estramustine (BioDeep_00000858522)
Main id: BioDeep_00000008551
代谢物信息卡片
estra-1,3,5(10)-triene-3,17beta-diol, 3-[bis(2-chloroethyl)carbamate]
化学式: C23H31Cl2NO3 (439.16808760000004)
中文名称: 雌莫司汀
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(=CC2=C(C=1)[C@@]1([H])CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CC2)OC(N(CCCl)CCCl)=O
InChI: InChI=1S/C23H31Cl2NO3/c1-23-9-8-18-17-5-3-16(29-22(28)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)27/h3,5,14,18-21,27H,2,4,6-13H2,1H3/t18-,19-,20+,21+,23+/m1/s1
描述信息
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C273 - Antimitotic Agent
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents
D009676 - Noxae > D000477 - Alkylating Agents
Same as: D04066
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:4868
- KEGG: C11228
- KEGGdrug: D04066
- PubChem: 259331
- DrugBank: DB01196
- ChEMBL: CHEMBL1575
- LipidMAPS: LMST02010038
- MeSH: Estramustine
- CAS: 2998-57-4
- PubChem: 13407
- NIKKAJI: J7.659G
- RefMet: Estramustine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Clément Dumont, Giulia Baciarello, Pierre-Olivier Bosset, Pernelle Lavaud, Emeline Colomba, Christophe Massard, Yohann Loriot, Laurence Albiges, Pierre Blanchard, Alberto Bossi, Soazig Nenan, Karim Fizazi. Long-term Castration-related Outcomes in Patients With High-risk Localized Prostate Cancer Treated With Androgen Deprivation Therapy With or Without Docetaxel and Estramustine in the UNICANCER GETUG-12 Trial.
Clinical genitourinary cancer.
2020 12; 18(6):444-451. doi:
10.1016/j.clgc.2020.03.017. [PMID: 32349927] - Vikram Patial, Supriya Sharma, Ugir Hossain Sk. Dendrimer conjugated estramustine nanocrystalline 'Dendot': An effective inhibitor of DMBA-TPA induced papilloma formation in mouse.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Nov; 109(?):316-323. doi:
10.1016/j.ejps.2017.08.026. [PMID: 28842350] - Atsushi Mizokami, Kouji Izumi, Hiroyuki Konaka, Yasuhide Kitagawa, Yoshifumi Kadono, Kazutaka Narimoto, Takahiro Nohara, Amit K Bahl, Mikio Namiki. Understanding prostate-specific antigen dynamics in monitoring metastatic castration-resistant prostate cancer: implications for clinical practice.
Asian journal of andrology.
2017 Mar; 19(2):143-148. doi:
10.4103/1008-682x.179159. [PMID: 27270339] - Yasutomo Nakai, Kazuo Nishimura, Masashi Nakayama, Motohide Uemura, Hitoshi Takayama, Norio Nonomura, Akira Tsujimura. Weekly, low-dose docetaxel combined with estramustine for Japanese castration-resistant prostate cancer: its efficacy and safety profile compared with tri-weekly standard-dose treatment.
International journal of clinical oncology.
2014 Feb; 19(1):165-72. doi:
10.1007/s10147-013-0536-7. [PMID: 23456140] - Kazuhiro Matsumoto, Nobuyuki Tanaka, Nozomi Hayakawa, Taisuke Ezaki, Kenjiro Suzuki, Takahiro Maeda, Akiharu Ninomiya, So Nakamura. Efficacy of estramustine phosphate sodium hydrate (EMP) monotherapy in castration-resistant prostate cancer patients: report of 102 cases and review of literature.
Medical oncology (Northwood, London, England).
2013 Dec; 30(4):717. doi:
10.1007/s12032-013-0717-2. [PMID: 24005812] - Ugir Hossain Sk, Deobrat Dixit, Ellora Sen. Comparative study of microtubule inhibitors--estramustine and natural podophyllotoxin conjugated PAMAM dendrimer on glioma cell proliferation.
European journal of medicinal chemistry.
2013 Oct; 68(?):47-57. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2012 Sep; 66(6):403-8. doi:
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International journal of clinical oncology.
2012 Jun; 17(3):204-11. doi:
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Advances in urology.
2012; 2012(?):979154. doi:
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Case reports in oncology.
2011 Sep; 4(3):517-20. doi:
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2011 Aug; 5(?):413. doi:
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Journal of medical case reports.
2011 Aug; 5(?):355. doi:
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Korean journal of urology.
2011 Jul; 52(7):461-5. doi:
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American journal of clinical oncology.
2011 Apr; 34(2):140-4. doi:
10.1097/coc.0b013e3181d2ed7d. [PMID: 20686407] - Yukiyoshi Hirayama, Yoshihiro Ito, Tomohiro Kanamaru, Teppei Sonoda, Masato Aoyama, Norihiro Nakamura, Masaki Kawamura. [A case of castration-refractory prostate cancer showing marked decrease of serum PSA level after zoledronic acid treatment with estramustine phosphate and prednisolone].
Gan to kagaku ryoho. Cancer & chemotherapy.
2011 Mar; 38(3):485-7. doi:
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Journal of hematology & oncology.
2010 Aug; 3(?):26. doi:
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International journal of urology : official journal of the Japanese Urological Association.
2010 Jul; 17(7):629-34. doi:
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2010 Jun; 16(3):200-5. doi:
10.1007/s10156-010-0047-7. [PMID: 20221782] - Yoshitatsu Sei, Zhen Li, Jian Song, Renee Ren-Patterson, Elizabeth M Tunbridge, Yukihiko Iizuka, Masahiro Inoue, Berenice T Alfonso, Senda Beltaifa, Yoko Nakai, Bhaskar S Kolachana, Jingshan Chen, Daniel R Weinberger. Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
PloS one.
2010 May; 5(5):e10789. doi:
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Cancer management and research.
2010 May; 2(?):111-22. doi:
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Oncology reports.
2009 Aug; 22(2):345-8. doi:
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British journal of cancer.
2009 Jul; 101(2):263-8. doi:
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Annals of oncology : official journal of the European Society for Medical Oncology.
2009 Apr; 20(4):703-8. doi:
10.1093/annonc/mdn694. [PMID: 19179557] - Taku Naiki, Takehiko Okamura, Noriyasu Kawai, Hiroshi Sakagami, Yasuyuki Yamada, Keiji Fujita, Hidetoshi Akita, Yoshihiro Hashimoto, Keiichi Tozawa, Kenjiro Kohri. Advantages of second line estramustine for overall survival of hormone-refractory prostate cancer (HRPC) patients.
Asian Pacific journal of cancer prevention : APJCP.
2009 Jan; 10(1):71-4. doi:
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Annals of oncology : official journal of the European Society for Medical Oncology.
2008 Jul; 19(7):1308-1311. doi:
10.1093/annonc/mdn062. [PMID: 18356135] - Shuichiro Kobayashi, Tetsuro Tsukamoto, Akira Tohsaka, Tsuguhiro Tohma. [Estramustine phosphate withdrawal syndrome in relapsed prostate cancer: two case reports].
Hinyokika kiyo. Acta urologica Japonica.
2008 Jun; 54(6):423-6. doi:
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Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2008 Mar; 19(3):321-7. doi:
10.1007/s00198-007-0472-3. [PMID: 17906826] - Atsushi Takenaka, Yuji Yamada, Toshifumi Kurahashi, Hideo Soga, Hideaki Miyake, Masato Fujisawa. Combination chemotherapy with weekly docetaxel and estramustine for hormone refractory prostate cancer in Japanese patients.
International journal of urology : official journal of the Japanese Urological Association.
2008 Jan; 15(1):106-9. doi:
10.1111/j.1442-2042.2007.01929.x. [PMID: 18184188] - Karim Fizazi, Aurelie Le Maitre, Gary Hudes, William R Berry, W Kevin Kelly, Jean-Christophe Eymard, Christopher J Logothetis, Jean-Pierre Pignon, Stefan Michiels. Addition of estramustine to chemotherapy and survival of patients with castration-refractory prostate cancer: a meta-analysis of individual patient data.
The Lancet. Oncology.
2007 Nov; 8(11):994-1000. doi:
10.1016/s1470-2045(07)70284-x. [PMID: 17942366] - Takahiko Sakuma, Takahiro Yoshida, Hiroshi Ohashi, Kensaku Nishimura, Kiyoshi Kawano. [Prostatic carcinoma that arose with hearing loss: a case report].
Hinyokika kiyo. Acta urologica Japonica.
2007 Jun; 53(6):413-6. doi:
. [PMID: 17628942] - Hideyuki Akaza, Malcolm A Moore, Shu-Jen Chang, Christopher Cheng, Han Yong Choi, Kesavan Esuvaranathan, Shiro Hinotsu, Sung-Joon Hong, Choung-Soo Kim, Wun-Jae Kim, Masaru Murai, Seiji Naito, Doddy Soebadi, Jae-Mann Song, Rainy Umbas, Michiyuki Usami, Shujie Xia, Chi-Rei Yang. The 5th Conference on Asian Trends in Prostate Cancer Hormone Therapy.
Asian Pacific journal of cancer prevention : APJCP.
2007 Jan; 8(1):3-12. doi:
NULL. [PMID: 17477764] - Kyogo Itoh, Akira Yamada. Personalized peptide vaccines: a new therapeutic modality for cancer.
Cancer science.
2006 Oct; 97(10):970-6. doi:
10.1111/j.1349-7006.2006.00272.x. [PMID: 16984371] - G Kramer, S Schwarz, M Hägg, A Mandic Havelka, S Linder. Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles.
British journal of cancer.
2006 Jun; 94(11):1592-8. doi:
10.1038/sj.bjc.6603129. [PMID: 16685278] - John D Hainsworth, Anthony A Meluch, David R Spigel, Kathleen Yost, Christina Meng, F Anthony Greco. Weekly docetaxel/estramustine phosphate in patients with increasing serum prostate- specific antigen levels after primary treatment for prostate cancer: a phase II trial of the Minnie Pearl Cancer Research Network.
Clinical genitourinary cancer.
2006 Mar; 4(4):287-92. doi:
10.3816/cgc.2006.n.009. [PMID: 16729913] - Angela Boehmer, Aristotelis G Anastasiadis, Susan Feyerabend, Udo Nagele, Markus Kuczyk, David Schilling, Stefan Corvin, Axel S Merseburger, Arnulf Stenzl. Docetaxel, estramustine and prednisone for hormone-refractory prostate cancer: a single-center experience.
Anticancer research.
2005 Nov; 25(6C):4481-6. doi:
NULL. [PMID: 16334130] - Atsuro Sawada, Takehiko Segawa, Shinichi Nakanishi, Hidefumi Kinoshita, Shingo Yamamoto, Toshiyuki Kamoto, Osamu Ogawa. [Prostate cancer with penile metastasis: a case report].
Hinyokika kiyo. Acta urologica Japonica.
2005 Nov; 51(11):771-3. doi:
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International journal of clinical oncology.
2005 Oct; 10(5):333-7. doi:
10.1007/s10147-005-0513-x. [PMID: 16247660] - A Berruti, M Tucci, A Mosca, R Tarabuzzi, G Gorzegno, C Terrone, F Vana, G Lamanna, M Tampellini, F Porpiglia, A Angeli, R M Scarpa, L Dogliotti. Predictive factors for skeletal complications in hormone-refractory prostate cancer patients with metastatic bone disease.
British journal of cancer.
2005 Sep; 93(6):633-8. doi:
10.1038/sj.bjc.6602767. [PMID: 16222309] - Georgios Fotios Samelis, Haralambos Kalofonos, Adamos Adamou, Paris Kosmides, Dimosthenis Skarlos, Gerasimos Aravantinos, Christos Kiamouris, Oneynadum Adimchi, Georgios Fountzilas, Athanasios Meletios Dimopoulos. The combination of estramustine, vinorelbine, and mitoxantrone in hormone-refractory prostate cancer: a Phase II feasibility study conducted by the Hellenic Cooperative Oncology Group.
Urology.
2005 Aug; 66(2):382-5. doi:
10.1016/j.urology.2005.02.023. [PMID: 16098366] - Masanori Noguchi, Kyogo Itoh, Akihisa Yao, Takashi Mine, Akira Yamada, Yayoi Obata, Masatoshi Furuta, Mamoru Harada, Shigetaka Suekane, Kei Matsuoka. Immunological evaluation of individualized peptide vaccination with a low dose of estramustine for HLA-A24+ HRPC patients.
The Prostate.
2005 Apr; 63(1):1-12. doi:
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Expert opinion on pharmacotherapy.
2005 Apr; 6(4):667-70. doi:
10.1517/14656566.6.4.667. [PMID: 15934892] - Teodoro Sava, Umberto Basso, Antonio Porcaro, Gian Luigi Cetto. New standards in the chemotherapy of metastatic hormone-refractory prostate cancer.
Expert review of anticancer therapy.
2005 Feb; 5(1):53-62. doi:
10.1586/14737140.5.1.53. [PMID: 15757438] - Daisaku Hirano, Sadatsugu Minei, Yuichi Kishimoto, Kenya Yamaguchi, Takahiko Hachiya, Toshio Yoshida, Tetsuo Yoshikawa, Makoto Endoh, Yataroh Yamanaka, Tadao Yamamoto, Yasuo Satoh, Hajime Ishida, Kiyoki Okada, Yukie Takimoto. Prospective study of estramustine phosphate for hormone refractory prostate cancer patients following androgen deprivation therapy.
Urologia internationalis.
2005; 75(1):43-9. doi:
10.1159/000085926. [PMID: 16037707] - Costantino Cerulli, Alessandro Sciarra, Gianfilippo Salvatori, Franco Di Silverio. Long-term response to combination therapy with estramustine and somatostatin analogue in a patient with androgen ablation-refractory prostate cancer.
Urology.
2004 Dec; 64(6):1231.e1-3. doi:
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The New England journal of medicine.
2004 Oct; 351(15):1513-20. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2004 Oct; 58(8):447-50. doi:
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Hinyokika kiyo. Acta urologica Japonica.
2004 Aug; 50(8):521-4. doi:
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The Prostate.
2004 Jun; 60(1):32-45. doi:
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Biomedical chromatography : BMC.
2004 Jun; 18(5):293-301. doi:
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International journal of oncology.
2004 Jun; 24(6):1393-9. doi:
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British journal of cancer.
2004 Apr; 90(7):1312-7. doi:
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Japanese journal of clinical oncology.
2004 Mar; 34(3):137-41. doi:
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Journal of cellular biochemistry.
2004 Feb; 91(3):491-503. doi:
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The Journal of urology.
2004 Feb; 171(2 Pt 1):709-13. doi:
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International journal of urology : official journal of the Japanese Urological Association.
2004 Feb; 11(2):103-9. doi:
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Urology.
2003 Dec; 62 Suppl 1(?):55-62. doi:
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The Journal of urology.
2003 Dec; 170(6 Pt 2):S28-32; discussion S33. doi:
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Cancer.
2003 Nov; 98(9):1837-41. doi:
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