerbo, Antonio Battisti. Death of captive-bred vultures caused by flunixin poisoning in Italy.
Environmental toxicology and pharmacology.
2019 May; 68(?):91-93. doi:
10.1016/j.etap.2019.03.011. [PMID: 30878718] - Dafne Garcia-Mateos, Alba Maria Garcia-Lino, Indira Alvarez-Fernandez, Esther Blanco-Paniagua, Alvaro de la Fuente, Ana Isabel Alvarez, Gracia Merino. Role of ABCG2 in Secretion into Milk of the Anti-Inflammatory Flunixin and Its Main Metabolite: In Vitro-In Vivo Correlation in Mice and Cows.
Drug metabolism and disposition: the biological fate of chemicals.
2019 05; 47(5):516-524. doi:
10.1124/dmd.118.085506. [PMID: 30858238] - Emily J Reppert, Michael D Kleinhenz, Shawnee R Montgomery, Heather N Bornheim, Geraldine Magnin, Pritam K Sidhu, Yuntao Zhang, Hyun Joo, Johann F Coetzee. Pharmacokinetics and pharmacodynamics of intravenous and transdermal flunixin meglumine in meat goats.
Journal of veterinary pharmacology and therapeutics.
2019 May; 42(3):309-317. doi:
10.1111/jvp.12756. [PMID: 30802981] - Callum G Donnelly, Jenny L Sones, Jenna C Dockweiler, Lauren A Norberg, Lindsey E Norberg, Soon H Cheong, Robert O Gilbert. Effects of flunixin meglumine on postponement of ovulation in mares.
American journal of veterinary research.
2019 Mar; 80(3):306-310. doi:
10.2460/ajvr.80.3.306. [PMID: 30801209] - Raies A Mir, Michael D Kleinhenz, Johann F Coetzee, Heather K Allen, Indira T Kudva. Fecal microbiota changes associated with dehorning and castration stress primarily affects light-weight dairy calves.
PloS one.
2019; 14(1):e0210203. doi:
10.1371/journal.pone.0210203. [PMID: 30673718] - Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira. Cortisol, progesterone, 17αOHprogesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis.
Theriogenology.
2019 Jan; 123(?):139-144. doi:
10.1016/j.theriogenology.2018.06.024. [PMID: 30308389] - M Abass, S Picek, J F G Garzón, C Kühnle, A Zaghlou, R Bettschart-Wolfensberger. Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release.
Equine veterinary journal.
2018 Nov; 50(6):733-738. doi:
10.1111/evj.12947. [PMID: 29660154] - D A Mzyk, C M Bublitz, H Sylvester, K A E Mullen, G D Hobgood, R E Baynes, D M Foster. Short communication: Use of an ultrafiltration device in gland cistern for continuous sampling of healthy and mastitic quarters of lactating cattle for pharmacokinetic modeling.
Journal of dairy science.
2018 Nov; 101(11):10414-10420. doi:
10.3168/jds.2018-14849. [PMID: 30197136] - Michael D Kleinhenz, Nicholas K Van Engen, Patrick J Gorden, Katie E Kleinhenz, Butch Kukanich, Suzanne M Rajewski, Philip Walsh, Johann F Coetzee. The impact of pain on the pharmacokinetics of transdermal flunixin meglumine administered at the time of cautery dehorning in Holstein calves.
Veterinary anaesthesia and analgesia.
2018 Nov; 45(6):849-857. doi:
10.1016/j.vaa.2018.06.008. [PMID: 30122634] - M D Kleinhenz, P J Gorden, J S Smith, J A Schleining, K E Kleinhenz, L L Wulf, P K Sidhu, D Rea, J F Coetzee. Pharmacokinetics of multiple doses of transdermal flunixin meglumine in adult Holstein dairy cows.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):490-493. doi:
10.1111/jvp.12490. [PMID: 29460288] - Michael D Kleinhenz, Nicholas K Van Engen, Patrick J Gorden, Joe S Smith, Butch KuKanich, Suzanne M Rajewski, Philip Walsh, Steven Perkins, Johann F Coetzee. Effect of age on the pharmacokinetics and pharmacodynamics of flunixin meglumine following intravenous and transdermal administration to Holstein calves.
American journal of veterinary research.
2018 May; 79(5):568-575. doi:
10.2460/ajvr.79.5.568. [PMID: 29688783] - M Mendel, M Chłopecka, N Dziekan, W Karlik. Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study.
Journal of veterinary pharmacology and therapeutics.
2018 Apr; 41(2):281-291. doi:
10.1111/jvp.12455. [PMID: 28913883] - O L Levionnois, T K Fosse, B Ranheim. PK/PD modeling of flunixin meglumine in a kaolin-induced inflammation model in piglets.
Journal of veterinary pharmacology and therapeutics.
2018 Apr; 41(2):314-323. doi:
10.1111/jvp.12468. [PMID: 29143334] - Briony D Smith, Krystal J Vail, Gwendolyn L Carroll, Maggie C Taylor, Nicholas D Jeffery, Tracy H Vemulapalli, James J Elliott. Comparison of Etomidate, Benzocaine, and MS222 Anesthesia with and without Subsequent Flunixin Meglumine Analgesia in African Clawed Frogs (Xenopus laevis).
Journal of the American Association for Laboratory Animal Science : JAALAS.
2018 03; 57(2):202-209. doi:
NULL. [PMID: 29555009] - A W Bianco, G E Moore, B R Cooper, S D Taylor. In vitro anti-LPS dose determination of ketorolac tromethamine and in vivo safety of repeated dosing in healthy horses.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):98-104. doi:
10.1111/jvp.12425. [PMID: 28600856] - P J Gorden, M D Kleinhenz, L W Wulf, S J Rajewski, C Wang, R Gehring, J F Coetzee. Comparative plasma and interstitial fluid pharmacokinetics of flunixin meglumine and ceftiofur hydrochloride following individual and co-administration in dairy cows.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):76-82. doi:
10.1111/jvp.12437. [PMID: 28731206] - M D Kleinhenz, N K Van Engen, P J Gorden, J Ji, P Walsh, J F Coetzee. Effects of transdermal flunixin meglumine on pain biomarkers at dehorning in calves.
Journal of animal science.
2017 May; 95(5):1993-2000. doi:
10.2527/jas.2016.1138. [PMID: 28726995] - M D Kleinhenz, N K Van Engen, P J Gorden, B KuKanich, S M Rajewski, P Walsh, J F Coetzee. The pharmacokinetics of transdermal flunixin meglumine in Holstein calves.
Journal of veterinary pharmacology and therapeutics.
2016 Dec; 39(6):612-615. doi:
10.1111/jvp.12314. [PMID: 27121728] - Lindsey W Kissell, Patrick D Brinson, Ronette Gehring, Lisa A Tell, Scott E Wetzlich, Ronald E Baynes, Jim E Riviere, Geof W Smith. Pharmacokinetics and tissue elimination of flunixin in veal calves.
American journal of veterinary research.
2016 Jun; 77(6):634-40. doi:
10.2460/ajvr.77.6.634. [PMID: 27227502] - Weilin L Shelver, David J Smith, Lisa A Tell, Ronald E Baynes, J W Schroeder, Jim E Riviere. Screening and Confirmatory Analyses of Flunixin in Tissues and Bodily Fluids after Intravenous or Intramuscular Administration to Cull Dairy Cows with or without Lipopolysaccharide Challenge.
Journal of agricultural and food chemistry.
2016 Jan; 64(1):336-45. doi:
10.1021/acs.jafc.5b04793. [PMID: 26695354] - D Marini, J Pippia, I G Colditz, G Hinch, J C Petherick, C Lee. Randomised trial of the bioavailability and efficacy of orally administered flunixin, carprofen and ketoprofen in a pain model in sheep.
Australian veterinary journal.
2015 Aug; 93(8):265-70. doi:
10.1111/avj.12351. [PMID: 26220318] - D R Paull, A H Small, C Lee, L Labeur, I G Colditz. Effect of local infusion of NSAID analgesics administered alone or in combination on the pain associated with band castration in calves.
Australian veterinary journal.
2015 Aug; 93(8):271-7. doi:
10.1111/avj.12348. [PMID: 26220319] - David J Smith, Weilin L Shelver, Ronald E Baynes, Lisa Tell, Ronette Gehring, Mengjie Li, Terry Dutko, J W Schroeder, Grant Herges, Jim E Riviere. Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows.
Journal of agricultural and food chemistry.
2015 May; 63(19):4893-901. doi:
10.1021/acs.jafc.5b01509. [PMID: 25950946] - Irene Zorrilla, Rosa Martinez, Mark A Taggart, Ngaio Richards. Suspected flunixin poisoning of a wild Eurasian Griffon Vulture from Spain.
Conservation biology : the journal of the Society for Conservation Biology.
2015 Apr; 29(2):587-92. doi:
10.1111/cobi.12417. [PMID: 25303011] - Marco Duz, Tim D Parkin, Rose M Cullander, John F Marshall. Effect of flunixin meglumine and firocoxib on ex vivo cyclooxygenase activity in horses undergoing elective surgery.
American journal of veterinary research.
2015 Mar; 76(3):208-15. doi:
10.2460/ajvr.76.3.208. [PMID: 25710756] - Tamsyn Fourie, Duncan Cromarty, Neil Duncan, Kerri Wolter, Vinny Naidoo. The Safety and Pharmacokinetics of Carprofen, Flunixin and Phenylbutazone in the Cape Vulture (Gyps coprotheres) following Oral Exposure.
PloS one.
2015; 10(10):e0141419. doi:
10.1371/journal.pone.0141419. [PMID: 26512724] - Boobalan Gopu, Rasakatla Dileep, Matukumalli Usha Rani, C S V Satish Kumar, Matham Vijay Kumar, Alla Gopala Reddy. Protective Role of Curcumin and Flunixin Against Acetic Acid-Induced Inflammatory Bowel Disease via Modulating Inflammatory Mediators and Cytokine Profile in Rats.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2015; 34(4):309-20. doi:
10.1615/jenvironpatholtoxicoloncol.2015013049. [PMID: 26756424] - Lindsey W Kissell, Teresa L Leavens, Ronald E Baynes, Jim E Riviere, Geof W Smith. Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis.
Journal of the American Veterinary Medical Association.
2015 Jan; 246(1):118-25. doi:
10.2460/javma.246.1.118. [PMID: 25517334] - J T Howard, R E Baynes, J D Brooks, J L Yeatts, B Bellis, M S Ashwell, P Routh, A T O'Nan, C Maltecca. The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine.
Journal of veterinary pharmacology and therapeutics.
2014 Dec; 37(6):531-41. doi:
10.1111/jvp.12128. [PMID: 24731191] - E M Mintline, A Varga, J Banuelos, K A Walker, B Hoar, Daniel Drake, D M Weary, J F Coetzee, M L Stock, C B Tucker. Healing of surgical castration wounds: a description and an evaluation of flunixin.
Journal of animal science.
2014 Dec; 92(12):5659-65. doi:
10.2527/jas.2014-7885. [PMID: 25367511] - R J Naylor, A H Taylor, E J Knowles, S Wilford, W Linnenkohl, T S Mair, I C Johns. Comparison of flunixin meglumine and meloxicam for post operative management of horses with strangulating small intestinal lesions.
Equine veterinary journal.
2014 Jul; 46(4):427-34. doi:
10.1111/evj.12224. [PMID: 24372991] - Shuna A Jones, Robert S Salter, Tim Goldsmith, Julio Quintana, Paul Rapnicki, Karen Shuck, Jim E Wells, Marilyn J Schneider, Dee Griffin. Development and model testing of antemortem screening methodology to predict required drug withholds in heifers.
Journal of food protection.
2014 Feb; 77(2):292-8. doi:
10.4315/0362-028x.jfp-13-267. [PMID: 24490924] - C D Lee, L K Maxwell. Effect of body weight on the pharmacokinetics of flunixin meglumine in miniature horses and quarter horses.
Journal of veterinary pharmacology and therapeutics.
2014 Feb; 37(1):35-42. doi:
10.1111/jvp.12056. [PMID: 23659780] - O Yilmaz, M Korkmaz, J J Jaroszewski, E Yazici, E Ulutas, Z K Saritas. Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches.
Polish journal of veterinary sciences.
2014; 17(3):493-9. doi:
10.2478/pjvs-2014-0071. [PMID: 25286659] - Teresa L Leavens, Lisa A Tell, Lindsey W Kissell, Geoffrey W Smith, David J Smith, Sarah A Wagner, Weilin L Shelver, Huali Wu, Ronald E Baynes, Jim E Riviere. Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus).
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2014; 31(9):1506-21. doi:
10.1080/19440049.2014.938363. [PMID: 25082521] - H D Glynn, J F Coetzee, L N Edwards-Callaway, J C Dockweiler, K A Allen, B Lubbers, M Jones, E Fraccaro, L L Bergamasco, B KuKanich. The pharmacokinetics and effects of meloxicam, gabapentin, and flunixin in postweaning dairy calves following dehorning with local anesthesia.
Journal of veterinary pharmacology and therapeutics.
2013 Dec; 36(6):550-61. doi:
10.1111/jvp.12042. [PMID: 23473342] - R F Cooke, B I Cappellozza, T A Guarnieri Filho, D W Bohnert. Effects of flunixin meglumine administration on physiological and performance responses of transported feeder cattle.
Journal of animal science.
2013 Nov; 91(11):5500-6. doi:
10.2527/jas.2013-6336. [PMID: 24045487] - H B Webster, D Morin, V Jarrell, C Shipley, L Brown, A Green, R Wallace, P D Constable. Effects of local anesthesia and flunixin meglumine on the acute cortisol response, behavior, and performance of young dairy calves undergoing surgical castration.
Journal of dairy science.
2013 Oct; 96(10):6285-300. doi:
10.3168/jds.2012-6238. [PMID: 23972493] - Ai-Ling Zhu, Tao Peng, Liang Liu, Xi Xia, Ting Hu, Xiao-Qi Tao, Kai Wen, Lin-Li Cheng, Jian-Cheng Li, Shuang-Yang Ding, Xing-Yuan Cao, Hai-Yang Jiang. Ultra-performance liquid chromatography-tandem mass spectrometry determination and depletion profile of flunixin residues in tissues after single oral administration in rabbits.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Sep; 934(?):8-15. doi:
10.1016/j.jchromb.2013.07.002. [PMID: 23891913] - Monique D Pairis-Garcia, Locke A Karriker, Anna K Johnson, Butch Kukanich, Larry Wulf, Suzanne Sander, Suzanne T Millman, Kenneth J Stalder, Johann F Coetzee. Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration.
BMC veterinary research.
2013 Aug; 9(?):165. doi:
10.1186/1746-6148-9-165. [PMID: 23941181] - E Fraccaro, J F Coetzee, R Odore, L N Edwards-Callaway, B Kukanich, P Badino, L Bertolotti, H Glynn, J Dockweiler, K Allen, L Bergamasco. A study to compare circulating flunixin, meloxicam and gabapentin concentrations with prostaglandin E₂ levels in calves undergoing dehorning.
Research in veterinary science.
2013 Aug; 95(1):204-11. doi:
10.1016/j.rvsc.2013.01.018. [PMID: 23434065] - H Wu, R E Baynes, T Leavens, L A Tell, J E Riviere. Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle.
Journal of veterinary pharmacology and therapeutics.
2013 Jun; 36(3):248-57. doi:
10.1111/j.1365-2885.2012.01420.x. [PMID: 22712521] - Weilin L Shelver, Lisa A Tell, Sarah Wagner, Scott E Wetzlich, Ronald E Baynes, Jim E Riviere, David J Smith. Comparison of ELISA and LC-MS/MS for the measurement of flunixin plasma concentrations in beef cattle after intravenous and subcutaneous administration.
Journal of agricultural and food chemistry.
2013 Mar; 61(11):2679-86. doi:
10.1021/jf304773p. [PMID: 23470029] - Lee Ann Fugler, Susan C Eades, Rustin M Moore, Catherine E Koch, Michael L Keowen. Plasma matrix metalloproteinase activity in horses after intravenous infusion of lipopolysaccharide and treatment with matrix metalloproteinase inhibitors.
American journal of veterinary research.
2013 Mar; 74(3):473-80. doi:
10.2460/ajvr.74.3.473. [PMID: 23438126] - Jeffrey M B Musser, J Jill Heatley, David N Phalen. Pharmacokinetics after intravenous administration of flunixin meglumine in budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus).
Journal of the American Veterinary Medical Association.
2013 Jan; 242(2):205-8. doi:
10.2460/javma.242.2.205. [PMID: 23276097] - Aliasghar Chalmeh, Khalil Badiei, Mehrdad Pourjafar, Saeed Nazifi. Anti-inflammatory effects of insulin regular and flunixin meglumine on endotoxemia experimentally induced by Escherichia coli serotype O55:B5 in an ovine model.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2013 Jan; 62(1):61-7. doi:
10.1007/s00011-012-0551-6. [PMID: 22960692] - L W Kissell, G W Smith, T L Leavens, R E Baynes, H Wu, J E Riviere. Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle.
Journal of dairy science.
2012 Dec; 95(12):7151-7. doi:
10.3168/jds.2012-5754. [PMID: 23040013] - J H Foreman, B E Bergstrom, K S Golden, J J Roark, D S Coren, C R Foreman, S A Schumacher. Dose titration of the clinical efficacy of intravenously administered flunixin meglumine in a reversible model of equine foot lameness.
Equine veterinary journal. Supplement.
2012 Dec; ?(43):17-20. doi:
10.1111/j.2042-3306.2012.00655.x. [PMID: 23447872] - David R Paull, Alison H Small, Caroline Lee, Pierre Palladin, Ian G Colditz. Evaluating a novel analgesic strategy for ring castration of ram lambs.
Veterinary anaesthesia and analgesia.
2012 Sep; 39(5):539-49. doi:
10.1111/j.1467-2995.2012.00716.x. [PMID: 22524300] - Sharla M Peters, Haile Yancy, Christine Deaver, Yolanda L Jones, Elizabeth Kenyon, Oscar A Chiesa, Juan Esparza, Rudell Screven, Vicki Lancaster, John T Stubbs, Maocheng Yang, Paddy L Wiesenfeld, Michael J Myers. In vivo characterization of inflammatory biomarkers in swine and the impact of flunixin meglumine administration.
Veterinary immunology and immunopathology.
2012 Aug; 148(3-4):236-42. doi:
10.1016/j.vetimm.2012.05.001. [PMID: 22648045] - Julia Jeremejeva, Toomas Orro, Andres Waldmann, Kalle Kask. Treatment of dairy cows with PGF2α or NSAID, in combination with antibiotics, in cases of postpartum uterine inflammation.
Acta veterinaria Scandinavica.
2012 Aug; 54(?):45. doi:
10.1186/1751-0147-54-45. [PMID: 22883439] - Cynthia L Deyrup, Kristal J Southern, Julie A Cornett, Craig E Shultz, Deborah A Cera. Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey.
Journal of the American Veterinary Medical Association.
2012 Jul; 241(2):249-53. doi:
10.2460/javma.241.2.249. [PMID: 22765373] - Gerald Reiner, Frauke Schollasch, Sonja Hillen, Hermann Willems, Marion Piechotta, Klaus Failing. Effects of meloxicam and flunixin on pain, stress and discomfort in male piglets during and after surgical castration.
Berliner und Munchener tierarztliche Wochenschrift.
2012 Jul; 125(7-8):305-14. doi:
. [PMID: 22919924] - T W Geary. Effects of adrenocorticotropic hormone and flunixin meglumine on pregnancy retention in beef cows.
Journal of animal science.
2012 Jan; 90(1):207-11. doi:
10.2527/jas.2010-3564. [PMID: 21856895] - Kenji Takata, Yoshiaki Hikasa, Hiroshi Satoh. Therapeutic and adverse effects of flunixin-meglumine in adult and young cats.
The Journal of veterinary medical science.
2011 Dec; 73(12):1591-6. doi:
10.1292/jvms.11-0290. [PMID: 21817836] - M A Popot, P Garcia, Y Bonnaire. Doping control in horses: housing conditions and oral recycling of flunixin by ingestion of contaminated straw.
Journal of veterinary pharmacology and therapeutics.
2011 Dec; 34(6):612-4. doi:
10.1111/j.1365-2885.2011.01276.x. [PMID: 21995754] - Kara L Schulz, David E Anderson, Johann F Coetzee, Brad J White, Matt D Miesner. Effect of flunixin meglumine on the amelioration of lameness in dairy steers with amphotericin B-induced transient synovitis-arthritis.
American journal of veterinary research.
2011 Nov; 72(11):1431-8. doi:
10.2460/ajvr.72.11.1431. [PMID: 22023120] - J H Foreman, R Ruemmler. Phenylbutazone and flunixin meglumine used singly or in combination in experimental lameness in horses.
Equine veterinary journal. Supplement.
2011 Nov; ?(40):12-7. doi:
10.1111/j.2042-3306.2011.00485.x. [PMID: 22082440] - Ali Asghar Mozaffari, Amin Derakhshanfar. Evaluation of the brain, renal, and hepatic effects of flunixin meglumine, ketoprofen, and phenylbutazone administration in Iranian fat-tailed sheep.
Tropical animal health and production.
2011 Oct; 43(7):1389-93. doi:
10.1007/s11250-011-9866-5. [PMID: 21503752] - H G Hilton, K G Magdesian, A D Groth, H Knych, S D Stanley, S R Hollingsworth. Distribution of flunixin meglumine and firocoxib into aqueous humor of horses.
Journal of veterinary internal medicine.
2011 Sep; 25(5):1127-33. doi:
10.1111/j.1939-1676.2011.0763.x. [PMID: 21781166] - G Pugliesi, H K Shrestha, M A Hannan, G R Carvalho, M A Beg, O J Ginther. Effects of inhibition of prostaglandin F2α biosynthesis during preluteolysis and luteolysis in heifers.
Theriogenology.
2011 Sep; 76(4):640-51. doi:
10.1016/j.theriogenology.2011.03.017. [PMID: 21612816] - J Cuervo-Arango, M A Beg, O J Ginther. Follicle and systemic hormone interrelationships during induction of luteinized unruptured follicles with a prostaglandin inhibitor in mares.
Theriogenology.
2011 Jul; 76(2):361-73. doi:
10.1016/j.theriogenology.2011.02.015. [PMID: 21496901] - Jacquelyn T Tubbs, Grace E Kissling, Greg S Travlos, David R Goulding, James A Clark, Angela P King-Herbert, Terry L Blankenship-Paris. Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2011 Mar; 50(2):185-91. doi:
NULL. [PMID: 21439211] - Youn-Hwan Hwang, Hyo-In Yun. Effects of acute hepatic and renal failure on pharmacokinetics of flunixin meglumine in rats.
Experimental animals.
2011; 60(2):187-91. doi:
10.1538/expanim.60.187. [PMID: 21512275] - Thiago Vinicius Avila, Amanda Leite Bastos Pereira, Adriana De Oliveira Christoff, Bruna Da Silva Soley, José Ederaldo Queiroz Telles, Gabrielle Jacklin Eler, Adelar Bracht, Aleksander Roberto Zampronio, Alexandra Acco. Hepatic effects of flunixin-meglumin in LPS-induced sepsis.
Fundamental & clinical pharmacology.
2010 Dec; 24(6):759-69. doi:
10.1111/j.1472-8206.2009.00804.x. [PMID: 20030736] - P Kallings, S G B Persson, B Essén-Gustavsson. Effects of flunixin on cardiorespiratory, plasma lactate and stride length responses to intense treadmill exercise in Standardbred trotters.
Equine veterinary journal. Supplement.
2010 Nov; ?(38):618-23. doi:
10.1111/j.2042-3306.2010.00298.x. [PMID: 21059070] - Luís M Magalhães, Cláudia Nunes, Marlene Lúcio, Marcela A Segundo, Salette Reis, José L F C Lima. High-throughput microplate assay for the determination of drug partition coefficients.
Nature protocols.
2010 Nov; 5(11):1823-30. doi:
10.1038/nprot.2010.137. [PMID: 21030957] - A A Mozaffari, A Derakhshanfar, A Alinejad, M Morovati. A comparative study on the adverse effects of flunixin, ketoprofen and phenylbutazone in miniature donkeys: haematological, biochemical and pathological findings.
New Zealand veterinary journal.
2010 Oct; 58(5):224-8. doi:
10.1080/00480169.2010.69295. [PMID: 20927172]
