dimethyl maleate (BioDeep_00000858356)
Main id: BioDeep_00000026546
PANOMIX_OTCML-2023
代谢物信息卡片
Dimethyl fumarate
化学式: C6H8O4 (144.0422568)
中文名称: 顺丁烯二甲酸二甲酯, 富马酸二甲酯, 马来酸二甲酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C/C(=C(\C)/C(=O)O)/C(=O)O
InChI: InChI=1S/C6H8O4/c1-9-5(7)3-4-6(8)10-2/h3-4H,1-2H3/b4-3+
描述信息
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants
COVID info from COVID-19 Disease Map, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78284 - Agent Affecting Integumentary System > C29708 - Anti-psoriatic Agent
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent
D011838 - Radiation-Sensitizing Agents
D003879 - Dermatologic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:35460
- ChEBI: CHEBI:76004
- KEGGdrug: D03846
- PubChem: 5271565
- PubChem: 637568
- DrugBank: DB08908
- ChEMBL: CHEMBL2259700
- ChEMBL: CHEMBL2107333
- MeSH: Dimethyl Fumarate
- CAS: 624-48-6
- CAS: 23055-10-9
- CAS: 12287-98-8
- CAS: 624-49-7
- RefMet: Dimethyl maleate
- medchemexpress: HY-17363
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rui Zhang, Quanwei Zhang, ZiYi Cui, BenZeng Huang, Haitian Ma. Dimethyl fumarate restores Ca2+ dyshomeostasis through activation of the SIRT1 signal to treat nonalcoholic fatty liver disease.
Life sciences.
2024 Mar; 341(?):122505. doi:
10.1016/j.lfs.2024.122505. [PMID: 38364937] - Regina Viana de Carvalho Faria, Matheus Silva Duarte, Jeane de Souza Nogueira, Bianca Martins Gregório, Bruna Romana-Souza. Nrf2 activation by hydroxytyrosol and dimethyl fumarate ameliorates skin tissue repair in high-fat diet-fed mice by promoting M2 macrophage polarization and normalizing inflammatory response and oxidative damage.
Journal of biochemical and molecular toxicology.
2024 Feb; 38(2):e23652. doi:
10.1002/jbt.23652. [PMID: 38348708] - Sreya Subhash, Nishtha Chaurawal, Kaisar Raza. Promises of Lipid-Based Nanocarriers for Delivery of Dimethyl Fumarate to Multiple Sclerosis Brain.
Methods in molecular biology (Clifton, N.J.).
2024; 2761(?):457-475. doi:
10.1007/978-1-0716-3662-6_31. [PMID: 38427255] - Hossein Babaei, Alireza Kheirollah, Mina Ranjbaran, Maryam Cheraghzadeh, Alireza Sarkaki, Maryam Adelipour. Preconditioning adipose-derived mesenchymal stem cells with dimethyl fumarate promotes their therapeutic efficacy in the brain tissues of rats with Alzheimer's disease.
Biochemical and biophysical research communications.
2023 09; 672(?):120-127. doi:
10.1016/j.bbrc.2023.06.045. [PMID: 37348174] - Nizameddin Koca, Meral Seferoğlu. Effects of disease-modifying therapies on lipid parameters in patients with multiple sclerosis.
Multiple sclerosis and related disorders.
2023 Sep; 77(?):104876. doi:
10.1016/j.msard.2023.104876. [PMID: 37423049] - Shiva Saljoughi, Hadi Kalantar, Reza Azadnasab, Mohammad Javad Khodayar. Neuroprotective effects of dimethyl fumarate against manic-like behavior induced by ketamine in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Apr; ?(?):. doi:
10.1007/s00210-023-02505-6. [PMID: 37103520] - Mariaconcetta Sicurella, Walter Pula, Karolina Musiał, Katarzyna Cieślik-Boczula, Maddalena Sguizzato, Agnese Bondi, Markus Drechsler, Leda Montesi, Elisabetta Esposito, Peggy Marconi. Ethosomal Gel for Topical Administration of Dimethyl Fumarate in the Treatment of HSV-1 Infections.
International journal of molecular sciences.
2023 Feb; 24(4):. doi:
10.3390/ijms24044133. [PMID: 36835541] - He Fang, Xingtong Wang, Mahendra Damarla, Rongju Sun, Qingli He, Ruojing Li, Pengfei Luo, Jun O Liu, Zhaofan Xia. Dimethyl Fumarate Protects against Lipopolysaccharide- (LPS-) Induced Sepsis through Inhibition of NF-κB Pathway in Mice.
Mediators of inflammation.
2023; 2023(?):5133505. doi:
10.1155/2023/5133505. [PMID: 37840694] - Debin Qi, Peng Chen, Haili Bao, Lei Zhang, Keyan Sun, Shaohua Song, Tao Li. Dimethyl fumarate protects against hepatic ischemia-reperfusion injury by alleviating ferroptosis via the NRF2/SLC7A11/HO-1 axis.
Cell cycle (Georgetown, Tex.).
2022 Dec; ?(?):1-11. doi:
10.1080/15384101.2022.2155016. [PMID: 36482709] - Maria Assunta Lacavalla, Chiara Rita Inguscio, Barbara Cisterna, Paolo Bernardi, Manuela Costanzo, Mirco Galiè, Ilaria Scambi, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta. Ozone at low concentration modulates microglial activity in vitro: A multimodal microscopy and biomolecular study.
Microscopy research and technique.
2022 Dec; 85(12):3777-3792. doi:
10.1002/jemt.24233. [PMID: 36131631] - Shuang Guan, Ranran Zhang, Yanan Zhao, Zhuoqun Meng, Jing Lu. 1,3-Dichloro-2-propanol induced ferroptosis through Nrf2/ARE signaling pathway in hepatocytes.
Environmental toxicology.
2022 Oct; 37(10):2515-2528. doi:
10.1002/tox.23615. [PMID: 35870111] - Gisela Bevilacqua Rolfsen Ferreira da Silva, Sofia Pereira das Neves, Susana Cristina Roque Oliveira, Fernanda Marques, Anselmo Gomes de Oliveira, Fábio de Lima Leite, João José Cerqueira. Comparative effectiveness of preventive treatment with dimethyl fumarate-loaded solid lipid nanoparticles and oral dimethyl fumarate in a mouse model of multiple sclerosis.
Journal of autoimmunity.
2022 10; 132(?):102893. doi:
10.1016/j.jaut.2022.102893. [PMID: 36029715] - Giorgia Teresa Maniscalco, Anne Lise Ferrara, Antonietta Liotti, Valentino Manzo, Maria Elena Di Battista, Simona Salvatore, Daniela Graziano, Assunta Viola, Gerardino Amato, Ornella Moreggia, Daniele Di Giulio Cesare, Gennaro Alfieri, Walter Di Iorio, Gennaro Della Rocca, Vincenzo Andreone, Veronica De Rosa. Long term persistence of SARS-CoV-2 humoral response in multiple sclerosis subjects.
Multiple sclerosis and related disorders.
2022 Jun; 62(?):103800. doi:
10.1016/j.msard.2022.103800. [PMID: 35462168] - Achilles Ntranos, Hye-Jin Park, Maureen Wentling, Vladimir Tolstikov, Mario Amatruda, Benjamin Inbar, Seunghee Kim-Schulze, Carol Frazier, Judy Button, Michael A Kiebish, Fred Lublin, Keith Edwards, Patrizia Casaccia. Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma.
Brain : a journal of neurology.
2022 04; 145(2):569-583. doi:
10.1093/brain/awab320. [PMID: 34894211] - Zikai Sun, Xiaoqiang Liu, Yu Liu, Xin Zhao, Xuan Zang, Fang Wang. Immunosuppressive effects of dimethyl fumarate on dendritic cell maturation and migration: a potent protector for coronary heart disease.
Immunopharmacology and immunotoxicology.
2022 Apr; 44(2):178-185. doi:
10.1080/08923973.2021.2025245. [PMID: 35016591] - Tyler E Smith, Maya Madhavan, Daniel Gratch, Aneek Patel, Valerie Saha, Carrie Sammarco, Zoe Rimler, Guadalupe Zuniga, Dunia Gragui, Leigh Charvet, Gary Cutter, Lauren Krupp, Ilya Kister, Lana Zhovtis Ryerson. Risk of COVID-19 infection and severe disease in MS patients on different disease-modifying therapies.
Multiple sclerosis and related disorders.
2022 Apr; 60(?):103735. doi:
10.1016/j.msard.2022.103735. [PMID: 35398713] - Claudia Guerriero, Giulia Puliatti, Tamara Di Marino, Ada Maria Tata. Effects Mediated by Dimethyl Fumarate on In Vitro Oligodendrocytes: Implications in Multiple Sclerosis.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073615. [PMID: 35408975] - Pietro Iaffaldano, Giuseppe Lucisano, Alessia Manni, Damiano Paolicelli, Francesco Patti, Marco Capobianco, Vincenzo Brescia Morra, Patrizia Sola, Ilaria Pesci, Giacomo Lus, Giovanna De Luca, Alessandra Lugaresi, Paola Cavalla, Sara Montepietra, Giorgia Teresa Maniscalco, Franco Granella, Paolo Ragonese, Marika Vianello, Laura Brambilla, Rocco Totaro, Simona Toscano, Simona Malucchi, Maria Petracca, Lucia Moiola, Diana Ferraro, Vito Lepore, Paola Mosconi, Michela Ponzio, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Massimo Filippi, Maria Pia Amato, Maria Trojano. Risk of Getting COVID-19 in People With Multiple Sclerosis: A Case-Control Study.
Neurology(R) neuroimmunology & neuroinflammation.
2022 03; 9(2):. doi:
10.1212/nxi.0000000000001141. [PMID: 35046084] - Bárbara Fernandes Pinto, Lorena Natasha Brito Ribeiro, Gisela Bevilacqua Rolfsen Ferreira da Silva, Camila Simões Freitas, Lucas Kraemer, Fabrício Marcus Silva Oliveira, Marianna Carvalho Clímaco, Flávio Afonso Gonçalves Mourão, Gabryella Soares Pinheiro Dos Santos, Samantha Ribeiro Béla, Isabella Luísa da Silva Gurgel, Fábio de Lima Leite, Anselmo Gomes de Oliveira, Maura Regina Silva da Páscoa Vilela, Onésia Cristina Oliveira-Lima, Frederico Marianetti Soriani, Ricardo Toshio Fujiwara, Alexander Birbrair, Remo Castro Russo, Juliana Carvalho-Tavares. Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuate clinical signs of experimental autoimmune encephalomyelitis and pulmonary inflammatory dysfunction in mice.
Clinical science (London, England : 1979).
2022 01; 136(1):81-101. doi:
10.1042/cs20210792. [PMID: 34904644] - Xiaodi Sun, Xinjun Suo, Xianyou Xia, Chunshui Yu, Yan Dou. Dimethyl Fumarate is a Potential Therapeutic Option for Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2022; 85(1):443-456. doi:
10.3233/jad-215074. [PMID: 34842188] - Kejun Zhou, Mengyi Xie, Shuli Yi, Yun Tang, Haojun Luo, Qiong Xiao, Jun Xiao, Yi Li. Dimethyl fumarate ameliorates endotoxin-induced acute kidney injury against macrophage oxidative stress.
Renal failure.
2021 Dec; 43(1):1229-1239. doi:
10.1080/0886022x.2021.1963774. [PMID: 34402378] - Ciana Diskin, Alessia Zotta, Sarah E Corcoran, Victoria J Tyrrell, Zbigniew Zaslona, Valerie B O'Donnell, Luke A J O'Neill. 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages.
Journal of immunology (Baltimore, Md. : 1950).
2021 11; 207(10):2561-2569. doi:
10.4049/jimmunol.2100488. [PMID: 34635585] - Xiaowei Wang, Yanbo Wang, Haiyan Pan, Ci Yan. Dimethyl fumarate prevents acute lung injury related cognitive impairment potentially via reducing inflammation.
Journal of cardiothoracic surgery.
2021 Nov; 16(1):331. doi:
10.1186/s13019-021-01705-6. [PMID: 34772431] - Steve Simpson-Yap, Edward De Brouwer, Tomas Kalincik, Nick Rijke, Jan A Hillert, Clare Walton, Gilles Edan, Yves Moreau, Tim Spelman, Lotte Geys, Tina Parciak, Clement Gautrais, Nikola Lazovski, Ashkan Pirmani, Amin Ardeshirdavanai, Lars Forsberg, Anna Glaser, Robert McBurney, Hollie Schmidt, Arnfin B Bergmann, Stefan Braune, Alexander Stahmann, Rodden Middleton, Amber Salter, Robert J Fox, Anneke van der Walt, Helmut Butzkueven, Raed Alroughani, Serkan Ozakbas, Juan I Rojas, Ingrid van der Mei, Nupur Nag, Rumen Ivanov, Guilherme Sciascia do Olival, Alice Estavo Dias, Melinda Magyari, Doralina Brum, Maria Fernanda Mendes, Ricardo N Alonso, Richard S Nicholas, Johana Bauer, Aníbal Sebastián Chertcoff, Anna Zabalza, Georgina Arrambide, Alexander Fidao, Giancarlo Comi, Liesbet Peeters. Associations of Disease-Modifying Therapies With COVID-19 Severity in Multiple Sclerosis.
Neurology.
2021 11; 97(19):e1870-e1885. doi:
10.1212/wnl.0000000000012753. [PMID: 34610987] - Moogeh Baharnoori, Ryan Wilson, Shrishti Saxena, Cindy T Gonzalez, Marinos G Sotiropoulos, Kiandokht Keyhanian, Brian C Healy, Tanuja Chitnis. Altered adipokine levels are associated with dimethyl fumarate treatment in multiple sclerosis patients.
Multiple sclerosis and related disorders.
2021 Nov; 56(?):103311. doi:
10.1016/j.msard.2021.103311. [PMID: 34655958] - Atefeh Raesi Vanani, Heibatullah Kalantari, Masoud Mahdavinia, Mohammad Rashno, Layasadat Khorsandi, Mohammad Javad Khodayar. Dimethyl fumarate reduces oxidative stress, inflammation and fat deposition by modulation of Nrf2, SREBP-1c and NF-κB signaling in HFD fed mice.
Life sciences.
2021 Oct; 283(?):119852. doi:
10.1016/j.lfs.2021.119852. [PMID: 34332979] - Moussa Labsi, Imene Soufli, Houda Belguendouz, Sara Djebbara, Leila Hannachi, Zine-Charaf Amir, Chafia Touil-Boukoffa. Beneficial effect of dimethyl fumarate on experimental autoimmune uveitis is dependent of pro-inflammatory markers immunomodulation.
Inflammopharmacology.
2021 Oct; 29(5):1389-1398. doi:
10.1007/s10787-021-00864-1. [PMID: 34518966] - Anja Schmitt, Wendan Xu, Philip Bucher, Melanie Grimm, Martina Konantz, Heike Horn, Myroslav Zapukhlyak, Philipp Berning, Marc Brändle, Mohamed-Ali Jarboui, Caroline Schönfeld, Karsten Boldt, Andreas Rosenwald, German Ott, Michael Grau, Pavel Klener, Petra Vockova, Claudia Lengerke, Georg Lenz, Klaus Schulze-Osthoff, Stephan Hailfinger. Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL.
Blood.
2021 09; 138(10):871-884. doi:
10.1182/blood.2020009404. [PMID: 33876201] - Akitoshi Sano, Eiji Kakazu, Shin Hamada, Jun Inoue, Masashi Ninomiya, Tomoaki Iwata, Mio Tsuruoka, Kosuke Sato, Atsushi Masamune. Steatotic Hepatocytes Release Mature VLDL Through Methionine and Tyrosine Metabolism in a Keap1-Nrf2-Dependent Manner.
Hepatology (Baltimore, Md.).
2021 09; 74(3):1271-1286. doi:
10.1002/hep.31808. [PMID: 33724516] - P J Morrison, I Suhrkamp, S Gerdes, U Mrowietz. Oral dimethyl fumarate induces changes within the peripheral neutrophil compartment of patients with psoriasis that are linked with skin improvement.
The British journal of dermatology.
2021 09; 185(3):605-615. doi:
10.1111/bjd.19899. [PMID: 33657656] - Angelica Giuliani, Simona Lattanzi, Deborah Ramini, Laura Graciotti, Maura Chiara Danni, Antonio Domenico Procopio, Mauro Silvestrini, Fabiola Olivieri, Jacopo Sabbatinelli. Potential prognostic value of circulating inflamma-miR-146a-5p and miR-125a-5p in relapsing-remitting multiple sclerosis.
Multiple sclerosis and related disorders.
2021 Sep; 54(?):103126. doi:
10.1016/j.msard.2021.103126. [PMID: 34243103] - Xu Zhen, Li Jindong, Zhou Yang, Ruan Yashi, Guo Wei, Jiang Wei, Zhang Wei, Liang Sudong. Activation of Nrf2 Pathway by Dimethyl Fumarate Attenuates Renal Ischemia-Reperfusion Injury.
Transplantation proceedings.
2021 Sep; 53(7):2133-2139. doi:
10.1016/j.transproceed.2021.07.017. [PMID: 34426023] - Fioravante Capone, Elisabetta Ferraro, Francesco Motolese, Vincenzo Di Lazzaro. COVID-19 in multiple sclerosis patients treated with dimethyl fumarate.
Journal of neurology.
2021 Sep; 268(9):3132-3134. doi:
10.1007/s00415-021-10446-4. [PMID: 33611610] - Keith R Edwards, Aneesh Kamath, Judy Button, Vineetha Kamath, Jason P Mendoza, Bing Zhu, Tatiana Plavina, Caroline Woodward, Natalia Penner. A pharmacokinetic and biomarker study of delayed-release dimethyl fumarate in subjects with secondary progressive multiple sclerosis: evaluation of cerebrospinal fluid penetration and the effects on exploratory biomarkers.
Multiple sclerosis and related disorders.
2021 Jun; 51(?):102861. doi:
10.1016/j.msard.2021.102861. [PMID: 33773271] - Vittorio Mantero, Lucia Abate, Paola Basilico, Roberto Balgera, Andrea Salmaggi, Bardia Nourbakhsh, Christian Cordano. COVID-19 in dimethyl fumarate-treated patients with multiple sclerosis.
Journal of neurology.
2021 Jun; 268(6):2023-2025. doi:
10.1007/s00415-020-10015-1. [PMID: 32588182] - Roshan Lal, Jatinder Dhaliwal, Navneet Dhaliwal, Ravinder Naik Dharavath, Kanwaljit Chopra. Activation of the Nrf2/HO-1 signaling pathway by dimethyl fumarate ameliorates complete Freund's adjuvant-induced arthritis in rats.
European journal of pharmacology.
2021 May; 899(?):174044. doi:
10.1016/j.ejphar.2021.174044. [PMID: 33745959] - Thomas W Lategan, Laurene Wang, Tiffany N Sprague, Franck S Rousseau. Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera® (Dimethyl Fumarate).
CNS drugs.
2021 05; 35(5):567-574. doi:
10.1007/s40263-021-00799-9. [PMID: 33797063] - Tian-Zhi Guo, Xiaoyou Shi, Wenwu Li, Tzuping Wei, Wade S Kingery, J David Clark. Dimethyl Fumarate Reduces Oxidative Stress and Pronociceptive Immune Responses in a Murine Model of Complex Regional Pain Syndrome.
Anesthesia and analgesia.
2021 05; 132(5):1475-1485. doi:
10.1213/ane.0000000000005440. [PMID: 33646995] - Paulette Esperanza Walo-Delgado, Susana Sainz de la Maza, Noelia Villarrubia, Enric Monreal, Silvia Medina, Mercedes Espiño, José Ignacio Fernández-Velasco, Eulalia Rodríguez-Martín, Ernesto Roldán, Daniel Lourido, Alfonso Muriel, Jaime Masjuan-Vallejo, Lucienne Costa-Frossard, Luisa María Villar. Low serum neurofilament light chain values identify optimal responders to dimethyl fumarate in multiple sclerosis treatment.
Scientific reports.
2021 04; 11(1):9299. doi:
10.1038/s41598-021-88624-7. [PMID: 33927255] - Maria P Sormani, Nicola De Rossi, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Maria Trojano, Paola Zaratin, Gioacchino Tedeschi, Giancarlo Comi, Mario A Battaglia, Francesco Patti, Marco Salvetti. Disease-Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis.
Annals of neurology.
2021 04; 89(4):780-789. doi:
10.1002/ana.26028. [PMID: 33480077] - Yunwen Yang, Fangfang Cai, Ning Zhou, Suwen Liu, Peipei Wang, Shengnan Zhang, Yue Zhang, Aihua Zhang, Zhanjun Jia, Songming Huang. Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2.
Clinical and translational medicine.
2021 04; 11(4):e382. doi:
10.1002/ctm2.382. [PMID: 33931960] - Anthony T Reder, Diego Centonze, Maria L Naylor, Anjali Nagpal, Rajani Rajbhandari, Arman Altincatal, Michelle Kim, Aaron Berdofe, Maha Radhakrishnan, Eunice Jung, Alfred W Sandrock, Karen Smirnakis, Catrinel Popescu, Carl de Moor. COVID-19 in Patients with Multiple Sclerosis: Associations with Disease-Modifying Therapies.
CNS drugs.
2021 03; 35(3):317-330. doi:
10.1007/s40263-021-00804-1. [PMID: 33743151] - Brian T Wipke, Robert Hoepner, Katrin Strassburger-Krogias, Ankur M Thomas, Davide Gianni, Suzanne Szak, Melanie S Brennan, Maximilian Pistor, Ralf Gold, Andrew Chan, Robert H Scannevin. Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses.
Neurology(R) neuroimmunology & neuroinflammation.
2021 03; 8(2):. doi:
10.1212/nxi.0000000000000950. [PMID: 33468560] - Yuanyuan Wang, Hao Ma, Jiaxuan Huang, Zhengguang Yao, Jianqiang Yu, Wannian Zhang, Lichao Zhang, Zhibin Wang, Chunlin Zhuang. Discovery of bardoxolone derivatives as novel orally active necroptosis inhibitors.
European journal of medicinal chemistry.
2021 Feb; 212(?):113030. doi:
10.1016/j.ejmech.2020.113030. [PMID: 33248849] - Anahid Safari, Zahra Khodabandeh, Afshin Borhani-Haghighi. Dimethyl Fumarate Can Enhance the Potential Therapeutic Effects of Epidermal Neural Crest Stem Cells in COVID-19 Patients.
Stem cell reviews and reports.
2021 02; 17(1):300-301. doi:
10.1007/s12015-020-10094-7. [PMID: 33415541] - Mona A Kortam, Bassam Mohamed Ali, Nevine Fathy. The deleterious effect of stress-induced depression on rat liver: Protective role of resveratrol and dimethyl fumarate via inhibiting the MAPK/ERK/JNK pathway.
Journal of biochemical and molecular toxicology.
2021 Jan; 35(1):e22627. doi:
10.1002/jbt.22627. [PMID: 32905656] - David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E Jørgensen, Michelle Thomsen, Line S Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B Svenningsen, Thomas B Poulsen, Lydia Bartsch, Anne L Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H Mogensen, Søren R Paludan, Christian K Holm. SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.
Nature communications.
2020 10; 11(1):4938. doi:
10.1038/s41467-020-18764-3. [PMID: 33009401] - Sara Salama, Samar Farouk Ahmed, Ismail Ibrahim Ismail, Raed Alroughani. Impact of coronavirus disease (COVID-19) pandemic on multiple sclerosis care.
Clinical neurology and neurosurgery.
2020 10; 197(?):106203. doi:
10.1016/j.clineuro.2020.106203. [PMID: 32919242] - James D Bowen, Justine Brink, Ted R Brown, Elisabeth B Lucassen, Kyle Smoot, Annette Wundes, Pavle Repovic. COVID-19 in MS: Initial observations from the Pacific Northwest.
Neurology(R) neuroimmunology & neuroinflammation.
2020 09; 7(5):. doi:
10.1212/nxi.0000000000000783. [PMID: 32457226] - Fatma M Amin, Rania R Abdelaziz, Mohamed F Hamed, Manar A Nader, George S G Shehatou. Dimethyl fumarate ameliorates diabetes-associated vascular complications through ROS-TXNIP-NLRP3 inflammasome pathway.
Life sciences.
2020 Sep; 256(?):117887. doi:
10.1016/j.lfs.2020.117887. [PMID: 32497629] - Paolo Preziosa, Maria A Rocca, Massimo Filippi. COVID-19 will change MS care forever - No.
Multiple sclerosis (Houndmills, Basingstoke, England).
2020 09; 26(10):1149-1151. doi:
10.1177/1352458520929971. [PMID: 32567471] - Ye Zhang, Shuang Zhao, Ying Fu, Lu Yan, Yilu Feng, Yaqi Chen, Yijia Wu, Yalan Deng, Guiying Zhang, Zhuchu Chen, Yongheng Chen, Ting Liu. Computational repositioning of dimethyl fumarate for treating alcoholic liver disease.
Cell death & disease.
2020 08; 11(8):641. doi:
10.1038/s41419-020-02890-3. [PMID: 32811823] - Farinaz Safavi, Bardia Nourbakhsh, Amir Reza Azimi. B-cell depleting therapies may affect susceptibility to acute respiratory illness among patients with multiple sclerosis during the early COVID-19 epidemic in Iran.
Multiple sclerosis and related disorders.
2020 Aug; 43(?):102195. doi:
10.1016/j.msard.2020.102195. [PMID: 32460086] - David Baker, Sandra Amor, Angray S Kang, Klaus Schmierer, Gavin Giovannoni. The underpinning biology relating to multiple sclerosis disease modifying treatments during the COVID-19 pandemic.
Multiple sclerosis and related disorders.
2020 Aug; 43(?):102174. doi:
10.1016/j.msard.2020.102174. [PMID: 32464584] - Diaa Ragab, Dalaal M Abdallah, Hanan S El-Abhar. The dual reno- and neuro-protective effects of dimethyl fumarate against uremic encephalopathy in a renal ischemia/reperfusion model.
Pharmacological reports : PR.
2020 Aug; 72(4):969-983. doi:
10.1007/s43440-020-00076-4. [PMID: 32141026] - R A Zinovkin, O A Grebenchikov. Transcription Factor Nrf2 as a Potential Therapeutic Target for Prevention of Cytokine Storm in COVID-19 Patients.
Biochemistry. Biokhimiia.
2020 Jul; 85(7):833-837. doi:
10.1134/s0006297920070111. [PMID: 33040727] - Shaimaa G Ibrahim, Soad Z El-Emam, Eman A Mohamed, Mohamed F Abd Ellah. Dimethyl fumarate and curcumin attenuate hepatic ischemia/reperfusion injury via Nrf2/HO-1 activation and anti-inflammatory properties.
International immunopharmacology.
2020 Mar; 80(?):106131. doi:
10.1016/j.intimp.2019.106131. [PMID: 31981960] - Durgesh Kumar Dwivedi, G B Jena. Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide.
Biochemical and biophysical research communications.
2020 02; 522(2):381-387. doi:
10.1016/j.bbrc.2019.11.100. [PMID: 31761320] - Myla D Goldman, Lauren Dwyer, Rachael Coleman, Min-Woong Sohn, Olaf Stuve. Patient-specific factors modulate leukocyte response in dimethyl fumarate treated MS patients.
PloS one.
2020; 15(2):e0228617. doi:
10.1371/journal.pone.0228617. [PMID: 32045436] - Ewa Szczesny-Malysiak, Marta Stojak, Roberto Campagna, Marek Grosicki, Marek Jamrozik, Patrycja Kaczara, Stefan Chlopicki. Bardoxolone Methyl Displays Detrimental Effects on Endothelial Bioenergetics, Suppresses Endothelial ET-1 Release, and Increases Endothelial Permeability in Human Microvascular Endothelium.
Oxidative medicine and cellular longevity.
2020; 2020(?):4678252. doi:
10.1155/2020/4678252. [PMID: 33123312] - Tobias Sejbaek, Helle Hvilsted Nielsen, Natasha Penner, Tatiana Plavina, Jason P Mendoza, Nellie Anne Martin, Maria Louise Elkjaer, Mads Henrik Ravnborg, Zsolt Illes. Dimethyl fumarate decreases neurofilament light chain in CSF and blood of treatment naïve relapsing MS patients.
Journal of neurology, neurosurgery, and psychiatry.
2019 12; 90(12):1324-1330. doi:
10.1136/jnnp-2019-321321. [PMID: 31611264] - Randa Sghaier, Thomas Nury, Valerio Leoni, Claudio Caccia, Jean-Paul Pais De Barros, Ameur Cherif, Anne Vejux, Thibault Moreau, Khalifa Limem, Mohammad Samadi, John J Mackrill, Ahmed Slaheddine Masmoudi, Gérard Lizard, Amira Zarrouk. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol.
The Journal of steroid biochemistry and molecular biology.
2019 11; 194(?):105432. doi:
10.1016/j.jsbmb.2019.105432. [PMID: 31344443] - Yang Xu, Joshua Andrade, Beatrix Ueberheide, Benjamin G Neel. Activated Thiol Sepharose-based proteomic approach to quantify reversible protein oxidation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 11; 33(11):12336-12347. doi:
10.1096/fj.201900693r. [PMID: 31451050] - Man Luo, Qingsong Sun, Hongmei Zhao, Jiali Tao, Dongsheng Yan. The Effects of Dimethyl Fumarate on Atherosclerosis in the Apolipoprotein E-Deficient Mouse Model with Streptozotocin-Induced Hyperglycemia Mediated By the Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element (Nrf2/ARE) Signaling Pathway.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Oct; 25(?):7966-7975. doi:
10.12659/msm.918951. [PMID: 31645538] - Chien-Ning Hsu, Yu-Ju Lin, Hong-Ren Yu, I-Chun Lin, Jiunn-Ming Sheen, Li-Tung Huang, You-Lin Tain. Protection of Male Rat Offspring against Hypertension Programmed by Prenatal Dexamethasone Administration and Postnatal High-Fat Diet with the Nrf2 Activator Dimethyl Fumarate during Pregnancy.
International journal of molecular sciences.
2019 Aug; 20(16):. doi:
10.3390/ijms20163957. [PMID: 31416234] - Arie R Gafson, Constantinos Savva, Tom Thorne, Mark David, Maria Gomez-Romero, Matthew R Lewis, Richard Nicholas, Amanda Heslegrave, Henrik Zetterberg, Paul M Matthews. Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate.
Neurology(R) neuroimmunology & neuroinflammation.
2019 05; 6(3):e562. doi:
10.1212/nxi.0000000000000562. [PMID: 31086805] - Balyn W Zaro, Ekaterina V Vinogradova, Daniel C Lazar, Megan M Blewett, Radu M Suciu, Junichiro Takaya, Sean Studer, Juan Carlos de la Torre, Jean-Laurent Casanova, Benjamin F Cravatt, John R Teijaro. Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex.
Journal of immunology (Baltimore, Md. : 1950).
2019 05; 202(9):2737-2746. doi:
10.4049/jimmunol.1801627. [PMID: 30885957] - Atef Tadros Fahim, Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Bassam Mohamed Ali. Resveratrol and dimethyl fumarate ameliorate testicular dysfunction caused by chronic unpredictable mild stress-induced depression in rats.
Archives of biochemistry and biophysics.
2019 04; 665(?):152-165. doi:
10.1016/j.abb.2019.03.009. [PMID: 30904419] - Jianning Zhu, Qing Wang, Cong Li, Yuchao Lu, Henglong Hu, Baolong Qin, Yang Xun, Yunpeng Zhu, Yue Wu, Jiaqiao Zhang, Shaogang Wang. Inhibiting inflammation and modulating oxidative stress in oxalate-induced nephrolithiasis with the Nrf2 activator dimethyl fumarate.
Free radical biology & medicine.
2019 04; 134(?):9-22. doi:
10.1016/j.freeradbiomed.2018.12.033. [PMID: 30599261] - Mohamed E Mostafa, Ahmed A Shaaban, Hatem A Salem. Dimethylfumarate ameliorates hepatic injury and fibrosis induced by carbon tetrachloride.
Chemico-biological interactions.
2019 Apr; 302(?):53-60. doi:
10.1016/j.cbi.2019.01.029. [PMID: 30703375] - Lei Liu, Mary K Vollmer, Abdullah S Ahmad, Victoria M Fernandez, Hocheol Kim, Sylvain Doré. Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism.
Free radical biology & medicine.
2019 02; 131(?):98-114. doi:
10.1016/j.freeradbiomed.2018.11.017. [PMID: 30458277] - Pavan Bhargava, Kathryn C Fitzgerald, Swarajya L V Venkata, Matthew D Smith, Michael D Kornberg, Ellen M Mowry, Norman J Haughey, Peter A Calabresi. Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes.
Annals of clinical and translational neurology.
2019 01; 6(1):33-45. doi:
10.1002/acn3.676. [PMID: 30656182] - Ilana Katz Sand, Yunjiao Zhu, Achilles Ntranos, Jose C Clemente, Egle Cekanaviciute, Rachel Brandstadter, Elizabeth Crabtree-Hartman, Sneha Singh, Yadira Bencosme, Justine Debelius, Rob Knight, Bruce A C Cree, Sergio E Baranzini, Patrizia Casaccia. Disease-modifying therapies alter gut microbial composition in MS.
Neurology(R) neuroimmunology & neuroinflammation.
2019 01; 6(1):e517. doi:
10.1212/nxi.0000000000000517. [PMID: 30568995] - Amal Ahmed Abd El-Fattah, Atef Tadros Fahim, Nermin Abdel Hamid Sadik, Bassam Mohamed Ali. Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress.
Brain research.
2018 12; 1701(?):227-236. doi:
10.1016/j.brainres.2018.09.027. [PMID: 30244113] - Graciela Freitas Zarbato, Mariana Pereira de Souza Goldim, Amanda Della Giustina, Lucinéia Gainski Danielski, Khiany Mathias, Drielly Florentino, Aloir Neri de Oliveira Junior, Naiana da Rosa, Ana Olivia Laurentino, Taina Trombetta, Maria Luiza Gomes, Amanda Valnier Steckert, Ana Paula Moreira, Patricia Fernanda Schuck, Jucelia Jeremias Fortunato, Tatiana Barichello, Fabricia Petronilho. Dimethyl Fumarate Limits Neuroinflammation and Oxidative Stress and Improves Cognitive Impairment After Polymicrobial Sepsis.
Neurotoxicity research.
2018 Oct; 34(3):418-430. doi:
10.1007/s12640-018-9900-8. [PMID: 29713994] - Michael J Kerins, John Milligan, James A Wohlschlegel, Aikseng Ooi. Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction.
Cancer science.
2018 Sep; 109(9):2757-2766. doi:
10.1111/cas.13701. [PMID: 29917289] - Jeremias Motte, Janina Kneiphof, Katrin Straßburger-Krogias, Anja Klasing, Ortwin Adams, Aiden Haghikia, Ralf Gold. Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML.
Journal of neurology.
2018 Aug; 265(8):1880-1882. doi:
10.1007/s00415-018-8931-7. [PMID: 29948248] - Tiffany J Braley, Amanda K Huber, Benjamin M Segal, Neeraj Kaplish, Rachel Saban, Jesse M Washnock-Schmid, Ronald D Chervin. A randomized, subject and rater-blinded, placebo-controlled trial of dimethyl fumarate for obstructive sleep apnea.
Sleep.
2018 08; 41(8):. doi:
10.1093/sleep/zsy109. [PMID: 29800466] - Neha Singh, Sheekha Vijayanti, Lekha Saha, Alka Bhatia, Dibyajyoti Banerjee, Amitava Chakrabarti. Neuroprotective effect of Nrf2 activator dimethyl fumarate, on the hippocampal neurons in chemical kindling model in rat.
Epilepsy research.
2018 07; 143(?):98-104. doi:
10.1016/j.eplepsyres.2018.02.011. [PMID: 29691120] - Pramod Kumar, Gajanand Sharma, Varun Gupta, Ramanpreet Kaur, Kanika Thakur, Ruchi Malik, Anil Kumar, Naveen Kaushal, Kaisar Raza. Preclinical Explorative Assessment of Dimethyl Fumarate-Based Biocompatible Nanolipoidal Carriers for the Management of Multiple Sclerosis.
ACS chemical neuroscience.
2018 05; 9(5):1152-1158. doi:
10.1021/acschemneuro.7b00519. [PMID: 29357233] - Shinji Aoyama, Masahiro Mori, Akiyuki Uzawa, Tomohiko Uchida, Hiroki Masuda, Ryohei Ohtani, Satoshi Kuwabara. Serum anti-JCV antibody indexes in Japanese patients with multiple sclerosis: elevations along with fingolimod treatment duration.
Journal of neurology.
2018 May; 265(5):1145-1150. doi:
10.1007/s00415-018-8813-z. [PMID: 29532286] - Ewa Krzystanek, Przemyslawa Jarosz-Chobot. Dimethyl fumarate in a patient with multiple sclerosis and type 1 diabetes mellitus: The importance of ketonuria.
Multiple sclerosis and related disorders.
2018 Apr; 21(?):42-45. doi:
10.1016/j.msard.2018.02.007. [PMID: 29455073] - Oliver Oey, Padmashree Rao, Magdalena Luciuk, Carly Mannix, Natasha M Rogers, Priyanka Sagar, Annette Wong, Gopala Rangan. Effect of dimethyl fumarate on renal disease progression in a genetic ortholog of nephronophthisis.
Experimental biology and medicine (Maywood, N.J.).
2018 03; 243(5):428-436. doi:
10.1177/1535370218759313. [PMID: 29436846] - Francisco J Medina-Fernandez, Begoña M Escribano, Evelio Luque, Javier Caballero-Villarraso, Jose L Gomez-Chaparro, Montserrat Feijoo, Fe I Garcia-Maceira, Alvaro Pascual-Leone, René Drucker-Colin, Isaac Tunez. Comparative of transcranial magnetic stimulation and other treatments in experimental autoimmune encephalomyelitis.
Brain research bulletin.
2018 03; 137(?):140-145. doi:
10.1016/j.brainresbull.2017.11.018. [PMID: 29198860] - Amanda Della Giustina, Sandra Bonfante, Graciela Freitas Zarbato, Lucinéia Gainski Danielski, Khiany Mathias, Aloir Neri de Oliveira, Leandro Garbossa, Taise Cardoso, Maria Eduarda Fileti, Raquel Jaconi De Carli, Mariana Pereira Goldim, Tatiana Barichello, Fabricia Petronilho. Dimethyl Fumarate Modulates Oxidative Stress and Inflammation in Organs After Sepsis in Rats.
Inflammation.
2018 Feb; 41(1):315-327. doi:
10.1007/s10753-017-0689-z. [PMID: 29124567] - Yu-Ju Lin, I-Chun Lin, Hong-Ren Yu, Jiunn-Ming Sheen, Li-Tung Huang, You-Lin Tain. Early Postweaning Treatment with Dimethyl Fumarate Prevents Prenatal Dexamethasone- and Postnatal High-Fat Diet-Induced Programmed Hypertension in Male Rat Offspring.
Oxidative medicine and cellular longevity.
2018; 2018(?):5343462. doi:
10.1155/2018/5343462. [PMID: 29636848] - Ulrich Mrowietz, Peter John Morrison, Ina Suhrkamp, Margaret Kumanova, Bernd Clement. The Pharmacokinetics of Fumaric Acid Esters Reveal Their In Vivo Effects.
Trends in pharmacological sciences.
2018 01; 39(1):1-12. doi:
10.1016/j.tips.2017.11.002. [PMID: 29183628] - Vanesa Cunill, Margarita Massot, Antonio Clemente, Carmen Calles, Valero Andreu, Vanessa Núñez, Antonio López-Gómez, Rosa María Díaz, María de Los Reyes Jiménez, Jaime Pons, Cristòfol Vives-Bauzà, Joana Maria Ferrer. Relapsing-Remitting Multiple Sclerosis Is Characterized by a T Follicular Cell Pro-Inflammatory Shift, Reverted by Dimethyl Fumarate Treatment.
Frontiers in immunology.
2018; 9(?):1097. doi:
10.3389/fimmu.2018.01097. [PMID: 29896193] - Pramod Kumar, Gajanand Sharma, Rajendra Kumar, Ruchi Malik, Bhupinder Singh, Om Prakash Katare, Kaisar Raza. Stearic acid based, systematically designed oral lipid nanoparticles for enhanced brain delivery of dimethyl fumarate.
Nanomedicine (London, England).
2017 Dec; 12(23):2607-2621. doi:
10.2217/nnm-2017-0082. [PMID: 29094640] - Bing Zhu, Ivan Nestorov, Guolin Zhao, Venkata Meka, Mark Leahy, Jeanelle Kam, Sarah I Sheikh. Evaluation of Potential Drug-Drug Interaction Between Delayed-Release Dimethyl Fumarate and a Commonly Used Oral Contraceptive (Norgestimate/Ethinyl Estradiol) in Healthy Women.
Clinical pharmacology in drug development.
2017 Nov; 6(6):604-613. doi:
10.1002/cpdd.377. [PMID: 28783872] - Sriram Krishnamoorthy, Betty Pace, Dipti Gupta, Sarah Sturtevant, Biaoru Li, Levi Makala, Julia Brittain, Nancy Moore, Benjamin F Vieira, Timothy Thullen, Ivan Stone, Huo Li, William E Hobbs, David R Light. Dimethyl fumarate increases fetal hemoglobin, provides heme detoxification, and corrects anemia in sickle cell disease.
JCI insight.
2017 10; 2(20):. doi:
10.1172/jci.insight.96409. [PMID: 29046485] - Bettina Hjelm Clausen, Louise Lundberg, Minna Yli-Karjanmaa, Nellie Anne Martin, Martina Svensson, Maria Zeiler Alfsen, Simon Bertram Flæng, Kristina Lyngsø, Antonio Boza-Serrano, Helle H Nielsen, Pernille B Hansen, Bente Finsen, Tomas Deierborg, Zsolt Illes, Kate Lykke Lambertsen. Fumarate decreases edema volume and improves functional outcome after experimental stroke.
Experimental neurology.
2017 09; 295(?):144-154. doi:
10.1016/j.expneurol.2017.06.011. [PMID: 28602832] - Chie Takasu, Nosratola D Vaziri, Shiri Li, Lourdes Robles, Kelly Vo, Mizuki Takasu, Christine Pham, Seyed H Farzaneh, Mitsuo Shimada, Michael J Stamos, Hirohito Ichii. Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury.
World journal of gastroenterology.
2017 Jul; 23(25):4508-4516. doi:
10.3748/wjg.v23.i25.4508. [PMID: 28740339] - Pramod Kumar, Gajanand Sharma, Rajendra Kumar, Ruchi Malik, Bhupinder Singh, O P Katare, Kaisar Raza. Vitamin-Derived Nanolipoidal Carriers for Brain Delivery of Dimethyl Fumarate: A Novel Approach with Preclinical Evidence.
ACS chemical neuroscience.
2017 06; 8(6):1390-1396. doi:
10.1021/acschemneuro.7b00041. [PMID: 28157295] - Michael John Kerins, Ajay Amar Vashisht, Benjamin Xi-Tong Liang, Spencer Jordan Duckworth, Brandon John Praslicka, James Akira Wohlschlegel, Aikseng Ooi. Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes.
Molecular and cellular biology.
2017 06; 37(11):. doi:
10.1128/mcb.00079-17. [PMID: 28289076] - Elisabetta Esposito, Rita Cortesi, Markus Drechsler, Jie Fan, Bingmei M Fu, Laura Calderan, Silvia Mannucci, Federico Boschi, Claudio Nastruzzi. Nanoformulations for dimethyl fumarate: Physicochemical characterization and in vitro/in vivo behavior.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2017 Jun; 115(?):285-296. doi:
10.1016/j.ejpb.2017.04.011. [PMID: 28412473] - John D Belcher, Chunsheng Chen, Julia Nguyen, Ping Zhang, Fuad Abdulla, Phong Nguyen, Trevor Killeen, Pauline Xu, Gerry O'Sullivan, Karl A Nath, Gregory M Vercellotti. Control of Oxidative Stress and Inflammation in Sickle Cell Disease with the Nrf2 Activator Dimethyl Fumarate.
Antioxidants & redox signaling.
2017 05; 26(14):748-762. doi:
10.1089/ars.2015.6571. [PMID: 26914345] - Amira Zarrouk, Thomas Nury, El-Mostafa Karym, Anne Vejux, Randa Sghaier, Catherine Gondcaille, Pierre Andreoletti, Doriane Trompier, Stéphane Savary, Mustapha Cherkaoui-Malki, Meryam Debbabi, Agnès Fromont, Jean-Marc Riedinger, Thibault Moreau, Gérard Lizard. Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.
The Journal of steroid biochemistry and molecular biology.
2017 05; 169(?):29-38. doi:
10.1016/j.jsbmb.2016.02.024. [PMID: 26921765] - Begoña M Escribano, Francisco J Medina-Fernández, Macarena Aguilar-Luque, Eduardo Agüera, Montserrat Feijoo, Fe I Garcia-Maceira, Rafael Lillo, Patricia Vieyra-Reyes, Ana I Giraldo, Evelio Luque, René Drucker-Colín, Isaac Túnez. Lipopolysaccharide Binding Protein and Oxidative Stress in a Multiple Sclerosis Model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2017 01; 14(1):199-211. doi:
10.1007/s13311-016-0480-0. [PMID: 27718209]