3,N(4)-Ethenodeoxycytidine (BioDeep_00000853386)
代谢物信息卡片
化学式: C11H13N3O4 (251.0906)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C(OC1N2C=CC3=NC=CN3C2=O)CO)O
InChI: InChI=1S/C11H13N3O4/c15-6-8-7(16)5-10(18-8)14-3-1-9-12-2-4-13(9)11(14)17/h1-4,7-8,10,15-16H,5-6H2/t7-,8+,10+/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- H Li, S Cui, S Wang, X Jiang, S Zhang, R Zhang, P P Fu, X Sun. Ultrasensitive UPLC-MS/MS method for analysis of etheno-DNA adducts in human white blood cells.
Free radical research.
2015; 49(9):1049-54. doi:
10.3109/10715762.2015.1006213
. [PMID: 25968941] - Tomasz Obtułowicz, Alicja Winczura, Elzbieta Speina, Maja Swoboda, Justyna Janik, Beata Janowska, Jarosław M Cieśla, Paweł Kowalczyk, Arkadiusz Jawien, Daniel Gackowski, Zbigniew Banaszkiewicz, Ireneusz Krasnodebski, Andrzej Chaber, Ryszard Olinski, Jagadesaan Nair, Helmut Bartsch, Thierry Douki, Jean Cadet, Barbara Tudek. Aberrant repair of etheno-DNA adducts in leukocytes and colon tissue of colon cancer patients.
Free radical biology & medicine.
2010 Sep; 49(6):1064-71. doi:
10.1016/j.freeradbiomed.2010.06.027
. [PMID: 20600828] - Somkid Dechakhamphu, Somchai Pinlaor, Paiboon Sitthithaworn, Helmut Bartsch, Puangrat Yongvanit. Accumulation of miscoding etheno-DNA adducts and highly expressed DNA repair during liver fluke-induced cholangiocarcinogenesis in hamsters.
Mutation research.
2010 Sep; 691(1-2):9-16. doi:
10.1016/j.mrfmmm.2010.06.003
. [PMID: 20541562] - Mayura Meerang, Jagadeesan Nair, Pornpan Sirankapracha, Chonthida Thephinlap, Somdet Srichairatanakool, Khelifa Arab, Ruchaneekorn Kalpravidh, Jim Vadolas, Suthat Fucharoen, Helmut Bartsch. Accumulation of lipid peroxidation-derived DNA lesions in iron-overloaded thalassemic mouse livers: comparison with levels in the lymphocytes of thalassemia patients.
International journal of cancer.
2009 Aug; 125(4):759-66. doi:
10.1002/ijc.24412
. [PMID: 19480008] - K Arab, M Pedersen, J Nair, M Meerang, L E Knudsen, H Bartsch. Typical signature of DNA damage in white blood cells: a pilot study on etheno adducts in Danish mother-newborn child pairs.
Carcinogenesis.
2009 Feb; 30(2):282-5. doi:
10.1093/carcin/bgn264
. [PMID: 19037091] - Somkid Dechakhamphu, Puangrat Yongvanit, Jagadeesan Nair, Somchai Pinlaor, Paiboon Sitthithaworn, Helmut Bartsch. High excretion of etheno adducts in liver fluke-infected patients: protection by praziquantel against DNA damage.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008 Jul; 17(7):1658-64. doi:
10.1158/1055-9965.epi-08-0191
. [PMID: 18628417] - Mayura Meerang, Jagadeesan Nair, Pornpan Sirankapracha, Chonthida Thephinlap, Somdet Srichairatanakool, Suthat Fucharoen, Helmut Bartsch. Increased urinary 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine excretion in thalassemia patients: markers for lipid peroxidation-induced DNA damage.
Free radical biology & medicine.
2008 May; 44(10):1863-8. doi:
10.1016/j.freeradbiomed.2008.02.009
. [PMID: 18342016] - Qingming Fang, Jagadeesan Nair, Xin Sun, Dimiter Hadjiolov, Helmut Bartsch. Etheno-DNA adduct formation in rats gavaged with linoleic acid, oleic acid and coconut oil is organ- and gender specific.
Mutation research.
2007 Nov; 624(1-2):71-9. doi:
10.1016/j.mrfmmm.2007.04.002
. [PMID: 17521682] - Jagadeesan Nair, Silvio De Flora, Alberto Izzotti, Helmut Bartsch. Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions.
Mutation research.
2007 Aug; 621(1-2):95-105. doi:
10.1016/j.mrfmmm.2007.02.013
. [PMID: 17412369] - X Sun, A Karlsson, H Bartsch, J Nair. New ultrasensitive 32P-postlabelling method for the analysis of 3,N4-etheno-2'-deoxycytidine in human urine.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2006 Jul; 11(4):329-40. doi:
10.1080/13547500600709606
. [PMID: 16908440] - Jagadeesan Nair, Olga Sinitsina, Elena A Vasunina, Georgy A Nevinsky, Jacques Laval, Helmut Bartsch. Age-dependent increase of etheno-DNA-adducts in liver and brain of ROS overproducing OXYS rats.
Biochemical and biophysical research communications.
2005 Oct; 336(2):478-82. doi:
10.1016/j.bbrc.2005.08.114
. [PMID: 16137653] - R Godschalk, J Nair, F J van Schooten, A Risch, P Drings, K Kayser, H Dienemann, H Bartsch. Comparison of multiple DNA adduct types in tumor adjacent human lung tissue: effect of cigarette smoking.
Carcinogenesis.
2002 Dec; 23(12):2081-6. doi:
10.1093/carcin/23.12.2081
. [PMID: 12507931] - P Navasumrit, T H Ward, P J O'Connor, J Nair, N Frank, H Bartsch. Ethanol enhances the formation of endogenously and exogenously derived adducts in rat hepatic DNA.
Mutation research.
2001 Aug; 479(1-2):81-94. doi:
10.1016/s0027-5107(01)00156-7
. [PMID: 11470483] - J Nair, G Fürstenberger, F Bürger, F Marks, H Bartsch. Promutagenic etheno-DNA adducts in multistage mouse skin carcinogenesis: correlation with lipoxygenase-catalyzed arachidonic acid metabolism.
Chemical research in toxicology.
2000 Aug; 13(8):703-9. doi:
10.1021/tx000045d
. [PMID: 10956057] - K Schmid, J Nair, G Winde, I Velic, H Bartsch. Increased levels of promutagenic etheno-DNA adducts in colonic polyps of FAP patients.
International journal of cancer.
2000 Jul; 87(1):1-4. doi:
10.1002/1097-0215(20000701)87:1<1::aid-ijc1>3.0.co;2-c
. [PMID: 10861445] - D Cullinan, F Johnson, C de los Santos. Solution structure of an 11-mer duplex containing the 3, N(4)-ethenocytosine adduct opposite 2'-deoxycytidine: implications for the recognition of exocyclic lesions by DNA glycosylases.
Journal of molecular biology.
2000 Feb; 296(3):851-61. doi:
10.1006/jmbi.1999.3490
. [PMID: 10677286] - M Moriya, G A Pandya, F Johnson, A P Grollman. Cellular response to exocyclic DNA adducts.
IARC scientific publications.
1999; ?(150):263-70. doi:
NULL
. [PMID: 10626226] - J Nair. Lipid peroxidation-induced etheno-DNA adducts in humans.
IARC scientific publications.
1999; ?(150):55-61. doi:
NULL
. [PMID: 10626208] - W P Watson, J P Aston, T Barlow, A E Crane, D Potter, T Brown. Detection of 1,N6-etheno-2'-deoxyadenosine and 3,N4-etheno-2'-deoxycytidine occurring endogenously in DNA.
IARC scientific publications.
1999; ?(150):63-73. doi:
"
. [PMID: 10626209] - J Nair, A Gal, S Tamir, S R Tannenbaum, G N Wogan, H Bartsch. Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide.
Carcinogenesis.
1998 Dec; 19(12):2081-4. doi:
10.1093/carcin/19.12.2081
. [PMID: 9886560] - J Nair, C E Vaca, I Velic, M Mutanen, L M Valsta, H Bartsch. High dietary omega-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
1997 Aug; 6(8):597-601. doi:
"
. [PMID: 9264272] - G A Pandya, M Moriya. 1,N6-ethenodeoxyadenosine, a DNA adduct highly mutagenic in mammalian cells.
Biochemistry.
1996 Sep; 35(35):11487-92. doi:
10.1021/bi960170h
. [PMID: 8784204] - Y Guichard, F el Ghissassi, J Nair, H Bartsch, A Barbin. Formation and accumulation of DNA ethenobases in adult Sprague-Dawley rats exposed to vinyl chloride.
Carcinogenesis.
1996 Aug; 17(8):1553-9. doi:
10.1093/carcin/17.8.1553
. [PMID: 8761409] - J Nair, A Barbin, Y Guichard, H Bartsch. 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling.
Carcinogenesis.
1995 Mar; 16(3):613-7. doi:
10.1093/carcin/16.3.613
. [PMID: 7697821] - M Moriya, W Zhang, F Johnson, A P Grollman. Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.
Proceedings of the National Academy of Sciences of the United States of America.
1994 Dec; 91(25):11899-903. doi:
10.1073/pnas.91.25.11899
. [PMID: 7991554]