Cancidas (BioDeep_00000858430)
代谢物信息卡片
(4R,5S)-5-((2-aminoethyl)amino)-N(2)-(10,12-dimethyltetradecanoyl)-4-hydroxy-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4-(p-hydroxyphenyl)-L-threonyl-threo-3-hydroxy-L-ornithyl-trans-3-hydroxy-L-proline cyclic (6-1)-peptide
化学式: C52H88N10O15 (1092.6430298)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)CC(C)CCCCCCCCC(=O)NC1CC(C(NC(=O)C2C(CCN2C(=O)C(NC(=O)C(NC(=O)C3CC(CN3C(=O)C(NC1=O)C(C)O)O)C(C(C4=CC=C(C=C4)O)O)O)C(CCN)O)O)NCCN)O
InChI: InChI=1S/C52H88N10O15/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75)/t28-,29+,30+,33+,34-,35-,36+,37-,38+,40-,41-,42-,43-,44-,45-,46-/m0/s1
描述信息
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents > D054714 - Echinocandins
C254 - Anti-Infective Agent > C514 - Antifungal Agent
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:474180
- KEGGdrug: D07626
- PubChem: 16119814
- PubChem: 58012659
- PubChem: 2826718
- ChEMBL: CHEMBL499808
- MeSH: Caspofungin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yue Du, Yundi Zhang, Zhiyan Yang, Yue Li, Xinyu Wang, Ziqiang Li, Lei Ren, Yan Li. Artificial Neural Network Analysis of Determinants of Tacrolimus Pharmacokinetics in Liver Transplant Recipients.
The Annals of pharmacotherapy.
2024 May; 58(5):469-479. doi:
10.1177/10600280231190943. [PMID: 37559252] - Xiao-Chen Wei, Ming-Feng Zhao, Xia Xiao. Supratherapeutic posaconazole concentrations associated with hyperlipidemia in a patient with HSCT.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2024 Mar; 30(3):255-257. doi:
10.1016/j.jiac.2023.10.008. [PMID: 37832823] - Taylor J Schoen, Dante G Calise, Jin Woo Bok, Morgan A Giese, Chibueze D Nwagwu, Robert Zarnowski, David Andes, Anna Huttenlocher, Nancy P Keller. Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection.
PLoS pathogens.
2023 05; 19(5):e1011152. doi:
10.1371/journal.ppat.1011152. [PMID: 37126504] - Ke-Zhi Chen, Lu-Ling Wang, Jin-Yan Liu, Jun-Tao Zhao, Si-Jia Huang, Ming-Jie Xiang. P4-ATPase subunit Cdc50 plays a role in yeast budding and cell wall integrity in Candida glabrata.
BMC microbiology.
2023 04; 23(1):99. doi:
10.1186/s12866-023-02810-3. [PMID: 37046215] - Shulin Cao, Wenqiang Jiang, Yan Shu, Wei Li, Yani Zhang, Aixiang Zhang, Huaigu Chen. UDP-Galactopyranose Mutase Mediates Cell Wall Integrity, Polarity Growth, and Virulence in Fusarium graminearum.
Applied and environmental microbiology.
2023 Jan; ?(?):e0123522. doi:
10.1128/aem.01235-22. [PMID: 36656025] - Asiya Ramzan, Sajad Ahmad Padder, Khalid Z Masoodi, Syed Shafi, Inayatullah Tahir, Reiaz Ul Rehman, Rajendra Prasad, Abdul Haseeb Shah. β-Nitrostyrene derivatives as broad range potential antifungal agents targeting fungal cell wall.
European journal of medicinal chemistry.
2022 Oct; 240(?):114609. doi:
10.1016/j.ejmech.2022.114609. [PMID: 35932582] - Ertan Sal, Jannik Stemler, Jon Salmanton-García, Iker Falces-Romero, László Kredics, Elisabeth Meyer, Benjamin Würstl, Cornelia Lass-Flörl, Zdenek Racil, Nikolay Klimko, Simone Cesaro, Anupma Jyoti Kindo, Hilmar Wisplinghoff, Philipp Koehler, Oliver A Cornely, Danila Seidel. Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope® registry.
The Journal of antimicrobial chemotherapy.
2022 09; 77(10):2850-2858. doi:
10.1093/jac/dkac235. [PMID: 35929089] - Xiaoyun Ran, Pengfei Wang, An Zhang, Binfei Tang. Efficacy and safety of caspofungin for patients with hepatic insufficiency.
BMC infectious diseases.
2022 Jun; 22(1):560. doi:
10.1186/s12879-022-07527-8. [PMID: 35725403] - Zheng Wu, Jinhua Lan, Xipei Wang, Yijin Wu, Fen Yao, Yifan Wang, Bo-Xin Zhao, Yirong Wang, Jingchun Chen, Chunbo Chen. Population Pharmacokinetics of Caspofungin and Dose Simulations in Heart Transplant Recipients.
Antimicrobial agents and chemotherapy.
2022 05; 66(5):e0224921. doi:
10.1128/aac.02249-21. [PMID: 35389237] - Mahzad Erami, Omid Raiesi, Mansooreh Momen-Heravi, Muhammad Ibrahim Getso, Mojtaba Fakhrehi, Narges Mehri, Mohammad Yarahmadi, Sasan Amiri, Vahid Raissi, Seyed Jamal Hashemi. Clinical impact of Candida respiratory tract colonization and acute lung infections in critically ill patients with COVID-19 pneumonia.
Microbial pathogenesis.
2022 May; 166(?):105520. doi:
10.1016/j.micpath.2022.105520. [PMID: 35405278] - Nicolas Garbez, Litaty C Mbatchi, Steven C Wallis, Laurent Muller, Jeffrey Lipman, Jason A Roberts, Jean-Yves Lefrant, Claire Roger. Caspofungin Population Pharmacokinetic Analysis in Plasma and Peritoneal Fluid in Septic Patients with Intra-Abdominal Infections: A Prospective Cohort Study.
Clinical pharmacokinetics.
2022 05; 61(5):673-686. doi:
10.1007/s40262-021-01062-6. [PMID: 34931282] - Robert J Tancer, Yina Wang, Siddhi Pawar, Chaoyang Xue, Gregory R Wiedman. Development of Antifungal Peptides against Cryptococcus neoformans; Leveraging Knowledge about the cdc50Δ Mutant Susceptibility for Lead Compound Development.
Microbiology spectrum.
2022 04; 10(2):e0043922. doi:
10.1128/spectrum.00439-22. [PMID: 35377230] - Jana Marx, Vera Reinstadler, Tiziana Gasperetti, René Welte, Herbert Oberacher, Patrizia Moser, Michael Joannidis, Romuald Bellmann. Human tissue distribution of caspofungin.
International journal of antimicrobial agents.
2022 Apr; 59(4):106553. doi:
10.1016/j.ijantimicag.2022.106553. [PMID: 35176477] - Shu-Fang Zhang, Bo-Hao Tang, An-Hua Wei, Yue Du, Zi-Wan Guan, Yan Li. Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes.
Xenobiotica; the fate of foreign compounds in biological systems.
2022 Mar; 52(3):312-321. doi:
10.1080/00498254.2022.2064252. [PMID: 35395919] - Claire Pressiat, Nawel Ait-Ammar, Matthieu Daniel, Anne Hulin, Françoise Botterel, Eric Levesque. Pharmacokinetics/Pharmacodynamics of Caspofungin in Plasma and Peritoneal Fluid of Liver Transplant Recipients.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0118721. doi:
10.1128/aac.01187-21. [PMID: 34662185] - Keishi Yamasaki, Keiki Sakurama, Koji Nishi, Kenji Tsukigawa, Hakaru Seo, Masaki Otagiri, Kazuaki Taguchi. An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins.
The Journal of pharmacy and pharmacology.
2022 Jan; 74(1):88-93. doi:
10.1093/jpp/rgab157. [PMID: 34791369] - Siri Kurland, Elisabeth Löwdin, Mia Furebring, Ayda Shams, Erja Chryssanthou, Pernilla Lagerbäck, Thomas Tängden, Olof Breuer, Jan Sjölin. Human plasma protein levels alter the in vitro antifungal activity of caspofungin: An explanation to the effect in critically ill?.
Mycoses.
2022 Jan; 65(1):79-87. doi:
10.1111/myc.13386. [PMID: 34709674] - Chinmay Nakhwa. Endogenous fungal endopthalmitis treated with intravitreal caspofungin in a COVID-19 recovered patient: A case report.
Indian journal of ophthalmology.
2021 Dec; 69(12):3759-3761. doi:
10.4103/ijo.ijo_1192_21. [PMID: 34827041] - Fruzsina Nagy, Zoltán Tóth, Fanni Nyikos, Lajos Forgács, Ágnes Jakab, Andrew M Borman, László Majoros, Renátó Kovács. In vitro and in vivo interaction of caspofungin with isavuconazole against Candida auris planktonic cells and biofilms.
Medical mycology.
2021 Oct; 59(10):1015-1023. doi:
10.1093/mmy/myab032. [PMID: 34021571] - Farzad Pakdel, Kazem Ahmadikia, Mohammadreza Salehi, Azin Tabari, Rozita Jafari, Golfam Mehrparvar, Yasaman Rezaie, Shahin Rajaeih, Neda Alijani, Aleksandra Barac, Alireza Abdollahi, Sadegh Khodavaisy. Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran.
Mycoses.
2021 Oct; 64(10):1238-1252. doi:
10.1111/myc.13334. [PMID: 34096653] - Shay Brikman, Guy Dori, Carmel Kasher, Anna Yanovskay, Merav Strauss, Raul Colodner, Naiel Bisharat, Bibiana Chazan. Candida Bloodstream Infection, a Dire Complication in Hospitalized COVID-19 Patients: Three Cases from a Single Center in Northern Israel.
The Israel Medical Association journal : IMAJ.
2021 Oct; 23(10):615-617. doi:
NULL. [PMID: 34672440] - Raúl García, Kaori Itto-Nakama, José Manuel Rodríguez-Peña, Xiaolin Chen, Ana Belén Sanz, Alba de Lorenzo, Mónica Pavón-Vergés, Karen Kubo, Shinsuke Ohnuki, César Nombela, Laura Popolo, Yoshikazu Ohya, Javier Arroyo. Poacic acid, a β-1,3-glucan-binding antifungal agent, inhibits cell-wall remodeling and activates transcriptional responses regulated by the cell-wall integrity and high-osmolarity glycerol pathways in yeast.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 09; 35(9):e21778. doi:
10.1096/fj.202100278r. [PMID: 34383971] - Jean-Herlé Raphalen, Ambroise Marçais, Perrine Parize, Benoit Pilmis, Agnès Lillo-Lelouet, Lionel Lamhaut, Frédéric J Baud. Is caspofungin efficient to treat invasive candidiasis requiring continuous veno-venous hemofiltration? A case report.
Therapie.
2021 Sep; 76(5):512-515. doi:
10.1016/j.therap.2020.12.013. [PMID: 33423788] - M Ángeles Curto, Estefanía Butassi, Juan C Ribas, Laura A Svetaz, Juan C G Cortés. Natural products targeting the synthesis of β(1,3)-D-glucan and chitin of the fungal cell wall. Existing drugs and recent findings.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Jul; 88(?):153556. doi:
10.1016/j.phymed.2021.153556. [PMID: 33958276] - Ali Amanati, Parisa Badiee, Hadis Jafarian, Fatemeh Ghasemi, Samane Nematolahi, Sezaneh Haghpanah, Seyedeh Sedigheh Hamzavi. Impact of antifungal stewardship interventions on the susceptibility of colonized Candida species in pediatric patients with malignancy.
Scientific reports.
2021 07; 11(1):14099. doi:
10.1038/s41598-021-93421-3. [PMID: 34238976] - Iching G Yu, Sean E O'Brien, David M Ryckman. Pharmacokinetic and Pharmacodynamic Comparison of Intravenous and Inhaled Caspofungin.
Journal of aerosol medicine and pulmonary drug delivery.
2021 06; 34(3):197-203. doi:
10.1089/jamp.2020.1645. [PMID: 32985935] - Fangyi Li, Minggen Zhou, Zheng Jiao, Zijun Zou, Erqian Yu, Zhijie He. Caspofungin pharmacokinetics and probability of target attainment in ICU patients in China.
Journal of global antimicrobial resistance.
2021 06; 25(?):238-263. doi:
10.1016/j.jgar.2021.03.011. [PMID: 33845162] - Frederic J Baud, Vincent Jullien, Philippe-Henri Secrétan, Pascal Houzé, Lionel Lamhaut. Are we correctly treating invasive candidiasis under continuous renal replacement therapy with echinocandins? Preliminary in vitro assessment.
Anaesthesia, critical care & pain medicine.
2021 02; 40(1):100640. doi:
10.1016/j.accpm.2020.01.007. [PMID: 32251833] - Jéssica Tauany Andrade, William Gustavo Lima, Jaqueline França Sousa, Aline Aparecida Saldanha, Nívea Pereira De Sá, Fernanda Barbara Morais, Mayra Karla Prates Silva, Gustavo Henrique Ribeiro Viana, Susana Johann, Adriana Cristina Soares, Leonardo Allan Araújo, Simone Odília Antunes Fernandes, Valbert Nascimento Cardoso, Jaqueline Maria Siqueira Ferreira. Design, synthesis, and biodistribution studies of new analogues of marine alkaloids: Potent in vitro and in vivo fungicidal agents against Candida spp.
European journal of medicinal chemistry.
2021 Jan; 210(?):113048. doi:
10.1016/j.ejmech.2020.113048. [PMID: 33316690] - James M Apgar, Robert R Wilkening, Dann L Parker, Dongfang Meng, Kenneth J Wildonger, Donald Sperbeck, Mark L Greenlee, James M Balkovec, Amy M Flattery, George K Abruzzo, Andrew M Galgoci, Robert A Giacobbe, Charles J Gill, Ming-Jo Hsu, Paul Liberator, Andrew S Misura, Mary Motyl, Jennifer Nielsen Kahn, Maryann Powles, Fred Racine, Jasminka Dragovic, Weiming Fan, Robin Kirwan, Shu Lee, Hao Liu, Ahmed Mamai, Kingsley Nelson, Michael Peel. Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor.
Bioorganic & medicinal chemistry letters.
2021 01; 32(?):127661. doi:
10.1016/j.bmcl.2020.127661. [PMID: 33160023] - Francesca Gioia, Alicia Gomez-Lopez, Maria Elena Alvarez, Elia Gomez-García de la Pedrosa, Pilar Martín-Davila, Manuel Cuenca-Estrella, Santiago Moreno, Jesús Fortun. Pharmacokinetics of echinocandins in suspected candida peritonitis: A potential risk for resistance.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Dec; 101(?):24-28. doi:
10.1016/j.ijid.2020.09.019. [PMID: 32937195] - Sébastien Bailly, Elodie Gautier-Veyret, Minh P Lê, Lila Bouadma, Olivier Andremont, Mathilde Neuville, Bruno Mourvillier, Romain Sonneville, Eric Magalhaes, Jordane Lebut, Aguila Radjou, Roland Smonig, Michel Wolff, Laurent Massias, Claire Dupuis, Jean-François Timsit. Impact of Loading Dose of Caspofungin in Pharmacokinetic-Pharmacodynamic Target Attainment for Severe Candidiasis Infections in Patients in Intensive Care Units: the CASPOLOAD Study.
Antimicrobial agents and chemotherapy.
2020 11; 64(12):. doi:
10.1128/aac.01545-20. [PMID: 32958709] - Ying Wang, Siegfried Hekimi. Micellization of coenzyme Q by the fungicide caspofungin allows for safe intravenous administration to reach extreme supraphysiological concentrations.
Redox biology.
2020 09; 36(?):101680. doi:
10.1016/j.redox.2020.101680. [PMID: 32810741] - C Adembri, G Villa, E Rosi, L Tofani, S Fallani, A R De Gaudio, A Novelli. Caspofungin PK in critically ill patients after the first and fourth doses: suggestions for therapeutic drug monitoring?.
Journal of chemotherapy (Florence, Italy).
2020 May; 32(3):124-131. doi:
10.1080/1120009x.2020.1737783. [PMID: 32202224] - Nathan P Wiederhold, Laura K Najvar, Rosie Jaramillo, Marcos Olivo, Hoja Patterson, April Connell, Yoshiko Fukuda, Junichi Mitsuyama, Gabriel Catano, Thomas F Patterson. The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.02198-19. [PMID: 31844006] - Qianting Yang, Tao Zhang, Dan Zhao, Ying Zhang, Yuzhu Dong, Dan Sun, Qian Du, Jing Zheng, Haidong Lu, Yalin Dong. Factors influencing caspofungin plasma concentrations in kidney transplant patients with high incidence of invasive fungal infections.
Journal of clinical pharmacy and therapeutics.
2020 Feb; 45(1):72-80. doi:
10.1111/jcpt.13026. [PMID: 31468555] - Fan Jin, Xiao-Hang Liu, Wen-Can Chen, Zhang-Ling Fan, Huan-Ling Wang. High initial (1, 3) Beta-d-Glucan concentration may be a predictor of satisfactory response of c aspofungin combined with TMP/SMZ for HIV-negative patients with moderate to severe Pneumocystis jirovecii pneumonia.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2019 Nov; 88(?):141-148. doi:
10.1016/j.ijid.2019.08.015. [PMID: 31442630] - Yuhei Shibata, Yuri Miyahara, Yuna Sadaka, Mika Yasue, Minami Fujimura, Midori Soda, Miho Yamamoto, Hiroko Kato, Akio Suzuki, Katsura Tsukamoto, Takeshi Hara, Hisashi Tsurumi, Kiyoyuki Kitaichi. Evaluation of the effectiveness of caspofungin against febrile neutropenia and the factors related to the alteration in its plasma concentration.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2019 Oct; 25(10):801-805. doi:
10.1016/j.jiac.2019.04.011. [PMID: 31047782] - Qi Han, Chaoying Pan, Yueqing Wang, Na Wang, Yue Wang, Jianli Sang. The PP2A regulatory subunits, Cdc55 and Rts1, play distinct roles in Candida albicans' growth, morphogenesis, and virulence.
Fungal genetics and biology : FG & B.
2019 10; 131(?):103240. doi:
10.1016/j.fgb.2019.103240. [PMID: 31185286] - Deepak Kumar Choudhary, Priyanka Bhakt, Rupinder Kaur. Essential Role for the Phosphatidylinositol 3,5-Bisphosphate Synthesis Complex in Caspofungin Tolerance and Virulence in Candida glabrata.
Antimicrobial agents and chemotherapy.
2019 08; 63(8):. doi:
10.1128/aac.00886-19. [PMID: 31138567] - Feng Yang, Flora Teoh, Alrina Shin Min Tan, Yongbing Cao, Norman Pavelka, Judith Berman. Aneuploidy Enables Cross-Adaptation to Unrelated Drugs.
Molecular biology and evolution.
2019 08; 36(8):1768-1782. doi:
10.1093/molbev/msz104. [PMID: 31028698] - Yasemin Ay Altintop, Ayse Betul Ergul, Ayse Nedret Koc, Mustafa Altay Atalay. Evaluation of Candida colonization and use of the Candida Colonization Index in a paediatric Intensive Care Unit: a prospective observational study.
Le infezioni in medicina.
2019 Jun; 27(2):159-167. doi:
NULL. [PMID: 31205039] - S Kurland, M Furebring, E Löwdin, E Eliasson, E I Nielsen, J Sjölin. Pharmacokinetics of Caspofungin in Critically Ill Patients in Relation to Liver Dysfunction: Differential Impact of Plasma Albumin and Bilirubin Levels.
Antimicrobial agents and chemotherapy.
2019 06; 63(6):. doi:
10.1128/aac.02466-18. [PMID: 30962329] - Amir Arastehfar, Farnaz Daneshnia, Mohammad-Reza Salehi, Hossein Zarrinfar, Sadegh Khodavaisy, Pieter-Jan Haas, Maryam Roudbary, Mohammad-Javad Najafzadeh, Kamiar Zomorodian, Arezoo Charsizadeh, Carlo Brouwer, Weihua Pan, Ferry Hagen, Teun Boekhout. Molecular characterization and antifungal susceptibility testing of Candida nivariensis from blood samples - an Iranian multicentre study and a review of the literature.
Journal of medical microbiology.
2019 05; 68(5):770-777. doi:
10.1099/jmm.0.000963. [PMID: 30924763] - Nathan P Wiederhold, Shawn R Lockhart, Laura K Najvar, Elizabeth L Berkow, Rosie Jaramillo, Marcos Olivo, Edward P Garvey, Christopher M Yates, Robert J Schotzinger, Gabriel Catano, Thomas F Patterson. The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Antimicrobial agents and chemotherapy.
2019 03; 63(3):. doi:
10.1128/aac.02233-18. [PMID: 30530603] - Kening Zhao, Mark Bleackley, David Chisanga, Lahiru Gangoda, Pamali Fonseka, Michael Liem, Hina Kalra, Haidar Al Saffar, Shivakumar Keerthikumar, Ching-Seng Ang, Christopher G Adda, Lanzhou Jiang, Kuok Yap, Ivan K Poon, Peter Lock, Vincent Bulone, Marilyn Anderson, Suresh Mathivanan. Extracellular vesicles secreted by Saccharomyces cerevisiae are involved in cell wall remodelling.
Communications biology.
2019; 2(?):305. doi:
10.1038/s42003-019-0538-8. [PMID: 31428693] - Senaid Trnacevic, Amer Mujkanovic, Edin Nislic, Edin Begic, Zenaida Karasalihovic, Adnan Cickusic, Alma Trnacevic, Mirna Aleckovic Halilovic. Invasive Aspergillosis After Kidney Transplant-Treatment Approach.
Medical archives (Sarajevo, Bosnia and Herzegovina).
2018 Dec; 72(6):456-458. doi:
10.5455/medarh.2018.72.456-458. [PMID: 30814781] - Shuki Oya, Tsuyoshi Muta. Breakthrough infection of Geotrichum capitatum during empirical caspofungin therapy after umbilical cord blood transplantation.
International journal of hematology.
2018 Nov; 108(5):558-563. doi:
10.1007/s12185-018-2481-8. [PMID: 29926359] - Cheng-Wei Chen, Chyong-Hsin Hsu, Jin-Cherng Sheu, Hsin Chi, Jui-Hsing Chang, Chun-Chen Lin, Jeng-Daw Tsai. Retrograde Ureteral Catheterization: A Possible New Treatment for Renal Fungal Balls in Very Low Birth Weight Infants.
Urology.
2018 Oct; 120(?):234-237. doi:
10.1016/j.urology.2018.05.011. [PMID: 29778493] - Suguru Uemura, Akihiro Tamura, Nobuyuki Yamamoto, Atsuro Saito, Sayaka Nakamura, Takahiro Fujiwara, Teppei Tahara, Aiko Kozaki, Kenji Kishimoto, Toshiaki Ishida, Daiichiro Hasegawa, Yasunori Muraosa, Katsuhiko Kamei, Yoshiyuki Kosaka. Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient With Acute Lymphoblastic Leukemia.
The Pediatric infectious disease journal.
2018 10; 37(10):e251-e253. doi:
10.1097/inf.0000000000001941. [PMID: 29438132] - Benoit Pilmis, Dea Garcia-Hermoso, Alexandre Alanio, Emilie Catherinot, Anne Scemla, Vincent Jullien, Stéphane Bretagne, Olivier Lortholary. Failure of voriconazole therapy due to acquired azole resistance in Aspergillus fumigatus in a kidney transplant recipient with chronic necrotizing aspergillosis.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2018 09; 18(9):2352-2355. doi:
10.1111/ajt.14940. [PMID: 29790292] - Julian Hösl, André Gessner, Nahed El-Najjar. Liquid chromatography-tandem mass spectrometry for the quantification of moxifloxacin, ciprofloxacin, daptomycin, caspofungin, and isavuconazole in human plasma.
Journal of pharmaceutical and biomedical analysis.
2018 Aug; 157(?):92-99. doi:
10.1016/j.jpba.2018.05.015. [PMID: 29777985] - Rong Zhang, Ning Dong, Yonglu Huang, Hongwei Zhou, Miaomiao Xie, Edward Wai-Chi Chan, Yanyan Hu, Jiachang Cai, Sheng Chen. Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract.
Emerging microbes & infections.
2018 Jul; 7(1):127. doi:
10.1038/s41426-018-0129-7. [PMID: 29985412] - Tamás Kardos, Renátó Kovács, Gábor Kardos, Istvan Varga, Aliz Bozó, Zoltán Tóth, Fruzsina Nagy, László Majoros. Poor in vivo efficacy of caspofungin, micafungin and amphotericin B against wild-type Candida krusei clinical isolates does not correlate with in vitro susceptibility results.
Journal of chemotherapy (Florence, Italy).
2018 Jul; 30(4):233-239. doi:
10.1080/1120009x.2018.1487150. [PMID: 30025501] - Praveen R Juvvadi, M Arthur Moseley, Christopher J Hughes, Erik J Soderblom, Sarah Lennon, Simon R Perkins, J Will Thompson, Scott J Geromanos, Jason Wildgoose, Keith Richardson, James I Langridge, Johannes P C Vissers, William J Steinbach. Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.
Journal of proteome research.
2018 02; 17(2):780-793. doi:
10.1021/acs.jproteome.7b00499. [PMID: 29251506] - Nathan P Wiederhold, Laura K Najvar, Rosie Jaramillo, Marcos Olivo, Jason Pizzini, Gabriel Catano, Thomas F Patterson. Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata.
The Journal of antimicrobial chemotherapy.
2018 02; 73(2):448-451. doi:
10.1093/jac/dkx422. [PMID: 29177447] - Ayşe Bariş, Haşim Gencer, Nazan Dalgiç, Güntülü Şik, Fatma Özakkaş, Elif Aktaş. Magnusiomyces capitatus Peritonitis in a Child With Acute Lymphocytic Leukemia as a Breakthrough Infection During Caspofungin Therapy.
The Pediatric infectious disease journal.
2017 Dec; 36(12):e351-e353. doi:
10.1097/inf.0000000000001720. [PMID: 29145348] - Carlo Tascini, Emanuela Sozio, Antonello Di Paolo, Giancarlo Tintori, Alessandro Leonildi, Giacomo Bertolino, Franco Carmassi, Enrico Tagliaferri, Francesco Menichetti, Francesco Barchiesi. Fungicidal activity and PK/PD of caspofungin as tools to guide antifungal therapy in a fluconazole-resistant C. parapsilosis candidemia.
Journal of chemotherapy (Florence, Italy).
2017 Dec; 29(6):376-379. doi:
10.1080/1120009x.2017.1289308. [PMID: 28198656] - Rashmi Mishra, Paul Kelly, Omesh Toolsie, Puvanalingam Ayyadurai, Muhammad Adrish. Uncommon cause of fungemia in a patient with renal cell cancer: A case report of Candida lusitaniae Fungemia.
Medicine.
2017 11; 96(45):e8510. doi:
10.1097/md.0000000000008510. [PMID: 29137050] - Raimunda Sâmia Nogueira Brilhante, Aline Lobão da Silva, Frederico Ozanan Barros Monteiro, Glaucia Morgana de Melo Guedes, Jamille Alencar Sales, Jonathas Sales de Oliveira, José Erisvaldo Maia Junior, Stefânia Araújo Miranda, José Júlio Costa Sidrim, Lucas Pereira de Alencar, Débora Souza Collares Maia Castelo-Branco, Rossana de Aguiar Cordeiro, Waldemiro de Aquino Pereira Neto, Marcos Fábio Gadelha Rocha. Yeasts from Scarlet ibises (Eudocimus ruber): A focus on monitoring the antifungal susceptibility of Candida famata and closely related species.
Medical mycology.
2017 Oct; 55(7):725-732. doi:
10.1093/mmy/myw144. [PMID: 28204651] - Mitsutaka Nishimoto, Hideo Koh, Atsushi Tokuwame, Yosuke Makuuchi, Masatomo Kuno, Teruhito Takakuwa, Hiroshi Okamura, Shiro Koh, Takuro Yoshimura, Satoru Nanno, Mika Nakamae, Asao Hirose, Yasuhiro Nakashima, Takahiko Nakane, Masayuki Hino, Hirohisa Nakamae. Drug interactions and safety profiles with concomitant use of caspofungin and calcineurin inhibitors in allogeneic haematopoietic cell transplantation.
British journal of clinical pharmacology.
2017 Sep; 83(9):2000-2007. doi:
10.1111/bcp.13303. [PMID: 28407449] - George Dimopoulos, Frantzeska Frantzeskaki, Marinos Kosmopoulos, Fabio Sylvio Taccone, Anne-Marie Van den Abeele, Pierre Bulpa, Frederic Forêt, Dirk Vogelaers, Stijn Blot. Endomyocardial and pericardial aspergillosis in critically ill patients.
Mycoses.
2017 Sep; 60(9):576-580. doi:
10.1111/myc.12630. [PMID: 28497621] - Thomas D Michl, Carla Giles, Piotr Mocny, Kathryn Futrega, Michael R Doran, Harm-Anton Klok, Hans J Griesser, Bryan R Coad. Caspofungin on ARGET-ATRP grafted PHEMA polymers: Enhancement and selectivity of prevention of attachment of Candida albicans.
Biointerphases.
2017 Aug; 12(5):05G602. doi:
10.1116/1.4986054. [PMID: 28851227] - Rafael Ferriols-Lisart, Gerardo Aguilar, Alejandro Pérez-Pitarch, Jaume Puig, Carlos Ezquer-Garín, Manuel Alós. Plasma concentrations of caspofungin in a critically ill patient with morbid obesity.
Critical care (London, England).
2017 08; 21(1):200. doi:
10.1186/s13054-017-1774-2. [PMID: 28764793] - Volker Strenger, Fedja Farowski, Carsten Müller, Nora Hofer, Hans Jürgen Dornbusch, Daniela Sperl, Herwig Lackner, Martin Benesch, Christian Urban. Low penetration of caspofungin into cerebrospinal fluid following intravenous administration of standard doses.
International journal of antimicrobial agents.
2017 Aug; 50(2):272-275. doi:
10.1016/j.ijantimicag.2017.02.024. [PMID: 28527634] - Raúl García, Enrique Bravo, Sonia Diez-Muñiz, Cesar Nombela, Jose M Rodríguez-Peña, Javier Arroyo. A novel connection between the Cell Wall Integrity and the PKA pathways regulates cell wall stress response in yeast.
Scientific reports.
2017 07; 7(1):5703. doi:
10.1038/s41598-017-06001-9. [PMID: 28720901] - M S Rezai, A Vaezi, H Fakhim, A Soleimani, H Mohammad Jafari, S Mohseni, H Badali. Successful treatment with caspofungin of candiduria in a child with Wilms tumor; review of literature.
Journal de mycologie medicale.
2017 Jun; 27(2):261-265. doi:
10.1016/j.mycmed.2017.01.006. [PMID: 28188050] - Beata Sadowska, Aleksandra Budzyńska, Anna Stochmal, Jerzy Żuchowski, Barbara Różalska. Novel properties of Hippophae rhamnoides L. twig and leaf extracts - anti-virulence action and synergy with antifungals studied in vitro on Candida spp. model.
Microbial pathogenesis.
2017 Jun; 107(?):372-379. doi:
10.1016/j.micpath.2017.04.020. [PMID: 28428132] - C C Chang, M A Slavin, S C-A Chen. New developments and directions in the clinical application of the echinocandins.
Archives of toxicology.
2017 Apr; 91(4):1613-1621. doi:
10.1007/s00204-016-1916-3. [PMID: 28180946] - S A Ahmed, W Hofmüller, M Seibold, G S de Hoog, H Harak, I Tammer, A D van Diepeningen, W Behrens-Baumann. Tintelnotia, a new genus in Phaeosphaeriaceae harbouring agents of cornea and nail infections in humans.
Mycoses.
2017 Apr; 60(4):244-253. doi:
10.1111/myc.12588. [PMID: 27910191] - Jie Jiao, Feihu Zhou, Hongjun Kang, Chao Liu, Mengmeng Yang, Jie Hu. Unexpected extrapyramidal symptoms and pulmonary aspergillosis in exertional heatstroke with fulminant liver failure: a case report.
Journal of medical case reports.
2017 Feb; 11(1):37. doi:
10.1186/s13256-016-1184-0. [PMID: 28183359] - Gerardo Aguilar, Rafael Ferriols, Angels Lozano, Carlos Ezquer, José A Carbonell, Ana Jurado, Juan Carrizo, Ferran Serralta, Jaume Puig, David Navarro, Manuel Alos, F Javier Belda. Optimal doses of caspofungin during continuous venovenous hemodiafiltration in critically ill patients.
Critical care (London, England).
2017 Jan; 21(1):17. doi:
10.1186/s13054-016-1594-9. [PMID: 28132647] - Jana Leshinsky, Andrew McLachlan, David J R Foster, Ross Norris, Vanessa R Barrs. Pharmacokinetics of caspofungin acetate to guide optimal dosing in cats.
PloS one.
2017; 12(6):e0178783. doi:
10.1371/journal.pone.0178783. [PMID: 28575121] - David Cretella, Katie E Barber, S Travis King, Kayla R Stover. Comparison of susceptibility patterns using commercially available susceptibility testing methods performed on prevalent Candida spp.
Journal of medical microbiology.
2016 Dec; 65(12):1445-1451. doi:
10.1099/jmm.0.000383. [PMID: 27902377] - Kristy Koselny, Julianne Green, Louis DiDone, Justin P Halterman, Annette W Fothergill, Nathan P Wiederhold, Thomas F Patterson, Melanie T Cushion, Chad Rappelye, Melanie Wellington, Damian J Krysan. The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Antimicrobial agents and chemotherapy.
2016 12; 60(12):7115-7127. doi:
10.1128/aac.01061-16. [PMID: 27645246] - Hongjuan Li, Haoming Huang, Hangyong He. Successful treatment of severe Pneumocystis pneumonia in an immunosuppressed patient using caspofungin combined with clindamycin: a case report and literature review.
BMC pulmonary medicine.
2016 11; 16(1):144. doi:
10.1186/s12890-016-0307-0. [PMID: 27835947] - Michael A Pfaller, Shawn A Messer, Paul R Rhomberg, Ronald N Jones, Mariana Castanheira. Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates.
The Journal of antimicrobial chemotherapy.
2016 10; 71(10):2868-73. doi:
10.1093/jac/dkw214. [PMID: 27287236] - I Gassiep, J Douglas, E G Playford. First report of monomicrobial Candida parapsilosis necrotizing fasciitis.
Transplant infectious disease : an official journal of the Transplantation Society.
2016 Oct; 18(5):752-755. doi:
10.1111/tid.12571. [PMID: 27385469] - Martha Avilés-Robles, Carlos Gómez-Ponce, Jesús Reséndiz-Sánchez, Aída Verónica Rodríguez-Tovar, Adrián Ceballos-Bocanegra, Ángeles Martínez-Rivera. Disseminated penicilliosis due to Penicillium chrysogenum in a pediatric patient with Henoch-Schönlein syndrome.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2016 Oct; 51(?):78-80. doi:
10.1016/j.ijid.2016.08.026. [PMID: 27596684] - Jeffrey B Locke, Amanda L Almaguer, Douglas E Zuill, Ken Bartizal. Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species.
Antimicrobial agents and chemotherapy.
2016 10; 60(10):6100-7. doi:
10.1128/aac.00620-16. [PMID: 27480852] - Almudena Aranda-Martinez, Federico Lopez-Moya, Luis Vicente Lopez-Llorca. Cell wall composition plays a key role on sensitivity of filamentous fungi to chitosan.
Journal of basic microbiology.
2016 Oct; 56(10):1059-1070. doi:
10.1002/jobm.201500775. [PMID: 27259000] - Qilin Yu, Bing Zhang, Jianrong Li, Biao Zhang, Honggang Wang, Mingchun Li. Endoplasmic reticulum-derived reactive oxygen species (ROS) is involved in toxicity of cell wall stress to Candida albicans.
Free radical biology & medicine.
2016 10; 99(?):572-583. doi:
10.1016/j.freeradbiomed.2016.09.014. [PMID: 27650297] - Werner J Heinz, Dieter Buchheidt, Andrew J Ullmann. Clinical evidence for caspofungin monotherapy in the first-line and salvage therapy of invasive Aspergillus infections.
Mycoses.
2016 Aug; 59(8):480-93. doi:
10.1111/myc.12477. [PMID: 27324802] - Hassan Badrane, M Hong Nguyen, Cornelius J Clancy. Highly Dynamic and Specific Phosphatidylinositol 4,5-Bisphosphate, Septin, and Cell Wall Integrity Pathway Responses Correlate with Caspofungin Activity against Candida albicans.
Antimicrobial agents and chemotherapy.
2016 06; 60(6):3591-600. doi:
10.1128/aac.02711-15. [PMID: 27021331] - Lisa C Martial, Roger J M Brüggemann, Jeroen A Schouten, Henk J van Leeuwen, Arthur R van Zanten, Dylan W de Lange, Eline W Muilwijk, Paul E Verweij, David M Burger, Rob E Aarnoutse, Peter Pickkers, Thomas P C Dorlo. Dose Reduction of Caspofungin in Intensive Care Unit Patients with Child Pugh B Will Result in Suboptimal Exposure.
Clinical pharmacokinetics.
2016 06; 55(6):723-33. doi:
10.1007/s40262-015-0347-2. [PMID: 26649870] - Wei Huang, Guojian Liao, Gregory M Baker, Yina Wang, Richard Lau, Padmaja Paderu, David S Perlin, Chaoyang Xue. Lipid Flippase Subunit Cdc50 Mediates Drug Resistance and Virulence in Cryptococcus neoformans.
mBio.
2016 05; 7(3):. doi:
10.1128/mbio.00478-16. [PMID: 27165800] - Kristin Shirey, Kayla R Stover, John Cleary, Ngoc Hoang, Jonathan Hosler. Membrane-Anchored Cyclic Peptides as Effectors of Mitochondrial Oxidative Phosphorylation.
Biochemistry.
2016 Apr; 55(14):2100-11. doi:
10.1021/acs.biochem.5b01368. [PMID: 26985698] - Marta Sanchis, Adela Martin-Vicente, Javier Capilla, Josep Guarro. Antifungal therapies in murine infections by Candida kefyr.
Mycoses.
2016 Apr; 59(4):253-258. doi:
10.1111/myc.12468. [PMID: 26857550] - Soňa Kucharíková, Evelien Gerits, Katrijn De Brucker, Annabel Braem, Katerina Ceh, Gregor Majdič, Tanja Španič, Estera Pogorevc, Natalie Verstraeten, Hélène Tournu, Nicolas Delattin, Frédéric Impellizzeri, Martin Erdtmann, Annika Krona, Maria Lövenklev, Miomir Knezevic, Mirjam Fröhlich, Jef Vleugels, Maarten Fauvart, Wander Jose de Silva, Katleen Vandamme, Jordi Garcia-Forgas, Bruno P A Cammue, Jan Michiels, Patrick Van Dijck, Karin Thevissen. Covalent immobilization of antimicrobial agents on titanium prevents Staphylococcus aureus and Candida albicans colonization and biofilm formation.
The Journal of antimicrobial chemotherapy.
2016 Apr; 71(4):936-45. doi:
10.1093/jac/dkv437. [PMID: 26702917] - E M Shannon, M J A Reid, P Chin-Hong. Late aspergilloma of a renal allograft without need for operative management: a case report and review of the literature.
Transplant infectious disease : an official journal of the Transplantation Society.
2016 Apr; 18(2):261-5. doi:
10.1111/tid.12495. [PMID: 26751414] - Sylvian Cretton, Stéphane Dorsaz, Antonio Azzollini, Quentin Favre-Godal, Laurence Marcourt, Samad Nejad Ebrahimi, Francine Voinesco, Emilie Michellod, Dominique Sanglard, Katia Gindro, Jean-Luc Wolfender, Muriel Cuendet, Philippe Christen. Antifungal Quinoline Alkaloids from Waltheria indica.
Journal of natural products.
2016 Feb; 79(2):300-7. doi:
10.1021/acs.jnatprod.5b00896. [PMID: 26848627] - Kim Vriens, Tanne L Cools, Peta J Harvey, David J Craik, Annabel Braem, Jozef Vleugels, Barbara De Coninck, Bruno P A Cammue, Karin Thevissen. The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms.
Peptides.
2016 Jan; 75(?):71-9. doi:
10.1016/j.peptides.2015.11.001. [PMID: 26592804] - Marianna Domán, Renátó Kovács, Gábor Kardos, Rudolf Gesztelyi, Béla Juhász, Aliz Bozó, Tamás Kardos, Qasem Saleh, László Majoros. Killing Rates of Caspofungin in 50 Percent Serum Correlate with Caspofungin Efficacy Against Candida albicans in a Neutropenic Murine Model.
Current drug delivery.
2016; 13(2):255-64. doi:
10.2174/1567201812666150623091336. [PMID: 27146910] - Kiran Shekar, Jason A Roberts, Adrian G Barnett, Sara Diab, Steven C Wallis, Yoke L Fung, John F Fraser. Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models.
Critical care (London, England).
2015 Dec; 19(?):437. doi:
10.1186/s13054-015-1151-y. [PMID: 26667471] - Stefani S Griesser, Marek Jasieniak, Bryan R Coad, Hans J Griesser. Antifungal coatings by caspofungin immobilization onto biomaterials surfaces via a plasma polymer interlayer.
Biointerphases.
2015 Dec; 10(4):04A307. doi:
10.1116/1.4933108. [PMID: 26467660] - Petros Ioannou, Aggeliki Andrianaki, Tonia Akoumianaki, Irene Kyrmizi, Nathaniel Albert, David Perlin, George Samonis, Dimitrios P Kontoyiannis, Georgios Chamilos. Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae.
Antimicrobial agents and chemotherapy.
2015 Dec; 60(3):1226-33. doi:
10.1128/aac.02026-15. [PMID: 26643329] - A Forastiero, V Garcia-Gil, O Rivero-Menendez, R Garcia-Rubio, M C Monteiro, A Alastruey-Izquierdo, R Jordan, I Agorio, E Mellado. Rapid development of Candida krusei echinocandin resistance during caspofungin therapy.
Antimicrobial agents and chemotherapy.
2015 Nov; 59(11):6975-82. doi:
10.1128/aac.01005-15. [PMID: 26324281] - Raúl García, Javier Botet, José Manuel Rodríguez-Peña, Clara Bermejo, Juan Carlos Ribas, José Luis Revuelta, César Nombela, Javier Arroyo. Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature.
BMC genomics.
2015 Sep; 16(?):683. doi:
10.1186/s12864-015-1879-4. [PMID: 26341223] - Marianna Domán, Renátó Kovács, David S Perlin, Gábor Kardos, Rudolf Gesztelyi, Béla Juhász, Aliz Bozó, László Majoros. Dose escalation studies with caspofungin against Candida glabrata.
Journal of medical microbiology.
2015 Sep; 64(9):998-1007. doi:
10.1099/jmm.0.000116. [PMID: 26296340]