Tauroselcholic acid se-75 (BioDeep_00000849201)
Bile acids
代谢物信息卡片
Tauroselcholic acid se-75
化学式: C26H45NO7SSe (595.208179)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(bile_acids) 75%
分子结构信息
SMILES: CC(C[Se]CC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
InChI: InChI=1S/C26H45NO7SSe/c1-15(13-36-14-23(31)27-8-9-35(32,33)34)18-4-5-19-24-20(12-22(30)26(18,19)3)25(2)7-6-17(28)10-16(25)11-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1/i36-4
描述信息
V - Various > V09 - Diagnostic radiopharmaceuticals > V09D - Hepatic and reticulo endothelial system
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lauren E Hughes, Clare Ford, Matthew J Brookes, Rousseau Gama. Bile acid diarrhoea: Current and potential methods of diagnosis.
Annals of clinical biochemistry.
2021 01; 58(1):22-28. doi:
10.1177/0004563220966139. [PMID: 32998535] - Michael Camilleri, Priya Vijayvargiya. The Role of Bile Acids in Chronic Diarrhea.
The American journal of gastroenterology.
2020 10; 115(10):1596-1603. doi:
10.14309/ajg.0000000000000696. [PMID: 32558690] - Ian B Jeffery, Anubhav Das, Eileen O'Herlihy, Simone Coughlan, Katryna Cisek, Michael Moore, Fintan Bradley, Tom Carty, Meenakshi Pradhan, Chinmay Dwibedi, Fergus Shanahan, Paul W O'Toole. Differences in Fecal Microbiomes and Metabolomes of People With vs Without Irritable Bowel Syndrome and Bile Acid Malabsorption.
Gastroenterology.
2020 03; 158(4):1016-1028.e8. doi:
10.1053/j.gastro.2019.11.301. [PMID: 31843589] - Ivan Lyutakov, Francesco Ursini, Plamen Penchev, Giacomo Caio, Antonio Carroccio, Umberto Volta, Roberto De Giorgio. Methods for diagnosing bile acid malabsorption: a systematic review.
BMC gastroenterology.
2019 Nov; 19(1):185. doi:
10.1186/s12876-019-1102-1. [PMID: 31726982] - A Baena García, F Partida Palma, S García Martínez, M de Bonilla Candau, M Pajares Vinardell. 75Se-Homocholic acid taurine scintigraphy (75SeHCAT®), a standard benchmark test in bile acid malabsorption?.
Revista espanola de medicina nuclear e imagen molecular.
2019 Sep; 38(5):305-311. doi:
10.1016/j.remn.2018.12.005. [PMID: 30745130] - Priya Vijayvargiya, Michael Camilleri. Update on Bile Acid Malabsorption: Finally Ready for Prime Time?.
Current gastroenterology reports.
2018 Mar; 20(3):10. doi:
10.1007/s11894-018-0615-z. [PMID: 29582208] - N Mottacki, M Simrén, A Bajor. Review article: bile acid diarrhoea - pathogenesis, diagnosis and management.
Alimentary pharmacology & therapeutics.
2016 04; 43(8):884-898. doi:
10.1111/apt.13570. [PMID: 26913381] - Ian M Johnston, Jonathan D Nolan, Sanjeev S Pattni, Richard N Appleby, Justine H Zhang, Sarah L Kennie, Gaganjit K Madhan, Sina Jameie-Oskooei, Shivani Pathmasrirengam, Jeremy Lin, Albert Hong, Peter H Dixon, Catherine Williamson, Julian R F Walters. Characterizing Factors Associated With Differences in FGF19 Blood Levels and Synthesis in Patients With Primary Bile Acid Diarrhea.
The American journal of gastroenterology.
2016 Mar; 111(3):423-32. doi:
10.1038/ajg.2015.424. [PMID: 26856750] - F Phillips, A C G Muls, A Lalji, H J N Andreyev. Are bile acid malabsorption and bile acid diarrhoea important causes of loose stool complicating cancer therapy?.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.
2015 Aug; 17(8):730-4. doi:
10.1111/codi.12932. [PMID: 25728737] - Antal Bajor, Hans Törnblom, Mats Rudling, Kjell-Arne Ung, Magnus Simrén. Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.
Gut.
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10.1136/gutjnl-2013-305965. [PMID: 24727487] - S S Pattni, W G Brydon, T Dew, I M Johnston, J D Nolan, M Srinivas, P Basumani, K D Bardhan, J R F Walters. Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention.
Alimentary pharmacology & therapeutics.
2013 Oct; 38(8):967-76. doi:
10.1111/apt.12466. [PMID: 23981126] - Julian R F Walters, Ali M Tasleem, Omer S Omer, W Gordon Brydon, Tracy Dew, Carel W le Roux. A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2009 Nov; 7(11):1189-94. doi:
10.1016/j.cgh.2009.04.024. [PMID: 19426836] - Kjell-Arne Ung, Nima Mottacki, Mats Rudling, Antal Bajor. Biliary sphincterotomy does not relate to diarrhoea or major changes in bile acid synthesis or plasma lipids.
Scandinavian journal of gastroenterology.
2009; 44(9):1132-8. doi:
10.1080/00365520903131981. [PMID: 19811340] - G H Sauter, W Münzing, C von Ritter, G Paumgartner. Bile acid malabsorption as a cause of chronic diarrhea: diagnostic value of 7alpha-hydroxy-4-cholesten-3-one in serum.
Digestive diseases and sciences.
1999 Jan; 44(1):14-9. doi:
10.1023/a:1026681512303. [PMID: 9952217] - O Chazouillères, P Marteau, M Haniche, R Jian, R Poupon. Ileal absorption of bile acids in patients with chronic cholestasis: SeHCAT test results and effect of ursodeoxycholic acid (UDCA).
Digestive diseases and sciences.
1996 Dec; 41(12):2417-22. doi:
10.1007/bf02100137. [PMID: 9011452] - M A Färkkilä, K J Kairemo, M J Taavitsainen, T A Strandberg, T A Miettinen. Plasma lathosterol as a screening test for bile acid malabsorption due to ileal resection: correlation with 75SeHCAT test and faecal bile acid excretion.
Clinical science (London, England : 1979).
1996 Apr; 90(4):315-9. doi:
10.1042/cs0900315. [PMID: 8777839] - W G Brydon, H Nyhlin, M A Eastwood, M V Merrick. Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea.
European journal of gastroenterology & hepatology.
1996 Feb; 8(2):117-23. doi:
10.1097/00042737-199602000-00005. [PMID: 8723414] - J S de Caestecker, R P Jazrawi, J A Nisbett, A E Joseph, J D Maxwell, T C Northfield. Direct assessment of the mechanism for a raised serum bile acid level in chronic liver disease.
European journal of gastroenterology & hepatology.
1995 Oct; 7(10):955-61. doi:
10.1097/00042737-199510000-00009. [PMID: 8590141] - S O'Brien, H Mulcahy, H Fenlon, A O'Broin, M Casey, A Burke, M X FitzGerald, J E Hegarty. Intestinal bile acid malabsorption in cystic fibrosis.
Gut.
1993 Aug; 34(8):1137-41. doi:
10.1136/gut.34.8.1137. [PMID: 8174969] - S Eusufzai, M Axelson, B Angelin, K Einarsson. Serum 7 alpha-hydroxy-4-cholesten-3-one concentrations in the evaluation of bile acid malabsorption in patients with diarrhoea: correlation to SeHCAT test.
Gut.
1993 May; 34(5):698-701. doi:
10.1136/gut.34.5.698. [PMID: 8504974] - S Milutinović-Djurić, O S Popović, V Milović, D Necić, K M Kostić. Postcholecystectomy diarrhea from villous atrophy of the terminal ileum.
Journal of clinical gastroenterology.
1993 Apr; 16(3):227-30. doi:
10.1097/00004836-199304000-00013. [PMID: 8505495] - K Balzer, N Breuer, E Quebe-Fehling. [Postprandial serum bile acid level and 75SeHCAT retention in diagnosis of bile acid malabsorption syndrome. A comparative study].
Medizinische Klinik (Munich, Germany : 1983).
1993 Feb; 88 Suppl 1(?):23-8. doi:
NULL. [PMID: 8464395] - S Eusufzai, S Ericsson, T Cederlund, K Einarsson, B Angelin. Effect of ursodeoxycholic acid treatment on ileal absorption of bile acids in man as determined by the SeHCAT test.
Gut.
1991 Sep; 32(9):1044-8. doi:
10.1136/gut.32.9.1044. [PMID: 1916489] - A J van Tilburg, F W de Rooij, J W van den Berg, P P Kooij, M van Blankenstein. The selenium-75-homocholic acid taurine test reevaluated: combined measurement of fecal selenium-75 activity and 3 alpha-hydroxy bile acids in 211 patients.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
1991 Jun; 32(6):1219-24. doi:
NULL. [PMID: 2045936] - K J Hastie, P R Baker, A Reid, A Cuschieri. Effect of repeated intraperitoneal chemotherapy with epirubicin on the hepatic transport of bile acids and their enterohepatic circulation.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
1991 Feb; 17(1):54-8. doi:
NULL. [PMID: 1995359] - P Marteau, O Chazouilléres, A Myara, R Jian, J C Rambaud, R Poupon. Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man.
Hepatology (Baltimore, Md.).
1990 Nov; 12(5):1206-8. doi:
10.1002/hep.1840120521. [PMID: 2227819] - J W van den Berg, F W de Rooij, E P Bosman-Jacobs. [75Se]-selenohomotaurocholic acid degradation by bacterial enzymes in vitro and in vivo. Is it still a specific indicator for active ileal bile acid uptake?.
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Zeitschrift fur Gastroenterologie.
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Diseases of the colon and rectum.
1989 Mar; 32(3):230-4. doi:
10.1007/bf02554535. [PMID: 2493363] - R Monks, G S Boyd. Biologic stability of tauro-23-[75Se] selena-25-homocholic acid.
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10.1016/0016-5085(88)90253-3. [PMID: 3338647] - R Ferraris, R Jazrawi, C Bridges, T C Northfield. Use of a gamma-labeled bile acid (75SeHCAT) as a test of ileal function. Methods of improving accuracy.
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1985 Sep; 110(38):1452-7. doi:
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