Nimorazole (BioDeep_00000858515)
代谢物信息卡片
Nimorazole
化学式: C9H14N4O3 (226.1065854)
中文名称: 尼莫唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1COCCN1CCN2C=NC=C2[N+](=O)[O-]
InChI: InChI=1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,1-6H2
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases > P01AB - Nitroimidazole derivatives
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:134929
- KEGGdrug: D07352
- PubChem: 23009
- DrugBank: DB12172
- ChEMBL: CHEMBL435966
- MeSH: Nimorazole
- CAS: 6506-37-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Rajaji Umamaheswari, Muthumariappan Akilarasan, Shen-Ming Chen, Yi-Hui Cheng, Veerappan Mani, Sakthivel Kogularasu, Fahad M A Al-Hemaid, M Ajmal Ali, Xiaoheng Liu. One-pot synthesis of three-dimensional Mn3O4 microcubes for high-level sensitive detection of head and neck cancer drug nimorazole.
Journal of colloid and interface science.
2017 Nov; 505(?):1193-1201. doi:
10.1016/j.jcis.2017.07.006. [PMID: 28738516] - Soumyajit Das, Ramkumar Dubey, Subhradip Roychowdhury, Manik Ghosh, Barij Nayan Sinha, Kishanta Kumar Pradhan, Trishna Bal, Venkateswari Muthukrishnan, Julio A Seijas, Abhijit Pujarid. A rapid and sensitive determination of hypoxic radiosensitizer agent nimorazole in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2015 Oct; 29(10):1575-80. doi:
10.1002/bmc.3461. [PMID: 25845449] - M A Hassan Metwally, J A Jansen, J Overgaard. Study of the population pharmacokinetic characteristics of nimorazole in head and neck cancer patients treated in the DAHANCA-5 trial.
Clinical oncology (Royal College of Radiologists (Great Britain)).
2015 Mar; 27(3):168-75. doi:
10.1016/j.clon.2014.11.024. [PMID: 25530485] - Marianne Nordsmark, Jesper Grau Eriksen, Val Gebski, Jan Alsner, Michael R Horsman, Jens Overgaard. Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2007 Jun; 83(3):389-97. doi:
10.1016/j.radonc.2007.04.021. [PMID: 17499868] - Dirk Vordermark, Harun M Said, Astrid Katzer, Thomas Kuhnt, Gabriele Hänsgen, Jürgen Dunst, Michael Flentje, Matthias Bache. Plasma osteopontin levels in patients with head and neck cancer and cervix cancer are critically dependent on the choice of ELISA system.
BMC cancer.
2006 Aug; 6(?):207. doi:
10.1186/1471-2407-6-207. [PMID: 16911785] - Jens Overgaard, Jesper Grau Eriksen, Marianne Nordsmark, Jan Alsner, Michael R Horsman. Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial.
The Lancet. Oncology.
2005 Oct; 6(10):757-64. doi:
10.1016/s1470-2045(05)70292-8. [PMID: 16198981] - J Michael Henk, Kate Bishop, Stephen F Shepherd. Treatment of head and neck cancer with CHART and nimorazole: phase II study.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
2003 Jan; 66(1):65-70. doi:
10.1016/s0167-8140(02)00284-0. [PMID: 12559522] - C P Cottrill, K Bishop, M I Walton, J M Henk. Pilot study of nimorazole as a hypoxic-cell sensitizer with the 'chart' regimen in head and neck cancer.
International journal of radiation oncology, biology, physics.
1998 Nov; 42(4):807-10. doi:
10.1016/s0360-3016(98)00309-5. [PMID: 9845101] - H O Pamba, B B Estambale, C N Chunge, L Donno. Comparative study of aminosidine, etophamide and nimorazole, alone or in combination, in the treatment of intestinal amoebiasis in Kenya.
European journal of clinical pharmacology.
1990; 39(4):353-7. doi:
10.1007/bf00315409. [PMID: 2076717] - G L Biagi, G Cantelli-Forti, A M Barbaro, M C Guerra, P Hrelia, P A Borea. The influence of physicochemical parameters on the biliary excretion of a series of nitroimidazoles.
Journal of medicinal chemistry.
1987 Feb; 30(2):420-3. doi:
10.1021/jm00385a027. [PMID: 3806622] - G Cantelli-Forti, M C Guerra, A M Barbaro, P Hrelia, G L Biagi, P A Borea. Relationship between lipophilic character and urinary excretion of nitroimidazoles and nitrothiazoles in rats.
Journal of medicinal chemistry.
1986 Apr; 29(4):555-61. doi:
10.1021/jm00154a021. [PMID: 3959031] - A R Timothy, J Overgaard, M Overgaard. A phase I clinical study of Nimorazole as a hypoxic radiosensitizer.
International journal of radiation oncology, biology, physics.
1984 Sep; 10(9):1765-8. doi:
10.1016/0360-3016(84)90545-5. [PMID: 6480460] - J Overgaard, M Overgaard, A R Timothy. Studies of the pharmacokinetic properties of nimorazole.
British journal of cancer.
1983 Jul; 48(1):27-34. doi:
10.1038/bjc.1983.153. [PMID: 6871077] - J Overgaard, M Overgaard, O S Nielsen, A K Pedersen, A R Timothy. A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo.
British journal of cancer.
1982 Dec; 46(6):904-11. doi:
10.1038/bjc.1982.300. [PMID: 7150484] - C Pérez, M Vallejos, W Apt, M Gabor, G Doren. [Treatment of intestinal giardiasis with nimorazole].
Revista chilena de pediatria.
1978 Jan; 49(1-6):80-2. doi:
NULL. [PMID: 757008] - R Wise, J M Andrews, K A Bedford. The activity of four antimicrobial agents. Including three nitroimidazole compounds, against Bacteroides sp.
Chemotherapy.
1977; 23(1):19-24. doi:
10.1159/000221966. [PMID: 137803]