(-)-7-((7S)-7-Amino-5-azaspiro(2.4)hept-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, sesquihydrate (BioDeep_00000855789)
代谢物信息卡片
化学式: C38H42Cl2F4N6O9 (872.2326310000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC12CN(CC2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5CC5F)F.C1CC12CN(CC2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)C5CC5F)F.O.O.O
InChI: /m00.../s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Lu-Ning Sun, Guo-Xian Sun, Yu-Qing Yang, Ye Shen, Feng-Ru Huang, Li-Jun Xie, Juan Cheng, Hong-Wen Zhang, Xue-Hui Zhang, Yun Liu, Yong-Qing Wang. Effects of ABCB1, UGT1A1, and UGT1A9 Genetic Polymorphisms on the Pharmacokinetics of Sitafloxacin Granules in Healthy Subjects.
Clinical pharmacology in drug development.
2021 01; 10(1):57-67. doi:
10.1002/cpdd.848
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2020 Dec; 26(12):1272-1277. doi:
10.1016/j.jiac.2020.07.009
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BMC infectious diseases.
2020 Jun; 20(1):431. doi:
10.1186/s12879-020-05136-x
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Antimicrobial agents and chemotherapy.
2019 10; 63(10):. doi:
10.1128/aac.00800-19
. [PMID: 31405868] - Xiaohui Ding, Zili Suo, Qiaomei Sun, Ruixue Gan, Peixiao Tang, Quan Hou, Di Wu, Hui Li. Study of the interaction of broad-spectrum antimicrobial drug sitafloxacin with human serum albumin using spectroscopic methods, molecular docking, and molecular dynamics simulation.
Journal of pharmaceutical and biomedical analysis.
2018 Oct; 160(?):397-403. doi:
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2018 Aug; 24(8):610-614. doi:
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2017 Apr; 23(4):214-217. doi:
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2017 Apr; 100(4):469-78. doi:
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Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2017 Mar; 23(3):131-135. doi:
10.1016/j.jiac.2016.09.007
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International journal of clinical pharmacology and therapeutics.
2014 Dec; 52(12):1037-44. doi:
10.5414/cp202147
. [PMID: 25250613] - Yuanyuan Wang, Yang Liu, Hongwen Zhang, Yongqing Wang, Yun Liu, Libin Wang, Ning Ou. A simple LC-MS/MS method for determination of sitafloxacin in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Sep; 967(?):219-24. doi:
10.1016/j.jchromb.2014.07.015
. [PMID: 25128880] - Kai Huang, Jie Yang, Jing Zhang, Ying Ding, Lan Chen, Wen-Yan Xu, Xue-Jiao Xu, Ru Duan, Qing He. Determination of sitafloxacin in human plasma by liquid chromatography-tandem mass spectrometry method: application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Apr; 957(?):36-40. doi:
10.1016/j.jchromb.2014.03.004
. [PMID: 24657409] - Visanu Thamlikitkul, Surapee Tiengrim. In vitro susceptibility test of sitafloxacin against resistant gram-negative bacilli isolated from Thai patients by disk diffusion method.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2014 Mar; 97 Suppl 3(?):S7-12. doi:
NULL
. [PMID: 24772575] - Eiko Namba, Ryo Okumura, Megumi Chiba, Kazuki Hoshino, Kazuhiro Tateda. [Antimicrobial and rapid bactericidal activities of sitafloxacin and other agents against Streptococcus pyogenes].
The Japanese journal of antibiotics.
2013 Oct; 66(5):293-304. doi:
NULL
. [PMID: 24527519] - Shuichi Tsuruoka, Noritsugu Yokota, Tokie Hayasaka, Tetsuo Saito, Kunihiro Yamagata. Dialyzability and pharmacokinetics of sitafloxacin following multiple oral dosing in infected hemodialysis patients.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2013 Jun; 17(3):319-24. doi:
10.1111/j.1744-9987.2012.01150.x
. [PMID: 23735148] - Hiroko Kanda, Kazue Inoue, Ryo Okumura, Kazuki Hoshino. Rapid bactericidal activity of sitafloxacin against Streptococcus pneumoniae.
The Japanese journal of antibiotics.
2013 Feb; 66(1):9-23. doi:
. [PMID: 23777013]
- Shin Ito, Mitsuru Yasuda, Kensaku Seike, Takashi Sugawara, Tomohiro Tsuchiya, Shigeaki Yokoi, Masahiro Nakano, Takashi Deguchi. Clinical and microbiological outcomes in treatment of men with non-gonococcal urethritis with a 100-mg twice-daily dose regimen of sitafloxacin.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2012 Jun; 18(3):414-8. doi:
10.1007/s10156-012-0392-9
. [PMID: 22370921] - Tatsuo Yamamoto, Tomomi Takano, Wataru Higuchi, Akihito Nishiyama, Ikue Taneike, Kumi Yoshida, Hiroko Kanda, Yuichiro Imamura. Helicobacter pylori eradication by sitafloxacin-lansoprazole combination and sitafloxacin pharmacokinetics in Mongolian gerbils and its in vitro activity and resistance development.
Antimicrobial agents and chemotherapy.
2011 Sep; 55(9):4261-6. doi:
10.1128/aac.01105-10
. [PMID: 21730117] - Geoffrey S Payne, David J Collins, Peter Loynds, Graham Mould, Philip S Murphy, Andrzej S K Dzik-Jurasz, Preminda Kessar, Nazneen Haque, Masayuki Yamaguchi, Shogo Atarashi, Martin O Leach. Quantitative assessment of the hepatic pharmacokinetics of the antimicrobial sitafloxacin in humans using in vivoF magnetic resonance spectroscopy.
British journal of clinical pharmacology.
2005 Feb; 59(2):244-8. doi:
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. [PMID: 15676049] - Masaya Tachibana, Makoto Tanaka, Koichi Mitsugi, Yoshitaka Jin, Matsuo Takaichi, Osamu Okazaki. Pharmacokinetics, tissue distribution, and excretion of sitafloxacin, a new fluoroquinolone antibiotic, in rats, dogs, and monkeys.
Arzneimittel-Forschung.
2004; 54(12):898-905. doi:
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. [PMID: 15646375] - Kiyoshi Nakayama, Yohei Ishida, Masami Ohtsuka, Haruko Kawato, Ken-ichi Yoshida, Yoshihiro Yokomizo, Toshiharu Ohta, Kazuki Hoshino, Tsuyoshi Otani, Yuichi Kurosaka, Kumi Yoshida, Hiroko Ishida, Ving J Lee, Thomas E Renau, William J Watkins. MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.
Bioorganic & medicinal chemistry letters.
2003 Dec; 13(23):4205-8. doi:
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The British journal of dermatology.
2003 Dec; 149(6):1232-41. doi:
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. [PMID: 14674902] - J O'Grady, A Briggs, S Atarashi, H Kobayashi, R L Smith, J Ward, C Ward, D Milatovic. Pharmacokinetics and absolute bioavailability of sitafloxacin, a new fluoroquinolone antibiotic, in healthy male and female Caucasian subjects.
Xenobiotica; the fate of foreign compounds in biological systems.
2001 Nov; 31(11):811-22. doi:
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International journal of antimicrobial agents.
2001 Mar; 17(3):177-88. doi:
10.1016/s0924-8579(00)00344-7
. [PMID: 11282262] - K Shimoda, T Ikeda, S Okawara, M Kato. Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2000 Aug; 56(2):290-6. doi:
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Diagnostic microbiology and infectious disease.
1999 Aug; 34(4):301-7. doi:
10.1016/s0732-8893(99)00044-9
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Antimicrobial agents and chemotherapy.
1998 Jul; 42(7):1751-5. doi:
10.1128/aac.42.7.1751
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1998 Mar; 800(2):377-81. doi:
10.1016/s0021-9673(97)01126-6
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The Journal of pharmacology and experimental therapeutics.
1997 Aug; 282(2):955-60. doi:
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The Journal of antimicrobial chemotherapy.
1996 Jun; 37(6):1091-102. doi:
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The Japanese journal of antibiotics.
1995 Mar; 48(3):368-79. doi:
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Antimicrobial agents and chemotherapy.
1995 Jan; 39(1):170-4. doi:
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1994 Oct; 660(2):365-74. doi:
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Antimicrobial agents and chemotherapy.
1992 Jul; 36(7):1491-8. doi:
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