DC-Chol (BioDeep_00000852643)
代谢物信息卡片
DC-Chol
化学式: C32H56N2O2 (500.4341556)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)NCCN(C)C)C)C
InChI: InChI=1S/C32H56N2O2/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-24-21-25(36-30(35)33-19-20-34(6)7)15-17-31(24,4)29(26)16-18-32(27,28)5/h11,22-23,25-29H,8-10,12-21H2,1-7H3,(H,33,35)/t23-,25+,26+,27-,28+,29+,31+,32-/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xuan Gao, Wenjuan Zou, Binglei Jiang, Die Xu, Yong Luo, Jie Xiong, Sijing Yan, Yaotai Wang, Yu Tang, Chun Chen, Huanan Li, Hai Qiao, Qi Wang, Jianzhong Zou. Experimental Study of Retention on the Combination of Bifidobacterium with High-Intensity Focused Ultrasound (HIFU) Synergistic Substance in Tumor Tissues.
Scientific reports.
2019 04; 9(1):6423. doi:
10.1038/s41598-019-42832-4. [PMID: 31015517] - Sijia Wang, Xia Han, Danyang Liu, Mengya Li, Shouhong Xu, Honglai Liu. Melting Behavior of Zipper-Structured Lipopeptides in Lipid Bilayer.
Langmuir : the ACS journal of surfaces and colloids.
2017 02; 33(6):1478-1485. doi:
10.1021/acs.langmuir.6b04080. [PMID: 28099806] - Rui Tada, Shoko Muto, Tomoko Iwata, Akira Hidaka, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki. Attachment of class B CpG ODN onto DOTAP/DC-chol liposome in nasal vaccine formulations augments antigen-specific immune responses in mice.
BMC research notes.
2017 Jan; 10(1):68. doi:
10.1186/s13104-017-2380-8. [PMID: 28126014] - Jia Ju, Meng-Lei Huan, Ning Wan, Yi-Lin Hou, Xi-Xi Ma, Yi-Yang Jia, Chen Li, Si-Yuan Zhou, Bang-Le Zhang. Cholesterol derived cationic lipids as potential non-viral gene delivery vectors and their serum compatibility.
Bioorganic & medicinal chemistry letters.
2016 05; 26(10):2401-2407. doi:
10.1016/j.bmcl.2016.04.007. [PMID: 27072908] - Simona Motta, Valeria Rondelli, Laura Cantu, Elena Del Favero, Massimo Aureli, Daniela Pozzi, Giulio Caracciolo, Paola Brocca. What the cell surface does not see: The gene vector under the protein corona.
Colloids and surfaces. B, Biointerfaces.
2016 May; 141(?):170-178. doi:
10.1016/j.colsurfb.2016.01.045. [PMID: 26852100] - Lanxia Liu, Pingchuan Ma, Hai Wang, Chao Zhang, Hongfan Sun, Chun Wang, Cunxian Song, Xigang Leng, Deling Kong, Guilei Ma. Immune responses to vaccines delivered by encapsulation into and/or adsorption onto cationic lipid-PLGA hybrid nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society.
2016 Mar; 225(?):230-9. doi:
10.1016/j.jconrel.2016.01.050. [PMID: 26826307] - Pavlína Novotná, František Králík, Marie Urbanová. Chiral recognition of bilirubin and biliverdin in liposomes and micelles.
Biophysical chemistry.
2015 Oct; 205(?):41-50. doi:
10.1016/j.bpc.2015.06.001. [PMID: 26071845] - Jia Ju, Meng-Lei Huan, Ning Wan, Hai Qiu, Si-Yuan Zhou, Bang-Le Zhang. Novel cholesterol-based cationic lipids as transfecting agents of DNA for efficient gene delivery.
International journal of molecular sciences.
2015 Mar; 16(3):5666-81. doi:
10.3390/ijms16035666. [PMID: 25768346] - Rui Tada, Akira Hidaka, Naoko Iwase, Saeko Takahashi, Yuki Yamakita, Tomoko Iwata, Shoko Muto, Emi Sato, Noriko Takayama, Emi Honjo, Hiroshi Kiyono, Jun Kunisawa, Yukihiko Aramaki. Intranasal Immunization with DOTAP Cationic Liposomes Combined with DC-Cholesterol Induces Potent Antigen-Specific Mucosal and Systemic Immune Responses in Mice.
PloS one.
2015; 10(10):e0139785. doi:
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Journal of biomaterials science. Polymer edition.
2015; 26(4):264-76. doi:
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BioMed research international.
2014; 2014(?):703253. doi:
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Current pharmaceutical biotechnology.
2014; 15(9):800-5. doi:
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Molecular pharmaceutics.
2013 Dec; 10(12):4654-65. doi:
10.1021/mp400470p. [PMID: 24188138] - Shuo-ye Yang, Yi Zheng, Jia-yin Chen, Qiu-yang Zhang, Di Zhao, De-en Han, Xi-jing Chen. Comprehensive study of cationic liposomes composed of DC-Chol and cholesterol with different mole ratios for gene transfection.
Colloids and surfaces. B, Biointerfaces.
2013 Jan; 101(?):6-13. doi:
10.1016/j.colsurfb.2012.05.032. [PMID: 22789783] - Daniela Pozzi, Cristina Marchini, Francesco Cardarelli, Heinz Amenitsch, Chiara Garulli, Angelo Bifone, Giulio Caracciolo. Transfection efficiency boost of cholesterol-containing lipoplexes.
Biochimica et biophysica acta.
2012 Sep; 1818(9):2335-43. doi:
10.1016/j.bbamem.2012.05.017. [PMID: 22627109] - Francesco Cardarelli, Daniela Pozzi, Angelo Bifone, Cristina Marchini, Giulio Caracciolo. Cholesterol-dependent macropinocytosis and endosomal escape control the transfection efficiency of lipoplexes in CHO living cells.
Molecular pharmaceutics.
2012 Feb; 9(2):334-40. doi:
10.1021/mp200374e. [PMID: 22196199] - Anna L Capriotti, Giulio Caracciolo, Giuseppe Caruso, Patrizia Foglia, Daniela Pozzi, Roberto Samperi, Aldo Laganà. DNA affects the composition of lipoplex protein corona: a proteomics approach.
Proteomics.
2011 Aug; 11(16):3349-58. doi:
10.1002/pmic.201000803. [PMID: 21751361] - Malou Henriksen-Lacey, Dennis Christensen, Vincent W Bramwell, Thomas Lindenstrøm, Else Marie Agger, Peter Andersen, Yvonne Perrie. Comparison of the depot effect and immunogenicity of liposomes based on dimethyldioctadecylammonium (DDA), 3β-[N-(N',N'-Dimethylaminoethane)carbomyl] cholesterol (DC-Chol), and 1,2-Dioleoyl-3-trimethylammonium propane (DOTAP): prolonged liposome retention mediates stronger Th1 responses.
Molecular pharmaceutics.
2011 Feb; 8(1):153-61. doi:
10.1021/mp100208f. [PMID: 21117621] - Mónica Muñoz-Ubeda, Alberto Rodríguez-Pulido, Aurora Nogales, Alberto Martín-Molina, Emilio Aicart, Elena Junquera. Effect of lipid composition on the structure and theoretical phase diagrams of DC-Chol/DOPE-DNA lipoplexes.
Biomacromolecules.
2010 Dec; 11(12):3332-40. doi:
10.1021/bm1008124. [PMID: 21058732] - Anna Laura Capriotti, Giulio Caracciolo, Giuseppe Caruso, Chiara Cavaliere, Daniela Pozzi, Roberto Samperi, Aldo Laganà. Analysis of plasma protein adsorption onto DC-Chol-DOPE cationic liposomes by HPLC-CHIP coupled to a Q-TOF mass spectrometer.
Analytical and bioanalytical chemistry.
2010 Dec; 398(7-8):2895-903. doi:
10.1007/s00216-010-4104-y. [PMID: 20859620] - Marc-André Bellavance, Marie-Belle Poirier, David Fortin. Uptake and intracellular release kinetics of liposome formulations in glioma cells.
International journal of pharmaceutics.
2010 Aug; 395(1-2):251-9. doi:
10.1016/j.ijpharm.2010.05.017. [PMID: 20573571] - Emmanuel A Ho, Euan Ramsay, Mihaela Ginj, Malathi Anantha, Isaiah Bregman, Jonathan Sy, Janet Woo, Maryam Osooly-Talesh, Donald T Yapp, Marcel B Bally. Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties.
Journal of pharmaceutical sciences.
2010 Jun; 99(6):2839-53. doi:
10.1002/jps.22043. [PMID: 20091826] - Yang Zhang, Huimei Li, Jing Sun, Jie Gao, Wei Liu, Bohua Li, Yajun Guo, Jianming Chen. DC-Chol/DOPE cationic liposomes: a comparative study of the influence factors on plasmid pDNA and siRNA gene delivery.
International journal of pharmaceutics.
2010 May; 390(2):198-207. doi:
10.1016/j.ijpharm.2010.01.035. [PMID: 20116418] - Giulio Caracciolo, Luciano Callipo, Sofia Candeloro De Sanctis, Chiara Cavaliere, Daniela Pozzi, Aldo Laganà. Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol-DOPE/DNA lipoplexes in serum.
Biochimica et biophysica acta.
2010 Mar; 1798(3):536-43. doi:
10.1016/j.bbamem.2009.11.007. [PMID: 19917267] - Yoshie Maitani. Lipoplex formation using liposomes prepared by ethanol injection.
Methods in molecular biology (Clifton, N.J.).
2010; 605(?):393-403. doi:
10.1007/978-1-60327-360-2_27. [PMID: 20072896] - Julia Myschik, Warren T McBurney, Thomas Rades, Sarah Hook. Immunostimulatory lipid implants containing Quil-A and DC-cholesterol.
International journal of pharmaceutics.
2008 Nov; 363(1-2):91-8. doi:
10.1016/j.ijpharm.2008.07.014. [PMID: 18692555] - Alberto Rodríguez-Pulido, Francisco Ortega, Oscar Llorca, Emilio Aicart, Elena Junquera. A physicochemical characterization of the interaction between DC-Chol/DOPE cationic liposomes and DNA.
The journal of physical chemistry. B.
2008 Oct; 112(39):12555-65. doi:
10.1021/jp804066t. [PMID: 18729499] - Meng Meng, Yu Liu, Yi-Bo Wang, Jian-Cheng Wang, Hua Zhang, Xue-Qing Wang, Xuan Zhang, Wan-Liang Lu, Qiang Zhang. Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes.
Journal of controlled release : official journal of the Controlled Release Society.
2008 Jun; 128(2):113-9. doi:
10.1016/j.jconrel.2008.03.001. [PMID: 18423766] - Yoshie Maitani, Yukio Aso, Atsushi Yamada, Sumie Yoshioka. Effect of sugars on storage stability of lyophilized liposome/DNA complexes with high transfection efficiency.
International journal of pharmaceutics.
2008 May; 356(1-2):69-75. doi:
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Vaccine.
2008 May; 26(21):2657-66. doi:
10.1016/j.vaccine.2007.11.002. [PMID: 18068876] - Carlos R Benatti, M Teresa Lamy, Richard M Epand. Cationic amphiphiles and the solubilization of cholesterol crystallites in membrane bilayers.
Biochimica et biophysica acta.
2008 Apr; 1778(4):844-53. doi:
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Biomaterials.
2008 Mar; 29(9):1262-72. doi:
10.1016/j.biomaterials.2007.11.016. [PMID: 18076985] - Wei Zhao, Hui-Li Ma, Xian-Rong Qi. [Cationic liposomes loaded with doxorubicin targeting to the tumor neovasculature in vitro].
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2007 Sep; 42(9):982-8. doi:
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Journal of controlled release : official journal of the Controlled Release Society.
2007 Jul; 120(1-2):122-30. doi:
10.1016/j.jconrel.2007.04.012. [PMID: 17512626] - Laura Ciani, Angela Casini, Chiara Gabbiani, Sandra Ristori, Luigi Messori, Giacomo Martini. DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques.
Biophysical chemistry.
2007 May; 127(3):213-20. doi:
10.1016/j.bpc.2007.02.003. [PMID: 17350156] - Ildiko Badea, Shawn Wettig, Ronald Verrall, Marianna Foldvari. Topical non-invasive gene delivery using gemini nanoparticles in interferon-gamma-deficient mice.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 Mar; 65(3):414-22. doi:
10.1016/j.ejpb.2007.01.002. [PMID: 17292593] - Claudio Esposito, Johanna Generosi, Giuseppe Mossa, Andrea Masotti, Agostina Congiu Castellano. The analysis of serum effects on structure, size and toxicity of DDAB-DOPE and DC-Chol-DOPE lipoplexes contributes to explain their different transfection efficiency.
Colloids and surfaces. B, Biointerfaces.
2006 Dec; 53(2):187-92. doi:
10.1016/j.colsurfb.2006.09.011. [PMID: 17049213] - Anna Salvati, Laura Ciani, Sandra Ristori, Giacomo Martini, Alessio Masi, Annarosa Arcangeli. Physico-chemical characterization and transfection efficacy of cationic liposomes containing the pEGFP plasmid.
Biophysical chemistry.
2006 Apr; 121(1):21-9. doi:
10.1016/j.bpc.2005.12.009. [PMID: 16413096] - Dirk G Lendemans, Julia Myschik, Sarah Hook, Thomas Rades. Cationic cage-like complexes formed by DC-cholesterol, Quil-A, and phospholipid.
Journal of pharmaceutical sciences.
2005 Aug; 94(8):1794-807. doi:
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Experimental eye research.
2005 Jan; 80(1):93-101. doi:
10.1016/j.exer.2004.08.024. [PMID: 15652530] - Laura Ciani, Sandra Ristori, Anna Salvati, Luca Calamai, Giacomo Martini. DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra.
Biochimica et biophysica acta.
2004 Jul; 1664(1):70-9. doi:
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Pharmaceutical research.
2004 Jun; 21(6):1009-17. doi:
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2004 Jan; 39(1):72-6. doi:
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2003 Sep; 38(9):698-701. doi:
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Biochemistry.
2003 May; 42(20):6067-77. doi:
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Chembiochem : a European journal of chemical biology.
2003 Apr; 4(4):286-98. doi:
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Journal of drug targeting.
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Head & neck.
2002 Jul; 24(7):661-9. doi:
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Hepatology (Baltimore, Md.).
2001 Aug; 34(2):417-23. doi:
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Gene therapy.
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FEMS immunology and medical microbiology.
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Vaccine.
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Gene therapy.
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Vaccine.
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Journal of neuroscience research.
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Gene therapy.
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Analytical biochemistry.
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