Monensin Sodium (BioDeep_00000852587)
Secondary id: BioDeep_00000404738
Chemicals and Drugs
代谢物信息卡片
Monensin sodium salt
化学式: C36H61NaO11 (692.4111356)
中文名称: 莫能霉素钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1(CCC(O1)C2(CCC3(O2)CC(C(C(O3)C(C)C(C(C)C(=O)[O-])OC)C)O)C)C4C(CC(O4)C5C(CC(C(O5)(CO)O)C)C)C.[Na+]
InChI: /q
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents
D007476 - Ionophores > D061209 - Proton Ionophores
D007476 - Ionophores > D061210 - Sodium Ionophores
D049990 - Membrane Transport Modulators
Monensin sodium salt is an antibiotic secreted by the bacteria Streptomyces cinnamonensis. Monensin sodium salt is an ionophore that mediates Na+/H+ exchange. Monensin sodium salt causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion[1][2][3][4].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 23690927
- MeSH: Monensin
- CAS: 22136-43-2
- CAS: 22373-78-0
- medchemexpress: HY-N0150
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Pedro H V Carvalho, Brooke C Latack, Marcos V C Ferraz, Lester J R P Nolasco, Willi R Meireles, Heitor O M Oliveira, Richard A Zinn. Influence of low-level tannin supplementation on comparative growth performance of Holstein and Angus × Holstein cross calf-fed concentrate-based finishing diets for 328 d.
Journal of animal science.
2024 Jan; 102(?):. doi:
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Journal of dairy science.
2023 Sep; ?(?):. doi:
10.3168/jds.2023-23669. [PMID: 37730175] - Ahu Demirtas, Cátia Pacífico, Theresa Gruber, Remigius Chizzola, Qendrim Zebeli, Ratchaneewan Khiaosa-Ard. Sigla storax (Liquidambar orientalis) mitigates in vitro methane production without disturbances in rumen microbiota and nutrient fermentation in comparison to monensin.
Journal of applied microbiology.
2023 Aug; 134(8):. doi:
10.1093/jambio/lxad154. [PMID: 37475660] - Liqiang Chen, Peihang Jiang, Xinran Shen, Jiayan Lyu, Chendong Liu, Lian Li, Yuan Huang. Cascade Delivery to Golgi Apparatus and On-Site Formation of Subcellular Drug Reservoir for Cancer Metastasis Suppression.
Small (Weinheim an der Bergstrasse, Germany).
2023 03; 19(11):e2204747. doi:
10.1002/smll.202204747. [PMID: 36585358] - Chaoxia Zeng, Mingxia Long, Ying Lu. Monensin synergizes with chemotherapy in uveal melanoma through suppressing RhoA.
Immunopharmacology and immunotoxicology.
2023 Feb; 45(1):35-42. doi:
10.1080/08923973.2022.2112219. [PMID: 36043455] - Wenlin Liao, Mads E Nielsen, Carsten Pedersen, Wenjun Xie, Hans Thordal-Christensen. Barley endosomal MONENSIN SENSITIVITY1 is a target of the powdery mildew effector CSEP0162 and plays a role in plant immunity.
Journal of experimental botany.
2023 01; 74(1):118-129. doi:
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2022 Oct; 35(10):906-916. doi:
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BMC veterinary research.
2022 Sep; 18(1):356. doi:
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2022 Sep; 102(12):5132-5140. doi:
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Tropical animal health and production.
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Nano letters.
2022 02; 22(3):1415-1424. doi:
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2021 Sep; 104(9):10355-10362. doi:
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Parasites & vectors.
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Tropical animal health and production.
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2018 Dec; 96(12):5112-5123. doi:
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In vitro cellular & developmental biology. Animal.
2018 Dec; 54(10):736-742. doi:
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Environmental toxicology and chemistry.
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2018 Sep; 96(9):3916-3927. doi:
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2018 Aug; 101(8):7106-7116. doi:
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2016 Jun; 100(3):537-51. doi:
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Molecular pharmaceutics.
2016 Mar; 13(3):839-51. doi:
10.1021/acs.molpharmaceut.5b00763. [PMID: 26750564] - Belinda B Guo, Shayne A Bellingham, Andrew F Hill. Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions.
The Journal of biological chemistry.
2016 Mar; 291(10):5128-37. doi:
10.1074/jbc.m115.684258. [PMID: 26769968] - C Benchaar. Diet supplementation with cinnamon oil, cinnamaldehyde, or monensin does not reduce enteric methane production of dairy cows.
Animal : an international journal of animal bioscience.
2016 Mar; 10(3):418-25. doi:
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Antimicrobial agents and chemotherapy.
2015 Dec; 60(3):1304-18. doi:
10.1128/aac.01796-15. [PMID: 26666937] - John J Gildea, Peng Xu, Julia M Carlson, Robert T Gaglione, Dora Bigler Wang, Brandon A Kemp, Camellia M Reyes, Helen E McGrath, Robert M Carey, Pedro A Jose, Robin A Felder. The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions.
American journal of physiology. Regulatory, integrative and comparative physiology.
2015 Dec; 309(11):R1447-59. doi:
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Journal of animal science.
2015 Aug; 93(8):3941-9. doi:
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Journal of animal science.
2015 Jul; 93(7):3682-9. doi:
10.2527/jas.2015-8913. [PMID: 26440034] - M Hersom, A Imler, T Thrift, J Yelich, J Arthington. Comparison of feed additive technologies for preconditioning of weaned beef calves.
Journal of animal science.
2015 Jun; 93(6):3169-78. doi:
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Journal of dairy science.
2015 May; 98(5):3366-82. doi:
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Journal of dairy science.
2015 May; 98(5):3351-65. doi:
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Biochimica et biophysica acta.
2015 Apr; 1848(4):995-1004. doi:
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International journal of oncology.
2015 Apr; 46(4):1721-9. doi:
10.3892/ijo.2015.2871. [PMID: 25653196] - E Anassori, B Dalir-Naghadeh, R Pirmohammadi, M Hadian. Changes in blood profile in sheep receiving raw garlic, garlic oil or monensin.
Journal of animal physiology and animal nutrition.
2015 Feb; 99(1):114-122. doi:
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Journal of animal science.
2015 Feb; 93(2):776-85. doi:
10.2527/jas.2014-7958. [PMID: 26020758] - D M Oliveira, A Chalfun-Junior, M L Chizzotti, H G Barreto, T C Coelho, L V Paiva, C P Coelho, P D Teixeira, J P Schoonmaker, M M Ladeira. Expression of genes involved in lipid metabolism in the muscle of beef cattle fed soybean or rumen-protected fat, with or without monensin supplementation.
Journal of animal science.
2014 Dec; 92(12):5426-36. doi:
10.2527/jas.2014-7855. [PMID: 25403202] - Khalil Dayekh, Stephanie Johnson-Obaseki, Martin Corsten, Patrick J Villeneuve, Harmanjatinder S Sekhon, Johanne I Weberpals, Jim Dimitroulakos. Monensin inhibits epidermal growth factor receptor trafficking and activation: synergistic cytotoxicity in combination with EGFR inhibitors.
Molecular cancer therapeutics.
2014 Nov; 13(11):2559-71. doi:
10.1158/1535-7163.mct-13-1086. [PMID: 25189541] - Cynthia L Winkworth, Gavin Lear. Antimicrobial potential of the ionophore monensin on freshwater biofilm bacteria.
Environmental science and pollution research international.
2014 Sep; 21(17):10139-50. doi:
10.1007/s11356-014-2911-y. [PMID: 24809489] - Khodadad Pirali Kheirabadi, Jahangir Kaboutari Katadj, Shahab Bahadoran, Jaime A Teixeira da Silva, Amir Dehghani Samani, Mehdi Cheraghchi Bashi. Comparison of the anticoccidial effect of granulated extract of Artemisia sieberi with monensin in experimental coccidiosis in broiler chickens.
Experimental parasitology.
2014 Jun; 141(?):129-33. doi:
10.1016/j.exppara.2014.03.022. [PMID: 24703975] - Bruno A Rocha, Marilda D Assis, Ana P F Peti, Luiz A B Moraes, Fernanda L Moreira, Norberto P Lopes, Stanislav Pospíšil, Paul J Gates, Anderson R M de Oliveira. In vitro metabolism of monensin A: microbial and human liver microsomes models.
Xenobiotica; the fate of foreign compounds in biological systems.
2014 Apr; 44(4):326-35. doi:
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Journal of dairy science.
2014 Mar; 97(3):1611-22. doi:
10.3168/jds.2013-7162. [PMID: 24377801] - M Kim, M L Eastridge, Z Yu. Investigation of ruminal bacterial diversity in dairy cattle fed supplementary monensin alone and in combination with fat, using pyrosequencing analysis.
Canadian journal of microbiology.
2014 Feb; 60(2):65-71. doi:
10.1139/cjm-2013-0746. [PMID: 24498983] - Bruno Alves Rocha, Anderson Rodrigo Moraes de Oliveira, Murilo Pazin, Daniel Junqueira Dorta, Andresa Piacezzi Nascimento Rodrigues, Andresa Aparecida Berretta, Ana Paula Ferranti Peti, Luiz Alberto Beraldo de Moraes, Norberto Peporine Lopes, Stanislav Pospíšil, Paul Jonathan Gates, Marilda das Dores Assis. Jacobsen catalyst as a cytochrome P450 biomimetic model for the metabolism of monensin A.
BioMed research international.
2014; 2014(?):152102. doi:
10.1155/2014/152102. [PMID: 24987668] - Pierre Bonnafous, Marie-Claire Nicolaï, Jean-Christophe Taveau, Michel Chevalier, Fabienne Barrière, Julie Medina, Olivier Le Bihan, Olivier Adam, Frédéric Ronzon, Olivier Lambert. Treatment of influenza virus with beta-propiolactone alters viral membrane fusion.
Biochimica et biophysica acta.
2014 Jan; 1838(1 Pt B):355-63. doi:
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Meat science.
2014 Jan; 96(1):597-605. doi:
10.1016/j.meatsci.2013.04.062. [PMID: 24018278] - Lorena Sánchez-Felipe, Enrique Villar, Isabel Muñoz-Barroso. Entry of Newcastle Disease Virus into the host cell: role of acidic pH and endocytosis.
Biochimica et biophysica acta.
2014 Jan; 1838(1 Pt B):300-9. doi:
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Journal of animal science.
2013 Nov; 91(11):5438-47. doi:
10.2527/jas.2011-4885. [PMID: 24085413] - G-Y Wang, P Tu, X Chen, Y-G Guo, S-X Jiang. Effect of three polyether ionophores on pharmacokinetics of florfenicol in male broilers.
Journal of veterinary pharmacology and therapeutics.
2013 Oct; 36(5):494-501. doi:
10.1111/jvp.12020. [PMID: 23067134] - Nelmy Narvaez, Yuxi Wang, Tim McAllister. Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro.
Journal of the science of food and agriculture.
2013 Aug; 93(10):2517-22. doi:
10.1002/jsfa.6068. [PMID: 23483574] - Sh Khodamoradi, F Fatahnia, K Taherpour, V Pirani, L Rashidi, A Azarfar. Effect of monensin and vitamin E on milk production and composition of lactating dairy cows.
Journal of animal physiology and animal nutrition.
2013 Aug; 97(4):666-74. doi:
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The Canadian veterinary journal = La revue veterinaire canadienne.
2013 Jul; 54(7):693-7. doi:
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Molecular immunology.
2013 Jun; 54(2):115-21. doi:
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Molecular pharmaceutics.
2013 May; 10(5):1874-89. doi:
10.1021/mp3006566. [PMID: 23480483] - Daniel Aowicki, Adam Huczyński. Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.
BioMed research international.
2013; 2013(?):742149. doi:
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Nature communications.
2013; 4(?):2123. doi:
10.1038/ncomms3123. [PMID: 23828504] - Pinky Sharma, Shailender Singh Kanwar, S N Sanyal. Effect of cationic ionophore monensin on the lipid composition and fluidity of rat epididymal spermatozoal membrane.
Drug and chemical toxicology.
2013 Jan; 36(1):79-87. doi:
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PloS one.
2013; 8(7):e70283. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Dec; 50(12):4449-60. doi:
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