BHSar-SP (BioDeep_00000855603)

   


代谢物信息卡片


[Sar9,Met(O2)11]-Substance P TFA

化学式: C64H100N18O15S (1392.7335890000002)
中文名称: 精氨酰-脯氨酰-赖氨酰-脯氨酰-谷氨酰-谷氨酰-苯丙氨酰-苯丙氨酰-SAR-亮氨酸-蛋氨酸[O2]-胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CCS(=O)(=O)C)C(=O)N)NC(=O)CN(C)C(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N
InChI: InChI=1S/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-/m0/s1

描述信息

D018377 - Neurotransmitter Agents > D015320 - Tachykinins
[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

同义名列表

3 个代谢物同义名

[Sar9,Met(O2)11]-Substance P TFA; BHSar-SP; [Sar9,Met(O2)11]-Substance P



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pradeep Paudel, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Characterizing fucoxanthin as a selective dopamine D3/D4 receptor agonist: Relevance to Parkinson's disease. Chemico-biological interactions. 2019 Sep; 310(?):108757. doi: 10.1016/j.cbi.2019.108757. [PMID: 31323226]
  • M Juszczak, E Boczek-Leszczyk. Oxytocin release from the rat neurohypophysis into the blood: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2008 Sep; 59(3):553-62. doi: NULL. [PMID: 18953097]
  • M Juszczak, E Boczek-Leszczyk, B Stempniak. Effect of melatonin on the vasopressin secretion as influenced by tachykinin NK-1 receptor agonist and antagonist: in vivo and in vitro studies. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2007 Dec; 58(4):829-43. doi: NULL. [PMID: 18195491]
  • Fabien Schmidlin, Dirk Roosterman, Nigel W Bunnett. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. American journal of physiology. Cell physiology. 2003 Oct; 285(4):C945-58. doi: 10.1152/ajpcell.00541.2002. [PMID: 12958028]
  • A Robichaud, C Savoie, P B Stamatiou, N Lachance, P Jolicoeur, R Rasori, C C Chan. Assessing the emetic potential of PDE4 inhibitors in rats. British journal of pharmacology. 2002 Jan; 135(1):113-8. doi: 10.1038/sj.bjp.0704457. [PMID: 11786486]
  • R G Wiley, D A Lappi. Targeting neurokinin-1 receptor-expressing neurons with [Sar9,Met(O2)11 substance P-saporin. Neuroscience letters. 1999 Dec; 277(1):1-4. doi: 10.1016/s0304-3940(99)00846-0. [PMID: 10643883]
  • B Conte, M Parlani, G Lopez, R Cirillo, C A Maggi, S Manzini. Inflammatory and motor responses by tachykinins in the guinea-pig oesophageal sphincter. Journal of autonomic pharmacology. 1998 Oct; 18(5):313-7. doi: 10.1046/j.1365-2680.1998.185100.x. [PMID: 9831232]
  • L Singh, M J Field, J Hughes, B S Kuo, N Suman-Chauhan, B R Tuladhar, D S Wright, R J Naylor. The tachykinin NK1 receptor antagonist PD 154075 blocks cisplatin-induced delayed emesis in the ferret. European journal of pharmacology. 1997 Feb; 321(2):209-16. doi: 10.1016/s0014-2999(96)00950-8. [PMID: 9063690]
  • S Evangelista, S Paoli, A Giachetti, S Manzini. Involvement of tachykinin NK1 receptors in plasma protein extravasation induced by tachykinins in the guinea pig upper airways. Neuropeptides. 1997 Feb; 31(1):65-70. doi: 10.1016/s0143-4179(97)90022-6. [PMID: 9574840]
  • A Parenti, S Amerini, F Ledda, C A Maggi, M Ziche. The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture. Naunyn-Schmiedeberg's archives of pharmacology. 1996 Apr; 353(5):475-81. doi: 10.1007/bf00169165. [PMID: 8740139]
  • C A Yiamouyiannis, P W Stengel, S L Cockerham, S A Silbaugh. Pulmonary actions of the neurokinin1-specific agonist [Sar9,Met(O2)11]-substance P. Neuropeptides. 1995 Jan; 28(1):35-42. doi: 10.1016/0143-4179(95)90072-1. [PMID: 7538202]
  • X Emonds-Alt, J D Doutremepuich, M Heaulme, G Neliat, V Santucci, R Steinberg, P Vilain, D Bichon, J P Ducoux, V Proietto. In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. European journal of pharmacology. 1993 Dec; 250(3):403-13. doi: 10.1016/0014-2999(93)90027-f. [PMID: 7509286]
  • I Yamawaki, P Geppetti, C Bertrand, O Huber, L Daffonchio, C Omini, J A Nadel. Levodropropizine reduces capsaicin- and substance P-induced plasma extravasation in the rat trachea. European journal of pharmacology. 1993 Oct; 243(1):1-6. doi: 10.1016/0014-2999(93)90159-f. [PMID: 7504629]
  • G Hölzemann, H E Greiner, J Harting, G Barnickel, A Seelig. Do substance P agonists insert into the lipid membrane?. Regulatory peptides. 1993 Jul; 46(1-2):453-4. doi: 10.1016/0167-0115(93)90117-q. [PMID: 7692565]
  • C J Fowler, T Martinsson, G Brännström. 'Specific' binding of [3H]-[Sar9,Met(O2)11]-substance P to tissue culture plates is found when substance P is used to define non-specific binding. Methods and findings in experimental and clinical pharmacology. 1993 Jul; 15(6):337-43. doi: NULL. [PMID: 7694018]
  • Y Hirayama, Y H Lei, P J Barnes, D F Rogers. Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo. British journal of pharmacology. 1993 Mar; 108(3):844-51. doi: 10.1111/j.1476-5381.1993.tb12888.x. [PMID: 7682142]
  • A Seelig. Interaction of a substance P agonist and of substance P antagonists with lipid membranes. A thermodynamic analysis. Biochemistry. 1992 Mar; 31(11):2897-904. doi: 10.1021/bi00126a008. [PMID: 1372515]