Malonate (BioDeep_00000855567)
代谢物信息卡片
化学式: C3H2O4-2 (101.99530920000001)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 2.27%
分子结构信息
SMILES: C(C(=O)[O-])C(=O)[O-]
InChI: InChI=1S/C3H4O4/c4-2(5)1-3(6)7/h1H2,(H,4,5)(H,6,7)/p-2
描述信息
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(11)
- uracil degradation II (oxidative)
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass
- mixed acid fermentation
- superpathway of glyoxylate bypass and TCA
- superpathway of formononetin derivative biosynthesis
- afrormosin conjugates interconversion
- NADH to fumarate electron transfer
- succinate to cytochrome bo oxidase electron transfer
- hydrogen to fumarate electron transfer
- glycerol-3-phosphate to fumarate electron transfer
- succinate to cytochrome bd oxidase electron transfer
PlantCyc(3)
代谢反应
31 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(9)
- ethene and chloroethene degradation:
H+ + NADH + O2 + ethene ⟶ H2O + NAD+ + ethylene oxide
- afrormosin conjugates interconversion:
H2O + afrormosin-7-O-glucoside ⟶ D-glucopyranose + afrormosin
- formononetin conjugates interconversion:
H2O + ononin ⟶ D-glucopyranose + formononetin
- superpathway of formononetin derivative biosynthesis:
O2 + a reduced [NADPH-hemoprotein reductase] + formononetin ⟶ 2-hydroxyformononetin + H2O + an oxidized [NADPH-hemoprotein reductase]
- genistein conjugates interconversion:
H2O + malonylgenistin ⟶ H+ + genistin + malonate
- maackiain conjugates interconversion:
(-)-maackiain-3-O-glucoside + H2O ⟶ (-)-maackiain + D-glucopyranose
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- uracil degradation II (oxidative):
H+ + H2O + barbiturate ⟶ ureidomalonate
- daidzein conjugates interconversion:
H2O + daidzin ⟶ D-glucopyranose + daidzein
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(22)
- daidzein conjugates interconversion:
H2O + daidzin ⟶ D-glucopyranose + daidzein
- daidzein conjugates interconversion:
daidzin + malonyl-CoA ⟶ coenzyme A + malonyldaidzin
- daidzein conjugates interconversion:
H2O + malonyldaidzin ⟶ H+ + daidzin + malonate
- afrormosin conjugates interconversion:
H2O + afrormosin-7-O-glucoside ⟶ D-glucopyranose + afrormosin
- genistein conjugates interconversion:
H2O + genistin ⟶ D-glucopyranose + H+ + genistein
- genistein conjugates interconversion:
genistin + malonyl-CoA ⟶ coenzyme A + malonylgenistin
- genistein conjugates interconversion:
H2O + genistin ⟶ D-glucopyranose + H+ + genistein
- maackiain conjugates interconversion:
(-)-maackiain-3-O-glucoside + H2O ⟶ (-)-maackiain + D-glucopyranose
- maackiain conjugates interconversion:
(-)-maackiain-3-O-glucoside + malonyl-CoA ⟶ (-)-maackiain-3-O-glucoside-6''-malonate + coenzyme A
- maackiain conjugates interconversion:
(-)-maackiain-3-O-glucoside + H2O ⟶ (-)-maackiain + D-glucopyranose
- medicarpin conjugates interconversion:
(-)-medicarpin-3-O-glucoside + H2O ⟶ (-)-medicarpin + D-glucopyranose
- medicarpin conjugates interconversion:
(-)-medicarpin-3-O-glucoside + H2O ⟶ (-)-medicarpin + D-glucopyranose
- medicarpin conjugates interconversion:
(-)-medicarpin-3-O-glucoside + H2O ⟶ (-)-medicarpin + D-glucopyranose
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- biochanin A conjugates interconversion:
biochanin A-7-O-glucoside + malonyl-CoA ⟶ biochanin A-7-O-glucoside-6''-malonate + coenzyme A
- biochanin A conjugates interconversion:
H2O + biochanin A-7-O-glucoside ⟶ D-glucopyranose + H+ + biochanin-A
- biochanin A conjugates interconversion:
UDP-α-D-glucose + biochanin-A ⟶ UDP + biochanin A-7-O-glucoside
- biochanin A conjugates interconversion:
UDP-α-D-glucose + biochanin-A ⟶ UDP + biochanin A-7-O-glucoside
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Shubo Zhang, Wenfang Gao, Lina Xie, Guogang Zhang, Zimin Wei, Jie Li, Caihong Song, Mingkai Chang. Malonic acid shapes bacterial community dynamics in compost to promote carbon sequestration and humic substance synthesis.
Chemosphere.
2024 Feb; 350(?):141092. doi:
10.1016/j.chemosphere.2023.141092
. [PMID: 38169202] - Milica N Dimitrijević Stojanović, Andjela A Franich, Milena M Jurišević, Nevena M Gajović, Nebojša N Arsenijević, Ivan P Jovanović, Bojan S Stojanović, Slobodanka Lj Mitrović, Jakob Kljun, Snežana Rajković, Marija D Živković. Platinum(II) complexes with malonic acids: Synthesis, characterization, in vitro and in vivo antitumor activity and interactions with biomolecules.
Journal of inorganic biochemistry.
2022 06; 231(?):111773. doi:
10.1016/j.jinorgbio.2022.111773
. [PMID: 35279446] - Sarah Snanoudj, Stéphanie Torre, Bénédicte Sudrié-Arnaud, Lenaig Abily-Donval, Alice Goldenberg, Gajja S Salomons, Stéphane Marret, Soumeya Bekri, Abdellah Tebani. Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312633
. [PMID: 34884438] - Randy J Chandler, Leah E Venturoni, Jing Liao, Brandon T Hubbard, Jessica L Schneller, Victoria Hoffmann, Susana Gordo, Shengwen Zang, Chih-Wei Ko, Nelson Chau, Kyle Chiang, Mark A Kay, Adi Barzel, Charles P Venditti. Promoterless, Nuclease-Free Genome Editing Confers a Growth Advantage for Corrected Hepatocytes in Mice With Methylmalonic Acidemia.
Hepatology (Baltimore, Md.).
2021 06; 73(6):2223-2237. doi:
10.1002/hep.31570
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Molecules (Basel, Switzerland).
2021 Apr; 26(7):. doi:
10.3390/molecules26072079
. [PMID: 33916390] - Yanzhou Wang, Siyuan Zhu, Touming Liu, Bing Guo, Fu Li, Xuehua Bai. Identification of the rhizospheric microbe and metabolites that led by the continuous cropping of ramie (Boehmeria nivea L. Gaud).
Scientific reports.
2020 11; 10(1):20408. doi:
10.1038/s41598-020-77475-3
. [PMID: 33230149] - S S Efimova, D A Khaleneva, E V Litasova, L B Piotrovskiy, O S Ostroumova. The mechanisms of action of water-soluble aminohexanoic and malonic adducts of fullerene C60 with hexamethonium on model lipid membranes.
Biochimica et biophysica acta. Biomembranes.
2020 11; 1862(11):183433. doi:
10.1016/j.bbamem.2020.183433
. [PMID: 32763244] - Seung Hoon Lee, Jung Min Ko, Mi-Kyoung Song, Junghan Song, Kyung Sun Park. A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy.
Molecular genetics & genomic medicine.
2020 09; 8(9):e1379. doi:
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Biomedical chromatography : BMC.
2020 Feb; 34(2):e4738. doi:
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Proteomics. Clinical applications.
2020 01; 14(1):e1900103. doi:
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Neurochemical research.
2019 Sep; 44(9):2202-2214. doi:
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Journal of chromatographic science.
2019 Aug; 57(8):715-723. doi:
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Journal of inherited metabolic disease.
2019 01; 42(1):107-116. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Nov; 43(21):4288-4294. doi:
10.19540/j.cnki.cjcmm.2018.0115
. [PMID: 30583631] - Ben Zhao, Yafei Li, Changling Li, Hailin Yang, Wu Wang. Enhancement of Schizochytrium DHA synthesis by plasma mutagenesis aided with malonic acid and zeocin screening.
Applied microbiology and biotechnology.
2018 Mar; 102(5):2351-2361. doi:
10.1007/s00253-018-8756-4
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Journal of hazardous materials.
2018 Jan; 341(?):290-296. doi:
10.1016/j.jhazmat.2017.07.033
. [PMID: 28797944] - Christian Wölk, Christopher Janich, Udo Bakowsky, Andreas Langner, Gerald Brezesinski. Malonic acid based cationic lipids - The way to highly efficient DNA-carriers.
Advances in colloid and interface science.
2017 Oct; 248(?):20-34. doi:
10.1016/j.cis.2017.08.003
. [PMID: 28842122] - Chandra Shekar R Ambati, Furong Yuan, Lutfi A Abu-Elheiga, Yiqing Zhang, Vivekananda Shetty. Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics.
Journal of the American Society for Mass Spectrometry.
2017 05; 28(5):929-938. doi:
10.1007/s13361-017-1631-1
. [PMID: 28315235] - Ben Fan, Yu-Long Li, Lei Li, Xiao-Jun Peng, Chen Bu, Xiao-Qin Wu, Rainer Borriss. Malonylome analysis of rhizobacterium Bacillus amyloliquefaciens FZB42 reveals involvement of lysine malonylation in polyketide synthesis and plant-bacteria interactions.
Journal of proteomics.
2017 02; 154(?):1-12. doi:
10.1016/j.jprot.2016.11.022
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Journal of experimental botany.
2017 01; 68(3):457-467. doi:
10.1093/jxb/erw426
. [PMID: 28204578] - Bibi Rafeiza Khan, Daniel J Wherritt, David Huhman, Lloyd W Sumner, Kent D Chapman, Elison B Blancaflor. Malonylation of Glucosylated N-Lauroylethanolamine: A NEW PATHWAY THAT DETERMINES N-ACYLETHANOLAMINE METABOLIC FATE IN PLANTS.
The Journal of biological chemistry.
2016 12; 291(53):27112-27121. doi:
10.1074/jbc.m116.751065
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Proteins.
2016 08; 84(8):1075-96. doi:
10.1002/prot.25054
. [PMID: 27093562] - Tiyakhon Chatnaparat, Sutruedee Prathuangwong, Steven E Lindow. Global Pattern of Gene Expression of Xanthomonas axonopodis pv. glycines Within Soybean Leaves.
Molecular plant-microbe interactions : MPMI.
2016 Jun; 29(6):508-22. doi:
10.1094/mpmi-01-16-0007-r
. [PMID: 27003800] - Huan Liu, Dongqiong Tan, Lianshu Han, Jun Ye, Wenjuan Qiu, Xuefan Gu, Huiwen Zhang. A new case of malonyl-CoA decarboxylase deficiency with mild clinical features.
American journal of medical genetics. Part A.
2016 May; 170A(5):1347-51. doi:
10.1002/ajmg.a.37590
. [PMID: 26858006] - Xin Guan, Basil J Nikolau. AAE13 encodes a dual-localized malonyl-CoA synthetase that is crucial for mitochondrial fatty acid biosynthesis.
The Plant journal : for cell and molecular biology.
2016 Mar; 85(5):581-93. doi:
10.1111/tpj.13130
. [PMID: 26836315] - Yingjie Zhang, Stephen A Boyd, Brian J Teppen, James M Tiedje, Hui Li. Organic acids enhance bioavailability of tetracycline in water to Escherichia coli for uptake and expression of antibiotic resistance.
Water research.
2014 Nov; 65(?):98-106. doi:
10.1016/j.watres.2014.07.021
. [PMID: 25100186] - Nina A Dathan, Vincenzo Alterio, Elisa Troiano, Daniela Vullo, Martha Ludwig, Giuseppina De Simone, Claudiu T Supuran, Simona M Monti. Biochemical characterization of the chloroplastic β-carbonic anhydrase from Flaveria bidentis (L.) 'Kuntze'.
Journal of enzyme inhibition and medicinal chemistry.
2014 Aug; 29(4):500-4. doi:
10.3109/14756366.2013.813942
. [PMID: 23895630] - R Fernández, D Fernández-Fuego, A Bertrand, A González. Strategies for Cd accumulation in Dittrichia viscosa (L.) Greuter: role of the cell wall, non-protein thiols and organic acids.
Plant physiology and biochemistry : PPB.
2014 May; 78(?):63-70. doi:
10.1016/j.plaphy.2014.02.021
. [PMID: 24636908] - Leonardo Di Donna, Fabio Mazzotti, Domenico Taverna, Anna Napoli, Giovanni Sindona. Structural characterisation of malonyl flavonols in leek (Allium porrum L.) using high-performance liquid chromatography and mass spectrometry.
Phytochemical analysis : PCA.
2014 May; 25(3):207-12. doi:
10.1002/pca.2493
. [PMID: 24375682] - Yun Wang, Yi-Gang Wang, Teng-Fei Ma, Mei Li, Shu-Ling Gu. Dynamic metabolites profile of cerebral ischemia/reperfusion revealed by (1)H NMR-based metabolomics contributes to potential biomarkers.
International journal of clinical and experimental pathology.
2014; 7(7):4067-75. doi:
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Chemistry, an Asian journal.
2013 Oct; 8(10):2388-94. doi:
10.1002/asia.201300522
. [PMID: 23929723] - Wei Ning Chen, Kee Yang Tan. "Malonate uptake and metabolism in Saccharomyces cerevisiae".
Applied biochemistry and biotechnology.
2013 Sep; 171(1):44-62. doi:
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. [PMID: 23813405] - Ramakrishnan Karunakaran, Alison K East, Philip S Poole. Malonate catabolism does not drive N2 fixation in legume nodules.
Applied and environmental microbiology.
2013 Jul; 79(14):4496-8. doi:
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Molecular & cellular proteomics : MCP.
2013 Jan; 12(1):207-14. doi:
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Plant science : an international journal of experimental plant biology.
2013 Jan; 198(?):1-6. doi:
10.1016/j.plantsci.2012.09.001
. [PMID: 23199681] - Trina Ghosh Dastidar, Anil N Netravali. 'Green' crosslinking of native starches with malonic acid and their properties.
Carbohydrate polymers.
2012 Nov; 90(4):1620-8. doi:
10.1016/j.carbpol.2012.07.041
. [PMID: 22944425] - Alaa A Salem, Ibrahim M Abdou, Habiba A Saleh. Application of quantitative nuclear magnetic resonance spectroscopy for the determination ofamantadine and acyclovir in plasma and pharmaceutical samples.
Journal of AOAC International.
2012 Nov; 95(6):1644-51. doi:
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Phytochemistry.
2012 Sep; 81(?):80-9. doi:
10.1016/j.phytochem.2012.06.010
. [PMID: 22795763] - Sara Valdeolivas, Valentina Satta, Roger G Pertwee, Javier Fernández-Ruiz, Onintza Sagredo. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors.
ACS chemical neuroscience.
2012 May; 3(5):400-6. doi:
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Journal of pharmaceutical and biomedical analysis.
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. [PMID: 22387101] - Ahmed Alfares, Laura Dempsey Nunez, Khalid Al-Thihli, John Mitchell, Serge Melançon, Natascia Anastasio, Kevin C H Ha, Jacek Majewski, David S Rosenblatt, Nancy Braverman. Combined malonic and methylmalonic aciduria: exome sequencing reveals mutations in the ACSF3 gene in patients with a non-classic phenotype.
Journal of medical genetics.
2011 Sep; 48(9):602-5. doi:
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Biochimica et biophysica acta.
2011 Sep; 1808(9):2252-7. doi:
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The Plant cell.
2011 Jun; 23(6):2247-62. doi:
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Chemistry and physics of lipids.
2011 Feb; 164(2):144-50. doi:
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Diabetes research and clinical practice.
2010 Dec; 90(3):288-96. doi:
10.1016/j.diabres.2010.08.020
. [PMID: 20855122] - H Kalonia, P Kumar, A Kumar, B Nehru. Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats.
Neuroscience.
2010 Nov; 171(1):284-99. doi:
10.1016/j.neuroscience.2010.08.039
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Life sciences.
2010 Nov; 87(19-22):620-7. doi:
10.1016/j.lfs.2010.09.022
. [PMID: 20888349] - Ai-Min Chen, Yong-Bao Wang, Sun Jie, Ai-Yuan Yu, Li Luo, Guan-Qiao Yu, Jia-Bi Zhu, Yan-Zhang Wang. Identification of a TRAP transporter for malonate transport and its expression regulated by GtrA from Sinorhizobium meliloti.
Research in microbiology.
2010 Sep; 161(7):556-64. doi:
10.1016/j.resmic.2010.05.004
. [PMID: 20594941] - Ataru Higa, Yuko Mori, Yoshie Kitamura. Iron deficiency induces changes in riboflavin secretion and the mitochondrial electron transport chain in hairy roots of Hyoscyamus albus.
Journal of plant physiology.
2010 Jul; 167(11):870-8. doi:
10.1016/j.jplph.2010.01.011
. [PMID: 20181408] - Harikesh Kalonia, Puneet Kumar, Anil Kumar. Targeting oxidative stress attenuates malonic acid induced Huntington like behavioral and mitochondrial alterations in rats.
European journal of pharmacology.
2010 May; 634(1-3):46-52. doi:
10.1016/j.ejphar.2010.02.031
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Phytotherapy research : PTR.
2009 Oct; 23(10):1426-30. doi:
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Chemico-biological interactions.
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