gamma-Carboxyglutamic acid (BioDeep_00000855676)

 

Secondary id: BioDeep_00000402825

PANOMIX_OTCML-2023


代谢物信息卡片


gamma-Carboxyglutamic acid

化学式: C6H9NO6 (191.04298540000002)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.7%

分子结构信息

SMILES: C(C(C(=O)O)C(=O)O)C(C(=O)O)N
InChI: InChI=1S/C6H9NO6/c7-3(6(12)13)1-2(4(8)9)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)(H,12,13)/t3-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

gamma-Carboxyglutamic acid



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Hui Fang, Xiao-Yu Xu, Rui-Zhe Xu, Yan-Feng Zhen, Gang Xu, Yu-Kai Li. Decreased serum undercarboxylated osteocalcin is associated with cognitive impairment in male patients with type 2 diabetes. Journal of diabetes and its complications. 2018 01; 32(1):56-60. doi: 10.1016/j.jdiacomp.2017.09.004. [PMID: 29126874]
  • M P Muller, Y Wang, J H Morrissey, E Tajkhorshid. Lipid specificity of the membrane binding domain of coagulation factor X. Journal of thrombosis and haemostasis : JTH. 2017 10; 15(10):2005-2016. doi: 10.1111/jth.13788. [PMID: 28782177]
  • Abbhirami Rajagopal, Erica P Homan, Kyu Sang Joeng, Masataka Suzuki, Terry Bertin, Racel Cela, Elda Munivez, Brian Dawson, Ming-Ming Jiang, Frank Gannon, Susan Crawford, Brendan H Lee. Restoration of the serum level of SERPINF1 does not correct the bone phenotype in Serpinf1 null mice. Molecular genetics and metabolism. 2016 Mar; 117(3):378-82. doi: 10.1016/j.ymgme.2015.11.015. [PMID: 26693895]
  • Nicholas C Vanderslice, Amanda S Messer, Kanagasabai Vadivel, S Paul Bajaj, Martin Phillips, Mostafa Fatemi, Weijie Xu, William H Velander. Quantifying vitamin K-dependent holoprotein compaction caused by differential γ-carboxylation using high-pressure size exclusion chromatography. Analytical biochemistry. 2015 Jun; 479(?):6-14. doi: 10.1016/j.ab.2015.03.019. [PMID: 25804408]
  • Akiko Sumi, Jun Akiba, Sachiko Ogasawara, Masamichi Nakayama, Yoriko Nomura, Makiko Yasumoto, Sakiko Sanada, Osamu Nakashima, Toshi Abe, Hirohisa Yano. Des-γ-carboxyprothrombin (DCP) and NX-DCP expressions and their relationship with clinicopathological features in hepatocellular carcinoma. PloS one. 2015; 10(3):e0118452. doi: 10.1371/journal.pone.0118452. [PMID: 25739032]
  • Narjes Tavoosi, Stephanie A Smith, Rebecca L Davis-Harrison, James H Morrissey. Factor VII and protein C are phosphatidic acid-binding proteins. Biochemistry. 2013 Aug; 52(33):5545-52. doi: 10.1021/bi4006368. [PMID: 23879866]
  • Saotomo Itoh, Ryosuke Yokoyama, Go Kamoshida, Toshinobu Fujiwara, Hiromi Okada, Takemasa Takii, Tsutomu Tsuji, Satoshi Fujii, Hideki Hashizume, Kikuo Onozaki. Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain. The Journal of biological chemistry. 2013 Jul; 288(30):21569-80. doi: 10.1074/jbc.m113.451419. [PMID: 23754290]
  • Shuguang Yang, Yanhong Ma, Yong Liu, Haiping Que, Changqiang Zhu, Shaojun Liu. Arachidonic acid: a bridge between traumatic brain injury and fracture healing. Journal of neurotrauma. 2012 Nov; 29(17):2696-705. doi: 10.1089/neu.2012.2442. [PMID: 22867040]
  • Xueyan Fu, Judith Moreines, Sarah L Booth. Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats. Nutrition & metabolism. 2012 Feb; 9(1):12. doi: 10.1186/1743-7075-9-12. [PMID: 22348311]
  • Gabriela Ciapetti, Donatella Granchi, Valentina Devescovi, Serena R Baglio, Elisa Leonardi, Desirèe Martini, Maria Jesus Jurado, Beatriz Olalde, Ilaria Armentano, Josè M Kenny, Frank X Walboomers, Josè Inaki Alava, Nicola Baldini. Enhancing osteoconduction of PLLA-based nanocomposite scaffolds for bone regeneration using different biomimetic signals to MSCs. International journal of molecular sciences. 2012; 13(2):2439-58. doi: 10.3390/ijms13022439. [PMID: 22408463]
  • José Rafael Villafán-Bernal, Sergio Sánchez-Enríquez, José Francisco Muñoz-Valle. Molecular modulation of osteocalcin and its relevance in diabetes (Review). International journal of molecular medicine. 2011 Sep; 28(3):283-93. doi: 10.3892/ijmm.2011.706. [PMID: 21617842]
  • Jennifer Disse, Helle Heibroch Petersen, Katrine S Larsen, Egon Persson, Naomi Esmon, Charles T Esmon, Luc Teyton, Lars C Petersen, Wolfram Ruf. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. The Journal of biological chemistry. 2011 Feb; 286(7):5756-67. doi: 10.1074/jbc.m110.201228. [PMID: 21149441]
  • David F Houston, David J Timson. Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change. Molecular and cellular biochemistry. 2011 Feb; 348(1-2):109-15. doi: 10.1007/s11010-010-0644-x. [PMID: 21080035]
  • E Stenova, B Steno, Z Killinger, L Baqi, J Payer. Effect of long-term oral anticoagulant therapy on bone mineral density and bone turnover markers: a prospective 12 month study. Bratislavske lekarske listy. 2011; 112(2):71-6. doi: . [PMID: 21456505]
  • Chia-Chao Wu, Jin-Shuen Chen, Ching-Feng Huang, Chun-Chi Chen, Kuo-Chen Lu, Pauling Chu, Huey-Kang Sytwu, Yuh-Feng Lin. Approaching biomarkers of membranous nephropathy from a murine model to human disease. Journal of biomedicine & biotechnology. 2011; 2011(?):581928. doi: 10.1155/2011/581928. [PMID: 21234329]
  • Vladislav Tsiperson, Xiaosong Li, Gary J Schwartz, Cedric S Raine, Bridget Shafit-Zagardo. GAS6 enhances repair following cuprizone-induced demyelination. PloS one. 2010 Dec; 5(12):e15748. doi: 10.1371/journal.pone.0015748. [PMID: 21203420]
  • Yusuke Nakagawa, Koji Ikeda, Yoshiki Akakabe, Masahiro Koide, Maki Uraoka, Ko-Taro Yutaka, Ritsuko Kurimoto-Nakano, Tomosaburo Takahashi, Satoaki Matoba, Hiroyuki Yamada, Mitsuhiko Okigaki, Hiroaki Matsubara. Paracrine osteogenic signals via bone morphogenetic protein-2 accelerate the atherosclerotic intimal calcification in vivo. Arteriosclerosis, thrombosis, and vascular biology. 2010 Oct; 30(10):1908-15. doi: 10.1161/atvbaha.110.206185. [PMID: 20651281]
  • Sylvain Contié, Nathalie Voorzanger-Rousselot, Judith Litvin, Nicolas Bonnet, Serge Ferrari, Philippe Clézardin, Patrick Garnero. Development of a new ELISA for serum periostin: evaluation of growth-related changes and bisphosphonate treatment in mice. Calcified tissue international. 2010 Oct; 87(4):341-50. doi: 10.1007/s00223-010-9391-y. [PMID: 20567965]
  • Federica Chiappori, Ivan Merelli, Luciano Milanesi, Ermanna Rovida. Exploring the role of the phospholipid ligand in endothelial protein C receptor: a molecular dynamics study. Proteins. 2010 Sep; 78(12):2679-90. doi: 10.1002/prot.22782. [PMID: 20589634]
  • Rupa S Appa, Charlotte Theill, Lene Hansen, Judi Møss, Carsten Behrens, Else Marie Nicolaisen, Niels K Klausen, Michael S Christensen. Investigating clearance mechanisms for recombinant activated factor VII in a perfused liver model. Thrombosis and haemostasis. 2010 Aug; 104(2):243-51. doi: 10.1160/th09-10-0723. [PMID: 20508904]
  • Chunzhang Cao, Yamei Gao, Yang Li, Toni M Antalis, Francis J Castellino, Li Zhang. The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. The Journal of clinical investigation. 2010 Jun; 120(6):1971-80. doi: 10.1172/jci40380. [PMID: 20458145]
  • Jan Martel, Cheng-Yeu Wu, John D Young. Critical evaluation of gamma-irradiated serum used as feeder in the culture and demonstration of putative nanobacteria and calcifying nanoparticles. PloS one. 2010 Apr; 5(4):e10343. doi: 10.1371/journal.pone.0010343. [PMID: 20436679]
  • Benjamin D Parker, Douglas C Bauer, Kristine E Ensrud, Joachim H Ix. Association of osteocalcin and abdominal aortic calcification in older women: the study of osteoporotic fractures. Calcified tissue international. 2010 Mar; 86(3):185-91. doi: 10.1007/s00223-010-9332-9. [PMID: 20094707]
  • Yan Cai, Ming-Jiang Xu, Xu Teng, Ye Bo Zhou, Li Chen, Yi Zhu, Xian Wang, Chao Shu Tang, Yong Fen Qi. Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. Cardiovascular research. 2010 Mar; 85(4):864-73. doi: 10.1093/cvr/cvp366. [PMID: 19910445]
  • Takafumi Okura, Mie Kurata, Daijiro Enomoto, Masanori Jotoku, Tomoaki Nagao, Veena Rasika Desilva, Jun Irita, Ken-Ichi Miyoshi, Jitsuo Higaki. Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension. Kidney & blood pressure research. 2010; 33(1):66-71. doi: 10.1159/000289575. [PMID: 20197689]
  • Cheng-Yeu Wu, Jan Martel, David Young, John D Young. Fetuin-A/albumin-mineral complexes resembling serum calcium granules and putative nanobacteria: demonstration of a dual inhibition-seeding concept. PloS one. 2009 Nov; 4(11):e8058. doi: 10.1371/journal.pone.0008058. [PMID: 19956594]
  • Martin J Shearer. Vitamin K in parenteral nutrition. Gastroenterology. 2009 Nov; 137(5 Suppl):S105-18. doi: 10.1053/j.gastro.2009.08.046. [PMID: 19874942]
  • Sedigheh Safari, Alireza Zomorodipour, Nour Amirmozaffari, Morteza Daliri Choopari. Use of a bacterially expressed human factor IX light chain to develop polyclonal antibody anti-hFIX. Applied biochemistry and biotechnology. 2009 Nov; 159(2):404-14. doi: 10.1007/s12010-008-8506-7. [PMID: 19145409]
  • Younan Chen, Jianlin Qiao, Weidong Tan, Yanrong Lu, Shengfang Qin, Jie Zhang, Shengfu Li, Hong Bu, Jingqiu Cheng. Characterization of porcine factor VII, X and comparison with human factor VII, X. Blood cells, molecules & diseases. 2009 Jul; 43(1):111-8. doi: 10.1016/j.bcmd.2009.02.004. [PMID: 19286401]
  • Howard S Smith, Timothy R Deer. Safety and efficacy of intrathecal ziconotide in the management of severe chronic pain. Therapeutics and clinical risk management. 2009 Jun; 5(3):521-34. doi: 10.2147/tcrm.s4438. [PMID: 19707262]
  • Masayoshi Souri, Hiroki Iwata, Wei Guang Zhang, Akitada Ichinose. Unique secretion mode of human protein Z: its Gla domain is responsible for inefficient, vitamin K-dependent and warfarin-sensitive secretion. Blood. 2009 Apr; 113(16):3857-64. doi: 10.1182/blood-2008-07-171884. [PMID: 19188667]
  • Roger J S Preston, Sinh Tran, Jennifer A Johnson, Fionnuala Ní Áinle, Shona Harmon, Barry White, Owen P Smith, P Vince Jenkins, Björn Dahlbäck, James S O'Donnell. Platelet factor 4 impairs the anticoagulant activity of activated protein C. The Journal of biological chemistry. 2009 Feb; 284(9):5869-75. doi: 10.1074/jbc.m804703200. [PMID: 19129181]
  • Angela Yee-Moon Wang. Vascular and other tissue calcification in peritoneal dialysis patients. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2009 Feb; 29 Suppl 2(?):S9-S14. doi: 10.1177/089686080902902s01. [PMID: 19270239]
  • Ellen C M Cranenburg, Vincent M Brandenburg, Cees Vermeer, Melanie Stenger, Georg Mühlenbruch, Andreas H Mahnken, Ulrich Gladziwa, Markus Ketteler, Leon J Schurgers. Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients. Thrombosis and haemostasis. 2009 Feb; 101(2):359-66. doi: 10.1160/th08-04-0241. [PMID: 19190822]
  • R J M W Rennenberg, A G H Kessels, L J Schurgers, J M A van Engelshoven, P W de Leeuw, A A Kroon. Vascular calcifications as a marker of increased cardiovascular risk: a meta-analysis. Vascular health and risk management. 2009; 5(1):185-97. doi: 10.2147/vhrm.s4822. [PMID: 19436645]
  • John D Young, Jan Martel, David Young, Andrew Young, Chin-Ming Hung, Lena Young, Ying-Jie Chao, James Young, Cheng-Yeu Wu. Characterization of granulations of calcium and apatite in serum as pleomorphic mineralo-protein complexes and as precursors of putative nanobacteria. PloS one. 2009; 4(5):e5421. doi: 10.1371/journal.pone.0005421. [PMID: 19412552]
  • Yoel Rodríguez, Mihaly Mezei, Roman Osman. The PT1-Ca2+ Gla domain binds to a membrane through two dipalmitoylphosphatidylserines. A computational study. Biochemistry. 2008 Dec; 47(50):13267-78. doi: 10.1021/bi801199v. [PMID: 19086158]
  • Angela M Cheung, Lianne Tile, Yuna Lee, George Tomlinson, Gillian Hawker, Judy Scher, Hanxian Hu, Reinhold Vieth, Lilian Thompson, Sophie Jamal, Robert Josse. Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial. PLoS medicine. 2008 Oct; 5(10):e196. doi: 10.1371/journal.pmed.0050196. [PMID: 18922041]
  • Heinrich Topp, Gerhard Fusch, Gerhard Schöch, Christoph Fusch. Noninvasive markers of oxidative DNA stress, RNA degradation and protein degradation are differentially correlated with resting metabolic rate and energy intake in children and adolescents. Pediatric research. 2008 Sep; 64(3):246-50. doi: 10.1203/pdr.0b013e31817cfca6. [PMID: 18437098]
  • Alireza R Rezaie, Jong-Sup Bae, Chandrashekhara Manithody, Shabir H Qureshi, Likui Yang. Protein Z-dependent protease inhibitor binds to the C-terminal domain of protein Z. The Journal of biological chemistry. 2008 Jul; 283(29):19922-6. doi: 10.1074/jbc.m802639200. [PMID: 18502758]
  • Johannes Oldenburg, Milka Marinova, Clemens Müller-Reible, Matthias Watzka. The vitamin K cycle. Vitamins and hormones. 2008; 78(?):35-62. doi: 10.1016/s0083-6729(07)00003-9. [PMID: 18374189]
  • Ellen C M Cranenburg, Cees Vermeer, Ralf Koos, Marie-Louise Boumans, Tilman M Hackeng, Freek G Bouwman, Martijn Kwaijtaal, Vincent M Brandenburg, Markus Ketteler, Leon J Schurgers. The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcification. Journal of vascular research. 2008; 45(5):427-36. doi: 10.1159/000124863. [PMID: 18401181]
  • Mario Cozzolino, Sandro Mazzaferro, Francesco Pugliese, Diego Brancaccio. Vascular calcification and uremia: what do we know?. American journal of nephrology. 2008; 28(2):339-46. doi: 10.1159/000111827. [PMID: 18046081]
  • Francis J Castellino, Victoria A Ploplis, Li Zhang. gamma-Glutamate and beta-hydroxyaspartate in proteins. Methods in molecular biology (Clifton, N.J.). 2008; 446(?):85-94. doi: 10.1007/978-1-60327-084-7_6. [PMID: 18373251]
  • Makoto Hirao, Jun Hashimoto, Wataru Ando, Takeshi Ono, Hideki Yoshikawa. Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women. Journal of bone and mineral metabolism. 2008; 26(3):260-4. doi: 10.1007/s00774-007-0823-3. [PMID: 18470667]
  • Jong-Sup Bae, Likui Yang, Chandrashekhara Manithody, Alireza R Rezaie. The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood. 2007 Dec; 110(12):3909-16. doi: 10.1182/blood-2007-06-096651. [PMID: 17823308]
  • Michio Komai, Hitoshi Shirakawa. [Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. Clinical calcium. 2007 Nov; 17(11):1663-72. doi: clica071116631672. [PMID: 17982185]
  • Hiromichi Akizawa, Madoka Saito, Ikuko Tsukamoto, Tatsuya Ohkura, Takaya Shimizu, Youji Kitamura, Masaki Mifune, Yutaka Saito, Yasushi Arano, Hideo Saji. Effect of carboxyl-group of D-glutamic acid or gamma-carboxy-D-glutamic acid as N-terminal amino acid of (111)in-diethylenetriaminepentaacetic acid-octreotide on accumulation of radioactivity in kidney. Biological & pharmaceutical bulletin. 2007 Nov; 30(11):2226-8. doi: 10.1248/bpb.30.2226. [PMID: 17978507]
  • Dealba Gheduzzi, Federica Boraldi, Giulia Annovi, Chiara Paolinelli DeVincenzi, Leon J Schurgers, Cees Vermeer, Daniela Quaglino, Ivonne Pasquali Ronchetti. Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma elasticum patients. Laboratory investigation; a journal of technical methods and pathology. 2007 Oct; 87(10):998-1008. doi: 10.1038/labinvest.3700667. [PMID: 17724449]
  • Subash C B Gopinath, Yasuo Shikamoto, Hiroshi Mizuno, Penmetcha K R Kumar. Snake-venom-derived Factor IX-binding protein specifically blocks the gamma-carboxyglutamic acid-rich-domain-mediated membrane binding of human Factors IX and X. The Biochemical journal. 2007 Jul; 405(2):351-7. doi: 10.1042/bj20061737. [PMID: 17407444]
  • Yoel Rodríguez, Mihaly Mezei, Roman Osman. Association free energy of dipalmitoylphosphatidylserines in a mixed dipalmitoylphosphatidylcholine membrane. Biophysical journal. 2007 May; 92(9):3071-80. doi: 10.1529/biophysj.106.089078. [PMID: 17277191]
  • Rukshana C Shroff, Catherine M Shanahan. The vascular biology of calcification. Seminars in dialysis. 2007 Mar; 20(2):103-9. doi: 10.1111/j.1525-139x.2007.00255.x. [PMID: 17374082]
  • Susanne Bügel, A Dorthe Sørensen, Ole Hels, Mette Kristensen, Cees Vermeer, Jette Jakobsen, Albert Flynn, Christian Mølgaard, Kevin D Cashman. Effect of phylloquinone supplementation on biochemical markers of vitamin K status and bone turnover in postmenopausal women. The British journal of nutrition. 2007 Feb; 97(2):373-80. doi: 10.1017/s000711450715460x. [PMID: 17298708]
  • Sandro Mazzaferro, Marzia Pasquali, Francesco Pugliese, Giusi Barresi, Iacopo Carbone, Marco Francone, Daniela Sardella, Franco Taggi. Serum levels of calcification inhibition proteins and coronary artery calcium score: comparison between transplantation and dialysis. American journal of nephrology. 2007; 27(1):75-83. doi: 10.1159/000099095. [PMID: 17259697]
  • Juliana M Layzer, Bruce A Sullenger. Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection. Oligonucleotides. 2007; 17(1):1-11. doi: 10.1089/oli.2006.0059. [PMID: 17461758]
  • Fabrizio Montecucco, Sabine Steffens, François Mach. The immune response is involved in atherosclerotic plaque calcification: could the RANKL/RANK/OPG system be a marker of plaque instability?. Clinical & developmental immunology. 2007; 2007(?):75805. doi: 10.1155/2007/75805. [PMID: 18320012]
  • Rebecca C Johnson, Jane A Leopold, Joseph Loscalzo. Vascular calcification: pathobiological mechanisms and clinical implications. Circulation research. 2006 Nov; 99(10):1044-59. doi: 10.1161/01.res.0000249379.55535.21. [PMID: 17095733]
  • Xiaoyun Tan, Daozhang Cai, Yaoliang Wu, Bin Liu, Limin Rong, Zhusheng Chen, Qichun Zhao. Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head. Translational research : the journal of laboratory and clinical medicine. 2006 Sep; 148(3):114-9. doi: 10.1016/j.trsl.2006.05.001. [PMID: 16938648]
  • E C Azinge, D M Bolarin. Osteocalcin and bone-specific alkaline phosphatase in sickle cell haemoglobinopathies. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria. 2006 Jun; 21(1-2):21-5. doi: 10.4314/njps.v21i1-2.53934. [PMID: 17242729]
  • Yusuke Ohsaki, Hitoshi Shirakawa, Kazuyuki Hiwatashi, Yuji Furukawa, Takeo Mizutani, Michio Komai. Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Bioscience, biotechnology, and biochemistry. 2006 Apr; 70(4):926-32. doi: 10.1271/bbb.70.926. [PMID: 16636460]
  • Magali Taulan, Francois Paquet, Angel Argiles, Jacques Demaille, Marie-Catherine Romey. Comprehensive analysis of the renal transcriptional response to acute uranyl nitrate exposure. BMC genomics. 2006 Jan; 7(?):2. doi: 10.1186/1471-2164-7-2. [PMID: 16405725]
  • I Hasanbasic, I Rajotte, M Blostein. The role of gamma-carboxylation in the anti-apoptotic function of gas6. Journal of thrombosis and haemostasis : JTH. 2005 Dec; 3(12):2790-7. doi: 10.1111/j.1538-7836.2005.01662.x. [PMID: 16359517]
  • Sema S Hakki, Rahime M Nohutcu, Erdogan E Hakki, Janice E Berry, Mahinur S Akkaya, Martha J Somerman. Dexamethasone and basic-fibroblast growth factor regulate markers of mineralization in cementoblasts in vitro. Journal of periodontology. 2005 Sep; 76(9):1550-8. doi: 10.1902/jop.2005.76.9.1550. [PMID: 16171446]
  • Leon J Schurgers, Kirsten J F Teunissen, Marjo H J Knapen, Martijn Kwaijtaal, Rob van Diest, Ad Appels, Chris P Reutelingsperger, Jack P M Cleutjens, Cees Vermeer. Novel conformation-specific antibodies against matrix gamma-carboxyglutamic acid (Gla) protein: undercarboxylated matrix Gla protein as marker for vascular calcification. Arteriosclerosis, thrombosis, and vascular biology. 2005 Aug; 25(8):1629-33. doi: 10.1161/01.atv.0000173313.46222.43. [PMID: 15961706]
  • Nadeem Wajih, David C Sane, Susan M Hutson, Reidar Wallin. Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system. The Journal of biological chemistry. 2005 Mar; 280(11):10540-7. doi: 10.1074/jbc.m413982200. [PMID: 15640149]
  • Melvin R Hayden, Suresh C Tyagi, Lisa Kolb, James R Sowers, Ramesh Khanna. Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate. Cardiovascular diabetology. 2005 Mar; 4(?):4. doi: 10.1186/1475-2840-4-4. [PMID: 15777477]
  • Jihong Liu, Junhui Chen, Tao Wang, Shaogang Wang, Zhangqun Ye. Effects of urinary prothrombin fragment 1 in the formation of calcium oxalate calculus. The Journal of urology. 2005 Jan; 173(1):113-6. doi: 10.1097/01.ju.0000146847.24571.c8. [PMID: 15592049]
  • François Saller, Bruno O Villoutreix, Aymeric Amelot, Tahar Kaabache, Bernard F Le Bonniec, Martine Aiach, Sophie Gandrille, Delphine Borgel. The gamma-carboxyglutamic acid domain of anticoagulant protein S is involved in activated protein C cofactor activity, independently of phospholipid binding. Blood. 2005 Jan; 105(1):122-30. doi: 10.1182/blood-2004-06-2176. [PMID: 15308562]
  • Nadeem Wajih, Terete Borras, Wei Xue, Susan M Hutson, Reidar Wallin. Processing and transport of matrix gamma-carboxyglutamic acid protein and bone morphogenetic protein-2 in cultured human vascular smooth muscle cells: evidence for an uptake mechanism for serum fetuin. The Journal of biological chemistry. 2004 Oct; 279(41):43052-60. doi: 10.1074/jbc.m407180200. [PMID: 15280384]
  • Tuan-yu Fang, Er-yuan Liao, Xian-ping Wu, Shi-ping Liu, Hui Xie, Hong Zhang, Xiang-hang Luo, Xing-zhi Cao. [Serum osteoprotegrin and serum bone gamma-carboxyglutamine acid-containing protein are correlated with bone mineral density in normal women]. Zhonghua yi xue za zhi. 2004 Oct; 84(19):1607-9. doi: NULL. [PMID: 15569454]
  • Jonas Stenhoff, Björn Dahlbäck, Sassan Hafizi. Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts. Biochemical and biophysical research communications. 2004 Jul; 319(3):871-8. doi: 10.1016/j.bbrc.2004.05.070. [PMID: 15184064]
  • H C Whinna, E B Lesesky, D M Monroe, K A High, P J Larson, F C Church. Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. Journal of thrombosis and haemostasis : JTH. 2004 Jul; 2(7):1127-34. doi: 10.1111/j.1538-7836.2004.00796.x. [PMID: 15219196]
  • Ayumu Nakashima, Noriaki Yorioka, Shigehiro Doi, Takao Masaki, Takafumi Ito, Satoru Harada. Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels. Bone. 2004 Mar; 34(3):579-83. doi: 10.1016/j.bone.2003.11.016. [PMID: 15003806]
  • Jian-li Liu, Han-min Zhu, Qi-ren Huang, Zhong-lan Zhang, Hui-lin Li, Yue-juan Qin, Ying Zhang, Dao-lin Wei, Jing-hui Lu, Hui Liu, Xiao-ping Chen, Yu-juan Liu, Abie Ekangaki, Yi-man Zheng, Adolfo Diez-Perez, Kristine Harpe. [Effect of raloxifene hydrochloride on bone mineral density, bone metabolism and serum lipids in Chinese postmenopausal women with osteoporosis]. Zhonghua yi xue za zhi. 2004 Feb; 84(4):269-73. doi: NULL. [PMID: 15059505]
  • Sarah L Booth, Ligia Martini, James W Peterson, Edward Saltzman, Gerard E Dallal, Richard J Wood. Dietary phylloquinone depletion and repletion in older women. The Journal of nutrition. 2003 Aug; 133(8):2565-9. doi: 10.1093/jn/133.8.2565. [PMID: 12888638]
  • David E Fleming, Arie Van Riessen, Magali C Chauvet, Phulwinder K Grover, Brett Hunter, Wilhelm van Bronswijk, Rosemary L Ryall. Intracrystalline proteins and urolithiasis: a synchrotron X-ray diffraction study of calcium oxalate monohydrate. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2003 Jul; 18(7):1282-91. doi: 10.1359/jbmr.2003.18.7.1282. [PMID: 12854839]
  • R Cui, J He, F Zhang, B Wang, H Ding, H Shen, Y Li, X Chen. Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to alpha-fetoprotein. British journal of cancer. 2003 Jun; 88(12):1878-82. doi: 10.1038/sj.bjc.6601018. [PMID: 12799630]
  • Yong-Hui Sun, Lei Shen, Björn Dahlbäck. Gla domain-mutated human protein C exhibiting enhanced anticoagulant activity and increased phospholipid binding. Blood. 2003 Mar; 101(6):2277-84. doi: 10.1182/blood-2002-06-1691. [PMID: 12446455]
  • Aysar Aktimur, Melanie A Gabriel, David Gailani, John R Toomey. The factor IX gamma-carboxyglutamic acid (Gla) domain is involved in interactions between factor IX and factor XIa. The Journal of biological chemistry. 2003 Mar; 278(10):7981-7. doi: 10.1074/jbc.m212748200. [PMID: 12496253]
  • Shobha Seetharam, Kathleen Murphy, Charity Atkins, Giora Feuerstein. Cloning and expression of rat coagulation factor VII. Thrombosis research. 2003 Feb; 109(4):225-31. doi: 10.1016/s0049-3848(03)00149-x. [PMID: 12757778]
  • Mara Steinkamp, Alon Geva, Steven Joffe, Catherine N Lapp, Ellis J Neufeld. Chronic disseminated intravascular coagulation and childhood-onset skin necrosis resulting from homozygosity for a protein C Gla domain mutation, Arg15Trp. Journal of pediatric hematology/oncology. 2002 Nov; 24(8):685-8. doi: 10.1097/00043426-200211000-00018. [PMID: 12439046]
  • Michael O Hall, Martin S Obin, Anne L Prieto, Barry L Burgess, Toshka A Abrams. Gas6 binding to photoreceptor outer segments requires gamma-carboxyglutamic acid (Gla) and Ca(2+) and is required for OS phagocytosis by RPE cells in vitro. Experimental eye research. 2002 Oct; 75(4):391-400. doi: 10.1006/exer.2002.2030. [PMID: 12387786]
  • Joanna H Webb, Anna M Blom, Björn Dahlbäck. Vitamin K-dependent protein S localizing complement regulator C4b-binding protein to the surface of apoptotic cells. Journal of immunology (Baltimore, Md. : 1950). 2002 Sep; 169(5):2580-6. doi: 10.4049/jimmunol.169.5.2580. [PMID: 12193728]
  • Wen-Yang Hu, Noboru Fukuda, Katsuo Kanmatsuse. Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats. Journal of hypertension. 2002 Jul; 20(7):1323-33. doi: 10.1097/00004872-200207000-00019. [PMID: 12131529]
  • Tong Gui, Hui-Feng Lin, Da-Yun Jin, Maureane Hoffman, David L Straight, Harold R Roberts, Darrel W Stafford. Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. Blood. 2002 Jul; 100(1):153-8. doi: 10.1182/blood.v100.1.153. [PMID: 12070021]
  • Toru Naraki, Noriatsu Kohno, Hiroyuki Saito, Yoshinori Fujimoto, Motoyuki Ohhira, Takashi Morita, Yutaka Kohgo. gamma-Carboxyglutamic acid content of hepatocellular carcinoma-associated des-gamma-carboxy prothrombin. Biochimica et biophysica acta. 2002 Apr; 1586(3):287-98. doi: 10.1016/s0925-4439(01)00107-7. [PMID: 11997080]
  • Phulwinder K Grover, Rosemary L Ryall. Effect of prothrombin and its activation fragments on calcium oxalate crystal growth and aggregation in undiluted human urine in vitro: relationship between protein structure and inhibitory activity. Clinical science (London, England : 1979). 2002 Apr; 102(4):425-34. doi: NULL. [PMID: 11914105]
  • Paul A Price, Gethin R Thomas, Aaron W Pardini, William F Figueira, Jeffrey M Caputo, Matthew K Williamson. Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix gamma-carboxyglutamic acid protein in the serum of etidronate-treated rats. The Journal of biological chemistry. 2002 Feb; 277(6):3926-34. doi: 10.1074/jbc.m106366200. [PMID: 11724771]
  • Arvind Srivastava, Jianfang Wang, Rinku Majumder, Alireza R Rezaie, Johan Stenflo, Charles T Esmon, Barry R Lentz. Localization of phosphatidylserine binding sites to structural domains of factor Xa. The Journal of biological chemistry. 2002 Jan; 277(3):1855-63. doi: 10.1074/jbc.m105697200. [PMID: 11707438]
  • Toshihiro Sugiyama, Akira Yamaguchi, Shinya Kawai. Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the 'mechanostat' theory. Journal of bone and mineral metabolism. 2002; 20(4):196-200. doi: 10.1007/s007740200028. [PMID: 12115064]
  • O D Christophe, P J Lenting, G Cherel, M Boon-Spijker, J M Lavergne, R Boertjes, M E Briquel, A de Goede-Bolder, J Goudemand, S Gaillard, R d'Oiron, D Meyer, K Mertens. Functional mapping of anti-factor IX inhibitors developed in patients with severe hemophilia B. Blood. 2001 Sep; 98(5):1416-23. doi: 10.1182/blood.v98.5.1416. [PMID: 11520790]
  • A Farzaneh-Far, J D Davies, L A Braam, H M Spronk, D Proudfoot, S W Chan, K M O'Shaughnessy, P L Weissberg, C Vermeer, C M Shanahan. A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels. The Journal of biological chemistry. 2001 Aug; 276(35):32466-73. doi: 10.1074/jbc.m104909200. [PMID: 11425864]
  • D E Fleming, W van Bronswijk, R L Ryall. A comparative study of the adsorption of amino acids on to calcium minerals found in renal calculi. Clinical science (London, England : 1979). 2001 Aug; 101(2):159-68. doi: NULL. [PMID: 11473489]
  • K Tomokiyo, K Teshima, Y Nakatomi, T Watanabe, J Mizuguchi, C Nozaki, T Nakagaki, S Miyamoto, A Funatsu, S Iwanaga. Induction of acquired factor IX inhibitors in cynomolgus monkey (Macaca fascicularis): a new primate model of hemophilia B. Thrombosis research. 2001 May; 102(4):363-74. doi: 10.1016/s0049-3848(01)00253-5. [PMID: 11369429]
  • M J McMahon, A H James. Combined deficiency of factors II, VII, IX, and X (Borgschulte-Grigsby deficiency) in pregnancy. Obstetrics and gynecology. 2001 May; 97(5 Pt 2):808-9. doi: 10.1016/s0029-7844(00)01214-x. [PMID: 11336760]
  • T M Hackeng, J A Fernández, P E Dawson, S B Kent, J H Griffin. Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proceedings of the National Academy of Sciences of the United States of America. 2000 Dec; 97(26):14074-8. doi: 10.1073/pnas.260239797. [PMID: 11106381]
  • F Uras, A R Uras, T Yardimci, M K Sardana. Determination of the N-terminal amino acid sequence of the purified prothrombin from a patient with liver cirrhosis. Thrombosis research. 2000 Aug; 99(3):277-83. doi: 10.1016/s0049-3848(00)00232-2. [PMID: 10942794]
  • M A Brown, L M Stenberg, U Persson, J Stenflo. Identification and purification of vitamin K-dependent proteins and peptides with monoclonal antibodies specific for gamma -carboxyglutamyl (Gla) residues. The Journal of biological chemistry. 2000 Jun; 275(26):19795-802. doi: 10.1074/jbc.m002298200. [PMID: 10779512]
  • C J Refino, J Himber, L Burcklen, P Moran, M Peek, S Suggett, B Devaux, D Kirchhofer. A human antibody that binds to the gamma-carboxyglutamic acid domain of factor IX is a potent antithrombotic in vivo. Thrombosis and haemostasis. 1999 Sep; 82(3):1188-95. doi: 10.1055/s-0037-1614351. [PMID: 10494786]