Arsenic(III) oxide (BioDeep_00000855526)
代谢物信息卡片
Arsenic(III) oxide
化学式: As2O3 (197.827937)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: O=[As]O[As]=O
InChI: InChI=1S/As2O3/c3-1-5-2-4
描述信息
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zheng-Ting Deng, Shu-Fang Liang, Guo-Kai Huang, Yu-Qian Wang, Xiao-Yu Tu, Ya-Ni Zhang, Shu Li, Tao Liu, Bin-Bin Cheng. Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer.
Journal of integrative medicine.
2024 May; 22(3):295-302. doi:
10.1016/j.joim.2024.03.011. [PMID: 38599914] - Meng Yan, Hao Wang, Rui Wei, Wenwen Li. Arsenic trioxide: applications, mechanisms of action, toxicity and rescue strategies to date.
Archives of pharmacal research.
2024 Mar; 47(3):249-271. doi:
10.1007/s12272-023-01481-y. [PMID: 38147202] - Navid Omidifar, Ahmad Gholami, Mansoureh Shokripour, Mohammad Ali Nourani, Milad Mohkam, Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Bagher Khorram, Amir Nili Ahmadabadi, Mahintaj Dara. Protective Effects of Xanthine Derivatives Against Arsenic Trioxide-Induced Oxidative Stress in Mouse Hepatic and Renal Tissues.
Drug research.
2024 Mar; 74(3):133-144. doi:
10.1055/a-2247-5232. [PMID: 38350632] - Zhaoying Li, Xiaoyi Zou, Rongzhe Lu, Xin Wan, Song Sun, Shanjie Wang, Yinan Qu, Yun Zhang, Zhangyi Li, Liming Yang, Shaohong Fang. Arsenic trioxide alleviates atherosclerosis by inhibiting CD36-induced endocytosis and TLR4/NF-κB-induced inflammation in macrophage and ApoE-/- mice.
International immunopharmacology.
2024 Jan; 128(?):111452. doi:
10.1016/j.intimp.2023.111452. [PMID: 38237221] - Mingwei Su, Xiaoshan Liu, Yuhan Ma, Xiaomin Peng, Xilin Xiong, Wenjun Weng, Ke Huang, Yang Li. Arsenic trioxide induces ferroptosis in neuroblastoma by mediating GPX4 transcriptional inhibition.
Clinical and translational science.
2024 01; 17(1):e13716. doi:
10.1111/cts.13716. [PMID: 38266058] - Nathan Earl Rainey, Anne-Sophie Armand, Patrice X Petit. Sodium arsenite and arsenic trioxide differently affect the oxidative stress of lymphoblastoid cells: An intricate crosstalk between mitochondria, autophagy and cell death.
PloS one.
2024; 19(5):e0302701. doi:
10.1371/journal.pone.0302701. [PMID: 38728286] - Dan-Ping Huang, Liang-Chun Yang, Yi-Qiao Chen, Wu-Qing Wan, Dun-Hua Zhou, Hui-Rong Mai, Wan-Li Li, Li-Hua Yang, He-Kui Lan, Hui-Qin Chen, Bi-Yun Guo, Zi-Jun Zhen, Ri-Yang Liu, Guo-Hua Chen, Xiao-Qin Feng, Cong Liang, Li-Na Wang, Yu Li, Jie-Si Luo, Zhong Fan, Xue-Qun Luo, Bin Li, Yan-Lai Tang, Xiao-Li Zhang, Li-Bin Huang. Long-term outcome of children with acute promyelocytic leukemia: a randomized study of oral versus intravenous arsenic by SCCLG-APL group.
Blood cancer journal.
2023 12; 13(1):178. doi:
10.1038/s41408-023-00949-w. [PMID: 38052803] - Xiaohua Huang, Yuan Liu, Ruixuan Liu, Xiaoqiu Zou, Hongyong Yang. The efficacy and adverse events of arsenic trioxide for the patients with myelodysplastic syndrome: a systematic review and component network meta-analysis.
Hematology (Amsterdam, Netherlands).
2023 Dec; 28(1):2274149. doi:
10.1080/16078454.2023.2274149. [PMID: 37908176] - Faisal Raza, Mengyuan Zheng, Hongyu Zhong, Jing Su, Beixuan He, Wei-En Yuan, Mingfeng Qiu. Engineered tumor microvesicles modified by SP94 peptide for arsenic trioxide targeting drug delivery in liver cancer therapy.
Biomaterials advances.
2023 Dec; 155(?):213683. doi:
10.1016/j.bioadv.2023.213683. [PMID: 37925825] - Jixin Chen, Shuqi Chen, Huiyan Luo, Wanyin Wu, Sumei Wang. The application of arsenic trioxide in cancer: An umbrella review of meta-analyses based on randomized controlled trials.
Journal of ethnopharmacology.
2023 Nov; 316(?):116734. doi:
10.1016/j.jep.2023.116734. [PMID: 37290735] - Fatemeh Khosravani, Fatemeh Amiri, Rouzbeh Mahmoudi, Dina Morshedi, Farzad Kobarfard, Mohsen Alipour, Ebrahim Hosseini, Hassan Bardania. RGD-decorated nanoliposomes for combined delivery of arsenic trioxide and curcumin to prostate cancer cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Oct; ?(?):. doi:
10.1007/s00210-023-02752-7. [PMID: 37831114] - Yanan Jiang, Jianing Li, Yujie Liu, Xiuyun Shen, Junyi Li, Fengnan Zhi, Juan Xu, Xia Li, Tingting Shao, Yingqi Xu. Open a new epoch of arsenic trioxide investigation: ATOdb.
Computers in biology and medicine.
2023 10; 165(?):107465. doi:
10.1016/j.compbiomed.2023.107465. [PMID: 37699323] - Xuwang Pan, Jinsong Huang, Shourong Liu, Yidan Shao, Jianjun Xi, Ruoyu He, Tingting Shi, Rangxiao Zhuang, Wenying Yu. pH-Responsive and liver-targeting drug delivery system for combination delivery of artesunate with arsenic trioxide prodrug against hepatocellular carcinoma.
Drug development and industrial pharmacy.
2023 Jul; ?(?):1-12. doi:
10.1080/03639045.2023.2239342. [PMID: 37470495] - Kai-Yuan Chen, Wei-Lin Hsu, Shih-Wei Hsu, Chao-Hsuan Chen, Kun-Ting Hong, Chia-Wen Tsai, Wen-Shin Chang, Chao-Chun Chen, Jen-Sheng Pei, Hsu-Tung Lee, DA-Tian Bau. Involvement of Mitochondrial Damage and Oxidative Stress in Apoptosis Induced by Betulin Plus Arsenic Trioxide in Neuroblastoma Cells.
Anticancer research.
2023 Jun; 43(6):2467-2476. doi:
10.21873/anticanres.16414. [PMID: 37247918] - Rao Gan, Haiyan Liu, Shaofeng Wu, Riming Huang, Zhaoxin Tang, Ning Zhang, Lianmei Hu. Curcumin Alleviates Arsenic Trioxide-Induced Inflammation and Pyroptosis via the NF-κB/NLRP3 Signaling Pathway in the Hypothalamus of Ducks.
Biological trace element research.
2023 May; 201(5):2503-2511. doi:
10.1007/s12011-022-03321-4. [PMID: 35737258] - Jing Liu, Ming-Yi Sun, Hui-Min Wu, Hu-Lin-Yue Peng, Hua-Ting Huang, Ting-Ting Fu, Xiao-Xu Dong, Xing-Bin Yin, Chang-Hai Qu, Jian Ni. [Arsenic speciation and valence].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 May; 48(9):2396-2405. doi:
10.19540/j.cnki.cjcmm.20230213.601. [PMID: 37282869] - Junfeng Liu, Xi Li, Jiayao Chen, Xiaoting Zhang, Jingpei Guo, Jinyan Gu, Chaoming Mei, Yitai Xiao, Chao Peng, Junbin Liu, Xiaojun Hu, Ke Zhang, Dan Li, Bin Zhou. Arsenic-Loaded Biomimetic Iron Oxide Nanoparticles for Enhanced Ferroptosis-Inducing Therapy of Hepatocellular Carcinoma.
ACS applied materials & interfaces.
2023 Feb; 15(5):6260-6273. doi:
10.1021/acsami.2c14962. [PMID: 36695492] - Ying-Jian Zeng, Fan Liu, Min Wu, Xin-Ping Wu, Da-Ling Zhang, Qiu-Quan Yuan, Lu Zhou, Zhen-Hui Wu. Curcumin combined with arsenic trioxide in the treatment of acute myeloid leukemia: network pharmacology analysis and experimental validation.
Journal of cancer research and clinical oncology.
2023 Jan; 149(1):219-230. doi:
10.1007/s00432-022-04463-7. [PMID: 36352148] - Simin Yu, Zhuowang Ge, Weixiang Chen, Jinbin Han. Pyrrolidine Dithiocarbamate Enhances the Cytotoxic Effect of Arsenic Trioxide on Acute Promyelocytic Leukemia Cells.
Combinatorial chemistry & high throughput screening.
2023; 26(11):2067-2076. doi:
10.2174/1386207326666230123155944. [PMID: 36694317] - Oore-Oluwapo Daramola, Wahab Adekunle Oyeyemi Oyeyemi, Adeniran Oluwadamilare Akinola Akinola, Yinusa Raji Raji. Haematological and biochemical changes in arsenic trioxide-induced toxicity in Wistar rats treated with methanol extract of Parquetina nigrescens leaf.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2022 Dec; 37(2):235-246. doi:
10.54548/njps.v37i2.11. [PMID: 38243571] - Oore-Oluwapo Daramola, Wahab Adekunle Oyeyemi Oyeyemi, Adeniran Oluwadamilare Akinola Akinola, Yinusa Raji Raji. Haematoprotective and Hepatoprotective Effects of Methanolic Leaf Extract of Parquetina nigrescens on Arsenic trioxide-induced Toxicity in Male Wistar Rats.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2022 Dec; 37(2):235-246. doi:
10.54548/njps.v37i2.11. [PMID: 38243559] - Sangsang Tang, Yuanming Shen, Xinyi Wei, Zhangjin Shen, Weiguo Lu, Junfen Xu. Olaparib synergizes with arsenic trioxide by promoting apoptosis and ferroptosis in platinum-resistant ovarian cancer.
Cell death & disease.
2022 09; 13(9):826. doi:
10.1038/s41419-022-05257-y. [PMID: 36163324] - Ze Yang He, Hai Ying Li, Jiao Yan, Si Jin Li, Dao Cheng Li, Zhong Zhe Liang. A prospective trial to evaluate the clinical efficacy and safety of neoadjuvant chemotherapy with arsenic trioxide and carboplatin in locally advanced cervical cancer: a study protocol for randomized controlled clinical.
Trials.
2022 Jul; 23(1):556. doi:
10.1186/s13063-022-06489-1. [PMID: 35804452] - Liu-Hua Liao, Yi-Qiao Chen, Dan-Ping Huang, Li-Na Wang, Zhong-Lu Ye, Li-Hua Yang, Hui-Rong Mai, Yu Li, Cong Liang, Jie-Si Luo, Li-Na Wang, Xue-Qun Luo, Yan-Lai Tang, Xiao-Li Zhang, Li-Bin Huang. The comparison of plasma arsenic concentration and urinary arsenic excretion during treatment with Realgar-Indigo naturalis formula and arsenic trioxide in children with acute promyelocytic leukemia.
Cancer chemotherapy and pharmacology.
2022 Jul; 90(1):45-52. doi:
10.1007/s00280-022-04449-9. [PMID: 35760920] - Xinping Huang, Yongfeng Yang, Dan Zhu, Yan Zhao, Min Wei, Ke Li, Hong-Hu Zhu, Xiaofeng Zheng. PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα.
Cellular and molecular life sciences : CMLS.
2022 May; 79(6):319. doi:
10.1007/s00018-022-04358-3. [PMID: 35622143] - An-Liang Huang, Fan Yang, Ping Cheng, Dian-Ying Liao, Li Zhou, Xing-Li Ji, Dou-Dou Peng, Li Zhang, Ting-Ting Cheng, Li Ma, Xian-Gen Xia. Honokiol attenuate the arsenic trioxide-induced cardiotoxicity by reducing the myocardial apoptosis.
Pharmacology research & perspectives.
2022 04; 10(2):e00914. doi:
10.1002/prp2.914. [PMID: 35171536] - Mersad Bagherpour Kalo, Mohsen Rezaei. In vitro toxic interaction of arsenic and hyperglycemia in mitochondria: an important implication of increased vulnerability in pre-diabetics.
Environmental science and pollution research international.
2022 Apr; 29(19):28375-28385. doi:
10.1007/s11356-022-18513-7. [PMID: 34993818] - Guanghui Ni, Jingwen Tan, Mengjie Wang, Nina Ping, Min Liu, Yuefeng He. Polymorphisms of the AS3MT gene are associated with arsenic methylation capacity and damage to the P21 gene in arsenic trioxide plant workers.
Toxicology and industrial health.
2021 Dec; 37(12):727-736. doi:
10.1177/07482337211013321. [PMID: 34730462] - Chaoqun Li, Ke Zhang, Aidi Liu, Tianxiang Yue, Yinghui Wei, Hangsheng Zheng, Ji-Gang Piao, Fanzhu Li. MMP2-responsive dual-targeting drug delivery system for valence-controlled arsenic trioxide prodrug delivery against hepatic carcinoma.
International journal of pharmaceutics.
2021 Nov; 609(?):121209. doi:
10.1016/j.ijpharm.2021.121209. [PMID: 34678398] - Shaofeng Wu, Wenlan Yu, Xuanxuan Jiang, Riming Huang, Xiaoyong Zhang, Juan Lan, Gaolong Zhong, Fang Wan, Zhaoxin Tang, Lianmei Hu. Protective effects of curcumin on ATO-induced nephrotoxicity in ducks in relation to suppressed autophagy, apoptosis and dyslipidemia by regulating oxidative stress.
Ecotoxicology and environmental safety.
2021 Aug; 219(?):112350. doi:
10.1016/j.ecoenv.2021.112350. [PMID: 34022626] - Bing-Bing Zhang, Xiao-Jie Chen, Xu-Dong Fan, Jing-Jing Zhu, Ying-Hui Wei, Hang-Sheng Zheng, Hong-Yue Zheng, Bin-Hui Wang, Ji-Gang Piao, Fan-Zhu Li. Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells.
Acta pharmacologica Sinica.
2021 May; 42(5):832-842. doi:
10.1038/s41401-021-00648-x. [PMID: 33824461] - Gaolong Zhong, Fang Wan, Zhijun Ning, Shaofeng Wu, Xuanxuan Jiang, Zhaoxin Tang, Riming Huang, Lianmei Hu. The protective role of autophagy against arsenic trioxide-induced cytotoxicity and ROS-dependent pyroptosis in NCTC-1469 cells.
Journal of inorganic biochemistry.
2021 04; 217(?):111396. doi:
10.1016/j.jinorgbio.2021.111396. [PMID: 33610032] - Atefeh Gholami, Sara Ataei, Davoud Ahmadimoghaddam, Navid Omidifar, Amir Nili-Ahmadabadi. Pentoxifylline Attenuates Arsenic Trioxide-Induced Cardiac Oxidative Damage in Mice.
Oxidative medicine and cellular longevity.
2021; 2021(?):6406318. doi:
10.1155/2021/6406318. [PMID: 33505582] - Renyan Tang, Jianmin Zhu, Ying Liu, Ning Wu, Jinbin Han. Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts.
Technology in cancer research & treatment.
2021 Jan; 20(?):15330338211036324. doi:
10.1177/15330338211036324. [PMID: 34433326] - Yang Li, Chuchu Feng, Yantao Chen, Ke Huang, Chunmou Li, Xilin Xiong, Peng Li, Dunhua Zhou, Xiaomin Peng, Wenjun Weng, Xiaogeng Deng, Yaohao Wu, Jianpei Fang. Improved Outcomes with Induction Chemotherapy Combined with Arsenic Trioxide in Stage 4 Neuroblastoma: A Case Series.
Technology in cancer research & treatment.
2021 Jan; 20(?):15330338211041454. doi:
10.1177/15330338211041454. [PMID: 34569870] - Zhaonan Li, Quanjing Chen, Wenguang Zhang, Guangyan Si, Jing Li, Dechao Jiao, Xinwei Han. Efficacy and Safety of the Arsenic Trioxide/Lipiodol Emulsion in the Transcatheter Arterial Chemoembolization Combined with Apatinib in the Treatment of Advanced Hepatocellular Carcinoma.
Canadian journal of gastroenterology & hepatology.
2021; 2021(?):5565793. doi:
10.1155/2021/5565793. [PMID: 34458205] - Panpan Liu, Yurun Xue, Bin Zheng, Yingran Liang, Jianping Zhang, Jing Shi, Xi Chu, Xue Han, Li Chu. Crocetin attenuates the oxidative stress, inflammation and apoptosisin arsenic trioxide-induced nephrotoxic rats: Implication of PI3K/AKT pathway.
International immunopharmacology.
2020 Nov; 88(?):106959. doi:
10.1016/j.intimp.2020.106959. [PMID: 32919218] - Yingran Liang, Bin Zheng, Jinghan Li, Jing Shi, Li Chu, Xue Han, Xi Chu, Xuan Zhang, Jianping Zhang. Crocin ameliorates arsenic trioxide‑induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Nov; 131(?):110713. doi:
10.1016/j.biopha.2020.110713. [PMID: 32920515] - Faisal Thayyullathil, Anees Rahman Cheratta, Siraj Pallichankandy, Karthikeyan Subburayan, Saeed Tariq, Vivek M Rangnekar, Sehamuddin Galadari. Par-4 regulates autophagic cell death in human cancer cells via upregulating p53 and BNIP3.
Biochimica et biophysica acta. Molecular cell research.
2020 07; 1867(7):118692. doi:
10.1016/j.bbamcr.2020.118692. [PMID: 32135176] - Y He, R Zhang, J Chen, J Tan, M Wang, X Wu. The ability of arsenic metabolism affected the expression of lncRNA PANDAR, DNA damage, or DNA methylation in peripheral blood lymphocytes of laborers.
Human & experimental toxicology.
2020 May; 39(5):605-613. doi:
10.1177/0960327119897101. [PMID: 31885278] - Xinyang Li, Donglei Sun, Tianhe Zhao, Zunzhen Zhang. Long non-coding RNA ROR confers arsenic trioxide resistance to HepG2 cells by inhibiting p53 expression.
European journal of pharmacology.
2020 Apr; 872(?):172982. doi:
10.1016/j.ejphar.2020.172982. [PMID: 32017938] - Hanming Chen, Gaoyang Liu, Na Qiao, Zhenlong Kang, Lianmei Hu, Jianzhao Liao, Fan Yang, Congying Pang, Bingxian Liu, Qiwen Zeng, Yao Li, Ying Li. Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations.
Ecotoxicology and environmental safety.
2020 Mar; 190(?):110063. doi:
10.1016/j.ecoenv.2019.110063. [PMID: 31846860] - Subramaniyam Nithyananthan, Chinnasamy Thirunavukkarasu. Arsenic trioxide, a cancer chemo drug hampers fibrotic liver regeneration by interrupting oxidative stress rekindling and stellate cell rejuvenation.
Journal of cellular physiology.
2020 02; 235(2):1222-1234. doi:
10.1002/jcp.29037. [PMID: 31270803] - Yu-Ting Sun, Huan-Hua Xu, Yao Nie, Yu-Guang Wang, Zeng-Chun Ma, Wei Zhou, Hong-Ling Tan, Yue Gao. [Preliminary study of Realgar and arsenic trioxide on gut microbiota of mice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Jan; 45(1):142-148. doi:
10.19540/j.cnki.cjcmm.20190813.403. [PMID: 32237423] - Zhaonan Li, Guangyan Si, De-Chao Jiao, Xinwei Han, Wenguang Zhang, Yahua Li, Xueliang Zhou, Juanfang Liu, Jianjian Chen. Portal Vein Stenting Combined with 125I Particle Chain Implantation Followed by As2O3 in the Treatment of Hepatocellular Carcinoma with Portal Vein Tumour Thrombus.
BioMed research international.
2020; 2020(?):4109216. doi:
10.1155/2020/4109216. [PMID: 32090088] - Hongjing Zhao, Yu Wang, Juanjuan Liu, Menghao Guo, Dongxue Fei, Hongxian Yu, Mingwei Xing. The cardiotoxicity of the common carp (Cyprinus carpio) exposed to environmentally relevant concentrations of arsenic and subsequently relieved by zinc supplementation.
Environmental pollution (Barking, Essex : 1987).
2019 Oct; 253(?):741-748. doi:
10.1016/j.envpol.2019.07.065. [PMID: 31344536] - Lei Yang, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Sen Wei, Pei Pei, Zhidong Wang, Jie Bai, Xiaofang Liu, Guang Yang, Shuang Liu, Xiance Sun. Taurine protects against arsenic trioxide-induced insulin resistance via ROS-Autophagy pathway in skeletal muscle.
The international journal of biochemistry & cell biology.
2019 07; 112(?):50-60. doi:
10.1016/j.biocel.2019.05.001. [PMID: 31059810] - Soojong Park, Hyun-Tak Han, Sang-Seok Oh, Dong Hyeok Kim, Jin-Woo Jeong, Ki Won Lee, Minju Kim, Jong Seok Lim, Yong Yeon Cho, Cheol Hwangbo, Jiyun Yoo, Kwang Dong Kim. NDRG2 Sensitizes Myeloid Leukemia to Arsenic Trioxide via GSK3β-NDRG2-PP2A Complex Formation.
Cells.
2019 05; 8(5):. doi:
10.3390/cells8050495. [PMID: 31121982] - Zhidong Wang, Ye Tao, Tianming Qiu, Xiaofeng Yao, Liping Jiang, Ningning Wang, Sen Wei, Xue Jia, Pei Pei, Guang Yang, Xiaofang Liu, Shuang Liu, Xiance Sun. Taurine protected As2O3-induced the activation of hepatic stellate cells through inhibiting PPARα-autophagy pathway.
Chemico-biological interactions.
2019 Feb; 300(?):123-130. doi:
10.1016/j.cbi.2019.01.019. [PMID: 30677399] - Jiaoyang Tao, Weidong Fei, Hongxia Tang, Chaoqun Li, Chaofeng Mu, Hongyue Zheng, Fanzhu Li, Zhihong Zhu. Angiopep-2-Conjugated 'Core-Shell' Hybrid Nanovehicles for Targeted and pH-Triggered Delivery of Arsenic Trioxide into Glioma.
Molecular pharmaceutics.
2019 02; 16(2):786-797. doi:
10.1021/acs.molpharmaceut.8b01056. [PMID: 30620881] - Ruiying Wang, Jingyi Zhang, Shan Wang, Min Wang, Tianyuan Ye, Yuyang Du, Xueheng Xie, Jingxue Ye, Guibo Sun, Xiaobo Sun. The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress.
Molecules (Basel, Switzerland).
2019 Feb; 24(3):. doi:
10.3390/molecules24030543. [PMID: 30717322] - Ming-Hua Yang, Wu-Qing Wan, Jie-Si Luo, Min-Cui Zheng, Ke Huang, Li-Hua Yang, Hui-Rong Mai, Jian Li, Hui-Qin Chen, Xiao-Fei Sun, Ri-Yang Liu, Guo-Hua Chen, Xiaoqin Feng, Zhi-Yong Ke, Bin Li, Yan-Lai Tang, Li-Bin Huang, Xue-Qun Luo. Multicenter randomized trial of arsenic trioxide and Realgar-Indigo naturalis formula in pediatric patients with acute promyelocytic leukemia: Interim results of the SCCLG-APL clinical study.
American journal of hematology.
2018 12; 93(12):1467-1473. doi:
10.1002/ajh.25271. [PMID: 30160789] - Lin Zhang, Lei Liu, Shining Zhan, Lili Chen, Yueyuan Wang, Yujie Zhang, Jun Du, Yongping Wu, Luo Gu. Arsenic Trioxide Suppressed Migration and Angiogenesis by Targeting FOXO3a in Gastric Cancer Cells.
International journal of molecular sciences.
2018 Nov; 19(12):. doi:
10.3390/ijms19123739. [PMID: 30477221] - Chun-Ming Yen, Chia-Wen Tsai, Wen-Shin Chang, Yi-Chin Yang, Yi-Wen Hung, Hsu-Tung Lee, Chiung-Chyi Shen, Meei-Ling Sheu, Ju-Yu Wang, Chi-Li Gong, Wen-Yu Cheng, DA-Tian Bau. Novel Combination of Arsenic Trioxide (As2O3) Plus Resveratrol in Inducing Programmed Cell Death of Human Neuroblastoma SK-N-SH Cells.
Cancer genomics & proteomics.
2018 Nov; 15(6):453-460. doi:
10.21873/cgp.20104. [PMID: 30343279] - Hongye Hu, Enjiu Chen, Yongji Li, Xiaochun Zhu, Ting Zhang, Xiaofang Zhu. Effects of Arsenic Trioxide on INF-gamma Gene Expression in MRL/lpr Mice and Human Lupus.
Biological trace element research.
2018 Aug; 184(2):391-397. doi:
10.1007/s12011-017-1206-9. [PMID: 29159556] - P Binu, K Gifty, R C Vineetha, S Abhilash, P Arathi, R Harikumaran Nair. Eugenol, a plant-derived phenolic nutraceutical, protects thiol (SH) group in myocardium from ROS-mediated oxidation under chemotherapeutic stress induced by arsenic trioxide - a in vivo model study.
Drug and chemical toxicology.
2018 Jul; 41(3):352-357. doi:
10.1080/01480545.2018.1424179. [PMID: 29372663] - Yu Wang, Hongjing Zhao, Juanjuan Liu, Yizhi Shao, Jinglun Li, Liyang Luo, Mingwei Xing. Copper and arsenic-induced oxidative stress and immune imbalance are associated with activation of heat shock proteins in chicken intestines.
International immunopharmacology.
2018 Jul; 60(?):64-75. doi:
10.1016/j.intimp.2018.04.038. [PMID: 29705531] - Shu-Min Ding, Rui-Rong Xu, Jin-Yao Kan, Yan Wang. [Effects of Arsenic Trioxide on Cdc20 and Mad2 in Acute Myeloid Leukemia HL-60 Cell Line].
Zhongguo shi yan xue ye xue za zhi.
2018 Jun; 26(3):710-715. doi:
10.7534/j.issn.1009-2137.2018.03.013. [PMID: 29950208] - Sukanya Saha, Pritam Sadhukhan, Sushweta Mahalanobish, Sayanta Dutta, Parames C Sil. Ameliorative role of genistein against age-dependent chronic arsenic toxicity in murine brains via the regulation of oxidative stress and inflammatory signaling cascades.
The Journal of nutritional biochemistry.
2018 05; 55(?):26-40. doi:
10.1016/j.jnutbio.2017.11.010. [PMID: 29331881] - S Abhilash, R Siviyasankar, P Binu, P Arathi, R Harikumaran Nair. Different administration patterns of docosahexaenoic acid in combating cytotoxic manifestations due to arsenic trioxide (acute promyelocytic leukemia drug) induced redox imbalance in hepatocytes.
Prostaglandins & other lipid mediators.
2018 05; 136(?):64-75. doi:
10.1016/j.prostaglandins.2018.05.002. [PMID: 29751151] - Radhakrishnan Chandraprabha Vineetha, Viswanathan Archana, Prakash Binu, Pettamanna Arathi, Raveendran Harikumaran Nair. L-Ascorbic Acid and α-Tocopherol Reduces Hepatotoxicity Associated with Arsenic Trioxide Chemotherapy by Modulating Nrf2 and Bcl2 Transcription Factors in Chang liver Cells.
Nutrition and cancer.
2018 May; 70(4):684-696. doi:
10.1080/01635581.2018.1460676. [PMID: 29697268] - Peng Song, Yang Hai, Wantong Ma, Longhe Zhao, Xin Wang, Qinjian Xie, Yang Li, Zhengrong Wu, Yingdong Li, Hongyu Li. Arsenic trioxide combined with transarterial chemoembolization for unresectable primary hepatic carcinoma: A systematic review and meta-analysis.
Medicine.
2018 May; 97(18):e0613. doi:
10.1097/md.0000000000010613. [PMID: 29718867] - Wen Cui, Jin Wang, Rui-Min Nie, Ling-Ling Zhao, Meng-Qing Gao, Hong-Ming Zhu, Li Chen, Jiong Hu, Jun-Min Li, Zhi-Xiang Shen, Zhen-Yi Wang, Sai-Juan Chen, Zhu Chen, Kan-Kan Wang, Xiao-Dong Xi, Jian-Qing Mi. Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first-line treatment of adult acute promyelocytic leukemia.
European journal of haematology.
2018 Apr; 100(4):344-350. doi:
10.1111/ejh.13018. [PMID: 29266395] - An-Hao Huang, Shun-Ping Han, Yan-Ping Lu, Rui Ma, Hang-Sheng Zheng, Fan-Zhu Li. [Preparation and in vitro evaluation of arsenic trioxide glioma targeting drug delivery system loaded by PAMAM dendrimers co-modified with RGDyC and PEG].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Apr; 43(8):1618-1625. doi:
10.19540/j.cnki.cjcmm.20180117.010. [PMID: 29751708] - Yanping Lu, Shunping Han, Hongyue Zheng, Rui Ma, Yuting Ping, Jiafeng Zou, Hongxia Tang, Yongping Zhang, Xiuling Xu, Fanzhu Li. A novel RGDyC/PEG co-modified PAMAM dendrimer-loaded arsenic trioxide of glioma targeting delivery system.
International journal of nanomedicine.
2018; 13(?):5937-5952. doi:
10.2147/ijn.s175418. [PMID: 30323584] - Jian Wang, Jun-Bin Huang, Zu-Lin Liu, Bi-Hong Zhang, Hong-Gui Xu, Hong-Man Xue, Chun Chen. [Comparison of Curative Effect between Fu Fang Huang Dai Pian and Arsenic Trioxide in Treatment of 45 Patients with Acute Promyelocytic Leukaemia].
Zhongguo shi yan xue ye xue za zhi.
2017 Dec; 25(6):1605-1610. doi:
10.7534/j.issn.1009-2137.2017.06.004. [PMID: 29262883] - Mathews V Varghese, M Abhilash, Manju Alex, M V Sauganth Paul, A Prathapan, K G Raghu, R Harikumaran Nair. Attenuation of arsenic trioxide induced cardiotoxicity through flaxseed oil in experimental rats.
Redox report : communications in free radical research.
2017 Nov; 22(6):346-352. doi:
10.1080/13510002.2017.1289313. [PMID: 28209094] - Jian-Wei Wu, Wei-Ting Xiao, Ying-Jian Zeng, Jia-Xin Fan, Yong-Bin Ye, Yuan-Ming Li, Rong Zhen, Kun-Yuan Guo. [Synergistic Killing Effects of Arsenic Trioxide Combined with Itraconazole on KG1a Cells].
Zhongguo shi yan xue ye xue za zhi.
2017 Aug; 25(4):1003-1010. doi:
10.7534/j.issn.1009-2137.2017.04.008. [PMID: 28823259] - Michael Gülden, Daniel Appel, Malin Syska, Stephanie Uecker, Franziska Wages, Hasso Seibert. Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Jul; 105(?):486-497. doi:
10.1016/j.fct.2017.04.035. [PMID: 28458011] - Prakash Binu, Nellikunnath Priya, Surendran Abhilash, Radhakrishnan Chandraprabha Vineetha, Raveendran Harikumaran Nair. Studies on curative efficacy of monoterpene eugenol on anti- leukemic drug arsenic trioxide induced cardiotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jul; 91(?):559-566. doi:
10.1016/j.biopha.2017.04.087. [PMID: 28494415] - Haiyan He, Ran An, Jian Hou, Weijun Fu. Arsenic trioxide induced rhabdomyolysis, a rare but severe side effect, in an APL patient: a case report.
Frontiers of medicine.
2017 Jun; 11(2):284-286. doi:
10.1007/s11684-017-0514-y. [PMID: 28425042] - Xiaojin Yu, Zhenyu Wang, Zunpeng Shu, Zhengqing Li, Yuan Ning, Keli Yun, Haina Bai, Ruihai Liu, Wenli Liu. Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. flavonoids protect against arsenic trioxide-induced cardiotoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):1-10. doi:
10.1016/j.biopha.2016.12.130. [PMID: 28092839] - Mathews V Varghese, M Abhilash, M V Sauganth Paul, Manju Alex, R Harikumaran Nair. Omega-3 Fatty Acid Protects Against Arsenic Trioxide-Induced Cardiotoxicity In Vitro and In Vivo.
Cardiovascular toxicology.
2017 04; 17(2):109-119. doi:
10.1007/s12012-016-9361-3. [PMID: 26886836] - Yujin Liu, Feng Gao, Weixiang Song. Periostin contributes to arsenic trioxide resistance in hepatocellular carcinoma cells under hypoxia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Apr; 88(?):342-348. doi:
10.1016/j.biopha.2017.01.052. [PMID: 28119236] - Weidong Fei, Yan Zhang, Shunping Han, Jiaoyang Tao, Hongyue Zheng, Yinghui Wei, Jiazhen Zhu, Fanzhu Li, Xuanshen Wang. RGD conjugated liposome-hollow silica hybrid nanovehicles for targeted and controlled delivery of arsenic trioxide against hepatic carcinoma.
International journal of pharmaceutics.
2017 Mar; 519(1-2):250-262. doi:
10.1016/j.ijpharm.2017.01.031. [PMID: 28109899] - A Abudoureyimu, A Muhemaitibake. Arsenic trioxide regulates gastric cancer cell apoptosis by mediating cAMP.
European review for medical and pharmacological sciences.
2017 02; 21(3):612-617. doi:
". [PMID: 28239804] - Zhenzhen Guo, Mingjing Meng, Shengnan Geng, Zhenhua Du, Yaqiu Zheng, Jingjing Yao, Zibo Li, Guang Han, Haihong Lin, Gangjun Du. The optimal dose of arsenic trioxide induced opposite efficacy in autophagy between K562 cells and their initiating cells to eradicate human myelogenous leukemia.
Journal of ethnopharmacology.
2017 Jan; 196(?):29-38. doi:
10.1016/j.jep.2016.12.010. [PMID: 27965050] - Sabrina Krautbauer, Elisabeth M Haberl, Kristina Eisinger, Rebekka Pohl, Lisa Rein-Fischboeck, Carles Rentero, Anna Alvarez-Guaita, Carlos Enrich, Thomas Grewal, Christa Buechler, Markus Neumeier. Annexin A6 regulates adipocyte lipid storage and adiponectin release.
Molecular and cellular endocrinology.
2017 01; 439(?):419-430. doi:
10.1016/j.mce.2016.09.033. [PMID: 27702590] - Chia-Wen Tsai, Mei-Due Yang, Te-Chun Hsia, Wen-Shin Chang, Chin-Mu Hsu, Yi-Hsien Hsieh, Jing-Gung Chung, Da-Tian Bau. Dithiothreitol enhanced arsenic-trioxide-induced cell apoptosis in cultured oral cancer cells via mitochondrial dysfunction and endoplasmic reticulum stress.
Environmental toxicology.
2017 Jan; 32(1):17-27. doi:
10.1002/tox.22208. [PMID: 26494474] - Yanqin Ma, Zhenhua Ma, Shuqin Yin, Xiaoyan Yan, Jundong Wang. Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells.
Chemosphere.
2017 Jan; 167(?):454-461. doi:
10.1016/j.chemosphere.2016.10.025. [PMID: 27750169] - Jing-Yi Zhang, Gui-Bo Sun, Yun Luo, Min Wang, Wei Wang, Yu-Yang Du, Ying-Li Yu, Xiao-Bo Sun. Salvianolic Acid A Protects H9c2 Cells from Arsenic Trioxide-Induced Injury via Inhibition of the MAPK Signaling Pathway.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 41(5):1957-1969. doi:
10.1159/000472409. [PMID: 28391263] - Shuvasree Sarkar, Sandip Mukherjee, Ansuman Chattopadhyay, Shelley Bhattacharya. Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide.
Ecotoxicology and environmental safety.
2017 Jan; 135(?):173-182. doi:
10.1016/j.ecoenv.2016.09.025. [PMID: 27736677] - Chuanying Zhu, Renhua Zhou, Qing Zhou, Yuewen Chang, Mawei Jiang. microRNA-539 suppresses tumor growth and tumorigenesis and overcomes arsenic trioxide resistance in hepatocellular carcinoma.
Life sciences.
2016 Dec; 166(?):34-40. doi:
10.1016/j.lfs.2016.10.002. [PMID: 27717846] - Tain-Junn Cheng, Shu-Wen Lin, Chih-Wei Chen, How-Ran Guo, Ying-Jang Wang. Arsenic trioxide suppresses liver X receptor β and enhances cholesteryl ester transfer protein expression without affecting the liver X receptor α in HepG2 cells.
Chemico-biological interactions.
2016 Oct; 258(?):288-96. doi:
10.1016/j.cbi.2016.09.009. [PMID: 27622732] - Elaheh Nooshinfar, Davood Bashash, Ava Safaroghli-Azar, Samaneh Bayati, Mostafa Rezaei-Tavirani, Seyed H Ghaffari, Mohammad Esmaeil Akbari. Melatonin promotes ATO-induced apoptosis in MCF-7 cells: Proposing novel therapeutic potential for breast cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Oct; 83(?):456-465. doi:
10.1016/j.biopha.2016.07.004. [PMID: 27427852] - Jing Zhu, Dingcheng Ren. Arsenic prepared by Chinese alchemist-pharmacists.
Science China. Life sciences.
2016 Oct; 59(10):1086-1089. doi:
10.1007/s11427-015-0365-3. [PMID: 27687865] - S G Li, S Z Xu, Q Niu, Y S Ding, L J Pang, R L Ma, M X Jing, K Wang, X M Ma, G L Feng, J M Liu, X F Zhang, H L Xiang, F Li. Lutein alleviates arsenic-induced reproductive toxicity in male mice via Nrf2 signaling.
Human & experimental toxicology.
2016 May; 35(5):491-500. doi:
10.1177/0960327115595682. [PMID: 26187899] - Agnieszka Żuryń, Adrian Krajewski, Anna Litwiniec, Anna Klimaszewska-Wiśniewska, Alina Grzanka. Expression of cyclin A in A549 cell line after treatment with arsenic trioxide.
Postepy higieny i medycyny doswiadczalnej (Online).
2015 Dec; 69(?):1259-67. doi:
10.5604/17322693.1184239. [PMID: 26671917] - Bo Wang, Sheng-yun Lin, Ying-ying Shen, Li-qiang Wu, Zhen-zhen Chen, Jing Li, Zhi Chen, Wen-bin Qian, Jian-ping Jiang. Pure total flavonoids from Citrus paradisi Macfadyen act synergistically with arsenic trioxide in inducing apoptosis of Kasumi-1 leukemia cells in vitro.
Journal of Zhejiang University. Science. B.
2015 Jul; 16(7):580-5. doi:
10.1631/jzus.b1400234. [PMID: 26160715] - Hiromichi Matsushita. [Pathogenesis of Acute Promyelocytic Leukemia].
Rinsho byori. The Japanese journal of clinical pathology.
2015 May; 63(5):631-42. doi:
". [PMID: 26524903] - Ozkan Aksakal, Nevzat Esim. Evaluation of arsenic trioxide genotoxicity in wheat seedlings using oxidative system and RAPD assays.
Environmental science and pollution research international.
2015 May; 22(9):7120-8. doi:
10.1007/s11356-014-3932-2. [PMID: 25501642] - Chengzhi Chen, Xuejun Jiang, Yanhao Lai, Yuan Liu, Zunzhen Zhang. Resveratrol protects against arsenic trioxide-induced oxidative damage through maintenance of glutathione homeostasis and inhibition of apoptotic progression.
Environmental and molecular mutagenesis.
2015 Apr; 56(3):333-46. doi:
10.1002/em.21919. [PMID: 25339131] - Ruma Das, Avratanu Das, Amrita Roy, Uma Kumari, Sanjib Bhattacharya, Pallab Kanti Haldar. β-Carotene ameliorates arsenic-induced toxicity in albino mice.
Biological trace element research.
2015 Apr; 164(2):226-33. doi:
10.1007/s12011-014-0212-4. [PMID: 25542264] - Takashi Kasukabe, Junko Okabe-Kado, Nobuo Kato, Yoshio Honma, Shunichi Kumakura. Cotylenin A and arsenic trioxide cooperatively suppress cell proliferation and cell invasion activity in human breast cancer cells.
International journal of oncology.
2015 Feb; 46(2):841-8. doi:
10.3892/ijo.2014.2760. [PMID: 25405645] - Shiyan Gu, Chengzhi Chen, Xuejun Jiang, Zunzhen Zhang. Resveratrol synergistically triggers apoptotic cell death with arsenic trioxide via oxidative stress in human lung adenocarcinoma A549 cells.
Biological trace element research.
2015 Feb; 163(1-2):112-23. doi:
10.1007/s12011-014-0186-2. [PMID: 25431299] - Da Liu, Donglu Wu, Linhong Zhao, Yang Yang, Jian Ding, Liguo Dong, Lianghai Hu, Fei Wang, Xiaoming Zhao, Yong Cai, Jingji Jin. Arsenic Trioxide Reduces Global Histone H4 Acetylation at Lysine 16 through Direct Binding to Histone Acetyltransferase hMOF in Human Cells.
PloS one.
2015; 10(10):e0141014. doi:
10.1371/journal.pone.0141014. [PMID: 26473953] - Jian-Kun Gao, Li-Xia Wang, Bo Long, Xian-Tao Ye, Jing-Na Su, Xu-Yuan Yin, Xiu-Xia Zhou, Zhi-Wei Wang. Arsenic Trioxide Inhibits Cell Growth and Invasion via Down- Regulation of Skp2 in Pancreatic Cancer Cells.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(9):3805-10. doi:
10.7314/apjcp.2015.16.9.3805. [PMID: 25987041] - Tao Feng, Guanglei Qiao, Li Feng, Weixiang Qi, Yujing Huang, Yang Yao, Zan Shen. Stathmin is key in reversion of doxorubicin resistance by arsenic trioxide in osteosarcoma cells.
Molecular medicine reports.
2014 Dec; 10(6):2985-92. doi:
10.3892/mmr.2014.2618. [PMID: 25310700] - Varghese V Mathews, Mv Sauganth Paul, M Abhilash, Alex Manju, S Abhilash, R Harikumaran Nair. Mitigation of hepatotoxic effects of arsenic trioxide through omega-3 fatty acid in rats.
Toxicology and industrial health.
2014 Oct; 30(9):806-13. doi:
10.1177/0748233712463778. [PMID: 23081861]