Eritoran (BioDeep_00000855537)
代谢物信息卡片
Eritoran
化学式: C66H126N2O19P2 (1312.8429586)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCC(=O)CC(=O)NC1C(C(C(OC1OP(=O)(O)O)COC2C(C(C(C(O2)COC)OP(=O)(O)O)OCCC(CCCCCCC)OC)NC(=O)CCCCCCCCCC=CCCCCCC)O)OCCCCCCCCCC
InChI: InChI=1S/C66H126N2O19P2/c1-7-11-15-19-22-25-26-27-28-29-30-32-34-38-42-46-57(70)67-60-64(82-49-47-54(80-6)45-41-36-18-14-10-4)62(86-88(73,74)75)56(51-79-5)85-65(60)83-52-55-61(72)63(81-48-43-39-35-24-21-17-13-9-3)59(66(84-55)87-89(76,77)78)68-58(71)50-53(69)44-40-37-33-31-23-20-16-12-8-2/h25-26,54-56,59-66,72H,7-24,27-52H2,1-6H3,(H,67,70)(H,68,71)(H2,73,74,75)(H2,76,77,78)/b26-25-/t54-,55-,56-,59-,60-,61-,62-,63-,64-,65-,66-/m1/s1
描述信息
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
1 个代谢物同义名
数据库引用编号
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kappei Tsukahara. [Contribution to development of remedies for COVID-19: focusing on Eritoran].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2022; 157(1):38-40. doi:
10.1254/fpj.21041. [PMID: 34980810] - Atsuko Deguchi, Tomoko Yamamoto, Noriyuki Shibata, Yoshiro Maru. S100A8 may govern hyper-inflammation in severe COVID-19.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 09; 35(9):e21798. doi:
10.1096/fj.202101013. [PMID: 34339064] - A Landsem, H Fure, J Krey Ludviksen, D Christiansen, C Lau, M Mathisen, G Bergseth, S Nymo, K T Lappegård, T M Woodruff, T Espevik, T E Mollnes, O-L Brekke. Complement component 5 does not interfere with physiological hemostasis but is essential for Escherichia coli-induced coagulation accompanied by Toll-like receptor 4.
Clinical and experimental immunology.
2019 04; 196(1):97-110. doi:
10.1111/cei.13240. [PMID: 30444525] - Alessio Borio, Aurora Holgado, Jose Antonio Garate, Rudi Beyaert, Holger Heine, Alla Zamyatina. Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation.
ChemMedChem.
2018 11; 13(21):2317-2331. doi:
10.1002/cmdc.201800505. [PMID: 30276970] - Mira C Patel, Kari Ann Shirey, Marina S Boukhvalova, Stefanie N Vogel, Jorge C G Blanco. Serum High-Mobility-Group Box 1 as a Biomarker and a Therapeutic Target during Respiratory Virus Infections.
mBio.
2018 03; 9(2):. doi:
10.1128/mbio.00246-18. [PMID: 29535197] - Wei-Ting Kuo, Tsung-Chun Lee, Linda Chia-Hui Yu. Eritoran Suppresses Colon Cancer by Altering a Functional Balance in Toll-like Receptors That Bind Lipopolysaccharide.
Cancer research.
2016 08; 76(16):4684-95. doi:
10.1158/0008-5472.can-16-0172. [PMID: 27328732] - Rajesh Rajaiah, Darren J Perkins, Derek D C Ireland, Stefanie N Vogel. CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance.
Proceedings of the National Academy of Sciences of the United States of America.
2015 Jul; 112(27):8391-6. doi:
10.1073/pnas.1424980112. [PMID: 26106158] - Susu M Zughaier, Justin L Kandler, Jacqueline T Balthazar, William M Shafer. Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages.
PloS one.
2015; 10(12):e0144347. doi:
10.1371/journal.pone.0144347. [PMID: 26641098] - Yiben Yu, Yimou Wu, Gebo Wen, Wenqiong Yang. [Effect of pioglitazone on the expression of TLR4 in renal tissue of diabetic rats].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2014 Aug; 30(8):793-7. doi:
. [PMID: 25108428] - Guangjie Duan, Jiang Zhu, Jianhua Xu, Yousheng Liu. Targeting myeloid differentiation 2 for treatment of sepsis.
Frontiers in bioscience (Landmark edition).
2014 06; 19(6):904-15. doi:
10.2741/4256. [PMID: 24896325] - Kentaro Matsuo, Eita Sasaki, Satonori Higuchi, Shohei Takai, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Involvement of oxidative stress and immune- and inflammation-related factors in azathioprine-induced liver injury.
Toxicology letters.
2014 Jan; 224(2):215-24. doi:
10.1016/j.toxlet.2013.10.025. [PMID: 24184165] - Rossella Menghini, Umberto Campia, Manfredi Tesauro, Arianna Marino, Valentina Rovella, Giuseppe Rodia, Francesca Schinzari, Barbara Tolusso, Nicola di Daniele, Massimo Federici, Angelo Zoli, Gianfranco Ferraccioli, Carmine Cardillo. Toll-like receptor 4 mediates endothelial cell activation through NF-κB but is not associated with endothelial dysfunction in patients with rheumatoid arthritis.
PloS one.
2014; 9(6):e99053. doi:
10.1371/journal.pone.0099053. [PMID: 24918924] - Feyzahan Ekici, Emine Esra Karaca, Safak Korkmaz, Osman Yüksel, Özlem Gülbahar, Murat Alper, Sevim Ercan, Meral Or. Effect of the Toll-like receptor 4 antagonist eritoran on retinochoroidal inflammatory damage in a rat model of endotoxin-induced inflammation.
Mediators of inflammation.
2014; 2014(?):643525. doi:
10.1155/2014/643525. [PMID: 25165412] - Sebastian Korff, Patricia Loughran, Chanchun Cai, Yi Shan Lee, Melanie Scott, Timothy R Billiar. Eritoran attenuates tissue damage and inflammation in hemorrhagic shock/trauma.
The Journal of surgical research.
2013 Oct; 184(2):e17-25. doi:
10.1016/j.jss.2013.03.023. [PMID: 23777984] - Steven M Opal, Pierre-Francois Laterre, Bruno Francois, Steven P LaRosa, Derek C Angus, Jean-Paul Mira, Xavier Wittebole, Thierry Dugernier, Dominique Perrotin, Mark Tidswell, Luis Jauregui, Kenneth Krell, Jan Pachl, Takeshi Takahashi, Claus Peckelsen, Edward Cordasco, Chia-Sheng Chang, Sandra Oeyen, Naoki Aikawa, Tatsuya Maruyama, Roland Schein, Andre C Kalil, Marc Van Nuffelen, Melvyn Lynn, Daniel P Rossignol, Jogadish Gogate, Mary B Roberts, Janice L Wheeler, Jean-Louis Vincent. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.
JAMA.
2013 Mar; 309(11):1154-62. doi:
10.1001/jama.2013.2194. [PMID: 23512062] - Naoki Aikawa, Yoshio Okubo, Melvyn Lynn, Daniel P Rossignol, Y Nancy Wong, Edgar Schuck, Yasumi Kitahara, Tomohisa Nakano, Olena Sivak, Kishor M Wasan, Christa Nagy, Mark Yen. Safety, pharmacokinetics and pharmacodynamics of four-hour intravenous infusions of eritoran in healthy Japanese and Caucasian men.
Innate immunity.
2012 Dec; 18(6):793-803. doi:
10.1177/1753425912441845. [PMID: 22459966] - Sun Hong Park, Nam Doo Kim, Jae-Kyung Jung, Chong-Kil Lee, Sang-Bae Han, Youngsoo Kim. Myeloid differentiation 2 as a therapeutic target of inflammatory disorders.
Pharmacology & therapeutics.
2012 Mar; 133(3):291-8. doi:
10.1016/j.pharmthera.2011.11.001. [PMID: 22119168] - Jacklyn G Fleischer, Dan Rossignol, Gordon A Francis, Teddy Chan, Melvyn Lynn, Kishor M Wasan. Deactivation of the lipopolysaccharide antagonist eritoran (E5564) by high-density lipoprotein-associated apolipoproteins.
Innate immunity.
2012 Feb; 18(1):171-8. doi:
10.1177/1753425910394395. [PMID: 21382909] - M Liu, M Gu, D Xu, Q Lv, W Zhang, Y Wu. Protective effects of Toll-like receptor 4 inhibitor eritoran on renal ischemia-reperfusion injury.
Transplantation proceedings.
2010 Jun; 42(5):1539-44. doi:
10.1016/j.transproceed.2010.03.133. [PMID: 20620471] - Mark Tidswell, William Tillis, Steven P Larosa, Melvyn Lynn, Alec E Wittek, Richard Kao, Janice Wheeler, Jagadish Gogate, Steven M Opal. Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis.
Critical care medicine.
2010 Jan; 38(1):72-83. doi:
10.1097/ccm.0b013e3181b07b78. [PMID: 19661804] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Kishor M Wasan, Verica Risovic, Olena Sivak, Stephen D Lee, Douglas X Mason, Gregory R Chiklis, Jim McShane, Melvyn Lynn, Nancy Wong, Daniel P Rossignol. Influence of plasma cholesterol and triglyceride concentrations and eritoran (E5564) micelle size on its plasma pharmacokinetics and ex vivo activity following single intravenous bolus dose into healthy female rabbits.
Pharmaceutical research.
2008 Jan; 25(1):176-82. doi:
10.1007/s11095-007-9428-8. [PMID: 17849177] - Daniel Rossignol, Melvyn Lynn, Alec Wittek, Jeffrey Rose. Elevated plasma levels of limulus amoebocyte lysate-reactive material.
The Journal of infectious diseases.
2006 Nov; 194(9):1340; author reply 1340-1. doi:
10.1086/508223. [PMID: 17041863] - Daniel P Rossignol, Kishor M Wasan, Eugene Choo, Edwin Yau, Nancy Wong, Jeffrey Rose, Jeffrey Moran, Melvyn Lynn. Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers.
Antimicrobial agents and chemotherapy.
2004 Sep; 48(9):3233-40. doi:
10.1128/aac.48.9.3233-3240.2004. [PMID: 15328078] - R R Ingalls, B G Monks, R Savedra, W J Christ, R L Delude, A E Medvedev, T Espevik, D T Golenbock. CD11/CD18 and CD14 share a common lipid A signaling pathway.
Journal of immunology (Baltimore, Md. : 1950).
1998 Nov; 161(10):5413-20. doi:
". [PMID: 9820516]