n-trimethyllysine (BioDeep_00000855569)
BioNovoGene_Lab2019
代谢物信息卡片
n-trimethyllysine
化学式: C9H21N2O2+ (189.16029460000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+](C)(C)CCCCC(C(=O)O)N
InChI: InChI=1S/C9H20N2O2/c1-11(2,3)7-5-4-6-8(10)9(12)13/h8H,4-7,10H2,1-3H3/p+1/t8-/m0/s1
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:17311
- PubChem: 440121
- DrugBank: DB03977
- ChEMBL: CHEMBL1234168
- CAS: 19253-88-4
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-208
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
4 个相关的代谢反应过程信息。
Reactome(4)
- Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Branched-chain amino acid catabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Carnitine synthesis:
2OG + Oxygen + TMLYS ⟶ HTMLYS + SUCCA + carbon dioxide
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Haoran Wei, Mingming Zhao, Junfang Wu, Chenze Li, Man Huang, Jianing Gao, Qi Zhang, Liang Ji, Yan Wang, Chunxia Zhao, Erdan Dong, Lemin Zheng, Dao Wen Wang. Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events.
The Journal of clinical endocrinology and metabolism.
2022 11; 107(12):e4360-e4370. doi:
10.1210/clinem/dgac519. [PMID: 36062477] - Jie Xu, Mingming Zhao, Anxin Wang, Jing Xue, Si Cheng, Aichun Cheng, Jianing Gao, Qi Zhang, Rui Zhan, Xia Meng, Ming Xu, Hao Li, Lemin Zheng, Yongjun Wang. Association Between Plasma Trimethyllysine and Prognosis of Patients With Ischemic Stroke.
Journal of the American Heart Association.
2021 12; 10(23):e020979. doi:
10.1161/jaha.121.020979. [PMID: 34816729] - Edzard Schwedhelm, Mirjam von Lucadou, Sven Peine, Susanne Lezius, Götz Thomalla, Rainer Böger, Christian Gerloff, Chi-Un Choe. Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE).
Amino acids.
2021 Apr; 53(4):555-561. doi:
10.1007/s00726-021-02969-x. [PMID: 33788002] - E Ø Bjørnestad, H Olset, I Dhar, K Løland, E K R Pedersen, G F T Svingen, A Svardal, R K Berge, P M Ueland, G S Tell, D W T Nilsen, J E Nordrehaug, E Nygaard, O Nygård. Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease.
Journal of internal medicine.
2020 10; 288(4):446-456. doi:
10.1111/joim.13067. [PMID: 32270523] - Xinmin S Li, Slayman Obeid, Zeneng Wang, Benjamin J Hazen, Lin Li, Yuping Wu, Alex G Hurd, Xiaodong Gu, Alan Pratt, Bruce S Levison, Yoon-Mi Chung, Steven E Nissen, Wai Hong Wilson Tang, François Mach, Lorenz Räber, David Nanchen, Christian M Matter, Thomas F Lüscher, Stanley L Hazen. Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes.
European heart journal.
2019 08; 40(32):2700-2709. doi:
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Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Xinmin S Li, Zeneng Wang, Tomas Cajka, Jennifer A Buffa, Ina Nemet, Alex G Hurd, Xiaodong Gu, Sarah M Skye, Adam B Roberts, Yuping Wu, Lin Li, Christopher J Shahen, Matthew A Wagner, Jaana A Hartiala, Robert L Kerby, Kymberleigh A Romano, Yi Han, Slayman Obeid, Thomas F Lüscher, Hooman Allayee, Federico E Rey, Joseph A DiDonato, Oliver Fiehn, W H Wilson Tang, Stanley L Hazen. Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
JCI insight.
2018 03; 3(6):. doi:
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PloS one.
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PloS one.
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BMC veterinary research.
2012 Mar; 8(?):28. doi:
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Lipids.
2011 Aug; 46(8):679-89. doi:
10.1007/s11745-011-3536-2. [PMID: 21479675] - Tse-Min Lu, Shing-Jong Lin, Ming-Wei Lin, Chiao-Po Hsu, Ming-Yi Chung. The association of dimethylarginine dimethylaminohydrolase 1 gene polymorphism with type 2 diabetes: a cohort study.
Cardiovascular diabetology.
2011 Feb; 10(?):16. doi:
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BMC pregnancy and childbirth.
2010 Apr; 10(?):17. doi:
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2010 Apr; 7(?):30. doi:
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The British journal of nutrition.
2009 Jan; 101(2):190-6. doi:
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Experimental biology and medicine (Maywood, N.J.).
2008 Mar; 233(3):356-65. doi:
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Hepatology (Baltimore, Md.).
2000 Jun; 31(6):1217-23. doi:
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The Journal of pharmacology and experimental therapeutics.
1999 Nov; 291(2):778-84. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
1999 Aug; 731(1):89-95. doi:
10.1016/s0378-4347(99)00112-7. [PMID: 10491993] - B Melegh, G Tóth, K Adamovich, G Szekely, D A Gage, L L Bieber. Labeled trimethyllysine load depletes unlabeled carnitine in premature infants without evidence of incorporation.
Biology of the neonate.
1999 Jul; 76(1):19-25. doi:
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Pediatric research.
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The Journal of nutrition.
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The Journal of nutrition.
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Federation proceedings.
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