Bisoprolol monofumarate (BioDeep_00000852572)
代谢物信息卡片
Bisoprolol monofumarate
化学式: C22H35NO8 (441.236255)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O.C(=CC(=O)O)C(=O)O
InChI: 2-1+
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kamal Sharma, Hardik Desai, Neha Sharm, Mukesh Laddha, Kalpesh Hansora, Prashant Vazirani. To Evaluate the 'Real World' Clinical Performance of Bisoprolol in Post-Myocardial Infarction with Left Ventricular Dysfunction: Tenacity Study.
The Journal of the Association of Physicians of India.
2022 Apr; 70(4):11-12. doi:
. [PMID: 35443400] - Joshua Wong, Sameer Sharma, Jessica V Yao, Anuradha Aggarwal, Leeanne Grigg. COVID-19 mRNA vaccine (Comirnaty)-induced myocarditis.
The Medical journal of Australia.
2022 02; 216(3):122-123. doi:
10.5694/mja2.51394. [PMID: 35075640] - Ahmed Mohamed Youssef, Hesham Abdallah Elghoneimy, Maged Wasfy Helmy, Ahmed Mokhtar Abdelazeem, Noha Mahmoud El-Khodary. Effect of amlodipine versus bisoprolol in hypertensive patients on maintenance hemodialysis: A randomized controlled trial.
Medicine.
2021 Dec; 100(51):e28322. doi:
10.1097/md.0000000000028322. [PMID: 34941131] - Tommaso D'Angelo, Antonino Cattafi, Maria Ludovica Carerj, Christian Booz, Giorgio Ascenti, Giuseppe Cicero, Alfredo Blandino, Silvio Mazziotti. Myocarditis After SARS-CoV-2 Vaccination: A Vaccine-Induced Reaction?.
The Canadian journal of cardiology.
2021 10; 37(10):1665-1667. doi:
10.1016/j.cjca.2021.05.010. [PMID: 34118375] - Yuji Takahashi, Tomohiro Sonoo, Hidehiko Nakano, Hiromu Naraba, Hideki Hashimoto, Kensuke Nakamura. The influence of edema on the bisoprolol blood concentration after bisoprolol dermal patch application: A case-control study.
Medicine.
2021 Sep; 100(38):e27354. doi:
10.1097/md.0000000000027354. [PMID: 34559159] - Melanie McGinlay, Sam Straw, Jacob Jagger, Bako Nouri, John Gierula, Klaus K Witte. Impact of the COVID-19 pandemic on the management of chronic heart failure.
Reviews in cardiovascular medicine.
2021 06; 22(2):271-276. doi:
10.31083/j.rcm2202034. [PMID: 34258895] - Joyce S Macwan, Grace Fraczkiewicz, Mauro Bertolino, Phillip Krüger, Sheila-Annie Peters. Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol.
CPT: pharmacometrics & systems pharmacology.
2021 06; 10(6):622-632. doi:
10.1002/psp4.12634. [PMID: 34080804] - Philippe Bégin, Jeannie Callum, Nancy M Heddle, Richard Cook, Michelle P Zeller, Alan Tinmouth, Dean A Fergusson, Melissa M Cushing, Marshall J Glesby, Michaël Chassé, Dana V Devine, Nancy Robitalle, Renée Bazin, Nadine Shehata, Andrés Finzi, Allison McGeer, Damon C Scales, Lisa Schwartz, Alexis F Turgeon, Ryan Zarychanski, Nick Daneman, Richard Carl, Luiz Amorim, Caroline Gabe, Martin Ellis, Bruce S Sachais, Kent Cadogan Loftsgard, Erin Jamula, Julie Carruthers, Joanne Duncan, Kayla Lucier, Na Li, Yang Liu, Chantal Armali, Amie Kron, Dimpy Modi, Marie-Christine Auclair, Sabrina Cerro, Meda Avram, Donald M Arnold. Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial.
Trials.
2021 May; 22(1):323. doi:
10.1186/s13063-021-05235-3. [PMID: 33947446] - Rod J Azadan, Nadia H Agha, Hawley E Kunz, Forrest L Baker, Preteesh L Mylabathula, Tracy A Ledoux, Daniel P O'Connor, Charles R Pedlar, Richard J Simpson. The effects of normoxic endurance exercise on erythropoietin (EPO) production and the impact of selective β1 and non-selective β1 + β2 adrenergic receptor blockade.
European journal of applied physiology.
2021 May; 121(5):1499-1511. doi:
10.1007/s00421-020-04558-4. [PMID: 33646423] - Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 05; 77(5):704-712. doi:
10.1053/j.ajkd.2020.07.023. [PMID: 33010357] - Peter McGranaghan, Anshul Saxena, Hans-Dirk Düngen, Muni Rubens, Sandeep Appunni, Joseph Salami, Emir Veledar, Philipp Lacour, Florian Blaschke, Danilo Obradovic, Goran Loncar, Elvis Tahirovic, Frank Edelmann, Burkert Pieske, Tobias Daniel Trippel. Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure.
Scientific reports.
2021 04; 11(1):8164. doi:
10.1038/s41598-021-87776-w. [PMID: 33854188] - Jing Wang, Jing Liu, Liang Xie, Xiaomin Cai, Xiaohua Ma, Jianbin Gong. Bisoprolol, a β1 antagonist, protects myocardial cells from ischemia-reperfusion injury via PI3K/AKT/GSK3β pathway.
Fundamental & clinical pharmacology.
2020 Dec; 34(6):708-720. doi:
10.1111/fcp.12562. [PMID: 32363697] - Marina Krasnova, Alexander Kulikov, Sergey Okovityi, Dmitry Ivkin, Andrey Karpov, Elena Kaschina, Alexey Smirnov. Comparative efficacy of empagliflozin and drugs of baseline therapy in post-infarct heart failure in normoglycemic rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 09; 393(9):1649-1658. doi:
10.1007/s00210-020-01873-7. [PMID: 32377771] - Takuto Arita, Shinya Suzuki, Yuko Kato, Hiroto Kano, Junji Yajima, Shunsuke Matsuno, Takayuki Otsuka, Hiroaki Semba, Tokuhisa Uejima, Yuji Oikawa, Kazuyuki Nagashima, Naoharu Yagi, Koichi Sagara, Gen Tanabe, Takeshi Yamashita. Association Between Dose and Plasma Concentration of Bisoprolol in Patients with Heart Failure (CVI ARO 6).
International heart journal.
2020 Jul; 61(4):748-754. doi:
10.1536/ihj.20-052. [PMID: 32684605] - Masaya Shinohara, Ryou Wada, Shintaro Yao, Kensuke Yano, Katsuya Akitsu, Hideki Koike, Toshio Kinoshita, Hitomi Yuzawa, Takeya Suzuki, Tadashi Fujino, Takanori Ikeda. Comparison of the Transdermal Bisoprolol Patch with Oral Bisoprolol Fumarate Administration as a Therapeutic Agent for Idiopathic Frequent Premature Ventricular Contractions.
International heart journal.
2020 May; 61(3):510-516. doi:
10.1536/ihj.19-643. [PMID: 32418969] - Sven Fikenzer, Kati Fikenzer, Ulrich Laufs, Roberto Falz, Antina Schulze, Martin Busse. Effects of cardioselective beta-blockade on plasma catecholamines and performance during different forms of exercise.
The Journal of sports medicine and physical fitness.
2020 Apr; 60(4):643-649. doi:
10.23736/s0022-4707.19.10225-3. [PMID: 31818057] - Takuto Arita, Shinya Suzuki, Yuko Kato, Hiroto Kano, Junji Yajima, Shunsuke Matsuno, Takayuki Otsuka, Hiroaki Semba, Tokuhisa Uejima, Yuji Oikawa, Kazuyuki Nagashima, Naoharu Yagi, Koichi Sagara, Gen Tanabe, Takeshi Yamashita. Association between bisoprolol plasma concentration and worsening of heart failure: (CVI ARO 6).
Drug metabolism and pharmacokinetics.
2020 Apr; 35(2):228-237. doi:
10.1016/j.dmpk.2020.01.002. [PMID: 32044255] - Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan. Effect of Bisoprolol on the Level of Dabigatran.
American journal of therapeutics.
2020 Mar; 27(2):e159-e164. doi:
10.1097/mjt.0000000000000786. [PMID: 30074534] - Michael Doumas, Konstantinos P Imprialos, Manolis S Kallistratos, Athanasios J Manolis. Recent advances in understanding and managing resistant/refractory hypertension.
F1000Research.
2020; 9(?):. doi:
10.12688/f1000research.21669.1. [PMID: 32201574] - Sarah Al Fawaz, Mohammad Al Deeb, James L Huffman, Naji A Al Kholaif, Fiona Garlich, Ryan Chuang. A Case of Status Epilepticus and Transient Stress Cardiomyopathy Associated with Smoking the Synthetic Psychoactive Cannabinoid, UR-144.
The American journal of case reports.
2019 Dec; 20(?):1902-1906. doi:
10.12659/ajcr.918918. [PMID: 31857571] - O B Kuzmin, N N Buchneva, V V Zhezha, S V Serdyuk. [Uncontrolled Arterial Hypertension: Kidney, Neurohormonal Imbalance, and Approaches to Antihypertensive Drug Therapy].
Kardiologiia.
2019 Dec; 59(12):64-71. doi:
10.18087/cardio.2019.12.n547. [PMID: 31849313] - Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
10.1016/j.jchromb.2019.121793. [PMID: 31629310] - Maurizio Sessa, Annamaria Mascolo, Daniel Bech Rasmussen, Kristian Kragholm, Magnus Thorsten Jensen, Liberata Sportiello, Concetta Rafaniello, Giuseppe Michele Tari, Claudia Pagliaro, Morten Andersen, Francesco Rossi, Annalisa Capuano. Beta-blocker choice and exchangeability in patients with heart failure and chronic obstructive pulmonary disease: an Italian register-based cohort study.
Scientific reports.
2019 08; 9(1):11465. doi:
10.1038/s41598-019-47967-y. [PMID: 31391573] - Kazuyoshi Kakehi, Yoshitaka Iwanaga, Heitaro Watanabe, Takashi Sonobe, Tsuyoshi Akiyama, Shuji Shimizu, Hiromi Yamamoto, Shunichi Miyazaki. Modulation of Sympathetic Activity and Innervation With Chronic Ivabradine and β-Blocker Therapies: Analysis of Hypertensive Rats With Heart Failure.
Journal of cardiovascular pharmacology and therapeutics.
2019 07; 24(4):387-396. doi:
10.1177/1074248419829168. [PMID: 30786751] - Hiroyuki Tsutsui, Shin-Ichi Momomura, Tohru Masuyama, Yoshihiko Saito, Issei Komuro, Toyoaki Murohara, Shintaro Kinugawa. Tolerability, Efficacy, and Safety of Bisoprolol vs. Carvedilol in Japanese Patients With Heart Failure and Reduced Ejection Fraction - The CIBIS-J Trial.
Circulation journal : official journal of the Japanese Circulation Society.
2019 05; 83(6):1269-1277. doi:
10.1253/circj.cj-18-1199. [PMID: 30956267] - Ahmad Abdulrahman Almeman, Yasir Ahmed Beshir, Ahmad Hamad Aldosary. Comparison of the Effects of Metoprolol and Bisoprolol on Lipid and Glucose Profiles in Cardiovascular Patients.
Current drug safety.
2019; 14(1):27-30. doi:
10.2174/1574886313666181029101247. [PMID: 30370856] - Chaoying Hu, Xiao Hu, Chunhua Wang, Zirun Zhao, Dan Gao, Xiaoping Chen, Dongli Zhou, Yue Huang, Lin Li, Lan Zhang. Bioequivalence and Pharmacokinetics of Bisoprolol-Amlodipine 5 mg/5 mg Combination Tablet versus Bisoprolol 5 mg Tablet and Amlodipine 5 mg Tablet: An Open-Label, Randomized, Two-Sequence Crossover Study in Healthy Chinese Subjects.
Clinical drug investigation.
2018 Dec; 38(12):1145-1154. doi:
10.1007/s40261-018-0700-y. [PMID: 30232699] - Hanqing Zhao, Chao Liu, Degong Yang, Xiaocao Wan, Rui Shang, Peng Quan, Liang Fang. Molecular mechanism of ion-pair releasing from acrylic pressure sensitive adhesive containing carboxyl group: Roles of doubly ionic hydrogen bond in the controlled release process of bisoprolol ion-pair.
Journal of controlled release : official journal of the Controlled Release Society.
2018 11; 289(?):146-157. doi:
10.1016/j.jconrel.2018.09.024. [PMID: 30268589] - Richard Myles Turner, Vanessa Fontana, Mark Bayliss, Sarah Whalley, Anahi Santoyo Castelazo, Munir Pirmohamed. Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort.
Journal of pharmaceutical and biomedical analysis.
2018 Sep; 159(?):272-281. doi:
10.1016/j.jpba.2018.06.062. [PMID: 30005242] - Andrzej Madej, Józefa Dąbek, Michał Majewski, Justyna Szuta. Effect of perindopril and bisoprolol on IL-2, INF-γ, hs-CRP and T-cell stimulation and correlations with blood pressure in mild and moderate hypertension.
International journal of clinical pharmacology and therapeutics.
2018 Sep; 56(9):393-399. doi:
10.5414/cp203249. [PMID: 29809132] - Bryan Williams, Thomas M MacDonald, Steve V Morant, David J Webb, Peter Sever, Gordon T McInnes, Ian Ford, J Kennedy Cruickshank, Mark J Caulfield, Sandosh Padmanabhan, Isla S Mackenzie, Jackie Salsbury, Morris J Brown. Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies.
The lancet. Diabetes & endocrinology.
2018 06; 6(6):464-475. doi:
10.1016/s2213-8587(18)30071-8. [PMID: 29655877] - Alvin Tieu, Thomas J Velenosi, Andrew S Kucey, Matthew A Weir, Bradley L Urquhart. β-Blocker Dialyzability in Maintenance Hemodialysis Patients: A Randomized Clinical Trial.
Clinical journal of the American Society of Nephrology : CJASN.
2018 04; 13(4):604-611. doi:
10.2215/cjn.07470717. [PMID: 29519953] - Maurizio Sessa, Annamaria Mascolo, Rikke Nørmark Mortensen, Mikkel Porsborg Andersen, Giuseppe Massimo Claudio Rosano, Annalisa Capuano, Francesco Rossi, Gunnar Gislason, Henrik Enghusen-Poulsen, Christian Torp-Pedersen. Relationship between heart failure, concurrent chronic obstructive pulmonary disease and beta-blocker use: a Danish nationwide cohort study.
European journal of heart failure.
2018 03; 20(3):548-556. doi:
10.1002/ejhf.1045. [PMID: 29159953] - Elizabeth do Espirito Santo Cestário, Letícia Aparecida Barufi Fernandes, Luiz Tadeu Giollo-Júnior, Jéssica Rodrigues Roma Uyemura, Camila Suemi Sato Matarucco, Manoel Idelfonso Paz Landim, Luciana Neves Cosenso-Martin, Lúcia Helena Bonalume Tácito, Heitor Moreno, José Fernando Vilela-Martin, Juan Carlos Yugar-Toledo. Resistant Hypertension On Treatment (ResHypOT): sequential nephron blockade compared to dual blockade of the renin-angiotensin-aldosterone system plus bisoprolol in the treatment of resistant arterial hypertension - study protocol for a randomized controlled trial.
Trials.
2018 Feb; 19(1):101. doi:
10.1186/s13063-017-2343-3. [PMID: 29433578] - Nadia H Agha, Forrest L Baker, Hawley E Kunz, Rachel Graff, Rod Azadan, Chad Dolan, Mitzi S Laughlin, Chitra Hosing, Melissa M Markofski, Richard A Bond, Catherine M Bollard, Richard J Simpson. Vigorous exercise mobilizes CD34+ hematopoietic stem cells to peripheral blood via the β2-adrenergic receptor.
Brain, behavior, and immunity.
2018 02; 68(?):66-75. doi:
10.1016/j.bbi.2017.10.001. [PMID: 29017969] - Valentina N Nikolic, Slobodan M Jankovic, Marina Deljanin-Ilic, Sanja S Stojanovic, Miroslav Lj Nikolic, Slavoljub Zivanovic, Dragana Stokanovic, Tatjana Jevtovic-Stoimenov, Jasmina R Milovanovic. Population Pharmacokinetic Analysis of Bisoprolol in Patients with Stable Coronary Artery Disease.
European journal of drug metabolism and pharmacokinetics.
2018 Feb; 43(1):35-44. doi:
10.1007/s13318-017-0414-1. [PMID: 28577178] - Ali Sigaroudi, Martina Kinzig, Oliver Wahl, Christoph Stelzer, Michael Schroeter, Uwe Fuhr, Ulrike Holzgrabe, Fritz Sörgel. Quantification of Bisoprolol and Metoprolol in Simultaneous Human Serum and Cerebrospinal Fluid Samples.
Pharmacology.
2018; 101(1-2):29-34. doi:
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Journal of clinical pharmacology.
2017 Dec; 57(12):1534-1544. doi:
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Journal of the American College of Cardiology.
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Hypertension research : official journal of the Japanese Society of Hypertension.
2017 Jan; 40(1):79-86. doi:
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The Journal of pharmacy and pharmacology.
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European journal of clinical pharmacology.
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Polskie Archiwum Medycyny Wewnetrznej.
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Hypertension research : official journal of the Japanese Society of Hypertension.
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Journal of the American Heart Association.
2016 Jan; 5(1):. doi:
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Pharmacology.
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Journal of chromatography. A.
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Lancet (London, England).
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Pakistan journal of pharmaceutical sciences.
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Likars'ka sprava.
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Journal of chromatographic science.
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American journal of hypertension.
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European heart journal.
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International journal of cardiology.
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European journal of clinical pharmacology.
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