L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-N6-((4-hydroxyphenyl)iminomethyl)-L-lysyl)-, (S)- (BioDeep_00000849020)
代谢物信息卡片
L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-N6-((4-hydroxyphenyl)iminomethyl)-L-lysyl)-, (S)-
化学式: C28H36N4O6 (524.2634716)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(N(C1)C(=O)C(CCCCN=CNC2=CC=C(C=C2)O)NC(CCC3=CC=CC=C3)C(=O)O)C(=O)O
InChI: InChI=1S/C28H36N4O6/c33-22-14-12-21(13-15-22)30-19-29-17-5-4-9-23(26(34)32-18-6-10-25(32)28(37)38)31-24(27(35)36)16-11-20-7-2-1-3-8-20/h1-3,7-8,12-15,19,23-25,31,33H,4-6,9-11,16-18H2,(H,29,30)(H,35,36)(H,37,38)/t23-,24-,25-/m0/s1
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
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代谢反应
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- R A Hubner, E Kubota, D J Casley, C I Johnston, L M Burrell. In-vitro and in-vivo inhibition of rat neutral endopeptidase and angiotensin converting enzyme with the vasopeptidase inhibitor gemopatrilat.
Journal of hypertension.
2001 May; 19(5):941-6. doi:
10.1097/00004872-200105000-00015. [PMID: 11393678] - W Ribeiro, M N Muscará, A R Martins, H Moreno, G B Mendes, G de Nucci. Bioequivalence study of two enalapril maleate tablet formulations in healthy male volunteers. Pharmacokinetic versus pharmacodynamic approach.
European journal of clinical pharmacology.
1996; 50(5):399-405. doi:
10.1007/s002280050130. [PMID: 8839663] - R B Perich, B Jackson, C I Johnston. Structural constraints of inhibitors for binding at two active sites on somatic angiotensin converting enzyme.
European journal of pharmacology.
1994 Feb; 266(3):201-11. doi:
10.1016/0922-4106(94)90128-7. [PMID: 8174603] - R B Perich, B Jackson, F Rogerson, F A Mendelsohn, D Paxton, C I Johnston. Two binding sites on angiotensin-converting enzyme: evidence from radioligand binding studies.
Molecular pharmacology.
1992 Aug; 42(2):286-93. doi:
NULL. [PMID: 1325031] - K Jandeleit, J Rumble, B Jackson, M E Cooper. Mesenteric vascular angiotensin-converting enzyme is increased in experimental diabetes mellitus.
Clinical and experimental pharmacology & physiology.
1992 May; 19(5):343-7. doi:
10.1111/j.1440-1681.1992.tb00468.x. [PMID: 1325883] - C Gros, N Noël, A Souque, J C Schwartz, D Danvy, J C Plaquevent, L Duhamel, P Duhamel, J M Lecomte, J Bralet. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4.15.1) and enkephalinase (EC 3.4.24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril.
Proceedings of the National Academy of Sciences of the United States of America.
1991 May; 88(10):4210-4. doi:
10.1073/pnas.88.10.4210. [PMID: 1851998] - S Oparil, A J Narkates, R M Jackson, H S Ann. Altered angiotensin-converting enzyme in lung and extrapulmonary tissues of hypoxia-adapted rats.
Journal of applied physiology (Bethesda, Md. : 1985).
1988 Jul; 65(1):218-27. doi:
10.1152/jappl.1988.65.1.218. [PMID: 2841276] - B Jackson, R B Cubela, C I Johnston. Inhibition of tissue angiotensin converting enzyme by perindopril: in vivo assessment in the rat using radioinhibitor binding displacement.
The Journal of pharmacology and experimental therapeutics.
1988 Jun; 245(3):950-5. doi:
NULL. [PMID: 2838609] - K Sakaguchi, S Y Chai, B Jackson, C I Johnston, F A Mendelsohn. Inhibition of tissue angiotensin converting enzyme. Quantitation by autoradiography.
Hypertension (Dallas, Tex. : 1979).
1988 Mar; 11(3):230-8. doi:
10.1161/01.hyp.11.3.230. [PMID: 2832327] - B Jackson, R Cubela, C I Johnston. Measurement of angiotensin converting enzyme inhibitors in serum by radioinhibitor binding displacement assay.
Biochemical pharmacology.
1987 Apr; 36(8):1357-60. doi:
10.1016/0006-2952(87)90094-3. [PMID: 3036166] - C Grönhagen-Riska, I Tikkanen, F Fyhrquist. Competitive inhibitor binding assay (CIBA) of captopril and other ACE inhibitors.
Clinica chimica acta; international journal of clinical chemistry.
1987 Jan; 162(1):53-60. doi:
10.1016/0009-8981(87)90232-4. [PMID: 3026689] - C I Johnston, R Cubela, K Sakaguchi, B Jackson. Angiotensin converting enzyme inhibition in plasma and tissues.
Clinical and experimental hypertension. Part A, Theory and practice.
1987; 9(2-3):307-21. doi:
10.3109/10641968709164190. [PMID: 3038391] - B Jackson, R Cubela, C Johnston. Angiotensin converting enzyme (ACE), characterization by 125I-MK351A binding studies of plasma and tissue ACE during variation of salt status in the rat.
Journal of hypertension.
1986 Dec; 4(6):759-65. doi:
10.1097/00004872-198612000-00011. [PMID: 3029219] - B Jackson, R Cubela, C I Johnston. Characterization of angiotensin converting enzyme from rat tissue by radio-inhibitor binding studies.
Clinical and experimental pharmacology & physiology.
1986 Sep; 13(9):681-9. doi:
10.1111/j.1440-1681.1986.tb02397.x. [PMID: 3026703] - R K Allen, S Y Chai, M S Dunbar, F A Mendelsohn. In vitro autoradiographic localization of angiotensin-converting enzyme in sarcoid lymph nodes.
Chest.
1986 Sep; 90(3):315-20. doi:
10.1378/chest.90.3.315. [PMID: 3017640] - B Jackson, R Cubela, C I Johnston. Angiotensin-converting enzyme (ACE) measurement in human serum using radioinhibitor ligand binding.
The Australian journal of experimental biology and medical science.
1986 Apr; 64 ( Pt 2)(?):149-55. doi:
10.1038/icb.1986.16. [PMID: 3017276] - C Grönhagen-Riska, I Tikkanen, F Fyhrquist. Competitive inhibitor binding assay (CIBA) of ACE inhibitors.
Acta medica Scandinavica. Supplementum.
1986; 714(?):43-7. doi:
10.1111/j.0954-6820.1986.tb08966.x. [PMID: 3033999] - I Tikkanen, F Fyhrquist, T Forslund. Inhibitor binding assay of rat serum angiotensin converting enzyme.
Clinical science (London, England : 1979).
1984 Aug; 67(2):237-41. doi:
10.1042/cs0670237. [PMID: 6086211] - F F Tikkanen, C Grönhagen-Riska. Competitive inhibitor binding assay (IBA) of captopril and other inhibitors of angiotensin converting enzyme.
Scandinavian journal of urology and nephrology. Supplementum.
1984; 79(?):13-6. doi:
NULL. [PMID: 6089313]