Capastat (BioDeep_00000855572)
代谢物信息卡片
Capastat
化学式: C50H88N28O15 (1320.6983618000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)NC(C(=O)NCC(C(=O)N1)N)C2CCNC(=N2)N)CNC(=O)CC(CCCN)N.C1CNC(=NC1C2C(=O)NCC(C(=O)NC(C(=O)NC(C(=O)NC(=CNC(=O)N)C(=O)N2)CNC(=O)CC(CCCN)N)CO)N)N
InChI: 1-11-19(41)36-15(9-32-17(40)7-12(27)3-2-5-26)21(43)37-16(10-34-25(30)46)22(44)39-18(14-4-6-31-24(29)38-14)23(45)33-8-13(28)20(42)35-11/h9,11-14,16,18,40H,1-8,10,26-28H2,(H,32,41)(H,33,46)(H,35,43)(H,36,45)(H,37,42)(H,39,44)(H3,29,31,38)(H3,30,34,47)
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D000995 - Antitubercular Agents
C254 - Anti-Infective Agent > C52588 - Antibacterial Agent > C280 - Antitubercular Agent
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C254 - Anti-Infective Agent > C258 - Antibiotic
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jiao Zhao, Wenjing Wei, Huimin Yan, Ying Zhou, Zhenyan Li, Yanmei Chen, Chenchen Zhang, Jincheng Zeng, Tao Chen, Lin Zhou. Assessing capreomycin resistance on tlyA deficient and point mutation (G695A) Mycobacterium tuberculosis strains using multi-omics analysis.
International journal of medical microbiology : IJMM.
2019 Nov; 309(7):151323. doi:
10.1016/j.ijmm.2019.06.003. [PMID: 31279617] - Man Mohan Puri, Anil Kumar, Pooja Aneja, Rajnish Gupta, Lokender Kumar, Rohit Sarin. Tetany in an Extensively Drug Resistant Tuberculosis (XDR-TB) Patient Treated with Capreomycin.
The Journal of the Association of Physicians of India.
2019 Aug; 67(8):79-82. doi:
NULL. [PMID: 31562727] - Workineh Shibeshi, Anandi N Sheth, Addisu Admasu, Alemseged Beyene Berha, Zenebe Negash, Getnet Yimer. Nephrotoxicity and ototoxic symptoms of injectable second-line anti-tubercular drugs among patients treated for MDR-TB in Ethiopia: a retrospective cohort study.
BMC pharmacology & toxicology.
2019 05; 20(1):31. doi:
10.1186/s40360-019-0313-y. [PMID: 31122273] - Nafees Ahmad, Shama D Ahuja, Onno W Akkerman, Jan-Willem C Alffenaar, Laura F Anderson, Parvaneh Baghaei, Didi Bang, Pennan M Barry, Mayara L Bastos, Digamber Behera, Andrea Benedetti, Gregory P Bisson, Martin J Boeree, Maryline Bonnet, Sarah K Brode, James C M Brust, Ying Cai, Eric Caumes, J Peter Cegielski, Rosella Centis, Pei-Chun Chan, Edward D Chan, Kwok-Chiu Chang, Macarthur Charles, Andra Cirule, Margareth Pretti Dalcolmo, Lia D'Ambrosio, Gerard de Vries, Keertan Dheda, Aliasgar Esmail, Jennifer Flood, Gregory J Fox, Mathilde Fréchet-Jachym, Geisa Fregona, Regina Gayoso, Medea Gegia, Maria Tarcela Gler, Sue Gu, Lorenzo Guglielmetti, Timothy H Holtz, Jennifer Hughes, Petros Isaakidis, Leah Jarlsberg, Russell R Kempker, Salmaan Keshavjee, Faiz Ahmad Khan, Maia Kipiani, Serena P Koenig, Won-Jung Koh, Afranio Kritski, Liga Kuksa, Charlotte L Kvasnovsky, Nakwon Kwak, Zhiyi Lan, Christoph Lange, Rafael Laniado-Laborín, Myungsun Lee, Vaira Leimane, Chi-Chiu Leung, Eric Chung-Ching Leung, Pei Zhi Li, Phil Lowenthal, Ethel L Maciel, Suzanne M Marks, Sundari Mase, Lawrence Mbuagbaw, Giovanni B Migliori, Vladimir Milanov, Ann C Miller, Carole D Mitnick, Chawangwa Modongo, Erika Mohr, Ignacio Monedero, Payam Nahid, Norbert Ndjeka, Max R O'Donnell, Nesri Padayatchi, Domingo Palmero, Jean William Pape, Laura J Podewils, Ian Reynolds, Vija Riekstina, Jérôme Robert, Maria Rodriguez, Barbara Seaworth, Kwonjune J Seung, Kathryn Schnippel, Tae Sun Shim, Rupak Singla, Sarah E Smith, Giovanni Sotgiu, Ganzaya Sukhbaatar, Payam Tabarsi, Simon Tiberi, Anete Trajman, Lisa Trieu, Zarir F Udwadia, Tjip S van der Werf, Nicolas Veziris, Piret Viiklepp, Stalz Charles Vilbrun, Kathleen Walsh, Janice Westenhouse, Wing-Wai Yew, Jae-Joon Yim, Nicola M Zetola, Matteo Zignol, Dick Menzies. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis.
Lancet (London, England).
2018 09; 392(10150):821-834. doi:
10.1016/s0140-6736(18)31644-1. [PMID: 30215381] - Rubeshan Perumal, Neveen Abdelghani, Naressa Naidu, Nonhlanhla Yende-Zuma, Halima Dawood, Kogieleum Naidoo, Nalini Singh, Nesri Padayatchi. Risk of Nephrotoxicity in Patients With Drug-Resistant Tuberculosis Treated With Kanamycin/Capreomycin With or Without Concomitant Use of Tenofovir-Containing Antiretroviral Therapy.
Journal of acquired immune deficiency syndromes (1999).
2018 08; 78(5):536-542. doi:
10.1097/qai.0000000000001705. [PMID: 29683992] - Amber Arnold, Graham S Cooke, Onn Min Kon, Martin Dedicoat, Marc Lipman, Angela Loyse, Irina Chis Ster, Thomas S Harrison. Adverse Effects and Choice between the Injectable Agents Amikacin and Capreomycin in Multidrug-Resistant Tuberculosis.
Antimicrobial agents and chemotherapy.
2017 09; 61(9):. doi:
10.1128/aac.02586-16. [PMID: 28696239] - Ashwin S Dharmadhikari, Mohan Kabadi, Bob Gerety, Anthony J Hickey, P Bernard Fourie, Edward Nardell. Phase I, single-dose, dose-escalating study of inhaled dry powder capreomycin: a new approach to therapy of drug-resistant tuberculosis.
Antimicrobial agents and chemotherapy.
2013 Jun; 57(6):2613-9. doi:
10.1128/aac.02346-12. [PMID: 23529740] - L Garcia-Contreras, Pavan Muttil, John K Fallon, Mohan Kabadi, Robert Gerety, Anthony J Hickey. Pharmacokinetics of sequential doses of capreomycin powder for inhalation in guinea pigs.
Antimicrobial agents and chemotherapy.
2012 May; 56(5):2612-8. doi:
10.1128/aac.06145-11. [PMID: 22330920] - B Reisfeld, C P Metzler, M A Lyons, A N Mayeno, E J Brooks, M A Degroote. A physiologically based pharmacokinetic model for capreomycin.
Antimicrobial agents and chemotherapy.
2012 Feb; 56(2):926-34. doi:
10.1128/aac.05180-11. [PMID: 22143528] - Jennifer Fiegel, Lucila Garcia-Contreras, Matthew Thomas, Jarod VerBerkmoes, Katharina Elbert, Anthony Hickey, David Edwards. Preparation and in vivo evaluation of a dry powder for inhalation of capreomycin.
Pharmaceutical research.
2008 Apr; 25(4):805-11. doi:
10.1007/s11095-007-9381-6. [PMID: 17657592] - Sonya Shin, Jennifer Furin, Félix Alcántara, Anne Hyson, Keith Joseph, Epifanio Sánchez, Michael Rich. Hypokalemia among patients receiving treatment for multidrug-resistant tuberculosis.
Chest.
2004 Mar; 125(3):974-80. doi:
10.1378/chest.125.3.974. [PMID: 15006956] - Y Dong, X Zhao, B N Kreiswirth, K Drlica. Mutant prevention concentration as a measure of antibiotic potency: studies with clinical isolates of Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy.
2000 Sep; 44(9):2581-4. doi:
10.1128/aac.44.9.2581-2584.2000. [PMID: 10952625] - L J Norcia, A M Silvia, J P Dirlam, R C Schnur, J M Bergeron, J A Retsema, S F Hayashi. In vitro microbiological characterization of novel cyclic homopentapeptides, CP-101,680 and CP-163,234, for animal health use.
The Journal of antibiotics.
1999 Nov; 52(11):1007-16. doi:
10.7164/antibiotics.52.1007. [PMID: 10656573] - S S Zhang, H X Liu, Z B Yuan, C L Yu. A reproducible, simple, and sensitive high-performance capillary electrophoresis method for simultaneous determination of capreomycin, ofloxacin and pasiniazide in urine.
Journal of pharmaceutical and biomedical analysis.
1998 Aug; 17(4-5):617-22. doi:
10.1016/s0731-7085(98)00027-2. [PMID: 9682144] - N Rastogi, V Labrousse, K S Goh. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages.
Current microbiology.
1996 Sep; 33(3):167-75. doi:
10.1007/s002849900095. [PMID: 8672093] - P Le Conte, F Le Gallou, G Potel, L Struillou, D Baron, H B Drugeon. Pharmacokinetics, toxicity, and efficacy of liposomal capreomycin in disseminated Mycobacterium avium beige mouse model.
Antimicrobial agents and chemotherapy.
1994 Dec; 38(12):2695-701. doi:
10.1128/aac.38.12.2695. [PMID: 7535036] - C M Nolan, R E Sandblom, K E Thummel, J T Slattery, S D Nelson. Hepatotoxicity associated with acetaminophen usage in patients receiving multiple drug therapy for tuberculosis.
Chest.
1994 Feb; 105(2):408-11. doi:
10.1378/chest.105.2.408. [PMID: 7508362] - G M Shah, M A Kirschenbaum. Renal magnesium wasting associated with therapeutic agents.
Mineral and electrolyte metabolism.
1991; 17(1):58-64. doi:
NULL. [PMID: 1722865] - L Heifets, P Lindholm-Levy. Comparison of bactericidal activities of streptomycin, amikacin, kanamycin, and capreomycin against Mycobacterium avium and M. tuberculosis.
Antimicrobial agents and chemotherapy.
1989 Aug; 33(8):1298-301. doi:
10.1128/aac.33.8.1298. [PMID: 2478073] - C R Lehmann, L E Garrett, R E Winn, P D Springberg, S Vicks, D K Porter, W P Pierson, J D Wolny, G L Brier, H R Black. Capreomycin kinetics in renal impairment and clearance by hemodialysis.
The American review of respiratory disease.
1988 Nov; 138(5):1312-3. doi:
10.1164/ajrccm/138.5.1312. [PMID: 2462388] - R W Steiner, A S Omachi. A Bartter's-like syndrome from capreomycin, and a similar gentamicin tubulopathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
1986 Mar; 7(3):245-9. doi:
10.1016/s0272-6386(86)80012-9. [PMID: 2420173] - M Darr, S Hamburger, E Ellerbeck. Acid-base and electrolyte abnormalities due to capreomycin.
Southern medical journal.
1982 May; 75(5):627-8. doi:
10.1097/00007611-198205000-00037. [PMID: 6177055] - H R Osterhage, V Fischer, K Haubensak. Positive histological tuberculous findings despite stable sterility of the urine on culture: results of 111 nephrectomies and partial nephrectomies.
European urology.
1980; 6(2):116-8. doi:
10.1159/000473303. [PMID: 6153616] - R B Byrd, P D Kaplan, D R Gracey. Treatment of pulmonary tuberculosis.
Chest.
1974 Nov; 66(5):560-7. doi:
10.1378/chest.66.5.560. [PMID: 4139002] - M Akiyoshi, M Yoshizawa, K Hayano. [Histopathologic study on nephrotoxocity of tuberactinomycin-N, with special reference to interrelation between nephrotoxicity and ototoxicity (author's transl)].
Kekkaku : [Tuberculosis].
1974 Jul; 49(7):217-23. doi:
NULL. [PMID: 4139301] - W Wehrheim. [Modern view points on the therapy of urogenital tuberculosis].
Zeitschrift fur Urologie und Nephrologie.
1973 Aug; 66(8):627-30. doi:
NULL. [PMID: 4129653] - NULL. Evaluation of a new antituberculous agent. Capreomycin sulfate (capastat sulfate).
JAMA.
1973 Jan; 223(2):179-80. doi:
10.1001/jama.1973.03220020045016. [PMID: 4120232] - M Aquinas, K M Citron. Rifampicin, ethambutol and capreomycin in pulmonary tuberculosis, previously treated with both first and second line drugs: the results of 2 years chemotherapy.
Tubercle.
1972 Sep; 53(3):153-65. doi:
10.1016/0041-3879(72)90012-8. [PMID: 4116993] - P Hermann. [Ocular toxicity of ethambutol].
L'Annee therapeutique et clinique en ophtalmologie.
1971; 22(?):387-93. doi:
NULL. [PMID: 4127784] - A M Holmes, C M Hesling, T M Wilson. Capreomycin-induced serum electrolyte abnormalities.
Thorax.
1970 Sep; 25(5):608-11. doi:
10.1136/thx.25.5.608. [PMID: 5489186] - R Kropp, H Jungbluth, K L Radenbach. Influence of capreomycin on renal function. (Preliminary results).
Antibiotica et chemotherapia. Fortschritte. Advances. Progres.
1970; 16(?):59-68. doi:
10.1159/000386804. [PMID: 4108898] - M Lucchesi. The antimycobacterial activity of capreomycin.
Antibiotica et chemotherapia. Fortschritte. Advances. Progres.
1970; 16(?):27-31. doi:
10.1159/000386800. [PMID: 4108891] - M Wäre, O Heinivaara, R Elo, E Tala. Clinical experience of the treatment of drug-resistant pulmonary tuberculosis with rifampicin combined with ethambutol and capreomycin.
Scandinavian journal of respiratory diseases. Supplementum.
1969; 69(?):59-63. doi:
NULL. [PMID: 4906375] - W Y Yue, S S Cohen. Toxic nephritis with acute renal insufficiency caused by administration of capreomycin. Case report with necropsy findings.
Diseases of the chest.
1966 May; 49(5):549-51. doi:
10.1378/chest.49.5.549. [PMID: 5935897]