Refaximin (BioDeep_00000852589)
Chemicals and Drugs
代谢物信息卡片
化学式: C43H51N3O11 (785.3523416)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2N6C=CC(=CC6=N5)C)O)C
InChI: InChI=1S/C43H51N3O11/c1-19-14-16-46-28(18-19)44-32-29-30-37(50)25(7)40-31(29)41(52)43(9,57-40)55-17-15-27(54-10)22(4)39(56-26(8)47)24(6)36(49)23(5)35(48)20(2)12-11-13-21(3)42(53)45-33(34(32)46)38(30)51/h11-18,20,22-24,27,35-36,39,48-51H,1-10H3,(H,45,53)/b12-11-,17-15?,21-13-/t20-,22+,23+,24+,27-,35-,36+,39+,43-/m0/s1
描述信息
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D012294 - Rifamycins
D005765 - Gastrointestinal Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qi Yuan, Yuan Fang, Jingyun Guo, Zheng Zhang, Jinmao Liao, Jia Kuang. Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Toxicology and applied pharmacology.
2024 Mar; 484(?):116845. doi:
10.1016/j.taap.2024.116845. [PMID: 38331104] - Darshan Mehta, Miao Li, Noriko Nakamura, Mani Chidambaram, Xiaobo He, Matthew S Bryant, Ralph Patton, Kelly Davis, Jeffrey Fisher. In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats.
Reproductive toxicology (Elmsford, N.Y.).
2022 08; 111(?):194-203. doi:
10.1016/j.reprotox.2022.06.007. [PMID: 35714934] - Bálint Baráth, Dávid K Jász, Tamara Horváth, Bence Baráth, Gergely Maróti, Gerda Strifler, Gabriella Varga, Lilla Sándor, Domonkos Perényi, Szabolcs Tallósy, Tibor Donka, Péter Jávor, Mihály Boros, Petra Hartmann. Mitochondrial Side Effects of Surgical Prophylactic Antibiotics Ceftriaxone and Rifaximin Lead to Bowel Mucosal Damage.
International journal of molecular sciences.
2022 May; 23(9):. doi:
10.3390/ijms23095064. [PMID: 35563455] - Elisa Pose, Elsa Solà, Juan J Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit, Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T Ma, Marta Carol, Manuel Morales-Ruiz, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G Abraldes, Patrick S Kamath, Mark M Davis, Pere Ginès. Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
Hepatology communications.
2022 05; 6(5):1100-1112. doi:
10.1002/hep4.1881. [PMID: 34964311] - Xin Wen, Cong Shen, Jinyu Xia, Lan-Lan Zhong, Zhongwen Wu, Mohamed Abd El-Gawad El-Sayed Ahmed, Nana Long, Furong Ma, Guili Zhang, Wenwei Wu, Jianlve Luo, Yong Xia, Min Dai, Liyan Zhang, Kang Liao, Siyuan Feng, Cha Chen, Yishen Chen, Wenji Luo, Guo-Bao Tian. Whole-Genome Sequencing Reveals the High Nosocomial Transmission and Antimicrobial Resistance of Clostridioides difficile in a Single Center in China, a Four-Year Retrospective Study.
Microbiology spectrum.
2022 02; 10(1):e0132221. doi:
10.1128/spectrum.01322-21. [PMID: 35019676] - Yuki Fujimoto, Kosuke Kaji, Norihisa Nishimura, Masahide Enomoto, Koji Murata, Soichi Takeda, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji. Dual therapy with zinc acetate and rifaximin prevents from ethanol-induced liver fibrosis by maintaining intestinal barrier integrity.
World journal of gastroenterology.
2021 Dec; 27(48):8323-8342. doi:
10.3748/wjg.v27.i48.8323. [PMID: 35068872] - Junxiong Cheng, Yafang Chen, Wenfu Cao, Guoqing Zuo. Is rifaximin better than nonabsorbable disaccharides in hepatic encephalopathy?: A meta-analysis.
Medicine.
2021 Dec; 100(51):e28232. doi:
10.1097/md.0000000000028232. [PMID: 34941089] - Tomasz Banasiewicz, Jacek Paszkowski, Maciej Borejsza-Wysocki, Adam Bobkiewicz, Anna Pietrzak, Marek Szczepkowski, Wojciech Francuzik. Efficacy of combined prophylactic therapy (rifaximine alpha + prebiotic arabinogalactan with lactofferin) on GUT function in patients with diagnosed symptomatic uncomplicated diverticular disease.
Polski przeglad chirurgiczny.
2019 Aug; 91(4):1-8. doi:
10.5604/01.3001.0013.4115. [PMID: 31481638] - Xiao-Jun Cai, Lei Wang, Chun-Mei Hu. Efficacy of different drugs in the treatment of minimal hepatic encephalopathy: A network meta-analysis involving 826 patients based on 10 randomized controlled trials.
Journal of cellular biochemistry.
2018 11; 119(10):8336-8345. doi:
10.1002/jcb.26886. [PMID: 29932239] - Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Mohamed Refaey, Rasha Elzehery, Rania Elhelaly, Khaled Zalata, Mostafa Abdelsalam, Ahmed A Eldeeb, Mahmoud Awad, Ayman Elgamal, Ahmed Attia, Niveen El-Wakeel, Waleed Eldars. Rifaximin in nonalcoholic fatty liver disease: hit multiple targets with a single shot.
European journal of gastroenterology & hepatology.
2018 10; 30(10):1237-1246. doi:
10.1097/meg.0000000000001232. [PMID: 30096092] - Francesco Drago, Giulia Ciccarese, Eleonora Indemini, Vincenzo Savarino, Aurora Parodi. Psoriasis and small intestine bacterial overgrowth.
International journal of dermatology.
2018 01; 57(1):112-113. doi:
10.1111/ijd.13797. [PMID: 29057460] - Michael Camilleri, Guy Boeckxstaens. Dietary and pharmacological treatment of abdominal pain in IBS.
Gut.
2017 05; 66(5):966-974. doi:
10.1136/gutjnl-2016-313425. [PMID: 28232472] - Alam García-Heredia, Santos García, José Ángel Merino-Mascorro, Peter Feng, Norma Heredia. Natural plant products inhibits growth and alters the swarming motility, biofilm formation, and expression of virulence genes in enteroaggregative and enterohemorrhagic Escherichia coli.
Food microbiology.
2016 Oct; 59(?):124-32. doi:
10.1016/j.fm.2016.06.001. [PMID: 27375253] - Matteo Fornai, Luca Antonioli, Carolina Pellegrini, Rocchina Colucci, Deborah Sacco, Erika Tirotta, Gianfranco Natale, Alessia Bartalucci, Marina Flaibani, Cecilia Renzulli, Emilia Ghelardi, Corrado Blandizzi, Carmelo Scarpignato. Small bowel protection against NSAID-injury in rats: Effect of rifaximin, a poorly absorbed, GI targeted, antibiotic.
Pharmacological research.
2016 Feb; 104(?):186-96. doi:
10.1016/j.phrs.2015.12.031. [PMID: 26747402] - Venkatanarayana Gangarapu, Ali Tüzün Ince, Birol Baysal, Yusuf Kayar, Ulkan Kılıç, Özlem Gök, Ömer Uysal, Hakan Şenturk. Efficacy of rifaximin on circulating endotoxins and cytokines in patients with nonalcoholic fatty liver disease.
European journal of gastroenterology & hepatology.
2015 Jul; 27(7):840-5. doi:
10.1097/meg.0000000000000348. [PMID: 26043290] - Jie Cheng, Kristopher W Krausz, Naoki Tanaka, Frank J Gonzalez. Chronic exposure to rifaximin causes hepatic steatosis in pregnane X receptor-humanized mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Oct; 129(2):456-68. doi:
10.1093/toxsci/kfs211. [PMID: 22790967] - M Furnari, A Parodi, L Gemignani, E G Giannini, S Marenco, E Savarino, L Assandri, V Fazio, D Bonfanti, S Inferrera, V Savarino. Clinical trial: the combination of rifaximin with partially hydrolysed guar gum is more effective than rifaximin alone in eradicating small intestinal bacterial overgrowth.
Alimentary pharmacology & therapeutics.
2010 Oct; 32(8):1000-6. doi:
10.1111/j.1365-2036.2010.04436.x. [PMID: 20937045]