2,4-Thiazolidinedione, 5-((3,4-dihydro-2-(phenylmethyl)-2H-1-benzopyran-6-yl)methyl)- (BioDeep_00000855708)

   


代谢物信息卡片


2,4-Thiazolidinedione, 5-((3,4-dihydro-2-(phenylmethyl)-2H-1-benzopyran-6-yl)methyl)-

化学式: C20H19NO3S (353.1085584000001)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC2=C(C=CC(=C2)CC3C(=O)NC(=O)S3)OC1CC4=CC=CC=C4
InChI: InChI=1S/C20H19NO3S/c22-19-18(25-20(23)21-19)12-14-6-9-17-15(10-14)7-8-16(24-17)11-13-4-2-1-3-5-13/h1-6,9-10,16,18H,7-8,11-12H2,(H,21,22,23)/t16-,18?/m1/s1

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29711 - Anti-diabetic Agent > C98241 - Thiazolidinedione Antidiabetic Agent
D007004 - Hypoglycemic Agents

同义名列表

1 个代谢物同义名

2,4-Thiazolidinedione, 5-((3,4-dihydro-2-(phenylmethyl)-2H-1-benzopyran-6-yl)methyl)-



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代谢反应

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文献列表

  • Julio Sevillano, Inmaculada C López-Pérez, Emilio Herrera, María Del Pilar Ramos, Carlos Bocos. Englitazone administration to late pregnant rats produces delayed body growth and insulin resistance in their fetuses and neonates. The Biochemical journal. 2005 Aug; 389(Pt 3):913-8. doi: 10.1042/bj20041837. [PMID: 15810879]
  • W C Stewart, R F Morrison, S L Young, J M Stephens. Regulation of signal transducers and activators of transcription (STATs) by effectors of adipogenesis: coordinate regulation of STATs 1, 5A, and 5B with peroxisome proliferator-activated receptor-gamma and C/AAAT enhancer binding protein-alpha. Biochimica et biophysica acta. 1999 Nov; 1452(2):188-96. doi: 10.1016/s0167-4889(99)00129-9. [PMID: 10559472]
  • M D Adams, P Raman, R L Judd. Comparative effects of englitazone and glyburide on gluconeogenesis and glycolysis in the isolated perfused rat liver. Biochemical pharmacology. 1998 Jun; 55(11):1915-20. doi: 10.1016/s0006-2952(98)00052-5. [PMID: 9714310]
  • J Granneman, R Skoff, X Yang. Member of the peroxisome proliferator-activated receptor family of transcription factors is differentially expressed by oligodendrocytes. Journal of neuroscience research. 1998 Mar; 51(5):563-73. doi: 10.1002/(sici)1097-4547(19980301)51:5<563::aid-jnr3>3.0.co;2-d. [PMID: 9512000]
  • R Sarges, R F Hank, J F Blake, J Bordner, D L Bussolotti, D M Hargrove, J L Treadway, E M Gibbs. Glucose transport-enhancing and hypoglycemic activity of 2-methyl-2-phenoxy-3-phenylpropanoic acids. Journal of medicinal chemistry. 1996 Nov; 39(24):4783-803. doi: 10.1021/jm950364f. [PMID: 8941393]
  • S P Weinstein, A Holand, E O'Boyle, R S Haber. Effects of thiazolidinediones on glucocorticoid-induced insulin resistance and GLUT4 glucose transporter expression in rat skeletal muscle. Metabolism: clinical and experimental. 1993 Oct; 42(10):1365-9. doi: 10.1016/0026-0495(93)90139-f. [PMID: 8412752]
  • R W Stevenson, R K McPherson, P E Genereux, B H Danbury, D K Kreutter. Antidiabetic agent englitazone enhances insulin action in nondiabetic rats without producing hypoglycemia. Metabolism: clinical and experimental. 1991 Dec; 40(12):1268-74. doi: 10.1016/0026-0495(91)90027-t. [PMID: 1961119]
  • L Bowen, P P Stein, R Stevenson, G I Shulman. The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism: clinical and experimental. 1991 Oct; 40(10):1025-30. doi: 10.1016/0026-0495(91)90124-f. [PMID: 1943727]
  • D K Kreutter, K M Andrews, E M Gibbs, N J Hutson, R W Stevenson. Insulinlike activity of new antidiabetic agent CP 68722 in 3T3-L1 adipocytes. Diabetes. 1990 Nov; 39(11):1414-9. doi: 10.2337/diab.39.11.1414. [PMID: 2227113]
  • R W Stevenson, N J Hutson, M N Krupp, R A Volkmann, G F Holland, J F Eggler, D A Clark, R K McPherson, K L Hall, B H Danbury. Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsulinemic ob/ob mice. Diabetes. 1990 Oct; 39(10):1218-27. doi: 10.2337/diab.39.10.1218. [PMID: 2210074]