Ridaura (BioDeep_00000855483)
代谢物信息卡片
Ridaura
化学式: C20H35AuO9PS (679.1405)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC[PH+](CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au]
InChI: /m1../s1
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01C - Specific antirheumatic agents > M01CB - Gold preparations
D018501 - Antirheumatic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:2922
- PubChem: 70788951
- DrugBank: DB00995
- ChEMBL: CHEMBL1366
- MeSH: Auranofin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Lanlan Fan, Panyu Du, Yaru Li, Xuefei Chen, Fang Liu, Yuning Liu, Alexey M Petrov, Xin Li, Zheng Wang, Yanjun Zhao. Targeted Liposomes Sensitize Plastic Melanoma to Ferroptosis via Senescence Induction and Coenzyme Depletion.
ACS nano.
2024 Mar; 18(9):7011-7023. doi:
10.1021/acsnano.3c10142. [PMID: 38390865] - Xiuli Chen, Shibo Sun, Sheng Huang, Han Yang, Qing Ye, Lin Lv, Yanshan Liang, Jinjun Shan, Jianqiang Xu, Wukun Liu, Tonghui Ma. Gold(I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting thioredoxin reductase.
Redox biology.
2023 04; 60(?):102621. doi:
10.1016/j.redox.2023.102621. [PMID: 36758467] - Zdeněk Trávníček, Ján Vančo, Jan Belza, Jan Hošek, Zdeněk Dvořák, René Lenobel, Igor Popa, Karel Šmejkal, Pavel Uhrin. The Gold(I) Complex with Plant Hormone Kinetin Shows Promising In Vitro Anticancer and PPARγ Properties.
International journal of molecular sciences.
2023 Jan; 24(3):. doi:
10.3390/ijms24032293. [PMID: 36768617] - Seung Min Lee, Dong Hee Koh, Dae Won Jun, Yoon Jin Roh, Hyeon Tae Kang, Ju Hee Oh, Hyun Sung Kim. Auranofin attenuates hepatic steatosis and fibrosis in nonalcoholic fatty liver disease via NRF2 and NF- κB signaling pathways.
Clinical and molecular hepatology.
2022 10; 28(4):827-840. doi:
10.3350/cmh.2022.0068. [PMID: 35730208] - Yann Le Gal, Agathe Filatre-Furcate, Dominique Lorcy, Olivier Jeannin, Thierry Roisnel, Vincent Dorcet, Diana Fontinha, Denise Francisco, Miguel Prudncio, Marta Martins, Catarina Soeiro, Sílvia A Sousa, Jorge H Leitão, Tnia S Morais, Ins Bártolo, Nuno Taveira, Joana F Guerreiro, Fernanda Marques. Broad Spectrum Functional Activity of Structurally Related Monoanionic Au(III) Bis(Dithiolene) Complexes.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23137146. [PMID: 35806151] - Yingxiao Yu, Huimin Zhao, Jiayin Lin, Zongshao Li, Guobao Tian, Yi Yan Yang, Peiyan Yuan, Xin Ding. Repurposing Non-Antibiotic Drugs Auranofin and Pentamidine in Combination to Combat Multidrug-Resistant Gram-Negative Bacteria.
International journal of antimicrobial agents.
2022 May; 59(5):106582. doi:
10.1016/j.ijantimicag.2022.106582. [PMID: 35378227] - Wioletta Jakubczak, Maja Haczyk-Więcek, Katarzyna Pawlak. Attomole-per Cell Atomic Mass Spectrometry Measurement of Platinum and Gold Drugs in Cultured Lung Cancer Cells.
Molecules (Basel, Switzerland).
2021 Dec; 26(24):. doi:
10.3390/molecules26247627. [PMID: 34946708] - Masamichi Yamashita. Auranofin: Past to Present, and repurposing.
International immunopharmacology.
2021 Dec; 101(Pt B):108272. doi:
10.1016/j.intimp.2021.108272. [PMID: 34731781] - Jinthe Van Loenhout, Laurie Freire Boullosa, Delphine Quatannens, Jorrit De Waele, Céline Merlin, Hilde Lambrechts, Ho Wa Lau, Christophe Hermans, Abraham Lin, Filip Lardon, Marc Peeters, Annemie Bogaerts, Evelien Smits, Christophe Deben. Auranofin and Cold Atmospheric Plasma Synergize to Trigger Distinct Cell Death Mechanisms and Immunogenic Responses in Glioblastoma.
Cells.
2021 10; 10(11):. doi:
10.3390/cells10112936. [PMID: 34831159] - Ayman Abo Elmaaty, Mohammed I A Hamed, Muhammad I Ismail, Eslam B Elkaeed, Hamada S Abulkhair, Muhammad Khattab, Ahmed A Al-Karmalawy. Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization.
Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123772. [PMID: 34205704] - Mateja Manček-Keber, Iva Hafner-Bratkovič, Duško Lainšček, Mojca Benčina, Tea Govednik, Sara Orehek, Tjaša Plaper, Vid Jazbec, Valter Bergant, Vincent Grass, Andreas Pichlmair, Roman Jerala. Disruption of disulfides within RBD of SARS-CoV-2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 06; 35(6):e21651. doi:
10.1096/fj.202100560r. [PMID: 34004056] - Laurie Freire Boullosa, Jinthe Van Loenhout, Tal Flieswasser, Jorrit De Waele, Christophe Hermans, Hilde Lambrechts, Bart Cuypers, Kris Laukens, Esther Bartholomeus, Vasiliki Siozopoulou, Winnok H De Vos, Marc Peeters, Evelien L J Smits, Christophe Deben. Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer.
Redox biology.
2021 06; 42(?):101949. doi:
10.1016/j.redox.2021.101949. [PMID: 33812801] - Haroon Mohammad, Nader S Abutaleb, Alexandra M Dieterly, L Tiffany Lyle, Mohamed N Seleem. Investigating auranofin for the treatment of infected diabetic pressure ulcers in mice and dermal toxicity in pigs.
Scientific reports.
2021 05; 11(1):10935. doi:
10.1038/s41598-021-90360-x. [PMID: 34035383] - Karine Sonzogni-Desautels, Momar Ndao. Will Auranofin Become a Golden New Treatment Against COVID-19?.
Frontiers in immunology.
2021; 12(?):683694. doi:
10.3389/fimmu.2021.683694. [PMID: 34630379] - Maria Gil-Moles, Uttara Basu, Rolf Büssing, Henrik Hoffmeister, Sebastian Türck, Agnieszka Varchmin, Ingo Ott. Gold Metallodrugs to Target Coronavirus Proteins: Inhibitory Effects on the Spike-ACE2 Interaction and on PLpro Protease Activity by Auranofin and Gold Organometallics*.
Chemistry (Weinheim an der Bergstrasse, Germany).
2020 Nov; 26(66):15140-15144. doi:
10.1002/chem.202004112. [PMID: 32915473] - Sara Staples, Stephanie B Wall, Rui Li, Trent E Tipple. Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages.
Life sciences.
2020 Oct; 259(?):118285. doi:
10.1016/j.lfs.2020.118285. [PMID: 32798556] - Hussin A Rothan, Shannon Stone, Janhavi Natekar, Pratima Kumari, Komal Arora, Mukesh Kumar. The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells.
Virology.
2020 08; 547(?):7-11. doi:
10.1016/j.virol.2020.05.002. [PMID: 32442105] - I F Abou-El-Naga, M R Gaafar, M M Gomaa, S I Khedr, S X A N X A El Achy. Encephalitozoon intestinalis: A new target for auranofin in a mice model.
Medical mycology.
2020 Aug; 58(6):810-819. doi:
10.1093/mmy/myz126. [PMID: 31868212] - Lei Yang, Hao Wang, Xiang Yang, Qian Wu, Peng An, Xi Jin, Weiwei Liu, Xin Huang, Yuzhu Li, Shiyu Yan, Shuying Shen, Tingbo Liang, Junxia Min, Fudi Wang. Auranofin mitigates systemic iron overload and induces ferroptosis via distinct mechanisms.
Signal transduction and targeted therapy.
2020 07; 5(1):138. doi:
10.1038/s41392-020-00253-0. [PMID: 32732975] - Eva-Maria Hanschmann, Sebastian Friedrich Petry, Susanne Eitner, Constanze Christin Maresch, Neelam Lingwal, Christopher Horst Lillig, Thomas Linn. Paracrine regulation and improvement of β-cell function by thioredoxin.
Redox biology.
2020 07; 34(?):101570. doi:
10.1016/j.redox.2020.101570. [PMID: 32473461] - Chao Liu, Yan Zhao, Jianing Wang, Yan Yang, Yan Zhang, Xinliang Qu, Sishi Peng, Zhaoying Yao, Shuli Zhao, Bangshun He, Qiongyu Mi, Yubing Zhu, Xiuting Liu, Jianjun Zou, Xu Zhang, Qianming Du. FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway.
Cancer letters.
2020 02; 470(?):29-42. doi:
10.1016/j.canlet.2019.11.042. [PMID: 31811910] - Pengfei She, Yiqing Liu, Yangxia Wang, Fang Tan, Zhen Luo, Yong Wu. Antibiofilm efficacy of the gold compound auranofin on dual species biofilms of Staphylococcus aureus and Candida sp.
Journal of applied microbiology.
2020 Jan; 128(1):88-101. doi:
10.1111/jam.14443. [PMID: 31509623] - Damiano Cirri, Maria Giulia Fabbrini, Lara Massai, Serena Pillozzi, Annalisa Guerri, Alessio Menconi, Luigi Messori, Tiziano Marzo, Alessandro Pratesi. Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2019 12; 32(6):939-948. doi:
10.1007/s10534-019-00224-1. [PMID: 31686259] - Erlend Skaga, Ida Ø Skaga, Zanina Grieg, Cecilie J Sandberg, Iver A Langmoen, Einar O Vik-Mo. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy.
Journal of cancer research and clinical oncology.
2019 Jun; 145(6):1495-1507. doi:
10.1007/s00432-019-02920-4. [PMID: 31028540] - Alessandro Pratesi, Damiano Cirri, Lorenzo Ciofi, Luigi Messori. Reactions of Auranofin and Its Pseudohalide Derivatives with Serum Albumin Investigated through ESI-Q-TOF MS.
Inorganic chemistry.
2018 Sep; 57(17):10507-10510. doi:
10.1021/acs.inorgchem.8b02177. [PMID: 30109928] - Ahmed AbdelKhalek, Nader S Abutaleb, Khalifa A Elmagarmid, Mohamed N Seleem. Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci.
Scientific reports.
2018 05; 8(1):8353. doi:
10.1038/s41598-018-26674-0. [PMID: 29844350] - D B Shpakovsky, A A Shtil, E V Kharitonashvili, V Yu Tyurin, T A Antonenko, A A Nazarov, V P Osipova, N T Berberova, L S Foteeva, C Schmidt, I Ott, E R Milaeva. The antioxidant 2,6-di-tert-butylphenol moiety attenuates the pro-oxidant properties of the auranofin analogue.
Metallomics : integrated biometal science.
2018 03; 10(3):406-413. doi:
10.1039/c7mt00286f. [PMID: 29399682] - Ming Hu, Zhenhui Zhang, Bin Liu, Shuangwei Zhang, Renjie Chai, Xiaohua Chen, Tianyu Kong, Fangcheng Zhang, Jingzhi Zhang, Shiming Liu, Ningning Liu. Deubiquitinase Inhibitor Auranofin Attenuated Cardiac Hypertrophy by Blocking NF-κB Activation.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 45(6):2421-2430. doi:
10.1159/000488230. [PMID: 29554646] - Elena Atrián-Blasco, Sonia Gascón, Ma Jesus Rodrı Guez-Yoldi, Mariano Laguna, Elena Cerrada. Novel Gold(I) Thiolate Derivatives Synergistic with 5-Fluorouracil as Potential Selective Anticancer Agents in Colon Cancer.
Inorganic chemistry.
2017 Jul; 56(14):8562-8579. doi:
10.1021/acs.inorgchem.7b01370. [PMID: 28682069] - Katarina Johansson, Marcus Cebula, Olle Rengby, Kristian Dreij, Karl E Carlström, Kristmundur Sigmundsson, Fredrik Piehl, Elias S J Arnér. Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution.
Antioxidants & redox signaling.
2017 02; 26(6):229-246. doi:
10.1089/ars.2015.6419. [PMID: 26415122] - Edmund V Capparelli, Robin Bricker-Ford, M John Rogers, James H McKerrow, Sharon L Reed. Phase I Clinical Trial Results of Auranofin, a Novel Antiparasitic Agent.
Antimicrobial agents and chemotherapy.
2017 01; 61(1):. doi:
10.1128/aac.01947-16. [PMID: 27821451] - Wei Sun, Rebecca A Weingarten, Miao Xu, Noel Southall, Sheng Dai, Paul Shinn, Philip E Sanderson, Peter R Williamson, Karen M Frank, Wei Zheng. Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria.
Emerging microbes & infections.
2016 Nov; 5(11):e116. doi:
10.1038/emi.2016.123. [PMID: 27826141] - Le Zhang, Qing Cheng, Longjie Zhang, Yijun Wang, Gary F Merrill, Tal Ilani, Deborah Fass, Elias S J Arnér, Jinsong Zhang. Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms.
Free radical biology & medicine.
2016 10; 99(?):426-435. doi:
10.1016/j.freeradbiomed.2016.08.028. [PMID: 27581528] - Prahlad V Raninga, Giovanna Di Trapani, Slavica Vuckovic, Kathryn F Tonissen. Cross-talk between two antioxidants, thioredoxin reductase and heme oxygenase-1, and therapeutic implications for multiple myeloma.
Redox biology.
2016 08; 8(?):175-85. doi:
10.1016/j.redox.2016.01.007. [PMID: 26795735] - Joshua P Owings, Nina N McNair, Yiu Fung Mui, Tomas N Gustafsson, Arne Holmgren, Maria Contel, Joanna B Goldberg, Jan R Mead. Auranofin and N-heterocyclic carbene gold-analogs are potent inhibitors of the bacteria Helicobacter pylori.
FEMS microbiology letters.
2016 07; 363(14):. doi:
10.1093/femsle/fnw148. [PMID: 27279627] - Elena García-Moreno, Alejandro Tomás, Elena Atrián-Blasco, Sonia Gascón, Eduardo Romanos, Mary Jesus Rodriguez-Yoldi, Elena Cerrada, Mariano Laguna. In vitro and in vivo evaluation of organometallic gold(I) derivatives as anticancer agents.
Dalton transactions (Cambridge, England : 2003).
2016 Feb; 45(6):2462-75. doi:
10.1039/c5dt01802a. [PMID: 26469679] - Bo Hu, Yuhong Wu, Jie Liu, Xiaohua Shen, Fei Tong, Guangtao Xu, Ruilin Shen. GSK-3beta Inhibitor Induces Expression of Nrf2/TrxR2 Signaling Pathway to Protect against Renal Ischemia/Reperfusion Injury in Diabetic Rats.
Kidney & blood pressure research.
2016; 41(6):937-946. doi:
10.1159/000452598. [PMID: 27924803] - Prahlad V Raninga, Giovanna Di Trapani, Slavica Vuckovic, Kathryn F Tonissen. TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition.
Cell cycle (Georgetown, Tex.).
2016; 15(4):559-72. doi:
10.1080/15384101.2015.1136038. [PMID: 26743692] - Tam T T N Nguyen, Jesper Østergaard, Bente Gammelgaard. A method for studies on interactions between a gold-based drug and plasma proteins based on capillary electrophoresis with inductively coupled plasma mass spectrometry detection.
Analytical and bioanalytical chemistry.
2015 Nov; 407(28):8497-503. doi:
10.1007/s00216-015-8997-3. [PMID: 26329282] - Prahlad V Raninga, Giovanna Di Trapani, Slavica Vuckovic, Maneet Bhatia, Kathryn F Tonissen. Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma.
Oncotarget.
2015 Jun; 6(17):15410-24. doi:
10.18632/oncotarget.3795. [PMID: 25945832] - Yozane Hokai, Boruch Jurkowicz, Jacob Fernández-Gallardo, Nuruddinkodja Zakirkhodjaev, Mercedes Sanaú, Theodore R Muth, María Contel. Auranofin and related heterometallic gold(I)-thiolates as potent inhibitors of methicillin-resistant Staphylococcus aureus bacterial strains.
Journal of inorganic biochemistry.
2014 Sep; 138(?):81-88. doi:
10.1016/j.jinorgbio.2014.05.008. [PMID: 24935090] - Radka Křikavová, Jan Hošek, Pavel Suchý, Ján Vančo, Zdeněk Trávníček. Diverse in vitro and in vivo anti-inflammatory effects of trichlorido-gold(III) complexes with N6-benzyladenine derivatives.
Journal of inorganic biochemistry.
2014 May; 134(?):92-9. doi:
10.1016/j.jinorgbio.2014.02.002. [PMID: 24584156] - Zengying Wu, Jose L Soulages, Bharat D Joshi, Stuart M Daniel, Zachary J Hager, Estela L Arrese. TGL-mediated lipolysis in Manduca sexta fat body: possible roles for lipoamide-dehydrogenase (LipDH) and high-density lipophorin (HDLp).
Insect biochemistry and molecular biology.
2014 Feb; 45(?):58-68. doi:
10.1016/j.ibmb.2013.12.001. [PMID: 24333838] - J M Madeira, C J Renschler, B Mueller, S Hashioka, D L Gibson, A Klegeris. Novel protective properties of auranofin: inhibition of human astrocyte cytotoxic secretions and direct neuroprotection.
Life sciences.
2013 Jun; 92(22):1072-80. doi:
10.1016/j.lfs.2013.04.005. [PMID: 23624233] - Noriyuki Hatano, Hiroka Suzuki, Yukiko Muraki, Katsuhiko Muraki. Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin.
American journal of physiology. Cell physiology.
2013 Feb; 304(4):C354-61. doi:
10.1152/ajpcell.00096.2012. [PMID: 23220116] - Esther Schuh, Carolin Pflüger, Anna Citta, Alessandra Folda, Maria Pia Rigobello, Alberto Bindoli, Angela Casini, Fabian Mohr. Gold(I) carbene complexes causing thioredoxin 1 and thioredoxin 2 oxidation as potential anticancer agents.
Journal of medicinal chemistry.
2012 Jun; 55(11):5518-28. doi:
10.1021/jm300428v. [PMID: 22621714] - Takashi Ashino, Jinko Sugiuchi, Junna Uehara, Yumiko Naito-Yamamoto, Sachiyo Kenmotsu, Yoichiro Iwakura, Seiji Shioda, Satoshi Numazawa, Takemi Yoshida. Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-1.
The Journal of toxicological sciences.
2011 Oct; 36(5):635-43. doi:
10.2131/jts.36.635. [PMID: 22008538] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - L Messori, A Balerna, I Ascone, C Castellano, C Gabbiani, A Casini, C Marchioni, G Jaouen, A Congiu Castellano. X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2011 Mar; 16(3):491-9. doi:
10.1007/s00775-010-0748-5. [PMID: 21181484] - David T Hill, Anvarhusein A Isab, Don E Griswold, Michael J DiMartino, Elizabeth D Matz, Angel L Figueroa, Joyce E Wawro, Charles DeBrosse, William M Reiff, Richard C Elder, Benjamin Jones, James W Webb, C Frank Shaw. Seleno-auranofin (Et3PAuSe-tagl): synthesis, spectroscopic (EXAFS, 197Au Mössbauer, 31P, 1H, 13C, and 77Se NMR, ESI-MS) characterization, biological activity, and rapid serum albumin-induced triethylphosphine oxide generation.
Inorganic chemistry.
2010 Sep; 49(17):7663-75. doi:
10.1021/ic902335z. [PMID: 20704360] - Mohammad S Iqbal, Syed G Taqi, Muhammad Arif, Muhammad Wasim, Muhammad Sher. In vitro distribution of gold in serum proteins after incubation of sodium aurothiomalate and auranofin with human blood and its pharmacological significance.
Biological trace element research.
2009 Sep; 130(3):204-9. doi:
10.1007/s12011-009-8330-0. [PMID: 19194667] - Adam P Lothrop, Erik L Ruggles, Robert J Hondal. No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.
Biochemistry.
2009 Jul; 48(26):6213-23. doi:
10.1021/bi802146w. [PMID: 19366212] - Maria Pia Rigobello, Alessandra Folda, Barbara Dani, Roberta Menabò, Guido Scutari, Alberto Bindoli. Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells.
European journal of pharmacology.
2008 Mar; 582(1-3):26-34. doi:
10.1016/j.ejphar.2007.12.026. [PMID: 18242600] - Jinsong Zhang, Hongjuan Lu. Ifosfamide induces acute renal failure via inhibition of the thioredoxin reductase activity.
Free radical biology & medicine.
2007 Dec; 43(12):1574-83. doi:
10.1016/j.freeradbiomed.2007.08.020. [PMID: 18037123] - Kouya Yamaki, Xiaojuan Li, Md Aslam Hossain, A H M Khurshid Alam, Shinji Taneda, Rie Yanagisawa, Hirohisa Takano, Shin Yoshino. Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice.
Immunological investigations.
2007; 36(2):131-45. doi:
10.1080/08820130600746008. [PMID: 17365015] - Jihan Talib, Jennifer L Beck, Stephen F Ralph. A mass spectrometric investigation of the binding of gold antiarthritic agents and the metabolite [Au(CN)2]- to human serum albumin.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.
2006 Jul; 11(5):559-70. doi:
10.1007/s00775-006-0103-z. [PMID: 16791640] - Maribel Navarro, Germán Fraile, Mait Velásquez, Eglys González, Jessnell Escalona, Rita Ilanjian, María Jesús Abad, Peter Taylor. Effect of a gold-chloroquine complex on inflammation-related leukocyte functions and cell viability. Comparison with auranofin.
Arzneimittel-Forschung.
2006; 56(12):826-33. doi:
10.1055/s-0031-1296794. [PMID: 17260670] - Aida Chircorian, Amy M Barrios. Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I).
Bioorganic & medicinal chemistry letters.
2004 Oct; 14(20):5113-6. doi:
10.1016/j.bmcl.2004.07.073. [PMID: 15380210] - Luigi Messori, Giordana Marcon. Gold complexes in the treatment of rheumatoid arthritis.
Metal ions in biological systems.
2004; 41(?):279-304. doi:
10.1201/9780203913703.ch9. [PMID: 15206120] - A C Falcão, M J Rocha, A M Almeida, M M Caramona. Theophylline pharmacokinetics with concomitant steroid and gold therapy.
Journal of clinical pharmacy and therapeutics.
2000 Jun; 25(3):191-5. doi:
10.1046/j.1365-2710.2000.00279.x. [PMID: 10886464] - J D Jessop, M M O'Sullivan, P A Lewis, L A Williams, J P Camilleri, M J Plant, E C Coles. A long-term five-year randomized controlled trial of hydroxychloroquine, sodium aurothiomalate, auranofin and penicillamine in the treatment of patients with rheumatoid arthritis.
British journal of rheumatology.
1998 Sep; 37(9):992-1002. doi:
10.1093/rheumatology/37.9.992. [PMID: 9783766] - J R Roberts, C F Shaw. Inhibition of erythrocyte selenium-glutathione peroxidase by auranofin analogues and metabolites.
Biochemical pharmacology.
1998 Apr; 55(8):1291-9. doi:
10.1016/s0006-2952(97)00634-5. [PMID: 9719485] - F Shabani, J McNeil, L Tippett. The oxidative inactivation of tissue inhibitor of metalloproteinase-1 (TIMP-1) by hypochlorous acid (HOCI) is suppressed by anti-rheumatic drugs.
Free radical research.
1998 Feb; 28(2):115-23. doi:
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