Samarium Sm 153 lexidronam (BioDeep_00000856930)
代谢物信息卡片
Samarium Sm 153 lexidronam
化学式: C6H17N2O12P4Sm (584.8929392)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CN(CP(=O)(O)[O-])CP(=O)(O)[O-])N(CP(=O)(O)O)CP(=O)(O)[O-].[Sm+3]
InChI: /q
描述信息
V - Various > V10 - Therapeutic radiopharmaceuticals > V10B - Pain palliation (bone seeking agents) > V10BX - Various pain palliation radiopharmaceuticals
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C1446 - Radiopharmaceutical Compound > C2124 - Radioconjugate
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Maryam Fallahpoor, Mehrshad Abbasi, Ali Asghar Parach, Faraz Kalantari. The importance of BMI in dosimetry of 153Sm-EDTMP bone pain palliation therapy: A Monte Carlo study.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2017 06; 124(?):1-6. doi:
10.1016/j.apradiso.2017.02.044. [PMID: 28284122] - Yasemin Parlak, Gul Gumuser, Elvan Sayit. Samarium-153 therapy for prostate cancer: the evaluation of urine activity, staff exposure and dose rate from patients.
Radiation protection dosimetry.
2015 Mar; 163(4):468-72. doi:
10.1093/rpd/ncu237. [PMID: 25063786] - Luis Correa-González, Consuelo Arteaga de Murphy, Pablo Pichardo-Romero, Martha Pedraza-López, Claudia Moreno-García, Luis Correa-Hernández. (153)Sm-EDTMP for pain relief of bone metastases from prostate and breast cancer and other malignancies.
Archives of medical research.
2014 May; 45(4):301-8. doi:
10.1016/j.arcmed.2014.03.006. [PMID: 24681187] - L Vigna, R Matheoud, S Ridone, D Arginelli, P Della Monica, M Rudoni, E Inglese, M Brambilla. Characterization of the [(153)Sm]Sm-EDTMP pharmacokinetics and estimation of radiation absorbed dose on an individual basis.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB).
2011 Jul; 27(3):144-52. doi:
10.1016/j.ejmp.2010.08.001. [PMID: 20864370] - Frank J Papatheofanis, Mohammad M Najib. Bone marrow recovery following use of systemic (153)Sm-lexidronam and (89)Sr-chloride for bone pain palliation after myelosuppressive therapy.
International journal of radiation biology.
2009 May; 85(5):448-53. doi:
10.1080/09553000902818899. [PMID: 19437245] - Arthur Villarim Neto, Maria Kadja Meneses Torres Açucena, Kércia Regina Santos Gomes Pereira, Amália Cínthia Meneses Rêgo, Italo Medeiros Azevedo, Mário Bernardo-Filho, Aldo Cunha Medeiros. Biodistribution of samarium-153-EDTMP in rats treated with docetaxel.
Acta cirurgica brasileira.
2009 Jan; 24(1):62-6. doi:
10.1590/s0102-86502009000100013. [PMID: 19169545] - Marnix G E H Lam, Amel Dahmane, Wil H M Stevens, Peter P van Rijk, John M H de Klerk, Bernard A Zonnenberg. Combined use of zoledronic acid and 153Sm-EDTMP in hormone-refractory prostate cancer patients with bone metastases.
European journal of nuclear medicine and molecular imaging.
2008 Apr; 35(4):756-65. doi:
10.1007/s00259-007-0659-z. [PMID: 18157530] - Sergio Ricci, Giuseppe Boni, Ilaria Pastina, Dario Genovesi, Claudia Cianci, Serena Chiacchio, Cinzia Orlandini, Mariano Grosso, Abedallatif Alsharif, Aldo Chioni, Samantha Di Donato, Francesco Francesca, Cesare Selli, Domenico Rubello, Giuliano Mariani. Clinical benefit of bone-targeted radiometabolic therapy with 153Sm-EDTMP combined with chemotherapy in patients with metastatic hormone-refractory prostate cancer.
European journal of nuclear medicine and molecular imaging.
2007 Jul; 34(7):1023-30. doi:
10.1007/s00259-006-0343-8. [PMID: 17242920] - Wei Fan, Li-Xin Chen, Xiao-Wei Liu, Qiang Tang, Guo-Hui Wang, Sheng-Fang Zhi, Zong-Yuan Zeng. [Primary investigation of dose-effect relationship of 153Sm-EDTMP in treating multiple bone metastases].
Ai zheng = Aizheng = Chinese journal of cancer.
2006 Nov; 25(11):1395-8. doi:
NULL. [PMID: 17094908] - Li-Xin Chen, Xiao-Wei Liu, Feng Gan, Qiang Tang, Ri-An You, Wei-Guang Zhang, Wei Fan. [Three-dimensional dose calculation of 153Sm-EDTMP in treating bone metastasis--comparison of Monte Carlo and S value calculation methods].
Ai zheng = Aizheng = Chinese journal of cancer.
2006 Nov; 25(11):1399-405. doi:
NULL. [PMID: 17094909] - Apollina Goel, Angela Dispenzieri, Susan M Geyer, Suzanne Greiner, Kah-Whye Peng, Stephen J Russell. Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma.
Blood.
2006 May; 107(10):4063-70. doi:
10.1182/blood-2005-09-3870. [PMID: 16424391] - Eduardo Galiano, Marco Stradiotto. A statistical analysis of the initial biodistribution of 153Sm-EDTMP in a canine.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2005 Jul; 63(1):79-85. doi:
10.1016/j.apradiso.2005.01.006. [PMID: 15866451] - Carlo L Maini, Serenella Bergomi, Luisa Romano, Rosa Sciuto. 153Sm-EDTMP for bone pain palliation in skeletal metastases.
European journal of nuclear medicine and molecular imaging.
2004 Jun; 31 Suppl 1(?):S171-8. doi:
10.1007/s00259-004-1540-y. [PMID: 15127241] - Piotr Garnuszek, Dariusz Pawlak, Iwona Licińska, Anna Kamińska. Evaluation of a freeze-dried kit for EDTMP-based bone-seeking radiopharmaceuticals.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2003 Apr; 58(4):481-8. doi:
10.1016/s0969-8043(03)00057-5. [PMID: 12672628] - J Dolezal, J Vizd'a, E Cermáková. [Myelotoxicity after systemic radionuclide therapy of painful bone metastases with 153Samarium-EDTMP ].
Vnitrni lekarstvi.
2003 Mar; 49(3):189-93. doi:
NULL. [PMID: 12728593] - Winfried Brenner, Willm Uwe Kampen, Corinna Brümmer, Corinna von Forstner, Maaz Zuhayra, Norbert Czech, Claus Muhle, Eberhard Henze. Bone uptake studies in rabbits before and after high-dose treatment with 153Sm-EDTMP or 186Re-HEDP.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2003 Feb; 44(2):247-51. doi:
NULL. [PMID: 12571217] - Lin Li, Zhenglu Liang, Honfu Deng, Anren Kuang, Tianzhi Tan, Shunzhong Luo. Samarium-153-EDTMP bone uptake rate and its relation to therapeutic effect.
Chinese medical journal.
2002 Jul; 115(7):1096-8. doi:
NULL. [PMID: 12173602] - W J Hogan, M Q Lacy, G A Wiseman, R D Fealey, A Dispenzieri, M A Gertz. Successful treatment of POEMS syndrome with autologous hematopoietic progenitor cell transplantation.
Bone marrow transplantation.
2001 Aug; 28(3):305-9. doi:
10.1038/sj.bmt.1703108. [PMID: 11536000] - P J Cameron, P F Klemp, A A Martindale, J H Turner. Prospective 153Sm-EDTMP therapy dosimetry by whole-body scintigraphy.
Nuclear medicine communications.
1999 Jul; 20(7):609-15. doi:
10.1097/00006231-199907000-00003. [PMID: 10423762] - J R Zeevaart, N V Jarvis, W K Louw, G E Jackson, I Cukrowski, C J Mouton. Metal-ion speciation in blood plasma incorporating the bisphosphonate, 1-hydroxy-4-aminopropilydenediphosphonate (APD), in therapeutic radiopharmaceuticals.
Journal of inorganic biochemistry.
1999 Apr; 73(4):265-72. doi:
10.1016/s0162-0134(99)00027-6. [PMID: 10376350] - I C Dormehl, W K Louw, F H Schneeweiss, R Milner, G Schmitt, U Carl, S A Croft. Uptake of ethylenediamine tetramethylene phosphonic acid in normal bone after multiple applications. A non-human primate study.
Arzneimittel-Forschung.
1998 Apr; 48(4):408-14. doi:
NULL. [PMID: 9608885] - H M Lamb, D Faulds. Samarium 153Sm lexidronam.
Drugs & aging.
1997 Nov; 11(5):413-8; discussion 419. doi:
10.2165/00002512-199711050-00007. [PMID: 9359026] - G Charmaine de Witt, P M May, J Webb, G Hefter. Biospeciation, by potentiometry and computer simulation, of Sm-EDTMP, a bone tumor palliative agent.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
1996 Oct; 9(4):351-61. doi:
10.1007/bf00140604. [PMID: 8837456] - H Deng, T Tan, T Mo, S Zhong, A Kuan, Y Hu. [Effect of 153Sm-EDTMP on hematopoiesis and vital organs of 93 patients with bone tumor].
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao.
1995 Jun; 26(2):155-9. doi:
NULL. [PMID: 7490021] - C Collins, J F Eary, G Donaldson, C Vernon, N E Bush, S Petersdorf, R B Livingston, E E Gordon, C R Chapman, F R Appelbaum. Samarium-153-EDTMP in bone metastases of hormone refractory prostate carcinoma: a phase I/II trial.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1993 Nov; 34(11):1839-44. doi:
NULL. [PMID: 8229221] - M Farhanghi, R A Holmes, W A Volkert, K W Logan, A Singh. Samarium-153-EDTMP: pharmacokinetic, toxicity and pain response using an escalating dose schedule in treatment of metastatic bone cancer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1992 Aug; 33(8):1451-8. doi:
NULL. [PMID: 1378887] - J H Turner, P G Claringbold, E L Hetherington, P Sorby, A A Martindale. A phase I study of samarium-153 ethylenediaminetetramethylene phosphonate therapy for disseminated skeletal metastases.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1989 Dec; 7(12):1926-31. doi:
10.1200/jco.1989.7.12.1926. [PMID: 2585026]