DALFOPRISTIN (BioDeep_00000855499)

   


代谢物信息卡片


DALFOPRISTIN

化学式: C34H50N4O9S (690.3298330000001)
中文名称: 达福普汀(甲磺酸盐)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCN(CC)CCS(=O)(=O)C1CCN2C1C(=O)OC(C(C=CC(=O)NCC=CC(=CC(CC(=O)CC3=NC(=CO3)C2=O)O)C)C)C(C)C
InChI: InChI=1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9+,12-11+,23-18+/t24-,25-,28-,31-,32-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D025361 - Streptogramins
C254 - Anti-Infective Agent > C258 - Antibiotic

同义名列表

2 个代谢物同义名

DALFOPRISTIN; Dalfopristin



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • L Drago, L Nicola, E De Vecchi. A comparative in-vitro evaluation of resistance selection after exposure to teicoplanin, vancomycin, linezolid and quinupristin-dalfopristin in Staphylococcus aureus and Enterococcus spp. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2008 Jun; 14(6):608-11. doi: 10.1111/j.1469-0691.2008.01993.x. [PMID: 18397336]
  • A Chaudhury, A G Kumar. In vitro activity of antimicrobial agents against oxacillin resistant staphylococci with special reference to Staphylococcus haemolyticus. Indian journal of medical microbiology. 2007 Jan; 25(1):50-2. doi: 10.4103/0255-0857.31062. [PMID: 17377353]
  • Robert L Thompson, Bruce Lavin, George H Talbot. Endocarditis due to vancomycin-resistant Enterococcus faecium in an immunocompromised patient: cure by administering combination therapy with quinupristin/dalfopristin and high-dose ampicillin. Southern medical journal. 2003 Aug; 96(8):818-20. doi: 10.1097/01.smj.0000047962.61701.57. [PMID: 14515928]
  • V Schwenger, E Mündlein, E E Dagrosa, A M Fahr, M Zeier, G Mikus, K Andrassy. Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report. Infection. 2002 Oct; 30(5):257-61. doi: 10.1007/s15010-002-2076-3. [PMID: 12382082]
  • L C McDonald, S Rossiter, C Mackinson, Y Y Wang, S Johnson, M Sullivan, R Sokolow, E DeBess, L Gilbert, J A Benson, B Hill, F J Angulo. Quinupristin-dalfopristin-resistant Enterococcus faecium on chicken and in human stool specimens. The New England journal of medicine. 2001 Oct; 345(16):1155-60. doi: 10.1056/nejmoa010805. [PMID: 11642231]
  • D R Allington, M P Rivey. Quinupristin/dalfopristin: a therapeutic review. Clinical therapeutics. 2001 Jan; 23(1):24-44. doi: 10.1016/s0149-2918(01)80028-x. [PMID: 11219478]
  • G Werner, I Klare, H Heier, K H Hinz, G Böhme, M Wendt, W Witte. Quinupristin/dalfopristin-resistant enterococci of the satA (vatD) and satG (vatE) genotypes from different ecological origins in Germany. Microbial drug resistance (Larchmont, N.Y.). 2000; 6(1):37-47. doi: 10.1089/mdr.2000.6.37. [PMID: 10868806]
  • H M Lamb, D P Figgitt, D Faulds. Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections. Drugs. 1999 Dec; 58(6):1061-97. doi: 10.2165/00003495-199958060-00008. [PMID: 10651391]
  • C R Messick, K A Rodvold, S L Pendland. Modified time-kill assay against multidrug-resistant Enterococcus faecium with novel antimicrobial combinations. The Journal of antimicrobial chemotherapy. 1999 Dec; 44(6):831-4. doi: 10.1093/jac/44.6.831. [PMID: 10590287]
  • B M Lomaestro, L L Briceland. Streptogramins and their potential role in geriatric medicine. Drugs & aging. 1998 Dec; 13(6):443-65. doi: 10.2165/00002512-199813060-00004. [PMID: 9883400]
  • A Le Liboux, O Pasquier, G Montay. Simultaneous high-performance liquid chromatographic determination of quinupristin, dalfopristin and their main metabolites in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1998 Apr; 708(1-2):161-8. doi: 10.1016/s0378-4347(98)00005-x. [PMID: 9653958]