Deanol (BioDeep_00000858350)
代谢物信息卡片
N,N-dimethylethanolamine
化学式: C4H11NO (89.0841)
中文名称: N,N-二甲基乙醇胺, 脱醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCO
InChI: InChI=1S/C4H11NO/c1-5(2)3-4-6/h6H,3-4H2,1-2H3
描述信息
N - Nervous system > N06 - Psychoanaleptics > N06B - Psychostimulants, agents used for adhd and nootropics
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:271436
- KEGGdrug: D07777
- PubChem: 7902
- DrugBank: DB13352
- ChEMBL: CHEMBL1135
- MeSH: Deanol
- CAS: 108-01-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - K A Shipkowski, J M Sanders, J D McDonald, C E Garner, M Doyle-Eisele, C J Wegerski, S Waidyanatha. Comparative disposition of dimethylaminoethanol and choline in rats and mice following oral or intravenous administration.
Toxicology and applied pharmacology.
2019 09; 378(?):114592. doi:
10.1016/j.taap.2019.05.011. [PMID: 31100288] - Yaxiao Guo, Lei Meng, Yanhao Zhang, Wei Tang, Wenfen Zhang, Yan Xia, Fuguo Ban, Ningpeng Wu, Shusheng Zhang. Sensitive determination of four tetracycline antibiotics in pig plasma by field-amplified sample stacking open-tubular capillary electrochromatography with dimethylethanolamine aminated polychloromethyl styrene nano-latex coated capillary column.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Dec; 942-943(?):151-7. doi:
10.1016/j.jchromb.2013.10.039. [PMID: 24269909] - Vera Sampels, Anne Hartmann, Isabelle Dietrich, Isabelle Coppens, Lilach Sheiner, Boris Striepen, Andreas Herrmann, Richard Lucius, Nishith Gupta. Conditional mutagenesis of a novel choline kinase demonstrates plasticity of phosphatidylcholine biogenesis and gene expression in Toxoplasma gondii.
The Journal of biological chemistry.
2012 May; 287(20):16289-99. doi:
10.1074/jbc.m112.347138. [PMID: 22451671] - Gabriela Malanga, María Belen Aguiar, Hugo D Martinez, Susana Puntarulo. New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger.
Drug metabolism letters.
2012 Mar; 6(1):54-9. doi:
10.2174/187231212800229282. [PMID: 22300295] - Tawfeeq Shekh-Ahmad, Meir Bialer, Eylon Yavin. Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue.
Epilepsy research.
2012 Feb; 98(2-3):238-46. doi:
10.1016/j.eplepsyres.2011.10.005. [PMID: 22057163] - Monica Mazzarino, Xavier de la Torre, Francesco Botrè. Urinary excretion profiles of toremifene metabolites by liquid chromatography-mass spectrometry. Towards targeted analysis to relevant metabolites in doping control.
Analytical and bioanalytical chemistry.
2011 Aug; 401(2):529-41. doi:
10.1007/s00216-011-4695-y. [PMID: 21380606] - Dominique Slaets, Sylvie De Bruyne, Caroline Dumolyn, Lieselotte Moerman, Koen Mertens, Filip De Vos. Reduced dimethylaminoethanol in [(18)F]fluoromethylcholine: an important step towards enhanced tumour visualization.
European journal of nuclear medicine and molecular imaging.
2010 Nov; 37(11):2136-45. doi:
10.1007/s00259-010-1508-z. [PMID: 20556603] - Ilkka J Miinalainen, Werner Schmitz, Anne Huotari, Kaija J Autio, Raija Soininen, Emiel Ver Loren van Themaat, Myriam Baes, Karl-Heinz Herzig, Ernst Conzelmann, J Kalervo Hiltunen. Mitochondrial 2,4-dienoyl-CoA reductase deficiency in mice results in severe hypoglycemia with stress intolerance and unimpaired ketogenesis.
PLoS genetics.
2009 Jul; 5(7):e1000543. doi:
10.1371/journal.pgen.1000543. [PMID: 19578400] - B Sommerfeld. Randomised, placebo-controlled, double-blind, split-face study on the clinical efficacy of Tricutan on skin firmness.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2007 Nov; 14(11):711-5. doi:
10.1016/j.phymed.2007.09.015. [PMID: 17923398] - Kristin A Waite, Dennis E Vance. Dimethylethanolamine does not prevent liver failure in phosphatidylethanolamine N-methyltransferase-deficient mice fed a choline-deficient diet.
Biochimica et biophysica acta.
2004 Mar; 1636(2-3):175-82. doi:
10.1016/j.bbalip.2003.10.014. [PMID: 15164765] - J Luten, J H van Steenis, R van Someren, J Kemmink, N M E Schuurmans-Nieuwenbroek, G A Koning, D J A Crommelin, C F van Nostrum, W E Hennink. Water-soluble biodegradable cationic polyphosphazenes for gene delivery.
Journal of controlled release : official journal of the Controlled Release Society.
2003 May; 89(3):483-97. doi:
10.1016/s0168-3659(03)00127-5. [PMID: 12737850] - Imre Zs-Nagy. Pharmacological interventions against aging through the cell plasma membrane: a review of the experimental results obtained in animals and humans.
Annals of the New York Academy of Sciences.
2002 Apr; 959(?):308-20; discussion 463. doi:
10.1111/j.1749-6632.2002.tb02102.x. [PMID: 11976205] - Kálmán Magyar, József Lengyel, Andrea Bolehovszky, Gyula Grézal, Imre Klebovich. Studies of the side chain cleavage of deramciclane in rats with radiolabelled compounds.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2002 Mar; 15(2):217-23. doi:
10.1016/s0928-0987(02)00003-9. [PMID: 11849919] - A Brand, S Gil, R Seger, E Yavin. Lipid constituents in oligodendroglial cells alter susceptibility to H2O2-induced apoptotic cell death via ERK activation.
Journal of neurochemistry.
2001 Feb; 76(3):910-8. doi:
10.1046/j.1471-4159.2001.00085.x. [PMID: 11158263] - B Malewicz, J J Mukherjee, K S Crilly, W J Baumann, Z Kiss. Phosphorylation of ethanolamine, methylethanolamine, and dimethylethanolamine by overexpressed ethanolamine kinase in NIH 3T3 cells decreases the co-mitogenic effects of ethanolamines and promotes cell survival.
European journal of biochemistry.
1998 Apr; 253(1):10-9. doi:
10.1046/j.1432-1327.1998.2530010.x. [PMID: 9578455] - G W Moeckel, Y H Lien. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation.
The American journal of physiology.
1997 Jan; 272(1 Pt 2):F94-9. doi:
10.1152/ajprenal.1997.272.1.f94. [PMID: 9039054] - Z Kiss, K S Crilly. Ethanolamine analogues stimulate DNA synthesis by a mechanism not involving phosphatidylethanolamine synthesis.
FEBS letters.
1996 Feb; 381(1-2):67-70. doi:
10.1016/0014-5793(96)00084-1. [PMID: 8641441] - M Takano, T Katsura, Y Tomita, M Yasuhara, R Hori. Transport mechanism of choline in rat renal brush-border membrane.
Biological & pharmaceutical bulletin.
1993 Sep; 16(9):889-94. doi:
10.1248/bpb.16.889. [PMID: 8268856] - D Alvaro, M Angelico, A Cantafora, E Gaudio, C Gandin, M T Santini, R Masella, L Capocaccia. Improvement of estradiol 17 beta-D-glucuronide cholestasis by intravenous administration of dimethylethanolamine in the rat.
Hepatology (Baltimore, Md.).
1991 Jun; 13(6):1158-72. doi:
NULL. [PMID: 1646761] - V K Rybal'chenko, S A Lukoshko, G V Ostrovskaia, N V Kulikova. [The surface-active properties of dimethylethanolamine and its effect on the ecto-ATPase activity of plasma membranes].
Biulleten' eksperimental'noi biologii i meditsiny.
1991 Feb; 111(2):157-9. doi:
NULL. [PMID: 1830227] - N N Zolotov, O A Kutenova, T A Voronina, V F Pozdnev, L D Smirnov, K M Diumaev. [The possible participation of brain peptidases in regulating the memory function during aging].
Doklady Akademii nauk SSSR.
1991; 317(1):234-7. doi:
". [PMID: 1868772] - C Bevan, R K Kinne. Choline transport in collecting duct cells isolated from the rat renal inner medulla.
Pflugers Archiv : European journal of physiology.
1990 Nov; 417(3):324-8. doi:
10.1007/bf00370999. [PMID: 2274417] - H Jamil, D E Vance. Head-group specificity for feedback regulation of CTP:phosphocholine cytidylyltransferase.
The Biochemical journal.
1990 Sep; 270(3):749-54. doi:
10.1042/bj2700749. [PMID: 2173550] - J Lohr, M Acara. Effect of dimethylaminoethanol, an inhibitor of betaine production, on the disposition of choline in the rat kidney.
The Journal of pharmacology and experimental therapeutics.
1990 Jan; 252(1):154-8. doi:
NULL. [PMID: 2405150] - Z M Yao, D E Vance. Head group specificity in the requirement of phosphatidylcholine biosynthesis for very low density lipoprotein secretion from cultured hepatocytes.
The Journal of biological chemistry.
1989 Jul; 264(19):11373-80. doi:
". [PMID: 2738069] - A B Kier, M T Parker, F Schroeder. Local and metastatic tumor growth and membrane properties of LM fibroblasts in athymic (nude) mice.
Biochimica et biophysica acta.
1988 Mar; 938(3):434-46. doi:
10.1016/0005-2736(88)90141-1. [PMID: 2831981] - G W Bielenberg, C Hayn, J Krieglstein. Effects of cerebro-protective agents on enzyme activities of rat primary glial cultures and rat cerebral cortex.
Biochemical pharmacology.
1986 Aug; 35(16):2693-702. doi:
10.1016/0006-2952(86)90177-2. [PMID: 2943286] - J J Volpe, Y Iimori, G G Haven, R I Goldberg. Relation of cellular phospholipid composition to oligodendroglial differentiation in C-6 glial cells.
Journal of neurochemistry.
1986 Feb; 46(2):475-82. doi:
10.1111/j.1471-4159.1986.tb12992.x. [PMID: 3001226] - Y Shimojima, T Shirai, T Baba, H Hayashi. 1H-2-Benzopyran-1-one derivatives, microbial products with pharmacological activity. Conversion into orally active derivatives with antiinflammatory and antiulcer activities.
Journal of medicinal chemistry.
1985 Jan; 28(1):3-9. doi:
10.1021/jm00379a002. [PMID: 3965711] - R C McKenzie, P J Brophy. Lipid composition and physical properties of membranes from C-6 glial cells with altered phospholipid polar headgroups.
Biochimica et biophysica acta.
1984 Jan; 769(2):357-62. doi:
10.1016/0005-2736(84)90317-1. [PMID: 6320875] - D R Haubrich, N H Gerber, A B Pflueger. Deanol affects choline metabolism in peripheral tissues of mice.
Journal of neurochemistry.
1981 Aug; 37(2):476-82. doi:
10.1111/j.1471-4159.1981.tb00480.x. [PMID: 7264671] - I Nagy, K Nagy. On the role of cross-linking of cellular proteins in aging.
Mechanisms of ageing and development.
1980 Sep; 14(1-2):245-51. doi:
10.1016/0047-6374(80)90124-4. [PMID: 7206814] - R Pal, W A Petri, R R Wagner. Alteration of the membrane lipid composition and infectivity of vesicular stomatitis virus by growth in a Chinese hamster ovary cell sterol mutant and in lipid-supplemented baby hamster kidney clone 21 cells.
The Journal of biological chemistry.
1980 Aug; 255(16):7688-93. doi:
NULL. [PMID: 6249809] - H Okabe, M Kita, K Netsu-Nakayama, T Yamamoto, K Watanabe, Y Shimizu, A Noma. o-Toluoylcholine as substrate for measurement of serum pseudo-cholinesterase activity.
Clinica chimica acta; international journal of clinical chemistry.
1980 May; 103(3):349-55. doi:
10.1016/0009-8981(80)90154-0. [PMID: 7398078] - M Maeda, O Doi, Y Akamatsu. Behavior of vesicular stomatitis virus glycoprotein in mouse LM cells with modified membrane-phospholipids.
Biochimica et biophysica acta.
1980 Apr; 597(3):552-63. doi:
10.1016/0005-2736(80)90227-8. [PMID: 6246939] - E Yavin. Regulation of phospholipid metabolism in differentiating cells from rat brain cerebral hemispheres in culture: ontogenesis of carrier-specific transport of choline and N-methyl-substituted choline analogs.
Journal of neurochemistry.
1980 Jan; 34(1):178-83. doi:
10.1111/j.1471-4159.1980.tb04637.x. [PMID: 7452234] - R S Jope, D J Jenden. Dimethylaminoethanol (deanol) metabolism in rat brain and its effect on acetylcholine synthesis.
The Journal of pharmacology and experimental therapeutics.
1979 Dec; 211(3):472-9. doi:
NULL. [PMID: 512912] - C P Siegers, M Younes. [Influence of 2-dimethylaminoethanol on the hepatotoxicity of paracetamol in rats and mice (author's transl)].
Arzneimittel-Forschung.
1979; 29(3):520-3. doi:
NULL. [PMID: 582737] - G Ceder, L Dahlberg, J Schuberth. Effects of 2-dimethylaminoethanol (Deanol) on the metabolism of choline in plasma.
Journal of neurochemistry.
1978 Jun; 30(6):1293-6. doi:
10.1111/j.1471-4159.1978.tb10458.x. [PMID: 670971] - N R Zahniser, D Chou, I Hanin. Is 2-dimethylaminoethanol (deanol) indeed a precursor of brain acetylcholine? A gas chromatographic evaluation.
The Journal of pharmacology and experimental therapeutics.
1977 Mar; 200(3):545-59. doi:
NULL. [PMID: 850128] - H Miyazaki, K Nambu, Y Minaki, M Hashimoto, K Nakamura. Comparative studies on the metabolism of beta-dimethylaminoethanol in the mouse brain and liver following administration of beta-dimethylaminoethanol and its p-chlorophenoxyacetate, meclofenoxate.
Chemical & pharmaceutical bulletin.
1976 Apr; 24(4):763-9. doi:
10.1248/cpb.24.763. [PMID: 779989] - Y Dormard, J C Levron, A Benakis. Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.
Arzneimittel-Forschung.
1975 Feb; 25(2):194-201. doi:
NULL. [PMID: 1173032] - Y Dormard, J C Levron, J M Le Fur. Pharmacokinetic study of maleate acid of 2-(N,N-dimethylaminoethanol-14C1)-cyclohexylpropionate (cyprodenate) and of N,N-dimethylaminoethanol-14C1 in animals.
Arzneimittel-Forschung.
1975 Feb; 25(2):201-7. doi:
NULL. [PMID: 1173033] - H Saito, Y Yoshida, K Takagi. Effect of Panax Ginseng root on exhaustive exercise in mice.
Japanese journal of pharmacology.
1974 Feb; 24(1):119-27. doi:
10.1254/jjp.24.119. [PMID: 4546047] - J D Latshaw, L S Jensen. Choline deficiency and synthesis of choline from precursors in mature Japanese quail.
The Journal of nutrition.
1972 Jun; 102(6):749-55. doi:
10.1093/jn/102.6.749. [PMID: 5028669] - H Miyazaki, A Kagemoto, M Ishi, Y Minaki, K Nakamura. Uptake by brain and distribution of radioactivity after intravenous administration of 14 C-labelled meclofenoxate in mice.
Chemical & pharmaceutical bulletin.
1971 Aug; 19(8):1681-90. doi:
10.1248/cpb.19.1681. [PMID: 4399332] - J K Balcom, W M Fitch. A method for the kinetic analysis of progress curves using horse serum cholinesterase as a model case.
The Journal of biological chemistry.
1970 Apr; 245(7):1637-47. doi:
10.1016/s0021-9258(19)77140-3. [PMID: 5461957] - R D Zoleva, A N Klimov, A L Remizov. [Effect of acetylmethionine, dimethylaminoethanol and vitamin B 12 on the development of experimental atherosclerosis in rabbits].
Voprosy meditsinskoi khimii.
1968 Mar; 14(2):179-85. doi:
. [PMID: 4176195] - L L BIEBER, R W NEWBURGH. THE INCORPORATION OF DIMETHYLAMINOETHANOL AND DIMETHYLAMINOISOPROPYL ALCOHOL INTO PHORMIA REGINA PHOSPHOLIPIDS.
Journal of lipid research.
1963 Oct; 4(?):397-401. doi:
10.1016/s0022-2275(20)40281-0. [PMID: 14168181] - Y PIERRON. [Action of vitamin B-12 and dimethylethanolamine on the lipid and pantothenic acid overload of the rat liver].
Comptes rendus des seances de la Societe de biologie et de ses filiales.
1961; 155(?):73-6. doi:
". [PMID: 13735588] - W P BLACKMORE. Effect of 2-dimethylaminoethanol on renal hemodynamics.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1958 May; 98(1):1-3. doi:
10.3181/00379727-98-23920. [PMID: 13554522] - C ARTOM, W E CORNATZER. The action of ethanolamine, methylethanolamine, and dimethylethanolamine on lipide phosphorylation.
The Journal of biological chemistry.
1948 Nov; 176(2):949-59. doi:
10.1016/s0021-9258(19)52709-0. [PMID: 18889949] - C ARTOM, W E CORNATZER. The action of ethanolamine, monomethyl- and dimethyl-ethanolamine on lipide phosphorylation.
Federation proceedings.
1948 Mar; 7(1 Pt 1):143. doi:
". [PMID: 18933914]
