Calcium Pantothenate (BioDeep_00000858499)
代谢物信息卡片
Calcium Pantothenate
化学式: C18H32CaN2O10 (476.16827620000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.CC(C)(CO)C(C(=O)NCCC(=O)[O-])O.[Ca+2]
InChI: /q
描述信息
D - Dermatologicals > D03 - Preparations for treatment of wounds and ulcers > D03A - Cicatrizants
A - Alimentary tract and metabolism > A11 - Vitamins
D018977 - Micronutrients > D014815 - Vitamins
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31345
- KEGGdrug: D70806
- KEGGdrug: D01082
- PubChem: 443753
- ChEMBL: CHEMBL1901349
- MeSH: Pantothenic Acid
- PubChem: 14420
- CAS: 137-08-6
- KEGG: C12276
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yangyang Sun, Yutong Zhou, Qiyuan Long, Junwei Xing, Peizhen Guo, Yanchen Liu, Changjian Zhang, Yuanyuan Zhang, Alisdair R Fernie, Yuheng Shi, Yuehua Luo, Jie Luo, Cheng Jin. OsBCAT2, a gene responsible for the degradation of branched-chain amino acids, positively regulates salt tolerance by promoting the synthesis of vitamin B5.
The New phytologist.
2024 Mar; 241(6):2558-2574. doi:
10.1111/nph.19551. [PMID: 38258425] - Richard Miallot, Virginie Millet, Franck Galland, Philippe Naquet. The vitamin B5/coenzyme A axis: A target for immunomodulation?.
European journal of immunology.
2023 Jul; ?(?):e2350435. doi:
10.1002/eji.202350435. [PMID: 37482959] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - H U Xingyao, Liu Hongning, Yan Xiaojun, Chen Zhong, F U Liu, Liu Ge, Chen Xuan, Shang Guangbin. Liver metabolomic characteristics in three different rat models of deficiency based on ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Apr; 43(2):274-285. doi:
10.19852/j.cnki.jtcm.20230201.001. [PMID: 36994515] - Paria Asadi, Miroslav P Milev, Djenann Saint-Dic, Chiara Gamberi, Michael Sacher. Vitamin B5, a coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells.
Journal of inherited metabolic disease.
2023 03; 46(2):358-368. doi:
10.1002/jimd.12579. [PMID: 36502486] - Min Li, Baodian Guo, Fengquan Liu, Zheng Qing Fu. Cross-kingdom vitamin B5 biosynthesis and cyst nematode susceptibility.
Trends in parasitology.
2023 Jan; 39(1):7-9. doi:
10.1016/j.pt.2022.11.004. [PMID: 36443162] - Shahid Siddique, Zoran S Radakovic, Clarissa Hiltl, Clement Pellegrin, Thomas J Baum, Helen Beasley, Andrew F Bent, Oliver Chitambo, Divykriti Chopra, Etienne G J Danchin, Eric Grenier, Samer S Habash, M Shamim Hasan, Johannes Helder, Tarek Hewezi, Julia Holbein, Martijn Holterman, Sławomir Janakowski, Georgios D Koutsovoulos, Olaf P Kranse, Jose L Lozano-Torres, Tom R Maier, Rick E Masonbrink, Badou Mendy, Esther Riemer, Mirosław Sobczak, Unnati Sonawala, Mark G Sterken, Peter Thorpe, Joris J M van Steenbrugge, Nageena Zahid, Florian Grundler, Sebastian Eves-van den Akker. The genome and lifestage-specific transcriptomes of a plant-parasitic nematode and its host reveal susceptibility genes involved in trans-kingdom synthesis of vitamin B5.
Nature communications.
2022 10; 13(1):6190. doi:
10.1038/s41467-022-33769-w. [PMID: 36261416] - Christian C Dibble, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Sarah E DuBois-Coyne, David Bartee, Thomas T Zengeya, Emily B Cohen, Min Yuan, Benjamin D Hopkins, Jordan L Meier, John G Clohessy, John M Asara, Lewis C Cantley, Alex Toker. PI3K drives the de novo synthesis of coenzyme A from vitamin B5.
Nature.
2022 08; 608(7921):192-198. doi:
10.1038/s41586-022-04984-8. [PMID: 35896750] - Azibe Yildiz, Tugba Demiralp, Nigar Vardi, Gul Otlu, Elif Taslidere, Hilal Cirik, Elif Gurel. Protective effects of dexpanthenol in carbon tetrachloride-induced myocardial toxicity in rats.
Tissue & cell.
2022 Aug; 77(?):101824. doi:
10.1016/j.tice.2022.101824. [PMID: 35653907] - Yuan Hong, Ziyi Zhou, Nan Zhang, Qiangqiang He, Zhangyou Guo, Lishun Liu, Yun Song, Ping Chen, Yaping Wei, Qiuyue Xu, Ya Li, Binyan Wang, Xianhui Qin, Xiping Xu, Yong Duan. Association between plasma Vitamin B5 levels and all-cause mortality: A nested case-control study.
Journal of clinical hypertension (Greenwich, Conn.).
2022 07; 24(7):945-954. doi:
10.1111/jch.14516. [PMID: 35699663] - Xi Zhao, Siquan Zhang, Hongyi Shao. Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice.
Bioengineered.
2022 05; 13(5):11625-11635. doi:
10.1080/21655979.2022.2070585. [PMID: 35510377] - Tess Holling, Sheela Nampoothiri, Bedirhan Tarhan, Pauline E Schneeberger, Kollencheri Puthenveettil Vinayan, Dhanya Yesodharan, Arun Grace Roy, Periyasamy Radhakrishnan, Malik Alawi, Lindsay Rhodes, Katta Mohan Girisha, Peter B Kang, Kerstin Kutsche. Novel biallelic variants expand the SLC5A6-related phenotypic spectrum.
European journal of human genetics : EJHG.
2022 04; 30(4):439-449. doi:
10.1038/s41431-021-01033-2. [PMID: 35013551] - Neslihan Pınar, Meyli Topaloğlu, İlke Evrim Seçinti, Esra Büyük, Mahir Kaplan. Protective effect of dexpanthenol on cisplatin induced nephrotoxicity in rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2022 Jan; 97(1):39-43. doi:
10.1080/10520295.2021.1890215. [PMID: 33632031] - Melanie Bourgin, Oliver Kepp, Guido Kroemer. Immunostimulatory effects of vitamin B5 improve anticancer immunotherapy.
Oncoimmunology.
2022; 11(1):2031500. doi:
10.1080/2162402x.2022.2031500. [PMID: 35096488] - Shanping Wang, Keai Sinn Tan, Huimin Beng, Fei Liu, Jiandong Huang, Yihe Kuai, Rui Zhang, Wen Tan. Protective effect of isosteviol sodium against LPS-induced multiple organ injury by regulating of glycerophospholipid metabolism and reducing macrophage-driven inflammation.
Pharmacological research.
2021 10; 172(?):105781. doi:
10.1016/j.phrs.2021.105781. [PMID: 34302975] - Yuping Liu, Siting Pan, Xinshuai Zhang, Hua Huang. In Vitro Reconstitution of the Pantothenic Acid Degradation Pathway in Ochrobactrum anthropi.
ACS chemical biology.
2021 08; 16(8):1350-1353. doi:
10.1021/acschembio.1c00492. [PMID: 34313416] - Arif Aydın, Mehmet Giray Sönmez, Gökhan Ecer, Fahriye Kılınç, Rahim Kocabaş, Adeviye Elçi Atılgan, Pembe Oltulu, Mehmet Balasar. The effect of intratesticular dexpanthenol on experimentally-induced testicular ischaemia/reperfusion injury.
Journal of pediatric urology.
2021 08; 17(4):440.e1-440.e7. doi:
10.1016/j.jpurol.2021.03.031. [PMID: 33883095] - Jing Tang, Yulong Feng, Bo Zhang, Yongbao Wu, Zhanbao Guo, Suyun Liang, Zhengkui Zhou, Ming Xie, Shuisheng Hou. Severe pantothenic acid deficiency induces alterations in the intestinal mucosal proteome of starter Pekin ducks.
BMC genomics.
2021 Jun; 22(1):491. doi:
10.1186/s12864-021-07820-x. [PMID: 34193047] - Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García, María Luisa Marina. Enantiomeric separation of panthenol by Capillary Electrophoresis. Analysis of commercial formulations and toxicity evaluation on non-target organisms.
Journal of chromatography. A.
2021 Feb; 1639(?):461919. doi:
10.1016/j.chroma.2021.461919. [PMID: 33535114] - Aitor Benedicto, Iera Hernandez-Unzueta, Eduardo Sanz, Joana Márquez. Ocoxin Increases the Antitumor Effect of BRAF Inhibition and Reduces Cancer Associated Fibroblast-Mediated Chemoresistance and Protumoral Activity in Metastatic Melanoma.
Nutrients.
2021 Feb; 13(2):. doi:
10.3390/nu13020686. [PMID: 33669949] - Anis Irawan Anwar, Anni Adriani, Sri Rimayani, Asvira Anis Anwar, Arifin Seweng, Rina Munirah, We Sagara Dewi, Ivan Kurniadi. The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color.
Skinmed.
2021; 19(2):110-115. doi:
NULL. [PMID: 33938432] - T Aslan, E M Guler, A Cakir, T Dundar, A S Gulgec, O Huseyinbas, M Celikten, G Coban, I N Hakyemez, A Kocyigit, B Durdu. Dexpanthenol and ascorbic acid ameliorate colistin-induced nephrotoxicity in rats.
European review for medical and pharmacological sciences.
2021 01; 25(2):1016-1023. doi:
10.26355/eurrev_202101_24671. [PMID: 33577057] - Aitor Benedicto, Eduardo Sanz, Joana Márquez. Ocoxin as a complement to first line treatments in cancer.
International journal of medical sciences.
2021; 18(3):835-845. doi:
10.7150/ijms.50122. [PMID: 33437220] - Giulio Auciello, Annalise Di Marco, Odalys Gonzalez Paz, Savina Malancona, Steven Harper, Maria Beconi, Ilaria Rossetti, Alina Ciammaichella, Paola Fezzardi, Andrea Vecchi, Elena Bracacel, Daniel Cicero, Edith Monteagudo, Daniel Elbaum. Cyclic Phosphopantothenic Acid Prodrugs for Treatment of Pantothenate Kinase-Associated Neurodegeneration.
Journal of medicinal chemistry.
2020 12; 63(24):15785-15801. doi:
10.1021/acs.jmedchem.0c01531. [PMID: 33320012] - Tao Ma, Tonghua Liu, Peifeng Xie, Sheng Jiang, Wenming Yi, Pei Dai, Xiangyu Guo. UPLC-MS-based urine nontargeted metabolic profiling identifies dysregulation of pantothenate and CoA biosynthesis pathway in diabetic kidney disease.
Life sciences.
2020 Oct; 258(?):118160. doi:
10.1016/j.lfs.2020.118160. [PMID: 32730837] - Jing Tang, Bo Zhang, Suyun Liang, Yongbao Wu, Yulong Feng, Zhanbao Guo, Guangnan Xing, Jinglin Jiao, Zhengkui Zhou, Ming Xie, Shuisheng Hou. Effects of pantothenic acid on growth performance and antioxidant status of growing male white Pekin ducks.
Poultry science.
2020 Sep; 99(9):4436-4441. doi:
10.1016/j.psj.2020.05.021. [PMID: 32867987] - Atanasio Pandiella-Alonso, Elena Díaz-Rodríguez, Eduardo Sanz. Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review.
Nutrients.
2020 Aug; 12(9):. doi:
10.3390/nu12092661. [PMID: 32878230] - Christina Spry, Leanne Barnard, Michélle Kok, Andrew K Powell, Darvina Mahesh, Erick T Tjhin, Kevin J Saliba, Erick Strauss, Marianne de Villiers. Toward a Stable and Potent Coenzyme A-Targeting Antiplasmodial Agent: Structure-Activity Relationship Studies of N-Phenethyl-α-methyl-pantothenamide.
ACS infectious diseases.
2020 07; 6(7):1844-1854. doi:
10.1021/acsinfecdis.0c00075. [PMID: 32375471] - Zhuo Wang, Weixiao Nan, Huazhe Si, Shiyong Wang, Haihua Zhang, Guangyu Li. Pantothenic acid promotes dermal papilla cell proliferation in hair follicles of American minks via inhibitor of DNA Binding 3/Notch signaling pathway.
Life sciences.
2020 Jul; 252(?):117667. doi:
10.1016/j.lfs.2020.117667. [PMID: 32304761] - Lucille Pourcel, Flavien Buron, Fanny Garcia, Margaux-Sarah Delaloix, Valérie Le Fourn, Pierre-Alain Girod, Nicolas Mermod. Transient vitamin B5 starving improves mammalian cell homeostasis and protein production.
Metabolic engineering.
2020 07; 60(?):77-86. doi:
10.1016/j.ymben.2020.03.008. [PMID: 32247827] - Nashwah Ismail, Nina Kureishy, Stephanie J Church, Melissa Scholefield, Richard D Unwin, Jingshu Xu, Stefano Patassini, Garth J S Cooper. Vitamin B5 (d-pantothenic acid) localizes in myelinated structures of the rat brain: Potential role for cerebral vitamin B5 stores in local myelin homeostasis.
Biochemical and biophysical research communications.
2020 01; 522(1):220-225. doi:
10.1016/j.bbrc.2019.11.052. [PMID: 31759626] - S J Nisbet, D Targett, A V Rawlings, K Qian, X Wang, C B Lin, M A Thompson, P A Bulsara, D J Moore. Clinical and in vitro evaluation of new anti-redness cosmetic products in subjects with winter xerosis and sensitive skin.
International journal of cosmetic science.
2019 Dec; 41(6):534-547. doi:
10.1111/ics.12559. [PMID: 31309600] - Joy E Chiu, Jose Thekkiniath, Sameet Mehta, Christoph Müller, Franz Bracher, Choukri Ben Mamoun. The yeast pantothenate kinase Cab1 is a master regulator of sterol metabolism and of susceptibility to ergosterol biosynthesis inhibitors.
The Journal of biological chemistry.
2019 10; 294(40):14757-14767. doi:
10.1074/jbc.ra119.009791. [PMID: 31409644] - Joost Schalkwijk, Erik L Allman, Patrick A M Jansen, Laura E de Vries, Julie M J Verhoef, Suzanne Jackowski, Peter N M Botman, Christien A Beuckens-Schortinghuis, Karin M J Koolen, Judith M Bolscher, Martijn W Vos, Karen Miller, Stacy A Reeves, Helmi Pett, Graham Trevitt, Sergio Wittlin, Christian Scheurer, Sibylle Sax, Christoph Fischli, Iñigo Angulo-Barturen, Mariá Belén Jiménez-Diaz, Gabrielle Josling, Taco W A Kooij, Roger Bonnert, Brice Campo, Richard H Blaauw, Floris P J T Rutjes, Robert W Sauerwein, Manuel Llinás, Pedro H H Hermkens, Koen J Dechering. Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.
Science translational medicine.
2019 09; 11(510):. doi:
10.1126/scitranslmed.aas9917. [PMID: 31534021] - Okan Aydın, Faruk Pehlivanlı, Gökhan Karaca, Gülçin Aydın, Canan Altunkaya, Huri Bulut. May dexpanthenol, platelet-rich plasma, and thymoquinone provide new hope to maintain liver regeneration after partial hepatectomy?.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2019 Sep; 30(9):826-834. doi:
10.5152/tjg.2019.18697. [PMID: 31530526] - Gokhan Zengin, Mehmet Yavuz Paksoy, Muhammad Zakariyyah Aumeeruddy, Jasmina Glamocilja, Marina Sokovic, Alina Diuzheva, József Jekő, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Mohamad Fawzi Mahomoodally. New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species.
Food research international (Ottawa, Ont.).
2019 09; 123(?):414-424. doi:
10.1016/j.foodres.2019.05.013. [PMID: 31284993] - Osman Sutcuoglu, Mehmet Kursat Derici, Ozge Tugce Pasaoglu, Burak Dumludag, Ozant Helvacı, Betul Ogut, Ipek Isık Gonul, Ulver Derici. Is it possible to prevent contrast-induced nephropathy with dexpanthenol?.
International urology and nephrology.
2019 Aug; 51(8):1387-1394. doi:
10.1007/s11255-019-02194-2. [PMID: 31190296] - Javier Pérez-Peña, Elena Díaz-Rodríguez, Eduardo Sanz, Atanasio Pandiella. Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin.
Nutrients.
2019 May; 11(5):. doi:
10.3390/nu11051068. [PMID: 31091680] - Mónica Álvarez-Córdoba, Aida Fernández Khoury, Marina Villanueva-Paz, Carmen Gómez-Navarro, Irene Villalón-García, Juan M Suárez-Rivero, Suleva Povea-Cabello, Mario de la Mata, David Cotán, Marta Talaverón-Rey, Antonio J Pérez-Pulido, Joaquín J Salas, Eva Mª Pérez-Villegas, Antonio Díaz-Quintana, José A Armengol, José A Sánchez-Alcázar. Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation.
Molecular neurobiology.
2019 May; 56(5):3638-3656. doi:
10.1007/s12035-018-1333-0. [PMID: 30173408] - Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner, Elimelda Moige Ongeri. Meprin β metalloproteases associated with differential metabolite profiles in the plasma and urine of mice with type 1 diabetes and diabetic nephropathy.
BMC nephrology.
2019 04; 20(1):141. doi:
10.1186/s12882-019-1313-2. [PMID: 31023251] - Iera Hernandez-Unzueta, Aitor Benedicto, Irene Romayor, Alba Herrero, Eduardo Sanz, Beatriz Arteta, Elvira Olaso, Joana Márquez. Ocoxin Oral Solution Exerts an Antitumoral Effect in Pancreatic Cancer and Reduces the Stromal-Mediated Chemoresistance.
Pancreas.
2019 04; 48(4):555-567. doi:
10.1097/mpa.0000000000001277. [PMID: 30946238] - Yusuke Yoshida, Hiroyuki Iguchi, Yasuyoshi Sakai, Hiroya Yurimoto. Pantothenate auxotrophy of Methylobacterium spp. isolated from living plants.
Bioscience, biotechnology, and biochemistry.
2019 Mar; 83(3):569-577. doi:
10.1080/09168451.2018.1549935. [PMID: 30475153] - Yasemin Sezgin, Mehtap Bilgin Çetin, Şule Bulut, Nilgün Özlem Alptekin, Pelin Börçek. Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model.
Balkan medical journal.
2019 02; 36(2):88-95. doi:
10.4274/balkanmedj.galenos.2018.2018.0167. [PMID: 30322831] - B Tutun, H Elbe, N Vardi, H Parlakpinar, A Polat, M Gunaltili, M M Guclu, E N Yasar. Dexpanthenol reduces diabetic nephropathy and renal oxidative stress in rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2019 Feb; 94(2):84-91. doi:
10.1080/10520295.2018.1508746. [PMID: 30317873] - Esther Hernández-SanMiguel, Ricardo Gargini, Teresa Cejalvo, Berta Segura-Collar, Paula Núñez-Hervada, Rafael Hortigüela, Juan M Sepúlveda-Sánchez, Aurelio Hernández-Laín, Angel Pérez-Núñez, Eduardo Sanz, Pilar Sánchez-Gómez. Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma.
Oxidative medicine and cellular longevity.
2019; 2019(?):9719730. doi:
10.1155/2019/9719730. [PMID: 31467641] - Caroline M I Lopes, Liriane Baratella-Evêncio, Ivone A DE Souza, Erwelly B DE Oliveira, Jéssica G A Sá, Marllon A N Santana, Pedro P Marcelino Neto, Eduarda S DE Santana, Luzia A DA Silva, Jeymesson R C Vieira. Evaluation of cytotoxicity and wound healing activity of Avicennia schaueriana in cream.
Anais da Academia Brasileira de Ciencias.
2019; 91(1):e20180171. doi:
10.1590/0001-3765201920180171. [PMID: 30994761] - Birgitta E Ebert, Eik Czarnotta, Lars M Blank. Physiologic and metabolic characterization of Saccharomyces cerevisiae reveals limitations in the synthesis of the triterpene squalene.
FEMS yeast research.
2018 12; 18(8):. doi:
10.1093/femsyr/foy077. [PMID: 30053028] - M Ucar, M S Aydogan, N Vardı, H Parlakpınar. Protective Effect of Dexpanthenol on Ischemia-Reperfusion-Induced Liver Injury.
Transplantation proceedings.
2018 Dec; 50(10):3135-3143. doi:
10.1016/j.transproceed.2018.07.012. [PMID: 30577179] - Yuxing Lin, Yuqi Gao, Zhao Ma, Zhenzhen Li, Chunchao Tang, Xiaojun Qin, Zheng Zhang, Guankai Wang, Lupei Du, Minyong Li. Bioluminescent Probe for Detection of Starvation-Induced Pantetheinase Upregulation.
Analytical chemistry.
2018 08; 90(15):9545-9550. doi:
10.1021/acs.analchem.8b02266. [PMID: 29976064] - Emily Evans, Laura Piccio, Anne H Cross. Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
JAMA neurology.
2018 08; 75(8):1013-1021. doi:
10.1001/jamaneurol.2018.0611. [PMID: 29710293] - Elena Díaz-Rodríguez, Eduardo Sanz, Atanasio Pandiella. Antitumoral effect of Ocoxin, a natural compound-containing nutritional supplement, in small cell lung cancer.
International journal of oncology.
2018 Jul; 53(1):113-123. doi:
10.3892/ijo.2018.4373. [PMID: 29658597] - Leanne Barnard, Konrad J Mostert, Willem A L van Otterlo, Erick Strauss. Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.
ACS infectious diseases.
2018 05; 4(5):736-743. doi:
10.1021/acsinfecdis.7b00240. [PMID: 29332383] - Alisson Diego Machado, Luz Marina Gómez, Dirce Maria Lobo Marchioni, Fernanda Silva Nogueira Dos Anjos, Maria Del Carmen Bisi Molina, Paulo Andrade Lotufo, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan. Association between Dietary Intake and Coronary Artery Calcification in Non-Dialysis Chronic Kidney Disease: The PROGREDIR Study.
Nutrients.
2018 Mar; 10(3):. doi:
10.3390/nu10030372. [PMID: 29562658] - Lili Huang, Michal Pyc, Saleh Alseekh, Donald R McCarty, Valérie de Crécy-Lagard, Jesse F Gregory, Christopher S Henry, Alisdair R Fernie, Robert T Mullen, Andrew D Hanson. A plastidial pantoate transporter with a potential role in pantothenate synthesis.
The Biochemical journal.
2018 02; 475(4):813-825. doi:
10.1042/bcj20170883. [PMID: 29382740] - Anna-Maria Dietl, Zohar Meir, Yona Shadkchan, Nir Osherov, Hubertus Haas. Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus.
Virulence.
2018; 9(1):1036-1049. doi:
10.1080/21505594.2018.1482181. [PMID: 30052132] - Yiming Hu, Hongyu Li, Wen Shi, Huimin Ma. Ratiometric Fluorescent Probe for Imaging of Pantetheinase in Living Cells.
Analytical chemistry.
2017 10; 89(20):11107-11112. doi:
10.1021/acs.analchem.7b03303. [PMID: 28911222] - Elif Ece Doğan, Reha Erkoç, İskender Ekinci, Jamshid Hamdard, Barış Döner, Mehmet Ali Çıkrıkçıoğlu, Cumali Karatoprak, Ganime Çoban, Ömer Faruk Özer, Rümeyza Kazancıoğlu. Protective effect of dexpanthenol against nephrotoxic effect of amikacin: An experimental study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 May; 89(?):1409-1414. doi:
10.1016/j.biopha.2017.03.019. [PMID: 28320109] - Hans Stettler, Peter Kurka, Nathalie Lunau, Caroline Manger, Arne Böhling, Stephan Bielfeldt, Klaus-Peter Wilhelm, Stephan Dähnhardt-Pfeiffer, Dorothee Dähnhardt, Florian H H Brill, Holger Lenz. A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora.
The Journal of dermatological treatment.
2017 Mar; 28(2):173-180. doi:
10.1080/09546634.2016.1214235. [PMID: 27425824] - Oya Soylu Karapinar, Neslihan Pinar, Tümay Özgür, Oğuzhan Özcan, H Suphi Bayraktar, Raziye Keskin Kurt, Orhan Nural. The Protective Role of Dexpanthenol on the Endometrial Implants in an Experimentally Induced Rat Endometriosis Model.
Reproductive sciences (Thousand Oaks, Calif.).
2017 02; 24(2):285-290. doi:
10.1177/1933719116653682. [PMID: 27313118] - Daxesh P Patel, Kristopher W Krausz, Cen Xie, Diren Beyoğlu, Frank J Gonzalez, Jeffrey R Idle. Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice.
PloS one.
2017; 12(5):e0177953. doi:
10.1371/journal.pone.0177953. [PMID: 28520815] - Charles Arber, Plamena R Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P Bhatia, Kevin Mills, Ivan Gout, Andrey Y Abramov, John Hardy, James A Duce, Henry Houlden, Selina Wray. iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
PloS one.
2017; 12(9):e0184104. doi:
10.1371/journal.pone.0184104. [PMID: 28863176] - Burak Çelik, Ali Asram Sağıroğlu, Samet Özdemir. Design, optimization and characterization of coenzyme Q10- and D-panthenyl triacetate-loaded liposomes.
International journal of nanomedicine.
2017; 12(?):4869-4878. doi:
10.2147/ijn.s140835. [PMID: 28744121] - Vanessa M Howieson, Elisa Tran, Annabelle Hoegl, Han Ling Fam, Jonathan Fu, Kate Sivonen, Xiao Xuan Li, Karine Auclair, Kevin J Saliba. Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.
Antimicrobial agents and chemotherapy.
2016 12; 60(12):7146-7152. doi:
10.1128/aac.01436-16. [PMID: 27645235] - Niloufar Kavian, Souad Mehlal, Wioleta Marut, Amélie Servettaz, Caroline Giessner, Christophe Bourges, Carole Nicco, Christiane Chéreau, Hervé Lemaréchal, Marie-Flore Dutilh, Olivier Cerles, Philippe Guilpain, Vincent Vuiblet, Sandrine Chouzenoux, Franck Galland, Isabelle Quere, Bernard Weill, Philippe Naquet, Frédéric Batteux. Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.
Journal of immunology (Baltimore, Md. : 1950).
2016 10; 197(8):3326-3335. doi:
10.4049/jimmunol.1502511. [PMID: 27647831] - Xiao Wei, Shan Jiang, Yuye Chen, Xiangna Zhao, Huan Li, Weishi Lin, Boxing Li, Xuesong Wang, Jing Yuan, Yansong Sun. Cirrhosis related functionality characteristic of the fecal microbiota as revealed by a metaproteomic approach.
BMC gastroenterology.
2016 Oct; 16(1):121. doi:
10.1186/s12876-016-0534-0. [PMID: 27716148] - José I Serrano-Contreras, Isabel García-Pérez, María E Meléndez-Camargo, L Gerardo Zepeda. NMR-Based Metabonomic Analysis of Physiological Responses to Starvation and Refeeding in the Rat.
Journal of proteome research.
2016 09; 15(9):3241-54. doi:
10.1021/acs.jproteome.6b00433. [PMID: 27518853] - Joana Márquez, Jorge Mena, Iera Hernandez-Unzueta, Aitor Benedicto, Eduardo Sanz, Beatriz Arteta, Elvira Olaso. Ocoxin® oral solution slows down tumor growth in an experimental model of colorectal cancer metastasis to the liver in Balb/c mice.
Oncology reports.
2016 Mar; 35(3):1265-72. doi:
10.3892/or.2015.4486. [PMID: 26676882] - Elena Díaz-Rodríguez, Susana Hernández-García, Eduardo Sanz, Atanasio Pandiella. Antitumoral effect of Ocoxin on acute myeloid leukemia.
Oncotarget.
2016 Feb; 7(5):6231-42. doi:
10.18632/oncotarget.6862. [PMID: 26756220] - Federica Gevi, Lello Zolla, Stefano Gabriele, Antonio M Persico. Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Molecular autism.
2016; 7(?):47. doi:
10.1186/s13229-016-0109-5. [PMID: 27904735] - Katsumi Shibata, Chifumi Nakata, Tsutomu Fukuwatari. High-performance liquid chromatographic method for profiling 2-oxo acids in urine and its application in evaluating vitamin status in rats.
Bioscience, biotechnology, and biochemistry.
2016; 80(2):304-12. doi:
10.1080/09168451.2015.1083395. [PMID: 26745680] - Gonzalo Ferreira, Alston N Brown, Christy L Teets. Effect of biotin and pantothenic acid on performance and concentrations of avidin-binding substances in blood and milk of lactating dairy cows.
Journal of dairy science.
2015 Sep; 98(9):6449-54. doi:
10.3168/jds.2015-9620. [PMID: 26117345] - Britta Zehnpfennig, Pattama Wiriyasermkul, David A Carlson, Matthias Quick. Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT).
The Journal of biological chemistry.
2015 Jun; 290(26):16372-82. doi:
10.1074/jbc.m114.622555. [PMID: 25971966] - Helmi E Pett, Patrick A M Jansen, Pedro H H Hermkens, Peter N M Botman, Christien A Beuckens-Schortinghuis, Richard H Blaauw, Wouter Graumans, Marga van de Vegte-Bolmer, Karin M J Koolen, Floris P J T Rutjes, Koen J Dechering, Robert W Sauerwein, Joost Schalkwijk. Novel pantothenate derivatives for anti-malarial chemotherapy.
Malaria journal.
2015 Apr; 14(?):169. doi:
10.1186/s12936-015-0673-8. [PMID: 25927675] - Claudia Stäubert, Hasanuzzaman Bhuiyan, Anna Lindahl, Oliver Jay Broom, Yafeng Zhu, Saiful Islam, Sten Linnarsson, Janne Lehtiö, Anders Nordström. Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine.
The Journal of biological chemistry.
2015 Mar; 290(13):8348-59. doi:
10.1074/jbc.m114.618769. [PMID: 25697355] - Yu Qian, Xiang-Fei Li, Ding-Dong Zhang, Dong-Sen Cai, Hong-Yan Tian, Wen-Bin Liu. Effects of dietary pantothenic acid on growth, intestinal function, anti-oxidative status and fatty acids synthesis of juvenile blunt snout bream Megalobrama amblycephala.
PloS one.
2015; 10(3):e0119518. doi:
10.1371/journal.pone.0119518. [PMID: 25781913] - Kei Takahashi, Tsutomu Fukuwatari, Katsumi Shibata. Exercise and a High Fat Diet Synergistically Increase the Pantothenic Acid Requirement in Rats.
Journal of nutritional science and vitaminology.
2015; 61(3):215-21. doi:
10.3177/jnsv.61.215. [PMID: 26226957] - Katsumi Shibata, Nobuya Morita, Tomoyo Kawamura, Ai Tsuji, Tsutomu Fukuwatari. Effects of Fatty Liver Induced by Excess Orotic Acid on B-Group Vitamin Concentrations of Liver, Blood, and Urine in Rats.
Journal of nutritional science and vitaminology.
2015; 61(5):355-61. doi:
10.3177/jnsv.61.355. [PMID: 26639842] - Huseyin Sen, Suleyman Deniz, A Erturk Yedekci, Gokhan Inangil, Tuba Muftuoglu, Aptullah Haholu, Sezai Ozkan. Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury.
Renal failure.
2014 Nov; 36(10):1570-4. doi:
10.3109/0886022x.2014.949768. [PMID: 25156619] - S A Petrov, A O Danilova, L M Karpov. [The effect of a water-soluble vitamins on the activity of some enzymes in diabetes].
Biomeditsinskaia khimiia.
2014 Nov; 60(6):623-30. doi:
10.18097/pbmc20146006623. [PMID: 25552500] - Ahmet Pişkin, Berrin Zuhal Altunkaynak, Gamze Tümentemur, Süleyman Kaplan, Ozgür Bülent Yazıcı, Murat Hökelek. The beneficial effects of Momordica charantia (bitter gourd) on wound healing of rabbit skin.
The Journal of dermatological treatment.
2014 Aug; 25(4):350-7. doi:
10.3109/09546634.2012.713459. [PMID: 22812507] - Kevin J Saliba, Christina Spry. Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.
Biochemical Society transactions.
2014 Aug; 42(4):1087-93. doi:
10.1042/bst20140158. [PMID: 25110007] - Joost Schalkwijk, Patrick Jansen. Chemical biology tools to study pantetheinases of the vanin family.
Biochemical Society transactions.
2014 Aug; 42(4):1052-5. doi:
10.1042/bst20140074. [PMID: 25110001] - Robert J Hart, Lauren Lawres, Emma Fritzen, Choukri Ben Mamoun, Ahmed S I Aly. Plasmodium yoelii vitamin B5 pantothenate transporter candidate is essential for parasite transmission to the mosquito.
Scientific reports.
2014 Jul; 4(?):5665. doi:
10.1038/srep05665. [PMID: 25012929] - G B Egorova, T S Mitichkina, A R Shamsudinova. [Corneal protection in contact lens users].
Vestnik oftalmologii.
2014 Mar; 130(2):59-64, 66. doi:
". [PMID: 24864502] - B Demirci, O Demir, T Dost, M Birincioglu. Protective effect of vitamin B5 (dexpanthenol) on cardiovascular damage induced by streptozocin in rats.
Bratislavske lekarske listy.
2014; 115(4):190-6. doi:
10.4149/bll_2014_040. [PMID: 24797592] - Zhi-Hao Zhang, Ying-Yong Zhao, Xian-Long Cheng, Rui-Chao Lin, Zhong Dai, Chao Zhou. Metabonomic study of biochemical changes in the rat urine induced by Pinellia ternata (Thunb.) Berit.
Journal of pharmaceutical and biomedical analysis.
2013 Nov; 85(?):186-93. doi:
10.1016/j.jpba.2013.07.026. [PMID: 23948763] - Patrick A M Jansen, Pedro H H Hermkens, Patrick L J M Zeeuwen, Peter N M Botman, Richard H Blaauw, Peter Burghout, Peter M van Galen, Johan W Mouton, Floris P J T Rutjes, Joost Schalkwijk. Combination of pantothenamides with vanin inhibitors as a novel antibiotic strategy against gram-positive bacteria.
Antimicrobial agents and chemotherapy.
2013 Oct; 57(10):4794-800. doi:
10.1128/aac.00603-13. [PMID: 23877685] - Konstanze Scheller, Thomas Röckl, Christian Scheller, Johannes Schubert. Lower concentrations of B-vitamin subgroups in the serum and amniotic fluid correlate to cleft lip and palate appearance in the offspring of A/WySn mice.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2013 Sep; 71(9):1601.e1-7. doi:
10.1016/j.joms.2013.02.020. [PMID: 23642547] - Pei Wang, Yun Zhao, Hua-bing Qi, Dong Yi, Feng-jun Wang, Shi-liang Wang, Xi Peng. [Effects of panthenol-glutamine on intestine of rats with burn injury and its dose-effect relationship].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2013 Aug; 29(4):338-43. doi:
. [PMID: 24351532] - Yoann Augagneur, Lise Jaubert, Matthieu Schiavoni, Niseema Pachikara, Aprajita Garg, Sahar Usmani-Brown, Donna Wesolowski, Skye Zeller, Abhisek Ghosal, Emmanuel Cornillot, Hamid M Said, Priti Kumar, Sidney Altman, Choukri Ben Mamoun. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum.
The Journal of biological chemistry.
2013 Jul; 288(28):20558-67. doi:
10.1074/jbc.m113.482992. [PMID: 23729665] - Andy Sun, Hung-Pin Lin, Yi-Ping Wang, Hsin-Ming Chen, Shih-Jung Cheng, Chun-Pin Chiang. Significant reduction of serum homocysteine level and oral symptoms after different vitamin-supplement treatments in patients with burning mouth syndrome.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2013 Jul; 42(6):474-9. doi:
10.1111/jop.12043. [PMID: 23297780] - Katsumi Shibata, Tsutomu Fukuwatari, Saori Higashiyama, Chisa Sugita, Isao Azumano, Masaaki Onda. Pantothenic acid refeeding diminishes the liver, perinephrical fats, and plasma fats accumulated by pantothenic acid deficiency and/or ethanol consumption.
Nutrition (Burbank, Los Angeles County, Calif.).
2013 May; 29(5):796-801. doi:
10.1016/j.nut.2013.01.002. [PMID: 23510569] - Katsumi Shibata, Kasumi Inomoto, Chifumi Nakata, Tsutomu Fukuwatari. Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats.
Journal of nutritional science and vitaminology.
2013; 59(6):509-15. doi:
10.3177/jnsv.59.509. [PMID: 24477247] - Marlene Thielecke, Vaomalala Raharimanga, Christophe Rogier, Manuela Stauss-Grabo, Vincent Richard, Hermann Feldmeier. Prevention of tungiasis and tungiasis-associated morbidity using the plant-based repellent Zanzarin: a randomized, controlled field study in rural Madagascar.
PLoS neglected tropical diseases.
2013; 7(9):e2426. doi:
10.1371/journal.pntd.0002426. [PMID: 24069481] - Abhisek Ghosal, Nils Lambrecht, Sandeep B Subramanya, Rubina Kapadia, Hamid M Said. Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.
American journal of physiology. Gastrointestinal and liver physiology.
2013 Jan; 304(1):G64-71. doi:
10.1152/ajpgi.00379.2012. [PMID: 23104561] - Christina Spry, Cristiano Macuamule, Zhiyang Lin, Kristopher G Virga, Richard E Lee, Erick Strauss, Kevin J Saliba. Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.
PloS one.
2013; 8(2):e54974. doi:
10.1371/journal.pone.0054974. [PMID: 23405100] - Katsumi Shibata, Takumi Nakai, Tsutomu Fukuwatari. Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats.
Analytical biochemistry.
2012 Nov; 430(2):151-5. doi:
10.1016/j.ab.2012.08.010. [PMID: 22922385] - Dong Won Lee, Sae Kwang Ku, Hyuk Jun Cho, Jeong Hwan Kim, Tran Tuan Hiep, Sang Duk Han, Bo Gyun Kim, Min Kyung Kang, Eui Seon Do, Joon Ho Jun, Sun Woo Jang, Mi-Won Son, Young Taek Sohn, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim. Effects of Noscarna™ on hypertrophic scarring in the rabbit ear model: histopathological aspects.
Archives of pharmacal research.
2012 Nov; 35(11):1999-2006. doi:
10.1007/s12272-012-1117-4. [PMID: 23212642] - Omer Bayrak, Ilker Seckiner, Mehmet Solakhan, Metin Karakok, Sakip M Erturhan, Faruk Yagci. Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model.
Urology.
2012 May; 79(5):1023-6. doi:
10.1016/j.urology.2012.01.025. [PMID: 22546378]