Hydrocortisone butyrate (BioDeep_00000855508)
代谢物信息卡片
化学式: C25H36O6 (432.2511756)
中文名称: 17-丁酸氢化可的松酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC(=O)OC1(CCC2C1(CC(C3C2CCC4=CC(=O)CCC34C)O)C)C(=O)CO
InChI: InChI=1S/C25H36O6/c1-4-5-21(30)31-25(20(29)14-26)11-9-18-17-7-6-15-12-16(27)8-10-23(15,2)22(17)19(28)13-24(18,25)3/h12,17-19,22,26,28H,4-11,13-14H2,1-3H3/t17-,18-,19-,22+,23-,24-,25-/m0/s1
描述信息
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AB - Corticosteroids, moderately potent (group ii)
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D003879 - Dermatologic Agents
Hydrocortisone 17-butyrate is an adrenocortical hormone active molecule.
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:31674
- KEGGdrug: D01619
- PubChem: 26133
- DrugBank: DB14540
- ChEMBL: CHEMBL1683
- CAS: 13609-67-1
- medchemexpress: HY-B0983
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Zhen Xie, Yan Zhang, Ya-Ting Yang, Yang Su, Hao Zhang. Allergic contact dermatitis caused by a traditional Chinese medicine treatment- moxibustion.
Contact dermatitis.
2021 Feb; 84(2):127-130. doi:
10.1111/cod.13694. [PMID: 32865256] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Leon H Kircik. A study to assess the occlusivity and moisturization potential of three topical corticosteroid products using the skin trauma after razor shaving (STARS) bioassay.
Journal of drugs in dermatology : JDD.
2014 May; 13(5):582-5. doi:
". [PMID: 24809882] - Louise B Jensen, Emily Magnussson, Linda Gunnarsson, Charlotte Vermehren, Hanne M Nielsen, Karsten Petersson. Corticosteroid solubility and lipid polarity control release from solid lipid nanoparticles.
International journal of pharmaceutics.
2010 May; 390(1):53-60. doi:
10.1016/j.ijpharm.2009.10.022. [PMID: 19836439] - P Mercy, A Ghorpade, M N Das, A Soud, S Puttoo, D Sharma, A Jain. Acquired Blaschkoid dermatitis.
Indian journal of dermatology, venereology and leprology.
2007 Nov; 73(6):415-6. doi:
10.4103/0378-6323.37062. [PMID: 18032863] - Lawrence Eichenfield, Charles N Ellis, David Fivenson, Adelaide A Hebert, Syd Dromgoole, Daniel Piacquadio. Evaluation of adrenal suppression of a lipid enhanced, topical emollient cream formulation of hydrocortisone butyrate 0.1\% in treating children with atopic dermatitis.
Pediatric dermatology.
2007 Jan; 24(1):81-4. doi:
10.1111/j.1525-1470.2007.00342.x. [PMID: 17300659] - L Juhlin. Comparison of fluticasone propionate cream, 0.05\%, and hydrocortisone-17-butyrate cream, 0.1\%, in the treatment of eczema.
Cutis.
1996 Feb; 57(2 Suppl):51-6. doi:
NULL. [PMID: 8646871] - H W Visscher, J T Ebels, G A Roders, J G Jonkman. Randomised crossover comparison of adrenal suppressive effects of dermal creams containing glucocorticosteroids.
European journal of clinical pharmacology.
1995; 48(2):123-5. doi:
10.1007/bf00192736. [PMID: 7589025] - A Thalén, R Brattsand, P H Andersson. Development of glucocorticosteroids with enhanced ratio between topical and systemic effects.
Acta dermato-venereologica. Supplementum.
1989; 151(?):11-9; discussion 47. doi:
. [PMID: 2624062] - G Herz. A study to ascertain whether hydrocortisone 17-butyrate (Locoid) 0.1\% cream has any effect on the hypothalamic-pituitary-adrenal axis in children with skin diseases.
The Journal of international medical research.
1982; 10(4):271-3. doi:
10.1177/030006058201000414. [PMID: 7117683] - Y Tarumoto, M Kimura, S Abe, A Kasai, K Noda, S Nakane, M Sasajima, M Ohzeki. [Studies on toxicity of hydrocortisone 17-butyrate 21-propionate -2. Subacute toxicity in rats by subcutaneous administration (author's transl)].
The Journal of toxicological sciences.
1981 Jul; 6 Suppl(?):17-46. doi:
10.2131/jts.6.supplement_17. [PMID: 7310932] - M Scott, L A Malmsten, I Thelin. Effect on plasma cortisol level and urinary cortisol excretion, in healthy volunteers, after application of three different topical steroid ointments under occlusion.
Acta dermato-venereologica.
1981; 61(6):543-6. doi:
NULL. [PMID: 6177167] - R P KNIGHT, D S KORNFELD, G H GLASER, P K BONDY. Effects of intravenous hydrocortisone on electrolytes of serum and urine in man.
The Journal of clinical endocrinology and metabolism.
1955 Feb; 15(2):176-81. doi:
10.1210/jcem-15-2-176. [PMID: 13233328]