ADAPALENE (BioDeep_00000858442)
代谢物信息卡片
ADAPALENE
化学式: C28H28O3 (412.2038338)
中文名称: 阿达帕林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5
InChI: InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30)
描述信息
D - Dermatologicals > D10 - Anti-acne preparations > D10A - Anti-acne preparations for topical use > D10AD - Retinoids for topical use in acne
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent
C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D003879 - Dermatologic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31174
- KEGGdrug: D01112
- PubChem: 60164
- DrugBank: DB00210
- ChEMBL: CHEMBL4303650
- ChEMBL: CHEMBL1265
- MeSH: Adapalene
- CAS: 106685-40-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chunmei Li, Tong Wang, Suiyu Luo, You Wu, Yan Song, Ying Su, Yuihui Zhang, Yuanyuan Zhang, Guangzhi Liu, Lu Wang. Expression profiles of human somatic mesenchymal stem cells derived from fresh endometrium, ectopic-endometrium and umbilical cord.
Ginekologia polska.
2023 Nov; ?(?):. doi:
10.5603/gpl.93052. [PMID: 37934895] - Jacquie Maignel, Virginie Albinet, Maud Chusseau, Eric Lacoste. AbobotulinumtoxinA improves skin properties and sebum quality in the rhino mouse.
Toxicon : official journal of the International Society on Toxinology.
2023 Sep; 233(?):107230. doi:
10.1016/j.toxicon.2023.107230. [PMID: 37517594] - Chanidapa Wongtada, Putthamas Pewlong, Pravit Asawanonda, Nopadon Noppakun, Pornkanok Pongpamorn, Atchara Paemanee, Supaart Sirikantaramas, Chanat Kumtornrut. Influence of moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid on facial skin lipidome among seborrhea participants.
Journal of cosmetic dermatology.
2022 Dec; 21(12):7081-7089. doi:
10.1111/jocd.15381. [PMID: 36102580] - Na Hyun Lee, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon. Adapalene induces adipose browning through the RARβ-p38 MAPK-ATF2 pathway.
Archives of pharmacal research.
2022 May; 45(5):340-351. doi:
10.1007/s12272-022-01384-4. [PMID: 35608792] - Anayatollah Salimi, Monasadat Emam, Saeed Mohammad Soleymani. Increase adapalene delivery using chemical and herbal enhancers.
Journal of cosmetic dermatology.
2021 Sep; 20(9):3011-3017. doi:
10.1111/jocd.13960. [PMID: 33528091] - Saman Ahmad Nasrollahi, Faezeh Koohestani, Atefeh Naeimifar, Aniseh Samadi, Alireza Vatanara, Alireza Firooz. Preparation and evaluation of adapalene nanostructured lipid carriers for targeted drug delivery in acne.
Dermatologic therapy.
2021 03; 34(2):e14777. doi:
10.1111/dth.14777. [PMID: 33433054] - Linna B O Rodrigues, Flávia A Lima, Camila P B Alves, Elisângela Martins-Santos, Marta M G Aguiar, Cleida A Oliveira, Rodrigo L Oréfice, Lucas A M Ferreira, Gisele A C Goulart. Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation.
Pharmaceutical research.
2020 Jul; 37(8):148. doi:
10.1007/s11095-020-02866-0. [PMID: 32681288] - Christoph Brammann, Christel C Mueller-Goymann. Incorporation of benzoyl peroxide nanocrystals into adapalene-loaded solid lipid microparticles: Part I - Nanocrystalline benzoyl peroxide.
International journal of pharmaceutics.
2019 Jun; 564(?):171-179. doi:
10.1016/j.ijpharm.2019.04.031. [PMID: 30999051] - Mario Barilani, Federica Banfi, Silvia Sironi, Enrico Ragni, Salomé Guillaumin, Francesca Polveraccio, Lorenzo Rosso, Monica Moro, Giuseppe Astori, Michela Pozzobon, Lorenza Lazzari. Low-affinity Nerve Growth Factor Receptor (CD271) Heterogeneous Expression in Adult and Fetal Mesenchymal Stromal Cells.
Scientific reports.
2018 06; 8(1):9321. doi:
10.1038/s41598-018-27587-8. [PMID: 29915318] - A Bouloc, E Roo, B Imko-Walczuk, A Moga, B Chadoutaud, B Dréno. A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne.
Journal of the European Academy of Dermatology and Venereology : JEADV.
2017 Oct; 31(10):1727-1731. doi:
10.1111/jdv.14379. [PMID: 28573779] - Ashay Jain, Neeraj K Garg, Atul Jain, Prashant Kesharwani, Amit Kumar Jain, Pradip Nirbhavane, Rajeev K Tyagi. A synergistic approach of adapalene-loaded nanostructured lipid carriers, and vitamin C co-administration for treating acne.
Drug development and industrial pharmacy.
2016; 42(6):897-905. doi:
10.3109/03639045.2015.1104343. [PMID: 26577703] - Mangesh Bhalekar, Prashant Upadhaya, Ashwini Madgulkar. Formulation and evaluation of Adapalene-loaded nanoparticulates for epidermal localization.
Drug delivery and translational research.
2015 Dec; 5(6):585-95. doi:
10.1007/s13346-015-0261-z. [PMID: 26483036] - Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain.
Journal of medicinal chemistry.
2015 Apr; 58(7):2958-2966. doi:
10.1021/jm501873p. [PMID: 25790278] - Takashi Yoshimasu, Takashi Kuramoto, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Fukumi Furukawa. Efficacy of 0.1\% adapalene in a non-inflammatory Kyoto Rhino Rat acne model.
Journal of dermatological science.
2014 Nov; 76(2):143-8. doi:
10.1016/j.jdermsci.2014.08.001. [PMID: 25217865] - Andreas Lauterbach, Christel C Müller-Goymann. Comparison of rheological properties, follicular penetration, drug release, and permeation behavior of a novel topical drug delivery system and a conventional cream.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2014 Nov; 88(3):614-24. doi:
10.1016/j.ejpb.2014.10.001. [PMID: 25460145] - Amit K Jain, Ashay Jain, Neeraj K Garg, Abhinav Agarwal, Atul Jain, Som Akshay Jain, Rajeev K Tyagi, Rakesh K Jain, Himanshu Agrawal, Govind P Agrawal. Adapalene loaded solid lipid nanoparticles gel: an effective approach for acne treatment.
Colloids and surfaces. B, Biointerfaces.
2014 Sep; 121(?):222-9. doi:
10.1016/j.colsurfb.2014.05.041. [PMID: 25016424] - Andreas Lauterbach, Christel C Mueller-Goymann. Development, formulation, and characterization of an adapalene-loaded solid lipid microparticle dispersion for follicular penetration.
International journal of pharmaceutics.
2014 May; 466(1-2):122-32. doi:
10.1016/j.ijpharm.2014.02.050. [PMID: 24607219] - Takashi Sato, Noriko Akimoto, Kimiko Kitamura, Hirokazu Kurihara, Nobukazu Hayashi, Akira Ito. Adapalene suppresses sebum accumulation via the inhibition of triacylglycerol biosynthesis and perilipin expression in differentiated hamster sebocytes in vitro.
Journal of dermatological science.
2013 Jun; 70(3):204-10. doi:
10.1016/j.jdermsci.2013.02.003. [PMID: 23473858] - Ha Eun Lee, Joo Yeon Ko, Young Hoon Kim, Seo Rye Yoo, Sang Ho Moon, Nack In Kim, Chun Wook Park, Jeong Hwan Kim, Hyun Ju Koh, Won Seok Park, Young Suck Ro. A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1\% adapalene gel in the treatment of mild-to-moderate acne vulgaris.
European journal of dermatology : EJD.
2011 Nov; 21(6):959-65. doi:
10.1684/ejd.2011.1546. [PMID: 21982956] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Laury Trichard, M Begoña Delgado-Charro, Richard H Guy, Elias Fattal, Amélie Bochot. Novel beads made of alpha-cyclodextrin and oil for topical delivery of a lipophilic drug.
Pharmaceutical research.
2008 Feb; 25(2):435-40. doi:
10.1007/s11095-007-9395-0. [PMID: 17671830] - A Thielitz, M Helmdach, E M Röpke, H Gollnick. Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents.
The British journal of dermatology.
2001 Jul; 145(1):19-27. doi:
10.1046/j.1365-2133.2001.04276.x. [PMID: 11453902] - M J Kim, N Ciletti, S Michel, U Reichert, R L Rosenfield. The role of specific retinoid receptors in sebocyte growth and differentiation in culture.
The Journal of investigative dermatology.
2000 Feb; 114(2):349-53. doi:
10.1046/j.1523-1747.2000.00868.x. [PMID: 10651997] - M Alirezai, J Meynadier, S Jablonska, J Czernielewski, M Verschoore. [Comparative study of the efficacy and tolerability of 0.1 and 0.03 p.100 adapalene gel and 0.025 p.100 tretinoin gel in the treatment of acne].
Annales de dermatologie et de venereologie.
1996; 123(3):165-70. doi:
NULL. [PMID: 8761775] - M Verschoore, A Langner, H Wolska, S Jablonska, J Czernielewski, H Schaefer. Efficacy and safety of CD 271 alcoholic gels in the topical treatment of acne vulgaris.
The British journal of dermatology.
1991 Apr; 124(4):368-71. doi:
10.1111/j.1365-2133.1991.tb00600.x. [PMID: 1827344]