Lumefantrine (BioDeep_00000858389)
代谢物信息卡片
Lumefantrine
化学式: C30H32Cl3NO (527.1549352000001)
中文名称: 苯芴醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(CCCC)CC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O
InChI: InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:156095
- KEGGdrug: D03821
- PubChem: 6437380
- DrugBank: DB06708
- ChEMBL: CHEMBL38827
- MeSH: Lumefantrine
- CAS: 120583-71-3
- CAS: 204133-10-8
- CAS: 120583-70-2
- CAS: 120583-69-9
- CAS: 82186-77-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ellen K G Mhango, Benjamin R Sveinbjornsson, Bergthora S Snorradottir, Sveinbjorn Gizurarson. Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria.
Drug delivery.
2024 Dec; 31(1):2299594. doi:
10.1080/10717544.2023.2299594. [PMID: 38180033] - Camilla Valente Pires, Debora Cassandra, Shulin Xu, Benoit Laleu, Jeremy N Burrows, John H Adams. Oxidative stress changes the effectiveness of artemisinin in Plasmodium falciparum.
mBio.
2024 Mar; 15(3):e0316923. doi:
10.1128/mbio.03169-23. [PMID: 38323831] - Solomon E Owumi, Angel O Umez, Uche Arunsi, Chioma E Irozuru. Dietary aflatoxin B1 and antimalarial-a lumefantrine/artesunate-therapy perturbs male rat reproductive function via pro-inflammatory and oxidative mechanisms.
Scientific reports.
2023 07; 13(1):12172. doi:
10.1038/s41598-023-39455-1. [PMID: 37500724] - Dancan M Wakoli, Bartholomew N Ondigo, Douglas O Ochora, Joseph G Amwoma, Winnie Okore, Edwin W Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H Opot, Agnes C Cheruiyot, Dennis Juma, Amanda Roth, Benhards R Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M Akala. Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs.
BMC medicine.
2022 11; 20(1):448. doi:
10.1186/s12916-022-02652-2. [PMID: 36397090] - Sri Riyati Sugiarto, Balbir Singh, Madhu Page-Sharp, Wendy A Davis, Sam Salman, King Ching Hii, Timothy M E Davis. The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with Plasmodium knowlesi malaria.
British journal of clinical pharmacology.
2022 02; 88(2):691-701. doi:
10.1111/bcp.15001. [PMID: 34296469] - M Farouk Chughlay, Karen I Barnes, Myriam El Gaaloul, Nada Abla, Jörg J Möhrle, Paul Griffin, Paul van Giersbergen, Stephanie E Reuter, Hayley B Schultz, Anita Kress, Peter Tapley, Rebecca A Webster, Timothy Wells, James S McCarthy, Bridget E Barber, Louise Marquart, Michelle J Boyle, Christian R Engwerda, Stephan Chalon. Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Antimicrobial agents and chemotherapy.
2022 01; 66(1):e0158421. doi:
10.1128/aac.01584-21. [PMID: 34694880] - Ripandeep Kaur, Varun Gorki, O P Katare, Neelima Dhingra, Monika Chauhan, Ranjot Kaur, Niroshini Nirmalan, Bhupinder Singh. Improved biopharmaceutical attributes of lumefantrine using choline mimicking drug delivery system: preclinical investigation on NK-65 P.berghei murine model.
Expert opinion on drug delivery.
2021 10; 18(10):1533-1552. doi:
10.1080/17425247.2021.1946512. [PMID: 34176411] - Mathias Ahii Chia, Ilu Ameh, Jerry Tersoo Agee, Regina Anya Otogo, Ahmad Fatima Shaba, Hadiza Bashir, Fatima Umar, Abraham Gana Yisa, Ejiroghene Ebelechukwu Uyovbisere, Ramatu Idris Sha'aba. Effects of the antimalarial lumefantrine on Lemna minor, Raphidocelis subcapitata and Chlorella vulgaris.
Environmental toxicology and pharmacology.
2021 Jul; 85(?):103635. doi:
10.1016/j.etap.2021.103635. [PMID: 33716093] - Vaidevi Sethuraman, Kumar Janakiraman, Venkateshwaran Krishnaswami, Subramanian Natesan, Ruckmani Kandasamy. In vivo synergistic anti-tumor effect of lumefantrine combined with pH responsive behavior of nano calcium phosphate based lipid nanoparticles on lung cancer.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Mar; 158(?):105657. doi:
10.1016/j.ejps.2020.105657. [PMID: 33271276] - Kabiru Abubakar Musa, Nor Farrah Wahidah Ridzwan, Saharuddin B Mohamad, Saad Tayyab. Exploring the combination characteristics of lumefantrine, an antimalarial drug and human serum albumin through spectroscopic and molecular docking studies.
Journal of biomolecular structure & dynamics.
2021 Feb; 39(2):691-702. doi:
10.1080/07391102.2020.1713215. [PMID: 31913089] - Adebanjo J Adegbola, Julius O Soyinka, Oluseye O Bolaji. Effect of CYP3A5*3 genotypes on lumefantrine plasma concentrations among malaria-HIV-infected women.
Pharmacogenomics.
2020 12; 21(18):1289-1297. doi:
10.2217/pgs-2020-0081. [PMID: 33243092] - Sarah Aparecida Siqueira, Christian Fernandes, Isabela Costa César. Microextraction by packed sorbent and high performance liquid chromatography for simultaneous determination of lumefantrine and desbutyl-lumefantrine in plasma samples.
Journal of pharmaceutical and biomedical analysis.
2020 Oct; 190(?):113486. doi:
10.1016/j.jpba.2020.113486. [PMID: 32755807] - Vinay Kiran, Narayanan Balaji, Bhavesh Babulal Gabani, Manjuanth Bajantri, Rajesh Chandran, Abhishek Dixit, Nuggehally R Srinivas, Ramesh Mullangi. Enantioselective LC-ESI-MS/MS method for quantitation of (-)-lumefantrine and (+)-lumefantrine in mice plasma and application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2020 Sep; 34(9):e4879. doi:
10.1002/bmc.4879. [PMID: 32386241] - Christi A Wilkins, Lissinda H du Plessis, Joe M Viljoen. Characterization of solid lipid dispersions prepared by hot fusion containing a double-fixed dose combination of artemether and lumefantrine.
Drug development and industrial pharmacy.
2020 Aug; 46(8):1289-1297. doi:
10.1080/03639045.2020.1788065. [PMID: 32594776] - Manase Kilonzi, Omary Minzi, Ritah Mutagonda, Vito Baraka, Philip Sasi, Eleni Aklillu, Appolinary Kamuhabwa. Usefulness of day 7 lumefantrine plasma concentration as a predictor of malaria treatment outcome in under-fives children treated with artemether-lumefantrine in Tanzania.
Malaria journal.
2020 Feb; 19(1):66. doi:
10.1186/s12936-020-3150-y. [PMID: 32046718] - Palang Chotsiri, Lise Denoeud-Ndam, Elisabeth Baudin, Ousmane Guindo, Halimatou Diawara, Oumar Attaher, Michiel Smit, Philippe J Guerin, Ogobara K Doumbo, Lubbe Wiesner, Karen I Barnes, Richard M Hoglund, Alassane Dicko, Jean-Francois Etard, Joel Tarning. Severe Acute Malnutrition Results in Lower Lumefantrine Exposure in Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria.
Clinical pharmacology and therapeutics.
2019 12; 106(6):1299-1309. doi:
10.1002/cpt.1531. [PMID: 31152555] - Kashif Shakeel, Sheikh Raisuddin, Sadath Ali, Syed Sarim Imam, Md Akhlaquer Rahman, Gaurav Kumar Jain, Farhan Jalees Ahmad. Development and in vitro/in vivo evaluation of artemether and lumefantrine co-loaded nanoliposomes for parenteral delivery.
Journal of liposome research.
2019 Mar; 29(1):35-43. doi:
10.1080/08982104.2017.1410173. [PMID: 29179636] - Stephen I Walimbwa, Mohammed Lamorde, Catriona Waitt, Julian Kaboggoza, Laura Else, Pauline Byakika-Kibwika, Alieu Amara, Joshua Gini, Markus Winterberg, Justin Chiong, Joel Tarning, Saye H Khoo. Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine.
Antimicrobial agents and chemotherapy.
2019 02; 63(2):. doi:
10.1128/aac.01310-18. [PMID: 30420479] - Jesmin Lohy Das, Stephen Rulisa, Peter J de Vries, Petra F Mens, Nadine Kaligirwa, Steven Agaba, Joel Tarning, Mats O Karlsson, Thomas P C Dorlo. Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.00518-18. [PMID: 30061282] - Adebanjo Adegbola, Rana Abutaima, Adeniyi Olagunju, Omotade Ijarotimi, Marco Siccardi, Andrew Owen, Julius Soyinka, Oluseye Bolaji. Effect of Pregnancy on the Pharmacokinetic Interaction between Efavirenz and Lumefantrine in HIV-Malaria Coinfection.
Antimicrobial agents and chemotherapy.
2018 10; 62(10):. doi:
10.1128/aac.01252-18. [PMID: 30082286] - Yinxian Yang, Hailing Gao, Shuang Zhou, Xiao Kuang, Zhenjie Wang, Hongzhuo Liu, Jin Sun. Optimization and evaluation of lipid emulsions for intravenous co-delivery of artemether and lumefantrine in severe malaria treatment.
Drug delivery and translational research.
2018 10; 8(5):1171-1179. doi:
10.1007/s13346-018-0537-1. [PMID: 29748832] - Pedro Henrique Reis da Silva, Melina Luiza Vieira Diniz, Gerson Antônio Pianetti, Isabela da Costa César, Maria Elisa Scarpelli Ribeiro E Silva, Roberto Fernando de Souza Freitas, Ricardo Geraldo de Sousa, Christian Fernandes. Molecularly imprinted polymer for determination of lumefantrine in human plasma through chemometric-assisted solid-phase extraction and liquid chromatography.
Talanta.
2018 Jul; 184(?):173-183. doi:
10.1016/j.talanta.2018.02.090. [PMID: 29674030] - Zaril Zakaria, Raj K S Badhan. The impact of CYP2B6 polymorphisms on the interactions of efavirenz with lumefantrine: Implications for paediatric antimalarial therapy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Jul; 119(?):90-101. doi:
10.1016/j.ejps.2018.04.012. [PMID: 29635009] - Yinxian Yang, Hailing Gao, Shanshan Hou, Ruijuan Su, Hongzhuo Liu, Jin Sun. A sensitive, high-throughput, and ecofriendly method for the determination of lumefantrine, artemether, and its active metabolite dihydroartemisinin by supercritical fluid chromatography and tandem mass spectrometry.
Journal of separation science.
2018 Jun; 41(12):2688-2696. doi:
10.1002/jssc.201800025. [PMID: 29660250] - Joanna Gallay, Sylvain Prod'hom, Thomas Mercier, Carine Bardinet, Dany Spaggiari, Emilie Pothin, Thierry Buclin, Blaise Genton, Laurent Arthur Decosterd. LC-MS/MS method for the simultaneous analysis of seven antimalarials and two active metabolites in dried blood spots for applications in field trials: Analytical and clinical validation.
Journal of pharmaceutical and biomedical analysis.
2018 May; 154(?):263-277. doi:
10.1016/j.jpba.2018.01.017. [PMID: 29579633] - Chihiro Hasegawa, Masaharu Kudo, Haruhiko Maruyama, Mikio Kimura. Severe delayed haemolytic anaemia associated with artemether-lumefantrine treatment of malaria in a Japanese traveller.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2018 Mar; 24(3):216-219. doi:
10.1016/j.jiac.2017.10.008. [PMID: 29127021] - Liusheng Huang, Norah Mwebaza, Richard Kajubi, Florence Marzan, Camilla Forsman, Sunil Parikh, Francesca T Aweeka. Strong correlation of lumefantrine concentrations in capillary and venous plasma from malaria patients.
PloS one.
2018; 13(8):e0202082. doi:
10.1371/journal.pone.0202082. [PMID: 30114201] - Arnold Donkor Forkuo, Charles Ansah, Kwesi Boadu Mensah, Kofi Annan, Ben Gyan, Anjo Theron, Dalu Mancama, Colin W Wright. In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine.
Malaria journal.
2017 12; 16(1):496. doi:
10.1186/s12936-017-2142-z. [PMID: 29282057] - Sandra Duffy, Vicky M Avery. Plasmodium falciparum in vitro continuous culture conditions: A comparison of parasite susceptibility and tolerance to anti-malarial drugs throughout the asexual intra-erythrocytic life cycle.
International journal for parasitology. Drugs and drug resistance.
2017 12; 7(3):295-302. doi:
10.1016/j.ijpddr.2017.07.001. [PMID: 28738214] - Ritah F Mutagonda, Appolinary A R Kamuhabwa, Omary M S Minzi, Siriel N Massawe, Muhammad Asghar, Manijeh V Homann, Anna Färnert, Eleni Aklillu. Effect of pharmacogenetics on plasma lumefantrine pharmacokinetics and malaria treatment outcome in pregnant women.
Malaria journal.
2017 07; 16(1):267. doi:
10.1186/s12936-017-1914-9. [PMID: 28673292] - Norah Mwebaza, Markus Jerling, Lars L Gustafsson, Antero V Silva, Anton Pohanka, Celestino Obua, Paul Waako, Olof Beck, Manijeh Vafa Homann, Anna Färnert, Urban Hellgren. Oil-Fortified Maize Porridge Increases Absorption of Lumefantrine in Children with Uncomplicated Falciparum Malaria.
Basic & clinical pharmacology & toxicology.
2017 May; 120(5):457-465. doi:
10.1111/bcpt.12714. [PMID: 27883269] - Anuj Garg, Kripal Bhalala, Devendra Singh Tomar, Wahajuddin. In-situ single pass intestinal permeability and pharmacokinetic study of developed Lumefantrine loaded solid lipid nanoparticles.
International journal of pharmaceutics.
2017 Jan; 516(1-2):120-130. doi:
10.1016/j.ijpharm.2016.10.064. [PMID: 27989820] - Liusheng Huang, Vincent Carey, Jane C Lindsey, Florence Marzan, David Gingrich, Bobbie Graham, Linda Barlow-Mosha, Phionah K Ssemambo, Portia Kamthunzi, Sharon Nachman, Sunil Parikh, Francesca T Aweeka. Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children.
PloS one.
2017; 12(10):e0186589. doi:
10.1371/journal.pone.0186589. [PMID: 29065172] - Justin A Green, Khadeeja Mohamed, Navin Goyal, Samia Bouhired, Azra Hussaini, Siôn W Jones, Gavin C K W Koh, Ivan Kostov, Maxine Taylor, Allen Wolstenholm, Stephan Duparc. Pharmacokinetic Interactions between Tafenoquine and Dihydroartemisinin-Piperaquine or Artemether-Lumefantrine in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2016 12; 60(12):7321-7332. doi:
10.1128/aac.01588-16. [PMID: 27697758] - Robert L Clark, Maureen Youreneff, Anthony M DeLise. Developmental toxicity studies of lumefantrine and artemether in rats and rabbits.
Birth defects research. Part B, Developmental and reproductive toxicology.
2016 Dec; 107(6):243-257. doi:
10.1002/bdrb.21189. [PMID: 28032463] - Chinazom Agbo, Chukwuebuka Umeyor, Franklin Kenechukwu, John Ogbonna, Salome Chime, Charles Lovelyn, Obumneme Agubata, Kenneth Ofokansi, Anthony Attama. Formulation design, in vitro characterizations and anti-malarial investigations of artemether and lumefantrine-entrapped solid lipid microparticles.
Drug development and industrial pharmacy.
2016 Oct; 42(10):1708-21. doi:
10.3109/03639045.2016.1171331. [PMID: 27095388] - Priyanka Prabhu, Shital Suryavanshi, Sulabha Pathak, Shobhona Sharma, Vandana Patravale. Artemether-lumefantrine nanostructured lipid carriers for oral malaria therapy: Enhanced efficacy at reduced dose and dosing frequency.
International journal of pharmaceutics.
2016 Sep; 511(1):473-487. doi:
10.1016/j.ijpharm.2016.07.021. [PMID: 27421912] - B A Maganda, O M S Minzi, E Ngaimisi, A A R Kamuhabwa, E Aklillu. CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients.
The pharmacogenomics journal.
2016 Feb; 16(1):88-95. doi:
10.1038/tpj.2015.37. [PMID: 25963334] - Deepa Parashar, N P Aditya, R S R Murthy. Development of artemether and lumefantrine co-loaded nanostructured lipid carriers: physicochemical characterization and in vivo antimalarial activity.
Drug delivery.
2016; 23(1):123-9. doi:
10.3109/10717544.2014.905883. [PMID: 24786480] - Isha Taneja, Kanumuri Siva Rama Raju, Sheelendra Pratap Singh, Muhammad Wahajuddin. Assessment of pharmacokinetic compatibility of short acting CDRI candidate trioxane derivative, 99-411, with long acting prescription antimalarials, lumefantrine and piperaquine.
Scientific reports.
2015 Nov; 5(?):17264. doi:
10.1038/srep17264. [PMID: 26602250] - A V Silva, N Mwebaza, M Ntale, L L Gustafsson, A Pohanka. A fast and sensitive method for quantifying lumefantrine and desbutyl-lumefantrine using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Nov; 1004(?):60-6. doi:
10.1016/j.jchromb.2015.09.027. [PMID: 26447936] - Frank Kloprogge, Rose McGready, Warunee Hanpithakpong, Daniel Blessborn, Nicholas P J Day, Nicholas J White, François Nosten, Joel Tarning. Lumefantrine and Desbutyl-Lumefantrine Population Pharmacokinetic-Pharmacodynamic Relationships in Pregnant Women with Uncomplicated Plasmodium falciparum Malaria on the Thailand-Myanmar Border.
Antimicrobial agents and chemotherapy.
2015 Oct; 59(10):6375-84. doi:
10.1128/aac.00267-15. [PMID: 26239986] - NULL. Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data.
BMC medicine.
2015 Sep; 13(?):227. doi:
10.1186/s12916-015-0456-7. [PMID: 26381375] - Quique Bassat, Bernhards Ogutu, Abdoulaye Djimde, Kirstin Stricker, Kamal Hamed. Tailoring a Pediatric Formulation of Artemether-Lumefantrine for Treatment of Plasmodium falciparum Malaria.
Antimicrobial agents and chemotherapy.
2015 Aug; 59(8):4366-74. doi:
10.1128/aac.00014-15. [PMID: 26014953] - Murat Yalçın, Erol Sevim, Arzu Duran. [Treated with Artemether-Lumefantrine Five Evaluation of P. Falciparum Malaria Cases in Terms of Hyponatremia and Thrombocytopenia].
Turkiye parazitolojii dergisi.
2015 Jun; 39(2):155-8. doi:
10.5152/tpd.2015.3520. [PMID: 26081891] - Sai Sandeep Mannemala, Janaki Sankarachari Krishnan Nagarajan. Development and validation of a generic liquid chromatographic method for the simultaneous determination of five commonly used antimalarial drugs: Application to pharmaceutical formulations and human plasma.
Journal of separation science.
2015 May; 38(9):1521-8. doi:
10.1002/jssc.201401465. [PMID: 25694118] - Betty A Maganda, Eliford Ngaimisi, Appolinary A R Kamuhabwa, Eleni Aklillu, Omary M S Minzi. The influence of nevirapine and efavirenz-based anti-retroviral therapy on the pharmacokinetics of lumefantrine and anti-malarial dose recommendation in HIV-malaria co-treatment.
Malaria journal.
2015 Apr; 14(?):179. doi:
10.1186/s12936-015-0695-2. [PMID: 25906774] - Muhammad Wahajuddin, Sheelendra P Singh, Isha Taneja, Kanumuri S R Raju, Jiaur R Gayen, Hefazat H Siddiqui, Shio K Singh. Simultaneous quantification of proposed anti-malarial combination comprising of lumefantrine and CDRI 97-78 in rat plasma using the HPLC-ESI-MS/MS method: application to drug interaction study.
Malaria journal.
2015 Apr; 14(?):172. doi:
10.1186/s12936-015-0684-5. [PMID: 25895956] - Katya Govender, Liezl Gibhard, Lissinda Du Plessis, Lubbe Wiesner. Development and validation of a LC-MS/MS method for the quantitation of lumefantrine in mouse whole blood and plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Mar; 985(?):6-13. doi:
10.1016/j.jchromb.2015.01.015. [PMID: 25647340] - Yufan Ma, Tingli Lu, Wen Zhao, Ying Wang, Ting Chen, Qibing Mei, Tao Chen. Enhanced antimalarial activity by a novel artemether-lumefantrine lipid emulsion for parenteral administration.
Antimicrobial agents and chemotherapy.
2014 Oct; 58(10):5658-65. doi:
10.1128/aac.01428-13. [PMID: 24982079] - Jérome Dormoi, Hélène Savini, Rémy Amalvict, Eric Baret, Bruno Pradines. In vitro interaction of lumefantrine and piperaquine by atorvastatin against Plasmodium falciparum.
Malaria journal.
2014 May; 13(?):189. doi:
10.1186/1475-2875-13-189. [PMID: 24886347] - Camille Desgrouas, Jérôme Dormoi, Charles Chapus, Evelyne Ollivier, Daniel Parzy, Nicolas Taudon. In vitro and in vivo combination of cepharanthine with anti-malarial drugs.
Malaria journal.
2014 Mar; 13(?):90. doi:
10.1186/1475-2875-13-90. [PMID: 24618129] - Fazli Khuda, Zafar Iqbal, Yasar Shah, Lateef Ahmmad, Fazli Nasir, Amir Zada Khan, Amanullah, Naila Shahbaz. Method development and validation for simultaneous determination of lumefantrine and its major metabolite, desbutyl lumefantrine in human plasma using RP-HPLC/UV detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jan; 944(?):114-22. doi:
10.1016/j.jchromb.2013.10.037. [PMID: 24316521] - Sushant Patil, Shital Suryavanshi, Sulabha Pathak, Shobhona Sharma, Vandana Patravale. Evaluation of novel lipid based formulation of β-Artemether and Lumefantrine in murine malaria model.
International journal of pharmaceutics.
2013 Oct; 455(1-2):229-34. doi:
10.1016/j.ijpharm.2013.07.033. [PMID: 23886650] - H Orth, B O Jensen, M C Holtfreter, S J Kocheril, S Mallach, C MacKenzie, I Müller-Stöver, B Henrich, M Imwong, N J White, D Häussinger, J Richter. Plasmodium knowlesi infection imported to Germany, January 2013.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.
2013 Oct; 18(40):. doi:
10.2807/1560-7917.es2013.18.40.20603. [PMID: 24128698] - T N Kakuda, R DeMasi, Y van Delft, P Mohammed. Pharmacokinetic interaction between etravirine or darunavir/ritonavir and artemether/lumefantrine in healthy volunteers: a two-panel, two-way, two-period, randomized trial.
HIV medicine.
2013 Aug; 14(7):421-9. doi:
10.1111/hiv.12019. [PMID: 23441978] - Omary M S Minzi, Ignace A Marealle, Seif Shekalaghe, Omar Juma, Eliford Ngaimisi, Mwajuma Chemba, Mastidia Rutaihwa, Salim Abdulla, Philip Sasi. Comparison of bioavailability between the most available generic tablet formulation containing artemether and lumefantrine on the Tanzanian market and the innovator's product.
Malaria journal.
2013 May; 12(?):174. doi:
10.1186/1475-2875-12-174. [PMID: 23718725] - Betty Maganda, Olivier Heudi, Agnes Cortinovis, Franck Picard, Olivier Kretz, Omary Minzi. A fast and reliable reversed phase high performance liquid chromatography method for simultaneous determination of selected anti-retroviral and lumefantrine in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Mar; 919-920(?):52-60. doi:
10.1016/j.jchromb.2013.01.009. [PMID: 23411019] - A O Abolaji, M U Eteng, O Omonua, Y Adenrele. Influence of coadministration of artemether and lumefantrine on selected plasma biochemical and erythrocyte oxidative stress indices in female Wistar rats.
Human & experimental toxicology.
2013 Feb; 32(2):206-15. doi:
10.1177/0960327112464666. [PMID: 23155202] - Joel Tarning, Frank Kloprogge, Patrice Piola, Mehul Dhorda, Sulaiman Muwanga, Eleanor Turyakira, Nitra Nuengchamnong, François Nosten, Nicholas P J Day, Nicholas J White, Philippe J Guerin, Niklas Lindegardh. Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
Malaria journal.
2012 Aug; 11(?):293. doi:
10.1186/1475-2875-11-293. [PMID: 22913677] - Syed Ahmed Zaki, Preeti Shanbag. Increased urinary frequency: an unusual presentation of Plasmodium falciparum malaria.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia.
2012 Jul; 23(4):844-5. doi:
10.4103/1319-2442.98182. [PMID: 22805407] - Kesinee Chotivanich, Mathirut Mungthin, Ronnatrai Ruengweerayuth, Rachanee Udomsangpetch, Arjen M Dondorp, Pratap Singhasivanon, Sasithon Pukrittayakamee, Nicholas J White. The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.
Malaria journal.
2012 May; 11(?):177. doi:
10.1186/1475-2875-11-177. [PMID: 22640826] - Liusheng Huang, Xiaohua Li, Florence Marzan, Patricia S Lizak, Francesca T Aweeka. Determination of lumefantrine in small-volume human plasma by LC-MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturation.
Bioanalysis.
2012 Jan; 4(2):157-66. doi:
10.4155/bio.11.303. [PMID: 22250798] - Sophie H Adjalley, Geoffrey L Johnston, Tao Li, Richard T Eastman, Eric H Ekland, Abraham G Eappen, Adam Richman, B Kim Lee Sim, Marcus C S Lee, Stephen L Hoffman, David A Fidock. Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Nov; 108(47):E1214-23. doi:
10.1073/pnas.1112037108. [PMID: 22042867] - Sam Salman, Madhu Page-Sharp, Susan Griffin, Kaye Kose, Peter M Siba, Kenneth F Ilett, Ivo Mueller, Timothy M E Davis. Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malaria.
Antimicrobial agents and chemotherapy.
2011 Nov; 55(11):5306-13. doi:
10.1128/aac.05136-11. [PMID: 21876056] - Wahajuddin, Sheelendra P Singh, Kanumuri S R Raju, Asad Nafis, Sunil K Puri, Girish K Jain. Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats.
Malaria journal.
2011 Oct; 10(?):293. doi:
10.1186/1475-2875-10-293. [PMID: 21985153] - Abdoulaye A Djimdé, Mamadou Tekete, Salim Abdulla, John Lyimo, Quique Bassat, Inacio Mandomando, Gilbert Lefèvre, Steffen Borrmann. Pharmacokinetic and pharmacodynamic characteristics of a new pediatric formulation of artemether-lumefantrine in African children with uncomplicated Plasmodium falciparum malaria.
Antimicrobial agents and chemotherapy.
2011 Sep; 55(9):3994-9. doi:
10.1128/aac.01115-10. [PMID: 21670177] - Timothy William, Jayaram Menon, Giri Rajahram, Leslie Chan, Gordon Ma, Samantha Donaldson, Serena Khoo, Charlie Frederick, Jenarun Jelip, Nicholas M Anstey, Tsin Wen Yeo. Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia.
Emerging infectious diseases.
2011 Jul; 17(7):1248-55. doi:
10.3201/eid1707.101017. [PMID: 21762579] - Rina P M Wong, Sam Salman, Kenneth F Ilett, Peter M Siba, Ivo Mueller, Timothy M E Davis. Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome.
Antimicrobial agents and chemotherapy.
2011 Mar; 55(3):1194-8. doi:
10.1128/aac.01312-10. [PMID: 21199927] - Isabela Costa César, José Antônio de Aquino Ribeiro, Leonardo de Souza Teixeira, Karini Bruno Bellorio, Fernanda Crunivel de Abreu, Josianny Mesquita Moreira, Paula Rocha Chellini, Gerson Antônio Pianetti. Liquid chromatography-tandem mass spectrometry for the simultaneous quantitation of artemether and lumefantrine in human plasma: application for a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2011 Jan; 54(1):114-20. doi:
10.1016/j.jpba.2010.07.027. [PMID: 20719459] - Insaf F Khalil, Ulla Abildrup, Lene H Alifrangis, Deogratius Maiga, Michael Alifrangis, Lotte Hoegberg, Lasse S Vestergaard, Ola Per-Eric Persson, Nyagonde Nyagonde, Martha M Lemnge, Thor G Theander, Ib C Bygbjerg. Measurement of lumefantrine and its metabolite in plasma by high performance liquid chromatography with ultraviolet detection.
Journal of pharmaceutical and biomedical analysis.
2011 Jan; 54(1):168-72. doi:
10.1016/j.jpba.2010.08.009. [PMID: 20832961] - Steffen Borrmann, William M Sallas, Sonia Machevo, Raquel González, Anders Björkman, Andreas Mårtensson, Mary Hamel, Elizabeth Juma, Judy Peshu, Bernhards Ogutu, Abdoulaye Djimdé, Umberto D'Alessandro, Anne-Claire Marrast, Gilbert Lefèvre, Steven E Kern. The effect of food consumption on lumefantrine bioavailability in African children receiving artemether-lumefantrine crushed or dispersible tablets (Coartem) for acute uncomplicated Plasmodium falciparum malaria.
Tropical medicine & international health : TM & IH.
2010 Apr; 15(4):434-41. doi:
10.1111/j.1365-3156.2010.02477.x. [PMID: 20180933] - Julia Mwesigwa, Sunil Parikh, Bryan McGee, Polina German, Troy Drysdale, Joan N Kalyango, Tamara D Clark, Grant Dorsey, Niklas Lindegardh, Anna Annerberg, Philip J Rosenthal, Moses R Kamya, Francesca Aweeka. Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda.
Antimicrobial agents and chemotherapy.
2010 Jan; 54(1):52-9. doi:
10.1128/aac.00679-09. [PMID: 19841149] - Joel Tarning, Rose McGready, Niklas Lindegardh, Elizabeth A Ashley, Mupawjay Pimanpanarak, Benjamas Kamanikom, Anna Annerberg, Nicholas P J Day, Kasia Stepniewska, Pratap Singhasivanon, Nicholas J White, François Nosten. Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.
Antimicrobial agents and chemotherapy.
2009 Sep; 53(9):3837-46. doi:
10.1128/aac.00195-09. [PMID: 19564366] - Polina German, Sunil Parikh, Jody Lawrence, Grant Dorsey, Philip J Rosenthal, Diane Havlir, Edwin Charlebois, Warunee Hanpithakpong, Niklas Lindegardh, Francesca T Aweeka. Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers.
Journal of acquired immune deficiency syndromes (1999).
2009 Aug; 51(4):424-9. doi:
10.1097/qai.0b013e3181acb4ff. [PMID: 19506482] - Quirijn de Mast, Edmee C van Dongen-Lases, Dorine W Swinkels, An-Emmie Nieman, Meta Roestenberg, Pierre Druilhe, Theo A Arens, Adrian J Luty, Cornelis C Hermsen, Robert W Sauerwein, Andre J van der Ven. Mild increases in serum hepcidin and interleukin-6 concentrations impair iron incorporation in haemoglobin during an experimental human malaria infection.
British journal of haematology.
2009 Jun; 145(5):657-64. doi:
10.1111/j.1365-2141.2009.07664.x. [PMID: 19344417] - Wahajuddin, Sheelendra Pratap Singh, Girish Kumar Jain. Determination of lumefantrine in rat plasma by liquid-liquid extraction using LC-MS/MS with electrospray ionization: assay development, validation and application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Apr; 877(11-12):1133-9. doi:
10.1016/j.jchromb.2009.02.058. [PMID: 19285925] - Warunee Hanpithakpong, Benjamas Kamanikom, Pratap Singhasivanon, Nicholas J White, Nicholas Pj Day, Niklas Lindegardh. A liquid chromatographic-tandem mass spectrometric method for determination of artemether and its metabolite dihydroartemisinin in human plasma.
Bioanalysis.
2009 Apr; 1(1):37-46. doi:
10.4155/bio.09.6. [PMID: 21083186] - Md Mushfiqur Rahman, Arjen M Dondorp, Nicholas P J Day, Niklas Lindegardh, Mallika Imwong, M A Faiz, A Mannan Bangali, A T M Mustafa Kamal, Jahirul Karim, Jaranit Kaewkungwal, Pratap Singhasivanon. Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomised controlled trial.
Transactions of the Royal Society of Tropical Medicine and Hygiene.
2008 Sep; 102(9):861-7. doi:
10.1016/j.trstmh.2008.05.022. [PMID: 18606428] - L G Visser, P Berger, Hartigh J den, J W van Wout. [Treatment of falciparum malaria with artemether-lumefantrine according to a 5-day schedule: results of a study in 21 patients and recommendations].
Nederlands tijdschrift voor geneeskunde.
2007 Oct; 151(40):2208-13. doi:
NULL. [PMID: 17969572] - Elizabeth A Ashley, Kasia Stepniewska, Niklas Lindegårdh, Rose McGready, Anna Annerberg, Robert Hutagalung, Thida Singtoroj, Gilvary Hla, Al Brockman, Stephane Proux, Jahser Wilahphaingern, Pratap Singhasivanon, Nicholas J White, François Nosten. Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malaria.
Tropical medicine & international health : TM & IH.
2007 Feb; 12(2):201-8. doi:
10.1111/j.1365-3156.2006.01785.x. [PMID: 17300626] - Elizabeth A Ashley, Kasia Stepniewska, Niklas Lindegårdh, Anna Annerberg, Am Kham, Al Brockman, Pratap Singhasivanon, Nicholas J White, François Nosten. How much fat is necessary to optimize lumefantrine oral bioavailability?.
Tropical medicine & international health : TM & IH.
2007 Feb; 12(2):195-200. doi:
10.1111/j.1365-3156.2006.01784.x. [PMID: 17300625] - Gilbert Kokwaro, Leah Mwai, Alexis Nzila. Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria.
Expert opinion on pharmacotherapy.
2007 Jan; 8(1):75-94. doi:
10.1517/14656566.8.1.75. [PMID: 17163809] - Rose McGready, Kasia Stepniewska, Niklas Lindegardh, Elizabeth A Ashley, Yar La, Pratap Singhasivanon, Nicholas J White, François Nosten. The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
European journal of clinical pharmacology.
2006 Dec; 62(12):1021-31. doi:
10.1007/s00228-006-0199-7. [PMID: 17053895] - Mey Bouth Denis, Reiko Tsuyuoka, Pharath Lim, Niklas Lindegardh, Poravuth Yi, Sophoan Narann Top, Duong Socheat, Thierry Fandeur, Anna Annerberg, Eva Maria Christophel, Pascal Ringwald. Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.
Tropical medicine & international health : TM & IH.
2006 Dec; 11(12):1800-7. doi:
10.1111/j.1365-3156.2006.01739.x. [PMID: 17176344] - Francesco Checchi, Patrice Piola, Carole Fogg, Francis Bajunirwe, Samuel Biraro, Francesco Grandesso, Eugene Ruzagira, Joseph Babigumira, Isaac Kigozi, James Kiguli, Juliet Kyomuhendo, Laurent Ferradini, Walter R J Taylor, Jean-Paul Guthmann. Supervised versus unsupervised antimalarial treatment with six-dose artemether-lumefantrine: pharmacokinetic and dosage-related findings from a clinical trial in Uganda.
Malaria journal.
2006 Jul; 5(?):59. doi:
10.1186/1475-2875-5-59. [PMID: 16854236] - Ric N Price, Anne-Catrin Uhlemann, Michele van Vugt, Al Brockman, Robert Hutagalung, Shalini Nair, Denae Nash, Pratap Singhasivanon, Tim J C Anderson, Sanjeev Krishna, Nicholas J White, François Nosten. Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2006 Jun; 42(11):1570-7. doi:
10.1086/503423. [PMID: 16652314] - A Annerberg, T Singtoroj, P Tipmanee, N J White, N P J Day, N Lindegårdh. High throughput assay for the determination of lumefantrine in plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Aug; 822(1-2):330-3. doi:
10.1016/j.jchromb.2005.06.022. [PMID: 16005694] - N Lindegårdh, A Annerberg, D Blessborn, Y Bergqvist, N Day, N J White. Development and validation of a bioanalytical method using automated solid-phase extraction and LC-UV for the simultaneous determination of lumefantrine and its desbutyl metabolite in plasma.
Journal of pharmaceutical and biomedical analysis.
2005 Apr; 37(5):1081-8. doi:
10.1016/j.jpba.2004.07.041. [PMID: 15862688] - Mayfong Mayxay, Maniphone Khanthavong, Niklas Lindegårdh, Siamphay Keola, Marion Barends, Tiengkham Pongvongsa, Ratsuda Yapom, Anna Annerberg, Samlane Phompida, Rattanaxay Phetsouvanh, Nicholas J White, Paul N Newton. Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2004 Oct; 39(8):1139-47. doi:
10.1086/424512. [PMID: 15486837] - Jochen Wiesner, Regina Ortmann, Hassan Jomaa, Martin Schlitzer. New antimalarial drugs.
Angewandte Chemie (International ed. in English).
2003 Nov; 42(43):5274-93. doi:
10.1002/anie.200200569. [PMID: 14613157] - Mei-Lin Go, Qiu-Tian Li. Interaction of the antimalarial agents halofantrine and lumefantrine with lipid bilayers.
Chemical & pharmaceutical bulletin.
2003 Mar; 51(3):241-6. doi:
10.1248/cpb.51.241. [PMID: 12612404] - Gilbert Lefèvre, Polly Carpenter, Claire Souppart, Heinz Schmidli, John M Martin, Andrew Lane, Chris Ward, Dereck Amakye. Interaction trial between artemether-lumefantrine (Riamet) and quinine in healthy subjects.
Journal of clinical pharmacology.
2002 Oct; 42(10):1147-58. doi:
10.1177/009127002401382632. [PMID: 12362930] - G Lefèvre, S Looareesuwan, S Treeprasertsuk, S Krudsood, U Silachamroon, I Gathmann, R Mull, R Bakshi. A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand.
The American journal of tropical medicine and hygiene.
2001 May; 64(5-6):247-56. doi:
10.4269/ajtmh.2001.64.247. [PMID: 11463111] - F Ezzet, M van Vugt, F Nosten, S Looareesuwan, N J White. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria.
Antimicrobial agents and chemotherapy.
2000 Mar; 44(3):697-704. doi:
10.1128/aac.44.3.697-704.2000. [PMID: 10681341] - M van Vugt, F Ezzet, F Nosten, I Gathmann, P Wilairatana, S Looareesuwan, N J White. No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine.
The American journal of tropical medicine and hygiene.
1999 Dec; 61(6):964-7. doi:
10.4269/ajtmh.1999.61.964. [PMID: 10674679] - D Colussi, C Parisot, F Legay, G Lefèvre. Binding of artemether and lumefantrine to plasma proteins and erythrocytes.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
1999 Oct; 9(1):9-16. doi:
10.1016/s0928-0987(99)00037-8. [PMID: 10493991] - N J White, M van Vugt, F Ezzet. Clinical pharmacokinetics and pharmacodynamics and pharmacodynamics of artemether-lumefantrine.
Clinical pharmacokinetics.
1999 Aug; 37(2):105-25. doi:
10.2165/00003088-199937020-00002. [PMID: 10496300] - K Na-Bangchang, J Karbwang, U Tasanor, A Thanavibul, E Farkad, R Mull. Pharmacokinetics of benflumetol given as a fixed combination artemether-benflumetol (CGP 56697) in Thai patients with uncomplicated falciparum malaria.
International journal of clinical pharmacology research.
1999; 19(2):41-6. doi:
NULL. [PMID: 10669897]