Pentetreotide (BioDeep_00000856768)
代谢物信息卡片
Pentetoreotide
化学式: C63H87N13O19S2 (1393.5682312000001)
中文名称: 喷曲肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)NC(=O)C(CC5=CC=CC=C5)NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)NC(CO)C(C)O)O
InChI: InChI=1S/C63H87N13O19S2/c1-37(78)48(34-77)70-62(94)50-36-97-96-35-49(71-58(90)45(25-39-13-5-3-6-14-39)66-51(80)29-75(31-53(83)84)23-21-74(30-52(81)82)22-24-76(32-54(85)86)33-55(87)88)61(93)68-46(26-40-15-7-4-8-16-40)59(91)69-47(27-41-28-65-43-18-10-9-17-42(41)43)60(92)67-44(19-11-12-20-64)57(89)73-56(38(2)79)63(95)72-50/h3-10,13-18,28,37-38,44-50,56,65,77-79H,11-12,19-27,29-36,64H2,1-2H3,(H,66,80)(H,67,92)(H,68,93)(H,69,91)(H,70,94)(H,71,90)(H,72,95)(H,73,89)(H,81,82)(H,83,84)(H,85,86)(H,87,88)
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C62799 - Somatostatin Receptor Agonist
同义名列表
2 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sho Koyasu, Yuji Nakamoto. 111In-Pentetreotide Uptake Due to COVID-19 Vaccination.
Clinical nuclear medicine.
2022 Mar; 47(3):271-272. doi:
10.1097/rlu.0000000000003935. [PMID: 34619700] - Ananda Kumar Kanduluru, Madduri Srinivasarao, Charity Wayua, Philip S Low. Evaluation of a Neurokinin-1 Receptor-Targeted Technetium-99m Conjugate for Neuroendocrine Cancer Imaging.
Molecular imaging and biology.
2020 04; 22(2):377-383. doi:
10.1007/s11307-019-01391-w. [PMID: 31292915] - Mechthild Schmitt, Eero Hippeläinen, Manuela Raviña, Blanca Arango-Gonzalez, Maxim Antopolsky, Kati-Sisko Vellonen, Anu J Airaksinen, Arto Urtti. Intravitreal Pharmacokinetics in Mice: SPECT/CT Imaging and Scaling to Rabbits and Humans.
Molecular pharmaceutics.
2019 10; 16(10):4399-4404. doi:
10.1021/acs.molpharmaceut.9b00679. [PMID: 31430156] - Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello. Radiopharmaceuticals for the Diagnosis and Therapy of Neuroendocrine Differentiated Prostate Cancer.
Current radiopharmaceuticals.
2017; 10(1):6-15. doi:
10.2174/1874471009666161229123126. [PMID: 28034291] - Samira M Sadowski, Vladimir Neychev, Corina Millo, Joanna Shih, Naris Nilubol, Peter Herscovitch, Karel Pacak, Stephen J Marx, Electron Kebebew. Prospective Study of 68Ga-DOTATATE Positron Emission Tomography/Computed Tomography for Detecting Gastro-Entero-Pancreatic Neuroendocrine Tumors and Unknown Primary Sites.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2016 Feb; 34(6):588-96. doi:
10.1200/jco.2015.64.0987. [PMID: 26712231] - Antonino Buffone, Dario Cavallaro, Salvatore Lo Bianco, Lidia Puzzo, Pietro Caglià, Matteo Angelo Cannizzaro. Synchronous ileal neuroendocrine tumor: diagnosis and treatment. A case report and review of the literature.
Annali italiani di chirurgia.
2016; 87(?):92-6. doi:
NULL. [PMID: 27026360] - Mathieu Gauthé, Astrid Lièvre, Jean-Louis Alberini. Primary Neuroendocrine Tumor in a Horseshoe Kidney With Positive 111In-Pentetreotide Somatostatin Receptor Scintigraphy and Negative 18F-DOPA PET/CT.
Clinical nuclear medicine.
2015 Nov; 40(11):e516-7. doi:
10.1097/rlu.0000000000000911. [PMID: 26204216] - Samira M Sadowski, Corina Millo, Candice Cottle-Delisle, Roxanne Merkel, Lily A Yang, Peter Herscovitch, Karel Pacak, William F Simonds, Stephen J Marx, Electron Kebebew. Results of (68)Gallium-DOTATATE PET/CT Scanning in Patients with Multiple Endocrine Neoplasia Type 1.
Journal of the American College of Surgeons.
2015 Aug; 221(2):509-17. doi:
10.1016/j.jamcollsurg.2015.04.005. [PMID: 26206648] - Steven P Rowe, Esther Vicente, Nadège Anizan, Hao Wang, Jeffrey P Leal, Martin A Lodge, Eric C Frey, Richard L Wahl. Repeatability of Radiotracer Uptake in Normal Abdominal Organs with ¹¹¹In-Pentetreotide Quantitative SPECT/CT.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2015 Jul; 56(7):985-8. doi:
10.2967/jnumed.115.155358. [PMID: 25977467] - Mark A Lewis, Geoffrey B Thompson, William F Young. Preoperative assessment of the pancreas in multiple endocrine neoplasia type 1.
World journal of surgery.
2012 Jun; 36(6):1375-81. doi:
10.1007/s00268-012-1539-7. [PMID: 22382771] - Alessandro Sciarra, Michele Innocenzi, Michele Ravaziol, Francesco Minisola, Andrea Alfarone, Susanna Cattarino, Valeria Panebianco, Valeria Buonocore, Vincenzo Gentile, Franco Di Silverio. [Current diagnostic procedure on neuroendocrine differentiation of prostate cancer].
Urologia.
2011 Apr; 78(2):132-6. doi:
10.5301/ru.2011.8336. [PMID: 21574146] - Miklós Tóth, Nikolette Szücs, Zsuzsa Jakab, Attila Doros, Zoltán Nemes, Károly Rácz. [Malignant insulinoma].
Orvosi hetilap.
2011 Mar; 152(10):398-402. doi:
10.1556/oh.2011.29058. [PMID: 21354956] - Dik J Kwekkeboom, Boen L Kam, Martijn van Essen, Jaap J M Teunissen, Casper H J van Eijck, Roelf Valkema, Marion de Jong, Wouter W de Herder, Eric P Krenning. Somatostatin-receptor-based imaging and therapy of gastroenteropancreatic neuroendocrine tumors.
Endocrine-related cancer.
2010 Mar; 17(1):R53-73. doi:
10.1677/erc-09-0078. [PMID: 19995807] - Ali Agool, Riemer H J A Slart, Rudi A J O Dierckx, Philip M Kluin, Lydia Visser, Pieter L Jager, Edo Vellenga. Somatostatin receptor scintigraphy might be useful for detecting skeleton abnormalities in patients with multiple myeloma and plasmacytoma.
European journal of nuclear medicine and molecular imaging.
2010 Jan; 37(1):124-30. doi:
10.1007/s00259-009-1199-5. [PMID: 19597816] - Monica Marazuela, Lia Nattero, Dolores Moure, Iluminada García-Polo, Nicte Figueroa-Vega, Carlos Guijarro. Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment.
Thyroid : official journal of the American Thyroid Association.
2008 Oct; 18(10):1119-23. doi:
10.1089/thy.2007.0375. [PMID: 18816177] - Kjell Oberg, Barbro Eriksson. Nuclear medicine in the detection, staging and treatment of gastrointestinal carcinoid tumours.
Best practice & research. Clinical endocrinology & metabolism.
2005 Jun; 19(2):265-76. doi:
10.1016/j.beem.2004.11.016. [PMID: 15763700] - George C Nikou, N J Lygidakis, Christos Toubanakis, Spiridon Pavlatos, Sofia Tseleni-Balafouta, Eleanna Giannatou, Elias Mallas, Michael Safioleas. Current diagnosis and treatment of gastrointestinal carcinoids in a series of 101 patients: the significance of serum chromogranin-A, somatostatin receptor scintigraphy and somatostatin analogues.
Hepato-gastroenterology.
2005 May; 52(63):731-41. doi:
NULL. [PMID: 15966194] - Patrick Mufarrij, Ioannis M Varkarakis, Kimberley D Studeman, Thomas W Jarrett. Primary renal carcinoid tumor with liver metastases detected with somatostatin receptor imaging.
Urology.
2005 May; 65(5):1002. doi:
10.1016/j.urology.2004.11.042. [PMID: 15882749] - I Vainas, Ch Koussis, K Pazaitou-Panayiotou, A Drimonitis, A Chrisoulidou, I Iakovou, M Boudina, A Kaprara, A Maladaki. Somatostatin receptor expression in vivo and response to somatostatin analog therapy with or without other antineoplastic treatments in advanced medullary thyroid carcinoma.
Journal of experimental & clinical cancer research : CR.
2004 Dec; 23(4):549-59. doi:
NULL. [PMID: 15743023] - Andreas Helisch, Gregor J Förster, Helmut Reber, Hans-Georg Buchholz, Rudolf Arnold, Burkhard Göke, Matthias M Weber, Bertram Wiedenmann, Stanislas Pauwels, Ulrike Haus, Hakim Bouterfa, Peter Bartenstein. Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phe1-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours.
European journal of nuclear medicine and molecular imaging.
2004 Oct; 31(10):1386-92. doi:
10.1007/s00259-004-1561-6. [PMID: 15175836] - SuEllen Toth-Fejel, Rodney F Pommier. Relationships among delay of diagnosis, extent of disease, and survival in patients with abdominal carcinoid tumors.
American journal of surgery.
2004 May; 187(5):575-9. doi:
10.1016/j.amjsurg.2004.01.019. [PMID: 15135668] - Orazio Schillaci, Angela Spanu, Francesco Scopinaro, Antonio Falchi, Vito Corleto, Roberta Danieli, Pietro Marongiu, Nicola Pisu, Giordano Madeddu, Gianfranco Delle Fave, Giuseppe Madeddu. Somatostatin receptor scintigraphy with 111In-pentetreotide in non-functioning gastroenteropancreatic neuroendocrine tumors.
International journal of oncology.
2003 Dec; 23(6):1687-95. doi:
NULL. [PMID: 14612942] - Ken Kishida, Makoto Moriwaki, Jun-ichiro Miyagawa, Kohei Okita, Takashi Kondo, Kimiko Itoh, Satoshi Umemura, Junji Kozawa, Hiromi Iwahashi, Tohru Yoshizumi, Akihisa Imagawa, Kazuya Yamagata, Takao Maruyama, Hiroyuki Toyoshima, Eiji Kurokawa, Tohru Funahashi, Yuji Matsuzawa. Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome.
Internal medicine (Tokyo, Japan).
2003 Oct; 42(10):996-1005. doi:
10.2169/internalmedicine.42.996. [PMID: 14606715] - David Bushnell, Yusuf Menda, Mark Madsen, Thomas O'Dorisio, Thomas Carlisle, Pamela Zehr, Laura Ponto, Mark Karwal, Stan Parker, James Ponto, Mary Connolly, Hakim Bouterfa. Assessment of hepatic toxicity from treatment with 90Y-SMT 487 (OctreoTher(TM)) in patients with diffuse somatostatin receptor positive liver metastases.
Cancer biotherapy & radiopharmaceuticals.
2003 Aug; 18(4):581-8. doi:
10.1089/108497803322287664. [PMID: 14503953] - Hans Jacobsson, Staffan Bremmer, Stig A Larsson. Visualisation of the normal adrenals at SPET examination with 111In-pentetreotide.
European journal of nuclear medicine and molecular imaging.
2003 Aug; 30(8):1169-72. doi:
10.1007/s00259-003-1210-5. [PMID: 12768335] - Tsuneo Saga, Nagara Tamaki, Keiichi Itoi, Tetsuro Yamazaki, Keigo Endo, Goro Watanabe, Hirotaka Maruno, Rikuo Machinami, Kiyoshi Koizumi, Taro Ichikawa, Hiroshi Takami, Miyuki Ishibashi, Atsushi Kubo, Kiyoko Kusakabe, Yukio Hirata, Yuji Murata, Yukitaka Miyachi, Masahiko Tsubuku, Harumi Sakahara, Kazuhiro Katada, Norihisa Tonami, Kazutaka Yamamoto, Junji Konishi, Masayuki Imamura, Ryuichiro Doi, Akira Shimatsu, Shinzaburo Noguchi, Yoshinao Hasegawa, Osamu Ishikawa, Yuji Watanabe, Masayuki Nakajo. [Phase III additional clinical study of 111In-pentetreotide (MP-1727): diagnosis of gastrointestinal hormone producing tumors based on the presence of somatostatin receptors].
Kaku igaku. The Japanese journal of nuclear medicine.
2003 May; 40(2):185-203. doi:
NULL. [PMID: 12884785] - P Loli, F Vignati, E Grossrubatscher, P Dalino, M Possa, F Zurleni, G Lomuscio, O Rossetti, M Ravini, A Vanzulli, C Bacchetta, C Galli, D Valente. Management of occult adrenocorticotropin-secreting bronchial carcinoids: limits of endocrine testing and imaging techniques.
The Journal of clinical endocrinology and metabolism.
2003 Mar; 88(3):1029-35. doi:
10.1210/jc.2001-011813. [PMID: 12629081] - John R Buscombe, Martyn E Caplin, Andrew J W Hilson. Long-term efficacy of high-activity 111in-pentetreotide therapy in patients with disseminated neuroendocrine tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2003 Jan; 44(1):1-6. doi:
NULL. [PMID: 12515868] - Maxime Lamarre-Cliche, Anne-Paule Gimenez-Roqueplo, Eliane Billaud, Eric Baudin, Jean-Pierre Luton, Pierre-François Plouin. Effects of slow-release octreotide on urinary metanephrine excretion and plasma chromogranin A and catecholamine levels in patients with malignant or recurrent phaeochromocytoma.
Clinical endocrinology.
2002 Nov; 57(5):629-34. doi:
10.1046/j.1365-2265.2002.01658.x. [PMID: 12390337] - R Görges, M Kaun, A Frilling, K W Schmid. [Recurrence of a renal cell carcinoma mimicking a multiple endocrine neoplasia with thyroid gland involvement].
Nuklearmedizin. Nuclear medicine.
2002 Jun; 41(3):N24-6. doi:
NULL. [PMID: 12109038] - Lowell B Anthony, Eugene A Woltering, Gregory D Espenan, Michele D Cronin, Tom J Maloney, Kevin E McCarthy. Indium-111-pentetreotide prolongs survival in gastroenteropancreatic malignancies.
Seminars in nuclear medicine.
2002 Apr; 32(2):123-32. doi:
10.1053/snuc.2002.31769. [PMID: 11965607] - Suzanne M Jan de Beur, Elizabeth A Streeten, A Cahid Civelek, Edward F McCarthy, Liliana Uribe, Stephen J Marx, Olufunmilayo Onobrakpeya, Lawrence G Raisz, Nelson B Watts, Michael Sharon, Michael A Levine. Localisation of mesenchymal tumours by somatostatin receptor imaging.
Lancet (London, England).
2002 Mar; 359(9308):761-3. doi:
10.1016/s0140-6736(02)07846-7. [PMID: 11888589] - G J Förster, M J Engelbach, J J Brockmann, H J Reber, H G Buchholz, H R Mäcke, F R Rösch, H R Herzog, P R Bartenstein. Preliminary data on biodistribution and dosimetry for therapy planning of somatostatin receptor positive tumours: comparison of (86)Y-DOTATOC and (111)In-DTPA-octreotide.
European journal of nuclear medicine.
2001 Dec; 28(12):1743-50. doi:
10.1007/s002590100628. [PMID: 11734910] - D J Kwekkeboom, W H Bakker, P P Kooij, M W Konijnenberg, A Srinivasan, J L Erion, M A Schmidt, J L Bugaj, M de Jong, E P Krenning. [177Lu-DOTAOTyr3]octreotate: comparison with [111In-DTPAo]octreotide in patients.
European journal of nuclear medicine.
2001 Sep; 28(9):1319-25. doi:
10.1007/s002590100574. [PMID: 11585290] - C Waldherr, T Schumacher, M Pless, A Crazzolara, H R Maecke, E U Nitzsche, A Haldemann, J Mueller-Brand. Radiopeptide transmitted internal irradiation of non-iodophil thyroid cancer and conventionally untreatable medullary thyroid cancer using.
Nuclear medicine communications.
2001 Jun; 22(6):673-8. doi:
10.1097/00006231-200106000-00011. [PMID: 11403179] - L D Mitzner, A Nohria, M Chacho, S E Inzucchi. Sequential hypoglycemia, hyperglycemia, and the carcinoid syndrome arising from a plurihormonal neuroendocrine neoplasm.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2000 Sep; 6(5):370-4. doi:
10.4158/ep.6.5.370. [PMID: 11141588] - J D Mediavilla García, M López de la Torre Casares, C Hidalgo Tenorio, C Fernández-Torres, L Aliaga Martínez, F Peran Mesa, M A Muros de Fuentes. [A comparative study of 9 cases of adrenal pheochromocytoma and 11 cases of extra-adrenal pheochromocytoma].
Revista clinica espanola.
1999 Jun; 199(6):343-8. doi:
NULL. [PMID: 10432807] - N Valli, B Catargi, N Ronci, F Leccia, M Guyot, P Roger, D Ducassou, A Tabarin. Evaluation of indium-111 pentetreotide somatostatin receptor scintigraphy to detect recurrent thyroid carcinoma in patients with negative radioiodine scintigraphy.
Thyroid : official journal of the American Thyroid Association.
1999 Jun; 9(6):583-9. doi:
10.1089/thy.1999.9.583. [PMID: 10411121] - D J Kwekkeboom, P P Kooij, W H Bakker, H R Mäcke, E P Krenning. Comparison of 111In-DOTA-Tyr3-octreotide and 111In-DTPA-octreotide in the same patients: biodistribution, kinetics, organ and tumor uptake.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999 May; 40(5):762-7. doi:
NULL. [PMID: 10319747] - F Gibril, J C Reynolds, C C Chen, F Yu, S U Goebel, J Serrano, J L Doppman, R T Jensen. Specificity of somatostatin receptor scintigraphy: a prospective study and effects of false-positive localizations on management in patients with gastrinomas.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1999 Apr; 40(4):539-53. doi:
NULL. [PMID: 10210211] - M Edgren, J E Westlin, K M Kälkner, A Sundin, S Nilsson. [111In-DPTA-D-Phe1]-octreotide scintigraphy in the management of patients with advanced renal cell carcinoma.
Cancer biotherapy & radiopharmaceuticals.
1999 Feb; 14(1):59-64. doi:
10.1089/cbr.1999.14.59. [PMID: 10850288] - F Montravers, C Rousseau, J D Doublet, B Gattengo, S Allard, P Fouret, J F Bernaudin, P Thibault, J N Talbot. In vivo inaccessibility of somatostatin receptors to 111In-pentreotide in primary renal cell carcinoma.
Nuclear medicine communications.
1998 Oct; 19(10):953-61. doi:
10.1097/00006231-199810000-00005. [PMID: 10234675] - D J Kwekkeboom, E P Krenning, G S Kho, W A Breeman, P M Van Hagen. Somatostatin receptor imaging in patients with sarcoidosis.
European journal of nuclear medicine.
1998 Sep; 25(9):1284-92. doi:
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Journal of endocrinological investigation.
1998 Sep; 21(8):512-9. doi:
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Clinical endocrinology.
1998 Mar; 48(3):303-9. doi:
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The Journal of clinical endocrinology and metabolism.
1997 Sep; 82(9):2962-5. doi:
10.1210/jcem.82.9.4217. [PMID: 9284727] - M Losa, P Magnani, P Mortini, L Persani, S Acerno, E Giugni, C Songini, F Fazio, P Beck-Peccoz, M Giovanelli. Indium-111 pentetreotide single-photon emission tomography in patients with TSH-secreting pituitary adenomas: correlation with the effect of a single administration of octreotide on serum TSH levels.
European journal of nuclear medicine.
1997 Jul; 24(7):728-31. doi:
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European journal of endocrinology.
1997 Jul; 137(1):79-83. doi:
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The Journal of small animal practice.
1997 Jul; 38(7):286-91. doi:
10.1111/j.1748-5827.1997.tb03466.x. [PMID: 9239629] - T M Behr, S Gratz, P M Markus, R M Dunn, M Hüfner, H Becker, W Becker. Enhanced bilateral somatostatin receptor expression in mediastinal lymph nodes ('chimney sign') in occult metastatic medullary thyroid cancer: a typical site of tumour manifestation?.
European journal of nuclear medicine.
1997 Feb; 24(2):184-91. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996 Dec; 37(12):7A, 1994. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996 Sep; 37(9):1452-6. doi:
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Metabolism: clinical and experimental.
1996 Aug; 45(8 Suppl 1):83-5. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1996 Jun; 37(6):916-22. doi:
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The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR).
1995 Dec; 39(4 Suppl 1):121-3. doi:
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The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR).
1995 Dec; 39(4 Suppl 1):131-3. doi:
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1995 Apr; 36(4):620-2. doi:
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