SPIRADOLINE (BioDeep_00000855596)
代谢物信息卡片
化学式: C22H30Cl2N2O2 (424.1684)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C1CCC2(CCCO2)CC1N3CCCC3)C(=O)CC4=CC(=C(C=C4)Cl)Cl
InChI: InChI=1S/C22H30Cl2N2O2/c1-25(21(27)14-16-5-6-17(23)18(24)13-16)19-7-9-22(8-4-12-28-22)15-20(19)26-10-2-3-11-26/h5-6,13,19-20H,2-4,7-12,14-15H2,1H3/t19-,20-,22-/m0/s1
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Vanessa Minervini, Sujata Dahal, Charles P France. Behavioral Characterization of κ Opioid Receptor Agonist Spiradoline and Cannabinoid Receptor Agonist CP55940 Mixtures in Rats.
The Journal of pharmacology and experimental therapeutics.
2017 Feb; 360(2):280-287. doi:
10.1124/jpet.116.235630. [PMID: 27903642] - Cheng Chang, Wonkyung Byon, Yifeng Lu, Leslie K Jacobsen, Lori L Badura, Aarti Sawant-Basak, Emily Miller, Jing Liu, Sarah Grimwood, Ellen Q Wang, Tristan S Maurer. Quantitative PK-PD model-based translational pharmacology of a novel kappa opioid receptor antagonist between rats and humans.
The AAPS journal.
2011 Dec; 13(4):565-75. doi:
10.1208/s12248-011-9296-3. [PMID: 21847689] - S Grimwood, Y Lu, A W Schmidt, M A Vanase-Frawley, A Sawant-Basak, E Miller, S McLean, J Freeman, S Wong, J P McLaughlin, P R Verhoest. Pharmacological characterization of 2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a high-affinity antagonist selective for κ-opioid receptors.
The Journal of pharmacology and experimental therapeutics.
2011 Nov; 339(2):555-66. doi:
10.1124/jpet.111.185108. [PMID: 21821697] - Aashish S Morani, Bronwyn Kivell, Thomas E Prisinzano, Susan Schenk. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats.
Pharmacology, biochemistry, and behavior.
2009 Dec; 94(2):244-9. doi:
10.1016/j.pbb.2009.09.002. [PMID: 19747933] - Supriya Srinivasan, Pamela Santiago, Cecile Lubrano, Christian Vaisse, Bruce R Conklin. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo.
PloS one.
2007 Aug; 2(7):e668. doi:
10.1371/journal.pone.0000668. [PMID: 17668051] - Mark A Smith, Paul A Bryant, Jacob M McClean. Social and environmental enrichment enhances sensitivity to the effects of kappa opioids: studies on antinociception, diuresis and conditioned place preference.
Pharmacology, biochemistry, and behavior.
2003 Aug; 76(1):93-101. doi:
10.1016/s0091-3057(03)00189-8. [PMID: 13679221] - E R Butelman, T J Harris, M J Kreek. Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys.
Psychopharmacology.
1999 Nov; 147(1):73-80. doi:
10.1007/s002130051144. [PMID: 10591871] - E Ur, D M Wright, P M Bouloux, A Grossman. The effects of spiradoline (U-62066E), a kappa-opioid receptor agonist, on neuroendocrine function in man.
British journal of pharmacology.
1997 Mar; 120(5):781-4. doi:
10.1038/sj.bjp.0700971. [PMID: 9138682] - J I Hubbard. Water transport in cultured cells from the rat inner medullary collecting duct.
Journal of the American Society of Nephrology : JASN.
1996 Oct; 7(10):2062-71. doi:
10.1681/asn.v7102062. [PMID: 8915966] - G H Rimoy, D M Wright, N K Bhaskar, P C Rubin. The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist.
European journal of clinical pharmacology.
1994; 46(3):203-7. doi:
10.1007/bf00192549. [PMID: 8070500] - G H Rimoy, N K Bhaskar, D M Wright, P C Rubin. Mechanism of diuretic action of spiradoline (U-62066E)--a kappa opioid receptor agonist in the human.
British journal of clinical pharmacology.
1991 Nov; 32(5):611-5. doi:
10.1111/j.1365-2125.1991.tb03960.x. [PMID: 1659438] - K Yamada, M Nakano, S Yoshida. Inhibition of elevated arginine vasopressin secretion in response to osmotic stimulation and acute haemorrhage by U-62066E, a kappa-opioid receptor agonist.
British journal of pharmacology.
1990 Feb; 99(2):384-8. doi:
10.1111/j.1476-5381.1990.tb14713.x. [PMID: 2158377] - G Hamon, S Jouquey. Kappa agonists and vasopressin secretion.
Hormone research.
1990; 34(3-4):129-32. doi:
10.1159/000181811. [PMID: 1966562] - K Yamada, M Imai, S Yoshida. Mechanism of diuretic action of U-62,066E, a kappa opioid receptor agonist.
European journal of pharmacology.
1989 Jan; 160(2):229-37. doi:
10.1016/0014-2999(89)90495-0. [PMID: 2547626] - J S Althaus, C A DiFazio, J C Moscicki, P F VonVoigtlander. Enhancement of anesthetic effect of halothane by spiradoline, a selective kappa-agonist.
Anesthesia and analgesia.
1988 Sep; 67(9):823-7. doi:
NULL. [PMID: 3414991] - G R Peters, N J Ward, E G Antal, P Y Lai, E W deMaar. Diuretic actions in man of a selective kappa opioid agonist: U-62,066E.
The Journal of pharmacology and experimental therapeutics.
1987 Jan; 240(1):128-31. doi:
NULL. [PMID: 3027300]
