Globo-H (BioDeep_00000856788)
代谢物信息卡片
化学式: C20H35NO15 (529.2006600000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OC2C(C(C(OC2OC3C(C(OC(C3O)CO)O)NC(=O)C)CO)O)O)O)O)O
InChI: InChI=1S/C20H35NO15/c1-5-10(25)13(28)15(30)19(32-5)36-17-14(29)11(26)7(3-22)34-20(17)35-16-9(21-6(2)24)18(31)33-8(4-23)12(16)27/h5,7-20,22-23,25-31H,3-4H2,1-2H3,(H,21,24)/t5-,7+,8+,9+,10+,11-,12+,13+,14-,15-,16+,17+,18+,19-,20-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Darren S Sigal, David J Hermel, Pei Hsu, Tillman Pearce. The role of Globo H and SSEA-4 in the development and progression of cancer, and their potential as therapeutic targets.
Future oncology (London, England).
2022 Jan; 18(1):117-134. doi:
10.2217/fon-2021-1110. [PMID: 34734786] - Sachi Asano, Rita Pal, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Kenichi G N Suzuki, Hiromune Ando. Development of Fluorescently Labeled SSEA-3, SSEA-4, and Globo-H Glycosphingolipids for Elucidating Molecular Interactions in the Cell Membrane.
International journal of molecular sciences.
2019 Dec; 20(24):. doi:
10.3390/ijms20246187. [PMID: 31817926] - Po-Kai Chuang, Michael Hsiao, Tsui-Ling Hsu, Chuan-Fa Chang, Chung-Yi Wu, Bo-Rui Chen, Han-Wen Huang, Kuo-Shiang Liao, Chen-Chun Chen, Chi-Long Chen, Shun-Min Yang, Chiung Wen Kuo, Peilin Chen, Ping-Tzu Chiu, I-Ju Chen, Jiann-Shiun Lai, Cheng-Der Tony Yu, Chi-Huey Wong. Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2019 02; 116(9):3518-3523. doi:
10.1073/pnas.1816946116. [PMID: 30808745] - Tatiana Pochechueva, Shahidul Alam, Andreas Schötzau, Alexander Chinarev, Nicolai V Bovin, Neville F Hacker, Francis Jacob, Viola Heinzelmann-Schwarz. Naturally occurring anti-glycan antibodies binding to Globo H-expressing cells identify ovarian cancer patients.
Journal of ovarian research.
2017 Feb; 10(1):8. doi:
10.1186/s13048-017-0305-8. [PMID: 28187738] - Chen-Shiou Wu, Chia-Jui Yen, Ruey-Hwang Chou, Jia-Ni Chen, Wei-Chien Huang, Chung-Yi Wu, Yung-Luen Yu. Downregulation of microRNA-15b by hepatitis B virus X enhances hepatocellular carcinoma proliferation via fucosyltransferase 2-induced Globo H expression.
International journal of cancer.
2014 Apr; 134(7):1638-47. doi:
10.1002/ijc.28501. [PMID: 24122375] - Christopher M Stead, Jinshi Zhao, Christian R H Raetz, M Stephen Trent. Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface.
Molecular microbiology.
2010 Nov; 78(4):837-52. doi:
10.1111/j.1365-2958.2010.07304.x. [PMID: 20659292] - Cheng-Chi Wang, Yen-Lin Huang, Chien-Tai Ren, Chin-Wei Lin, Jung-Tung Hung, Jyh-Cherng Yu, Alice L Yu, Chung-Yi Wu, Chi-Huey Wong. Glycan microarray of Globo H and related structures for quantitative analysis of breast cancer.
Proceedings of the National Academy of Sciences of the United States of America.
2008 Aug; 105(33):11661-6. doi:
10.1073/pnas.0804923105. [PMID: 18689688] - Cheng-Yuan Huang, Desiree A Thayer, Aileen Y Chang, Michael D Best, Julia Hoffmann, Steve Head, Chi-Huey Wong. Carbohydrate microarray for profiling the antibodies interacting with Globo H tumor antigen.
Proceedings of the National Academy of Sciences of the United States of America.
2006 Jan; 103(1):15-20. doi:
10.1073/pnas.0509693102. [PMID: 16373501] - R Mollicone, A Cailleau, A Imberty, P Gane, S Perez, R Oriol. Recognition of the blood group H type 2 trisaccharide epitope by 28 monoclonal antibodies and three lectins.
Glycoconjugate journal.
1996 Apr; 13(2):263-71. doi:
10.1007/bf00731501. [PMID: 8737251] - R Oriol, Y Ye, E Koren, D K Cooper. Carbohydrate antigens of pig tissues reacting with human natural antibodies as potential targets for hyperacute vascular rejection in pig-to-man organ xenotransplantation.
Transplantation.
1993 Dec; 56(6):1433-42. doi:
10.1097/00007890-199312000-00031. [PMID: 8279016]