n-acetyl-s-(2-hydroxyethyl)-l-cysteine (BioDeep_00000848892)
代谢物信息卡片
n-acetyl-s-(2-hydroxyethyl)-l-cysteine
化学式: C7H13NO4S (207.0565258)
中文名称: N-乙酰基-S-(2-羟乙基)-L-半胱氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC(CSCCO)C(=O)O
InChI: InChI=1S/C7H13NO4S/c1-5(10)8-6(7(11)12)4-13-3-2-9/h6,9H,2-4H2,1H3,(H,8,10)(H,11,12)/t6-/m0/s1
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Brandon M Kenwood, Caitlyn McLoughlin, Luyu Zhang, Wanzhe Zhu, Deepak Bhandari, Víctor R De Jesús, Benjamin C Blount. Characterization of the association between cigarette smoking intensity and urinary concentrations of 2-hydroxyethyl mercapturic acid among exclusive cigarette smokers in the National Health and Nutrition Examination Survey (NHANES) 2011-2016.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2021 Nov; 26(7):656-664. doi:
10.1080/1354750x.2021.1970809. [PMID: 34409911] - Zhang Xiaotao, Hou Hongwei, Xiong Wei, Hu Qingyuan. Simultaneous measurement of N-Acetyl-S-(2-cyanoethyl)-cysteine and N-acetyl-S-(2-hydroxyethyl)-cysteine in human urine by liquid chromatography-tandem mass spectrometry.
Journal of chromatographic science.
2014 Aug; 52(7):719-24. doi:
10.1093/chromsci/bmt106. [PMID: 23902664] - Hongwei Hou, Wei Xiong, Na Gao, Xiaotao Zhang, Gangling Tang, Qingyuan Hu. A column-switching liquid chromatography-tandem mass spectrometry method for quantitation of 2-cyanoethylmercapturic acid and 2-hydroxyethylmercapturic acid in Chinese smokers.
Analytical biochemistry.
2012 Nov; 430(1):75-82. doi:
10.1016/j.ab.2012.07.026. [PMID: 22868354] - Chia-Fang Wu, Shi-Nian Uang, Su-Yin Chiang, Wei-Chung Shih, Yu-Fang Huang, Kuen-Yuh Wu. Simultaneous quantitation of urinary cotinine and acrylonitrile-derived mercapturic acids with ultraperformance liquid chromatography-tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2012 Feb; 402(6):2113-20. doi:
10.1007/s00216-011-5661-4. [PMID: 22231508] - Yan S Ding, Benjamin C Blount, Liza Valentin-Blasini, Heather S Applewhite, Yang Xia, Clifford H Watson, David L Ashley. Simultaneous determination of six mercapturic acid metabolites of volatile organic compounds in human urine.
Chemical research in toxicology.
2009 Jun; 22(6):1018-25. doi:
10.1021/tx800468w. [PMID: 19522547] - Thomas Schettgen, Anita Musiol, Thomas Kraus. Simultaneous determination of mercapturic acids derived from ethylene oxide (HEMA), propylene oxide (2-HPMA), acrolein (3-HPMA), acrylamide (AAMA) and N,N-dimethylformamide (AMCC) in human urine using liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2008 Sep; 22(17):2629-38. doi:
10.1002/rcm.3659. [PMID: 18666198] - A M Calafat, D B Barr, J L Pirkle, D L Ashley. Reference range concentrations of N-acetyl-S-(2-hydroxyethyl)-L-cysteine, a common metabolite of several volatile organic compounds, in the urine of adults in the United States.
Journal of exposure analysis and environmental epidemiology.
1999 Jul; 9(4):336-42. doi:
10.1038/sj.jea.7500032. [PMID: 10489158] - D B Barr, D L Ashley. A rapid, sensitive method for the quantitation of N-acetyl-S-(2-hydroxyethyl)-L-cysteine in human urine using isotope-dilution HPLC-MS-MS.
Journal of analytical toxicology.
1998 Mar; 22(2):96-104. doi:
10.1093/jat/22.2.96. [PMID: 9547405] - W Popp, C Vahrenholz, H Przygoda, A Brauksiepe, S Goch, G Müller, C Schell, K Norpoth. DNA-protein cross-links and sister chromatid exchange frequencies in lymphocytes and hydroxyethyl mercapturic acid in urine of ethylene oxide-exposed hospital workers.
International archives of occupational and environmental health.
1994; 66(5):325-32. doi:
10.1007/bf00378365. [PMID: 7896417] - N P Vermeulen, J de Jong, E J van Bergen, R T van Welie. N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations.
Archives of toxicology.
1989; 63(3):173-84. doi:
10.1007/bf00316366. [PMID: 2669681] - I Linhart, J Smejkal, J Novák. N-acetyl-S-(1-cyano-2-hydroxyethyl)-L-cysteine, a new urinary metabolite of acrylonitrile and oxiranecarbonitrile.
Archives of toxicology.
1988; 61(6):484-8. doi:
10.1007/bf00293695. [PMID: 3190446] - B Scutaru, V Răileanu, D Scutaru. [Determination of hydroxy-ethyl-mercapturic acid by thin layer chromatography].
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi.
1987 Jul; 91(3):553-6. doi:
NULL. [PMID: 3445059] - M Gérin, R Tardif. Urinary N-acetyl-S-2-hydroxyethyl-L-cysteine in rats as biological indicator of ethylene oxide exposure.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1986 Oct; 7(3):419-23. doi:
NULL. [PMID: 3781131] - D Godeneche, M F Moreau, J C Madelmont, J Duprat, R Plagne. Disposition and metabolism in 1-(2-chloroethyl)-3-(2',3',4'-tri-o-acetyl, ribopyranosyl)-1-nitrosourea in rats.
Cancer research.
1982 Feb; 42(2):525-9. doi:
. [PMID: 6799188] - P J van Bladeren, L P Delbressine, J J Hoogeterp, A H Beaumont, D D Breimer, F Seutter-Berlage, A van der Gen. Formation of mercapturic acids from acrylonitrile, crotononitrile, and cinnamonitrile by direct conjugation and via an intermediate oxidation process.
Drug metabolism and disposition: the biological fate of chemicals.
1981 May; 9(3):246-9. doi:
NULL. [PMID: 6113934]